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encoding and decoding selectivity and promiscuity in the human chemokine GPCR interaction network

Published on

July 7, 2025

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How do chemokines and GPCRs decode selectivity? A landmark Cell paper delivers the answer—mapping how conserved and variable sequence–structure elements govern interaction logic across 46 chemokines and 23 GPCRs. The result: a framework for designing ligands with altered receptor preferences. 


♦️ Defines “public” vs. “private” binding determinants

♦️ Highlights role of structured + unstructured regions

♦️ Includes a web tool + viral chemokine engineering demo


This is a must-read for GPCR modelers, immunopharmacologists, and ligand engineers. 


➡️ Read the paper: https://www.cell.com/cell/fulltext/S0092-8674(25)00398-8


#DrGPCR #GPCR #Chemokines #StructuralBiology #Pharmacology #ProteinEngineering #Immunology #DrugDiscovery

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