Search Results

Dr. ResearchGate Twitter LinkedIn Universite de Montreal- Department of Biochemistry and Molecular Medicine Dr

Karim Ibrahim on the web X (Twitter) Google Scholar Dr.

Full Agenda Adhesion GPCR workshop 2024 CINVESTAV, Mexico City, Mexico October 23-25 Download PDF Program HERE < Back to Full Agenda Leaving for City Center Coming Soon < Previous Session Next Session >

iPSC-derived cellular models and biosensor approaches for studying GPCR signaling and improving translational pharmacology workflows. < Back Using iPSC-derived models to study GPCR function April 16, 2026 at 2:00:00 PM 🔒 Watch Recordings Access the full library of recorded Masterclass sessions. Get Live Updates Be notified when new live Masterclasses are scheduled. Introduction Drug discovery pipelines increasingly depend on screening platforms designed to identify therapeutically valuable compounds. Yet despite advances in screening technologies, the translation of these discoveries into clinical success remains limited. A major factor is the continued reliance on cellular systems that do not adequately reflect the complexity of human tissues and disease biology. This Masterclass explores how induced pluripotent stem cell (iPSC)–derived cellular models and organoid systems can provide more physiologically relevant environments for studying GPCR signaling and pharmacological responses. The discussion will examine how these models are generated, how biosensor-based approaches can be integrated to monitor signaling pathways, and how such systems can support more translationally relevant drug discovery workflows. Instructor Terry Hébert has a long-standing track record in identifying molecular mechanisms that regulate the function of G protein-coupled receptors. His research has focused extensively on GPCR oligomerization, signaling complex assembly, and biased signaling. His current work investigates the ontogeny, formation, and trafficking of GPCR-based signaling complexes in order to understand how GPCR signaling pathways are organized and integrated within cells. This research examines signaling architecture both at the cell surface and within the nucleus, providing insight into how receptor signaling networks are structured and regulated. Upcoming Live Sessions

Full Agenda Adhesion GPCR workshop 2024 CINVESTAV, Mexico City, Mexico October 23-25 Download PDF Program HERE < Back to Full Agenda Leave for dinner reception Coming Soon < Previous Session Next Session >

Full Agenda Adhesion GPCR workshop 2024 CINVESTAV, Mexico City, Mexico October 23-25 Download PDF Program HERE < Back to Full Agenda Complimentary Reception dinner MENU Four Mushroom Soup Tomato, Panela Cheese, and Spinach tower with Oregano Vinaigrette Cane Sugar and Arbol Chile Lacquered Duck Monte Cristo Chocolate Cake Coffee or Tea Vegetarian option* -Mushroom-stuffed chiles on refried bean sauce- instead of the duck < Previous Session Next Session >

Full Agenda Adhesion GPCR workshop 2024 CINVESTAV, Mexico City, Mexico October 23-25 Download PDF Program HERE < Back to Full Agenda Registration & Coffee with light breakfast < Previous Session Next Session >

Full Agenda Adhesion GPCR workshop 2024 CINVESTAV, Mexico City, Mexico October 23-25 Download PDF Program HERE < Back to Full Agenda Coffee Break with lights snacks Complimentary < Previous Session Next Session >

Full Agenda Adhesion GPCR workshop 2024 CINVESTAV, Mexico City, Mexico October 23-25 Download PDF Program HERE < Back to Full Agenda Board meeting/General assembly Welcome to Join Coming Soon < Previous Session Next Session >

Scott Leiser on the web University of Michigan Pubmed ResearchGate LinkedIn Dr.

Dr. Heidi Hamm on the web The Hamm Lab Vanderbilt School of Medicine Pubmed Google Scholar LinkedIn Twitter Dr

Sexton is also a co-founder of Septerna Inc. " Patrick Sexton on the web CCeMMP Monash University Dr.

Full Agenda Adhesion GPCR workshop 2024 CINVESTAV, Mexico City, Mexico October 23-25 Download PDF Program HERE < Back to Full Agenda Coffee Break with pastries announcement of the aGEM award Complimentary < Previous Session Next Session >

Full Agenda Adhesion GPCR workshop 2024 CINVESTAV, Mexico City, Mexico October 23-25 Download PDF Program HERE < Back to Full Agenda Mexico City Nocturnal Tour, Food and drinks Coming Soon < Previous Session Next Session >

Full Agenda Adhesion GPCR workshop 2024 CINVESTAV, Mexico City, Mexico October 23-25 Download PDF Program HERE < Back to Full Agenda Session IX / Technology capsule: Light on aGPCR signaling and function NovoiSMART - A new platform for GPCR antibody drug discovery Abstract Developing monoclonal antibody drugs against GPCRs and other multi-pass transmembrane targets, such as ion channels, remains a significant challenge. Novoprotein developed a NovoiSMART technology, utilizing mRNA-based immunization, which can overcome these obstacles by producing high-quality antibodies that more accurately mimic natural protein structures. This approach contrasts with other antigen forms like peptides or DNA, which face limitations in structural integrity and immunogenicity. mRNA technology, demonstrated in the success of COVID-19 vaccines, is emerging as a promising method for antibody discovery. Several case studies of GPCR and other multi-pass transmembrane targets are presented, including GPRC5D, Claudin 6 and Napi2b. These studies show that mRNA immunization yields higher antibody titers and greater epitope diversity compared to other methods. These examples underscore the potential of NovoiSMART technology in developing highly specific antibodies for complex targets, with implications for overcoming challenges like drug resistance and tumor escape. About Gavin Zhang Gavin is a currently a director of business and operations at Novoprotein Scientific. His research experience includes phylogenetics and cancer epigenetics. Gavin Zhang on the web LinkedIn < Previous Session Next Session >

The Ramsey Lab Amy Ramsey on the web University of Toronto Pubmed Google Scholar LinkedIn Twitter Dr.

Awkward... This page isn’t available. Go Home

Awkward... This page isn’t available. Go Home

Time Out This page isn’t available right now. But we’re working on a fix, ASAP. Try again soon. Go Back

Time Out This page isn’t available right now. But we’re working on a fix, ASAP. Try again soon. Go Back