Pharmacology’s hidden power? The model behind the data 💡

Terry Kenakin shows how experimental snapshots can reveal much more—and how predictive frameworks guide modern drug discovery.

🟢 Built for pharmacologists building stronger pipelines and those rethinking legacy models.

✳️ https://www.terrykenakin.com

#GPCR #DrGPCR #pharmacology #drugmodeling #terrykenakin

What drives Gq vs. Gs selectivity at PTH1R? This new Nature Chemical Biology paper reveals cryo-EM structures of Gq-bound PTH1R—highlighting how N-linked glycans and ICL2 interactions stabilize receptor conformations that favor Gq coupling.

♦️ Two distinct Gq-bound conformations

♦️ Comparison with Gs-bound PTH1R

♦️ Strategic implications for biased agonist design

A critical advance for anyone working on class B1 GPCRs, bone biology, or biased signaling.

➡️ Read the paper: https://www.nature.com/articles/s41589-025-01957-6?utm_content=buffer3b1fa&utm_medium=social&utm_source=twitter.com&utm_campaign=buffer

#DrGPCR #GPCR #PTH1R #BiasedAgonism #CryoEM #Pharmacology #Osteoporosis #DrugDiscovery

Linear, linkage, or probability?

Dive into the logic of drug modeling with Terry Kenakin. In his latest lesson, he breaks down the essential models shaping modern pharmacology.

Learn to “extend your eyes” and predict complex drug behaviors.

🟢 Browse the full catalog (and expect a new course every week!)

✳️ https://www.terrykenakin.com

#pharmacology #drugmechanism #kenakin #GPCR #DrGPCR

Most GPCR teams aren’t failing because of bad science.

They’re stalling because of slow decisions, misapplied models, and buried priorities.

This week’s GPCR Weekly News helps you fix that.

Terry’s Corner breaks down the 4 pharmacologic models that separate forecasting from guessing.

Dr. Sokhom S. Pin shares how he built high-output, low-burnout teams—and earned his PhD while working full time.

Yamina’s Corner exposes the silent drift killing GPCR programs (and how to reverse it).

💡Plus: New tools from Celtarys Research. Biotech strategy moves from Catalio Capital Management. And your voice in our survey.

If your competitors are already applying these insights… can you afford to skip this week’s update?

✳️ Read the Weekly News → https://www.ecosystem.drgpcr.com/post/crush-data-confusion-conquer-gpcr-drug-discovery?utm_content=bufferd9b30&utm_medium=social&utm_source=twitter.com&utm_campaign=buffer

#GPCR #Pharmacology #DrugDiscovery #ScientificLeadership #DrGPCR

Build the team you always wished you had. 

At Alkermes, Sokhom S. Pin didn’t just lead a lab. He built a culture. His team became known as “the happiest group in the company.” Why? Empowerment, trust, and zero tolerance for toxicity. It wasn’t luck. It was leadership.

✳️ Watch Ep. 169: https://www.ecosystem.drgpcr.com/dr-gpcr-podcast/ep-169-with-dr-sokhom-pin

#biotechleadership #GPCRresearchcommunity #DrGPCR #teamculture

What if a single experimental snapshot could predict an entire in vivo drug profile in a range of organs?

In Terry’s Corner latest lesson, discover how pharmacologic models do just that. From historical linkage theory to dynamic probability models, the comparison of data to theory will be discussed.

🟢 Read the full breakdown:

✳️ https://www.ecosystem.drgpcr.com/post/what-if-you-could-predict-drug-behavior-with-just-a-snapshot

#GPCR #DrGPCR #pharmacology #DrugDiscovery #TerryKenakin #FoundationalScience

Redefine what a PhD path can look like. Sokhom S. Pin didn’t quit his job, pause his career, or sacrifice family time. He built a PhD program inside BMS—while working full-time and raising three kids. Industry-based research. Employer-funded. Custom-built for impact.

🎧 Ep. 169 is available now: https://www.ecosystem.drgpcr.com/dr-gpcr-podcast/ep-169-with-dr-sokhom-pin

#GPCRtraining #GPCRscientistnetwork #DrGPCR #nontraditionalPhD #GPCR #DrGPCR

The wait is over! Terry's Corner is LIVE! ✨

We've poured our passion for pharmacology into creating this essential resource, designed to meet you exactly where you are in your drug discovery journey. Dr. Terry Kenakin delivers razor-sharp insights, all on-demand.

