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Think βCGRP is just αCGRP’s understudy? Think again.
New research shows that βCGRP triggers distinct receptor signaling profiles across the CGRP receptor family, challenging the long-held assumption of redundancy.

🔬 A closer look reveals differences in G protein coupling, second messenger production, and receptor trafficking.
📊 This could reshape how we understand CGRP-related physiology—and how we target it in drug design.
🧠 Pain, inflammation, metabolism: the implications go far beyond signaling bias.

🔗 Read the full paper in Biochemistry: Unique Biased Agonism Profile of βCGRP on CGRP Family Receptors
#GPCR #CGRP #DrugDiscovery #Pharmacology #SignalTransduction #Neuropeptides

Published on

June 16, 2025

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Think βCGRP is just αCGRP’s understudy? Think again. New research shows that βCGRP triggers distinct receptor signaling profiles across the CGRP receptor family, challenging the long-held assumption of redundancy.


🔬 A closer look reveals differences in G protein coupling, second messenger production, and receptor trafficking.

📊 This could reshape how we understand CGRP-related physiology—and how we target it in drug design.

🧠 Pain, inflammation, metabolism: the implications go far beyond signaling bias.


🔗 Read the full paper in Biochemistry: Unique Biased Agonism Profile of βCGRP on CGRP Family Receptors 


#GPCR #CGRP #DrugDiscovery #Pharmacology #SignalTransduction #Neuropeptides

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