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139 items found for " inflammation"

Posts (94)

  • Platelets in the NETworks interweaving inflammation and thrombosis

    chemokines and growth factors, which upon release may directly engage pathogens and/or contribute to inflammatory interplay between platelets and NETs and the potential of this alliance to influence the course of inflammatory

  • GPR84 signaling promotes intestinal mucosal inflammation via enhancing NLRP3 inflammasome activation

    September 2022 GPR84 signaling promotes intestinal mucosal inflammation via enhancing NLRP3 inflammasome The fact that GPR84 expression in leukocytes is remarkably increased under acute inflammatory stimuli Here we demonstrate that GPR84 is highly upregulated in inflamed colon tissues of active ulcerative colitis GPR84 activation imposes pro-inflammatory properties in colonic macrophages through enhancing NLRP3 inflammasome These results define a unique role of GPR84 in innate immune cells and intestinal inflammation, and suggest

  • Sweet taste receptor agonists attenuate macrophage IL‐1β expression and eosinophilic inflammation...

    September 2022 Sweet taste receptor agonists attenuate macrophage IL‐1β expression and eosinophilic inflammation linked to autophagy deficiency in myeloid cells "Background Eosinophilic inflammation is a hallmark Trehalose is a disaccharide sugar with known pro‐autophagy activity and effective in alleviating diverse inflammatory The mechanisms underlying their anti‐inflammatory effects were assessed using specific inhibitor, genetic

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Other Pages (45)

  • Ultrasensitive dose-response for asbestos cancer risk implied by new inflammation-mutation model

    GPCRs in Oncology and Immunology Ultrasensitive dose-response for asbestos cancer risk implied by new inflammation-mutation A recent Inflammation Somatic Mutation (ISM) theory of cancer posits instead that tissue-damage-associated inflammation that epigenetically recruits, activates and orchestrates stem cells to engage in tissue inhalation, one of the two types of ISM-required mutations is here hypothesized to block or impede inflammation Author Kenneth T Bogen Tags Asbestos , Cytotoxicity , Inflammation , Lung cancer , Mesothelioma , Mutation

  • Orphan receptor GPR50 attenuates inflammation and insulin signaling in 3T3-L1 preadipocytes

    < GPCR News < GPCRs in Oncology and Immunology Orphan receptor GPR50 attenuates inflammation and insulin Although the mechanism of T2DM is not yet fully known, inflammation and insulin resistance play a central The aim of this study was to investigate the effect of GPR50 on inflammation and insulin resistance in significantly increased in the adipose tissue of obese T2DM mice, while GPR50 deficiency increased inflammation These data suggest that GPR50 can attenuate inflammatory levels and regulate insulin signaling in adipocytes

  • Ep 134 with Dr. Neil Grimsey

    discovered a novel GPCR-dependent atypical kinase activation mechanism that drives vascular edema and inflammation My group studies the spatiotemporal dynamics of atypical inflammation and the control of disease progression

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