Ready to:

• Strengthen your pharmacology fundamentals?

• Bridge theory to practical drug development decisions?

• Push the boundaries with advanced concepts like allosteric modulation and residence time?

Terry's Corner helps you make better decisions through better pharmacology.

Enroll now: https://www.terrykenakin.com

#pharmacology #GPCRscience #drugdiscovery #TerrysCorner #biotechtraining #ScienceEducation #Pharma #GPCR #DrGPCR

How do chemokines and GPCRs decode selectivity? A landmark Cell paper delivers the answer—mapping how conserved and variable sequence–structure elements govern interaction logic across 46 chemokines and 23 GPCRs. The result: a framework for designing ligands with altered receptor preferences. 

♦️ Defines “public” vs. “private” binding determinants

♦️ Highlights role of structured + unstructured regions

♦️ Includes a web tool + viral chemokine engineering demo

This is a must-read for GPCR modelers, immunopharmacologists, and ligand engineers. 

➡️ Read the paper: https://www.cell.com/cell/fulltext/S0092-8674(25)00398-8

#DrGPCR #GPCR #Chemokines #StructuralBiology #Pharmacology #ProteinEngineering #Immunology #DrugDiscovery

Stronger pharmacology drives smarter decisions in GPCR discovery. Terry’s Corner is now live—an on-demand learning hub led by Dr. Terry Kenakin. New and unique lessons are released weekly on Tuesday. 

Elevate your drug discovery program with 45+ lessons yearly. Whether you’re refining assay strategy or evaluating data, these lessons give you the tools to think clearer and act faster. Explore on-demand lessons by Dr. Terry Kenakin with short videos, clear summaries, and curated references.

Also in this week’s Dr. GPCR Weekly:

♦️ Yamina’s Corner—GPCR consulting to de-risk and accelerate your pipeline

♦️ Celtarys’ validated TR-FRET assay for CB1/CB2

♦️ Chemokine-GPCR selectivity decoded

♦️ PTH1R structures reveal Gq bias mechanisms

♦️ NMBR simulations uncover new activation pathways

♦️ Axcelead & Superluminal expand collaboration

♦️ Industry momentum: collaborations, new data, and next-gen GLP-1 strategies

Unlock deeper insight—starting now.

➡️ Read the newsletter: https://www.ecosystem.drgpcr.com/post/pharmacology-at-your-fingertips-terry-s-corner-launches

#DrGPCR #GPCR #DrugDiscovery #pharmacology #biotechnews #terrykenakin #GPCRconsulting

Terry's Corner is Officially LIVE! 🎉

This is your new go-to for mastering drug discovery pharmacology. No fluff, just clear, on-demand insights from Terry Kenakin.

Building core expertise? Master dose-response, binding, kinetics, and foundational models.

Driving drug discovery? Apply pharmacology to selectivity, ADME, and strategic decision-making.

An experienced drug hunter? Sharpen your edge with allosteric bias, residence time, and translational PK/PD.

Learn on-demand, apply immediately: https://terrykenakin.com

#DrGPCR #GPCR #pharmacology #TerrysCorner #DrugDiscovery

Some biotech stories start in the lab. Celtarys began to with a thesis project, a new chemical strategy, and a vision to make fluorescence available for drug discovery. Now, they’re growing fast and partnering with Dr. GPCR to connect with the researchers who need them most.

✳️ Learn more about the partnership: https://www.ecosystem.drgpcr.com/celtarys-research-dr-gpcr-ecosystem

#GPCRcommunity #ScienceCollaboration #FluorescentLigands #BiotechStartup

10 GPCR pharmacology lessons. Zero fluff.

Launching July 1, Terry’s Corner gives you the clarity and confidence to make better decisions—starting with:

🟢 The role of pharmacology in discovery strategy

🟢 Black & Leff’s operational model—finally made practical

🟢 Binding curves, orthosteric vs allosteric function, and real vs apparent affinity

🟢 Molecular dynamics and how they guide ligand design

🟢 Why Terry built this—and how it sharpens your next move

📅 Learn anytime. New course every week.

📬 Subscribe to The Kenakin Brief → https://www.terrykenakin.com

#GPCRscience #drugdiscovery #TerrysCorner #GPCRpharmacology #ligandbindingv

Unlock your pharmacology potential with Terry’s Corner.

