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new antifibrotic cGAS/STING signaling pathway that suppresses pathological angiogenesis in liver and kidney We showed that cGAS expression was induced in fibrotic liver and kidney, but suppressed in endothelial cells. cGAS genetic deletion promoted liver and kidney fibrosis and pathological angiogenesis, including GPCR)-based antagonist that blocks the profibrotic activity of endothelial YAP, attenuated liver and kidney Further, pharmacological targeting of cGAS/STING-YAP axis exhibits the potential to alleviate liver and kidney

Here, we show that human GPR125 likely undergoes cis-autoproteolysis when expressed in canine kidney epithelial MDCK cells and human embryonic kidney HEK293 cells.

TGR5 is widely distributed in the brain, lung, heart, liver, spleen, pancreas, kidney, stomach, jejunum

Pluznick discovered that olfactory receptors in mice are also expressed in their kidneys and blood vessels This work contributes to a better understanding of how the kidney helps maintain homeostasis in humans

Rezwan Parag Identification of Differentially Expressed Gpr116 (Adgrf5) Transcript Variants in Mouse Kidney We detected and aligned three Adgrf5 exons that undergo differential expression in the kidney: exons These data demonstrate that Adgrf5 transcript variants are cell-specific in the kidney. Moreover, the complete repertoire of aGPCRs expressed in the kidney is undefined. These results reveal the complete set of aGPCRs expressed in the murine kidney.

GPR110 is also highly expressed in the kidney, however, little is known about the function of this receptor To extend our understanding of the role of GPR110 signaling in kidney, we evaluated the urine albumin provide the molecular basis for the renal phenotype, we analyzed in parallel differential expression of kidney