Search Results

previously solved class A GPCR-Gi complex structures is observed in CX3CR1, which may correlate with three cholesterol Thus, our data deepen the understanding of cholesterol modulation in GPCR (G protein-coupled receptor

We considered whether cholesterol, a prominent component of the plasma membrane, limits the ability of Here, we present comparative MSM analyses of 150-μs simulations of opsin in cholesterol-free and cholesterol-rich Our analyses reveal that cholesterol inhibits phospholipid scrambling by occupying the TM6/7 interface

"Lysosomes coordinate cellular metabolism and growth upon sensing of essential nutrients, including cholesterol Through bioinformatic analysis of lysosomal proteomes, we identified lysosomal cholesterol signaling Cholesterol bound to the amino-terminal permease-like region of LYCHOS, and mutating this site impaired At high cholesterol concentrations, LYCHOS bound to the GATOR1 complex, a guanosine triphosphatase (GTPase Thus, LYCHOS functions in a lysosomal pathway for cholesterol sensing and couples cholesterol concentrations

Cutting-edge cryo-EM reveals how LYCHOS, a lysosomal protein, senses cholesterol to regulate metabolism https://www.ecosystem.drgpcr.com/structural-and-molecular-insights-into-gpcr-function/cryo-em-reveals-cholesterol-binding-in-the-lysosomal-gpcr-like-protein-lychos Cutting-edge cryo-EM reveals how LYCHOS, a lysosomal protein, senses cholesterol to regulate metabolism https:// www.ecosystem.drgpcr.com/structural-and-molecular-insights-into-gpcr-function/cryo-em-reveals-cholesterol-binding-in-the-lysosomal-gpcr-like-protein-lychos

for Cellular and Molecular Biology at Hyderabad, India, where he studied the interaction of membrane cholesterol