protein-coupled receptors (GPCRs) regulate motivated behavior and how these receptors can be targeted for therapeutic distinct signaling pathways with their physiological effects and may serve as the basis for more selective therapeutics

To explore the therapeutic potential of GPR132 signaling, we screened and validated a natural product

mechanisms of G-protein activation dysregulated in disease, these findings warrant the exploration of therapeutic

receptors would be a significant breakthrough in cardiovascular biology as they could be targeted for therapeutic

Award and the Goodman and Gilman Award from the American Society for Pharmacology and Experimental Therapeutics

G-protein-coupled receptor (GPCR) ligand systems in cancer transcriptomics datasets to uncover new therapeutics

We suggest that SST2 and SST3 should be further explored as potential biomarkers and therapeutic tools

Award and the Goodman and Gilman Award from the American Society for Pharmacology and Experimental Therapeutics

receptors would be a significant breakthrough in cardiovascular biology as they could be targeted for therapeutic

heterogeneously in glioblastoma (GBM) and is involved in the mesenchymal transition, making it a promising therapeutic

of Canada (2014), the Julie Axelrod award from the American Society of Pharmacology and Exerimental Therapeutics

Therefore, these antagonists may aid in the development of novel cancer therapeutics and patient-based

interplay between CXCR4 and HRH1, and suggest the possibility of the CXCR4-HRH1 heteromer as a potential therapeutic

of Canada (2014), the Julie Axelrod award from the American Society of Pharmacology and Exerimental Therapeutics

of the month Chemical biology of noncanonical G protein-coupled receptor signaling: Toward advanced therapeutics Mu Opioid Receptor Heterodimers Emerge as Novel Therapeutic Targets: Recent Progress and Future Perspective Intrinsic efficacy of opioid ligands and its importance for apparent bias, operational analysis, and therapeutic

Lipopeptide Pepducins as Therapeutic Agents. Heptares reported its FY2021 financial results and provided an update on operational activities Ermium Therapeutics Keystone Symposia in-person meeting- GPCRs: An Odyssey from Structure, Signaling, and Regulation to Therapeutics

of Canada (2014), the Julie Axelrod award from the American Society of Pharmacology and Exerimental Therapeutics

pancreatic adenocarcinoma (PDAC) continues to present a formidable clinical challenge, demanding innovative therapeutic

Our results suggest that GPR15/GPR15L have a pathogenic role in RA and their antagonizing could be a therapeutic

targeting the Gs-GPCR or components of the downstream signaling pathway could serve as a promising therapeutic

an improved understanding of gut microbiota-immune-brain molecular interactions and their potential therapeutic

These findings have implications for therapeutically targeting TIPE proteins in human inflammatory and

mediator in the advancement of OSCC, offering a potential avenue for the development of innovative therapeutic

controlling the functions of monocytes and dendritic cells and that targeting GPR141 may be a possible therapeutic

Therefore, our findings demonstrated that GPR37 may represent a viable therapeutic target for NSCLC."

understanding of the designated value of GPCRs for molecular engineering of biomaterials with GPCRs in therapeutical

In the past, studies predicting therapeutic drug targets for cancer therapy focused on the assumption

Using co-immunoprecipitation, confocal immunofluorescence microscopy, and bioluminescence resonance energy