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Results found for "Maneesh Jain"
Posts (94)
- Signals in Motion: Pain, Metabolism & Terry’s Corner
CXCR4 takes on a nuclear role in red blood cell maturation CXCL13/CXCR5 emerges as a high-potential pain target ST171, a biased 5‑HT1A agonist, delivers selective pain relief in preclinical models Dr.GPCR Blocking this chemokine axis reduces pain hypersensitivity by dampening neuroinflammation and glial This novel agonist activates Gi/o selectively , avoiding β-arrestin and showing strong pain relief in
- When Pain Becomes a Catalyst: How Personal Experience Redefined One Scientist’s Mission
After years of living with unresolved pain following surgery for a pilonidal cyst, Alex was left without This is a story about how chronic pain doesn't just shape lives — it reshapes careers. “I wasn’t able to get stronger pain meds,” he said. “So I had to understand the biology myself.” Mike Caterina on pain mechanisms in the peripheral nervous system. , pain neuroscience
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- Session V | Adhesion GPCR Workshop 2024 | Dr. GPCR Ecosystem
Full Agenda Session V Structural mechanisms of AGPCR signaling and function Structural Determinants Of GAIN Unveiling the GPS Cleavage Mechanism in ADGRL1 with QM/MM Florian Seufert Structural Determinants Of GAIN ADGRs are autoproteo-lytically cleaved at the GPCR proteolysis site (GPS), an HXS/T motif within the GAIN We de-termined the crystal structure of the human ADGRB2/BAI2 hormone receptor (HormR) and GAIN domains domain partially re-instates cleavage, while its deletion reduces cleavage in the ADGRL1 GAIN domain
- Seeking to gain more knowledge on signaling bias? We’ve got the perfect opportunity for you 🚀 Registrations open until February 14th ⚠️ Last spots available for “The Practical Assessment of Signaling Bias” with Dr. Terry Kenakin ✳️Register today at https://www.ecosystem.drgpcr.com/event-details-registration/the-practical-assessment-of-signaling-bias #gpcr #drgpcr | Dr. GPCR Ecosystem
Home → Flash News → Seeking to gain more knowledge on signaling bias? GPCR Courses Seeking to gain more knowledge on signaling bias?
- Foundry for GPCR Organizations | Dr. GPCR Ecosystem
De-risk decisions: gain expert strategic guidance on study design, timelines, and partner selection before credible GPCR CROs and expert consultants 📚 Train and upskill your team with specialized programs 📢 Gain Gain confidence and direction with a customized roadmap aligned to your biotech’s goals and timeline Gain clarity and direction to move your biotech forward—faster and smarter. → Explore Timeline Strategy frameworks and resources tailored to the realities of discovery-stage GPCR work ✉ Contact Us Our Partners Join
