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How sensitive can a GPCR really be

How sensitive can a GPCR really be?

Published on

November 9, 2025

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Think femtomolar. That’s the scale we’re talking about.

This week on the Dr. GPCR Podcast, we sit down with Michelle Halls, leader of the Spatial Organisation of Signalling lab at Monash University. Her team is redefining how we understand GPCR signaling — not just at the cell surface, but in space, time, and disease context.

In this episode, you’ll learn:

  • How GPCR pre-assembly enables femto-level signal detection.

  • Why receptor location matters as much as receptor type.

  • How disease can hijack signaling organization — and what that means for drug discovery.

Michelle’s work bridges elegant mechanistic biology with translational impact — giving us new ways to think about receptor pharmacology, biased agonism, and therapeutic precision.

🔗 Listen here → https://www.ecosystem.drgpcr.com/dr-gpcr-podcast/leadership-luck-and-gpcr-signaling

🎓 Explore Dr. GPCR Premium → https://www.ecosystem.drgpcr.com/gpcr-university

#GPCR #DrGPCR #pharmacology #drugdiscovery #receptors #biotech #signaltransduction

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