📰 GPCR Weekly News, February 5 to 11, 2024

Hi readers! Check out our GPCR coverage for this week. We have 10 GPCR papers, six industry news, and two job ads.

This week's highlight includes congrats to:

• Drs. Magdalena M Scharf, Antonella Di Pizio, Ines Liebscher, Hannes Schihada, and Gunnar Schulte et al. on their study on understudied GPCRs and their dark sides.

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Dr. GPCR Symposia

Our upcoming symposium on March 15th is about GPCR activation and signaling. Confirmed speakers include Drs. Franziska Heydenreich, Sudarshan Rajagopal, Graham Ladds, Cesare Orlandi and Michel Bouvier. 

We will also have a poster session in breakout rooms on Zoom; if you are interested in sharing your work with our community, kindly fill out this form. Additionally, if you participated in our Symposia in 2023, please take a moment to fill out this survey.

Dr. GPCR University

Last week marked the beginning of our first Dr.GPCR University course, 'Applying Pharmacology to Drug Discovery, led by Dr. Terry Kenakin.

If you are interested in joining this course but missed the registration window, don't worry! You can sign up for our waitlist. We will be offering this live course later this year. If you are on the waitlist, you'll be the first notified and can register for the course ahead of everyone else.

Dr. GPCR Volunteers

Join our dynamic team as a volunteer! You'll share your contributor articles with the community, stay updated with GPCR literature, network with GPCR scientists at our events, and get a complimentary Premium Membership with only 4 hours/monthly commitment on your part.

If you are interested in applying, please email us your CV/Resume at  Hello@DrGPCR.com.

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Dr. GPCR Partnered Events

• March 5 - 7, 2024 | 3rd GPCRs - Targeted Drug Discovery Summit Join us at the 3rd GPCRs Summit in Boston on March 5-7, 2024. Dr. GPCR Members get 10% off with code MPDRGPCR10.

• April 22 - 23, 2024 | Endocrine Metabolic GPCRs Join our Founder Dr. Yamina Berchiche at the Endocrine Metabolic GPCRs event in Birmingham, UK, on April 22-23, 2024. 

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 Let’s dive into the Classified GPCR News from February 5th to 11th, 2024

GPCR Activation and Signaling

• Constitutive activation mechanism of a class C GPCR

• Allosteric modulation and G-protein selectivity of the Ca2+-sensing receptor

GPCRs in Cardiology, Endocrinology, and Taste

• G protein-coupled receptors driven intestinal glucagon-like peptide-1 reprogramming for obesity: Hope or hype?

• Doxorubicin alters G-protein coupled receptor-mediated vasocontraction in rat coronary arteries

• GPCRs involved in metabolic diseases: pharmacotherapeutic development updates

Methods & Updates in GPCR Research

• GPCR-BERT: Interpreting Sequential Design of G Protein-Coupled Receptors Using Protein Language Models

• Scaling up Functional Analyses of the G Protein-Coupled Receptor Rhodopsin

Reviews, GPCRs, and more

• The dark sides of the GPCR tree - research progress on understudied GPCRs

Structural and Molecular Insights into GPCR Function

• GPR161 structure uncovers the redundant role of sterol-regulated ciliary cAMP signaling in the Hedgehog pathway

• Unraveling the Interplay of Extracellular Domain Conformational Changes and Parathyroid Hormone Type 1 Receptor Activation in Class B1 G Protein-Coupled Receptors: Integrating Enhanced Sampling Molecular Dynamics Simulations and Markov State Models

Industry News

• Exscientia Initiates Clinical Study to Further Evaluate Functional Precision Medicine Platform in Cancer Patients

• Orion Biotechnology to Showcase GPCR Progress at 2024 OBIO Investment Summit 

• BioAge raises $170M as obesity spotlight shifts to oral options, muscle preservers

• Neurocrine Biosciences Reports Fourth Quarter and Fiscal 2023 Financial Results and Provides Financial Expectations for 2024

• Domain Therapeutics further strengthens leadership team with appointment of Sean A. MacDonald as Chief Business Officer.

• Septerna Appoints Industry Veterans Bernard Coulie, M.D., Ph.D., and Shalini Sharp to its Board of Directors 

GPCR Events, Meetings, and Webinars

• February 20, 2024 | Career Opportunities in Pharmacology and Drug Discovery

• March 13 - 15 | 9th German Pharm-Tox Summit 

• March 23 - 24, 2024 | Ligand Recognition and Molecular Gating Seminar

• March 24 - 29, 2024 | Ligand Recognition and Molecular Gating Conference

• April 1 - 4, 2024 | 19th Annual Drug Discovery Chemistry

• April 4 - 7, 2024 | American Physiology Summit

• April 5 - 10, 2024 | AACR Annual Meeting

• May 13 - 17, 2024 | 20th Annual PEGS Boston Summit

• May 16 - 19, 2024 | ASPET 2024

• May 27 - 29, 2024 | SLAS Europe 2024 Conference and Exhibition

• June 2 - 7, 2024 | Chemotactic Cytokines

• June 9 - 14, 2024 | 2024 Phosphorylation and G-Protein Mediated Signaling Networks

• June 25 - 29, 2024 | FENS Forum 2024

• October 2 - 4, 2024 | 9th GPCRs in Medicinal Chemistry

•  October 23 - 25, 2024 | 11th Adhesion GPCR Workshop

• July 12 - 17, 2026 | 20th World Congress of Basic and Clinical Pharmacology 2026

GPCR Jobs

• NEW Director of Laboratory Operations - Single-molecule Imaging Center

• NEW Scientific Assistant 

• Postdoctoral Fellowship- Mechanistic Biology 

• Research Scientist

• Post-Doc position

• Lead Researcher

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