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Weekly News October 23

Dr. GPCR Weekly News - Oct 23 - The Power and Peril of Irreversible Drugs

Published on

October 23, 2025

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This week’s Weekly News breaks down how to control target engagement—so duration, penetration, and PK/PD separation serve your program, not sink it. Premium sneak peek inside.


🔹 Terry’s Corner: A practical framework for irreversible drugs—defining “irreversible” in real systems, anticipating PK/PD decoupling, and using k_inact/K_I when Ki falls short.


🔹 Podcast Spotlight: Dr. Jens Carlsson on predictive modeling—where structure-based design and MD guide experiments (and where AlphaFold still needs a chaperone).


If you’re advancing covalent or tight-binding candidates—or building models meant to predict, not narrate—this edition is built to shorten cycles and reduce surprises.


Read the full Weekly News ➤ https://bit.ly/3KVlL4m


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