No fluff. Just clear, on-demand insight from Dr. Terry Kenakin—built for scientists at every level.

🟢 Building core expertise?

Learn dose-response, agonism, binding, bias, kinetics, and the models that build real confidence.

🟢 Driving drug discovery?

Apply pharmacology to selectivity, ADME, early safety, and smarter decision-making.

🟢 Already a drug hunter?

Sharpen your edge with allosteric modulation, residence time, molecular dynamics, and translational PK/PD.

Learn on-demand. Apply immediately.

Early access begins July 1 → https://www.terrykenakin.com

#pharmacology #GPCRscience #drugdiscovery #TerrysCorner #biotechtraining

Generic tools won’t solve tomorrow’s drug discovery challenges. That’s why Celtarys designs custom fluorescent probes for every target, built for real pharmacology, not just convenience. With Dr. GPCR and Celtarys joining forces, expect more visibility, more precision, and more scientific impact.

🚀 Get to know our media partner: https://www.ecosystem.drgpcr.com/celtarys-research-dr-gpcr-ecosystem

#GPCRdrugDiscovery #GPCRecosystem #CustomLigands

Started in medicinal chemistry. Got hooked on ligand design.

Dr. Maria Majellaro didn’t plan to run a biotech company. A thesis project, a mentor’s advice, and a leap during the pandemic changed everything. Now she’s leading Celtarys, building custom fluorescent probes, and partnering with Dr. GPCR to support assay development worldwide.

Meet Celtarys and learn more about its leading work on ligand-linker-fluorophore chemistry 🚀

✳️ Listen now: https://www.ecosystem.drgpcr.com/dr-gpcr-podcast/ep-168-with-dr.-maria-majellaro-from-celtarys 

#GPCRcommunity #DrGPCR #FluorescentLigands #GPCRdrugDiscovery #ScientificLeadership #BiotechInnovation

A casual postdoc in Santiago. A bold yes during the pandemic. Now? A biotech startup solving GPCR challenges worldwide 🌎 Celtarys Research didn’t follow the script, and neither does their chemistry. 🎧 In this week’s episode, Dr. Maria Majellaro talks about trusting your gut, learning to lead, and building science that scales.

✳️Celtarys is ready to support your assay development. Get to know more: Celtarys Research | Dr. GPCR Ecosystem | Dr. GPCR Ecosystem 

#GPCRtools #GPCRtrainingProgram #DrGPCR #BiotechLeadership

Think βCGRP is just αCGRP’s understudy? Think again. New research shows that βCGRP triggers distinct receptor signaling profiles across the CGRP receptor family, challenging the long-held assumption of redundancy.

🔬 A closer look reveals differences in G protein coupling, second messenger production, and receptor trafficking.

📊 This could reshape how we understand CGRP-related physiology—and how we target it in drug design.

🧠 Pain, inflammation, metabolism: the implications go far beyond signaling bias.

🔗 Read the full paper in Biochemistry: Unique Biased Agonism Profile of βCGRP on CGRP Family Receptors 

#GPCR #CGRP #DrugDiscovery #Pharmacology #SignalTransduction #Neuropeptides

Dr. Maria Majellaro perfected her focaccia recipe. Then, with Celtarys, the team did the same for ligand-linker-fluorophore chemistry. It’s not just culinary precision, it’s a metaphor for drug discovery done right.

In Ep. 168, she shares how Celtarys went from a thesis idea to a biotech reality. Meet Dr.GPCR’s new partner: Celtarys 🙌

👉 See what they’re cooking up now: Ep 168 with Dr. Maria Majellaro from Celtarys 

#GPCRresearchCommunity #DrGPCR #StartupScience #BiotechFounders #GPCRscientistNetwork

New strategic partnership alert! 🚀 Dr.GPCR x Celtarys are teaming up to revolutionize fluorescent ligand development for GPCR research.

Get custom, fast, and functional ligands backed by real scientists solving real assay problems.

🧪 “We don’t just deliver compounds. We solve assay problems.” – Dr. Maria Majellaro, CSO, Celtarys 

Listen to Ep. 168 now and meet your new assay partner 😉

✳️ https://www.ecosystem.drgpcr.com/dr-gpcr-podcast/ep-168-with-dr.-maria-majellaro-from-celtarys   

#GPCRdrugDiscovery #FluorescentLigands #DrGPCR #BiotechTools #AssayDevelopment