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Weekly News October 23
Dr. GPCR Weekly News - Oct 23 - The Power and Peril of Irreversible Drugs
Published on
October 23, 2025
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This week’s Weekly News breaks down how to control target engagement—so duration, penetration, and PK/PD separation serve your program, not sink it. Premium sneak peek inside.
🔹 Terry’s Corner: A practical framework for irreversible drugs—defining “irreversible” in real systems, anticipating PK/PD decoupling, and using k_inact/K_I when Ki falls short.
🔹 Podcast Spotlight: Dr. Jens Carlsson on predictive modeling—where structure-based design and MD guide experiments (and where AlphaFold still needs a chaperone).
If you’re advancing covalent or tight-binding candidates—or building models meant to predict, not narrate—this edition is built to shorten cycles and reduce surprises.
Read the full Weekly News ➤ https://bit.ly/3KVlL4m
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