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Full Agenda Adhesion GPCR workshop 2024 CINVESTAV, Mexico City, Mexico October 23-25 Download PDF Program HERE < Back to Full Agenda Session VIII Physiological and pathological roles of AGPCRs in the periphery ADGRG1/GPR56 regulates survival of terminally differentiated CD8+ T cells Cheng-Chih Hsiao Adhesion GPCR GPR116/Adgrf5 controls a lineage of anti-thermogenic adipocytes with implications for adaptive thermogenesis during prolonged cold exposure Anastasia Georgiadi ADGRF5-mediated regulation of cardiac health and disease Douglas Tilley ADGRG1/GPR56 regulates survival of terminally differentiated CD8+ T cells Cheng-Chih Hsiao Abstract Only available for AGPCR 24 Attendees Authors & Affiliations "Cheng-Chih Hsiao1,2, Hendrik J. Engelenburg1, Joost Smolders1,3, and Jörg Hamann1,2 1Department of Neuroimmunology, Netherlands Institute for Neuroscience, Amsterdam, The Netherlands; 2Department of Experimental Immunology, Amsterdam institute for Immunology and Infectious diseases, Amsterdam University Medical Center, Amsterdam, The Netherlands; 3MS center ErasMS, Departments of Neurology and Immunology, Erasmus Medical Center, Rotterdam, The Netherlands" About Cheng-Chih Hsiao "2012-2015: PhD in Immunology, University of Amsterdam; 2015-2019: Postdoctoral researcher, Amsterdam UMC; 2019-2022: Senior postdoctoral researcher, Netherlands Institute for Neuroscience; 2022 - present: Researcher associate, Netherlands Brain Bank" Cheng-Chih Hsiao on the web LinkedIn ReseachGate Adhesion GPCR GPR116/Adgrf5 controls a lineage of anti-thermogenic adipocytes with implications for adaptive thermogenesis during prolonged cold exposure Anastasia Georgiadi Abstract Only available for AGPCR 24 Attendees Authors & Affiliations "El Merabhi Rabih1*, Karagiannakou Vasiliki1*, Kardinal Ronja2, Jäckstein Michelle3 Yvonne, Kumar Jha Ankush1, Krokidi Sissy Thodou1, Wachten Dagmar2, Heeren Jörg3, Herzig Stephan1, Georgiadi Anastasia1 *equal contributions , Institutions : 1. Institute for Diabetes and Cancer, Helmholtz Centre Munich, Germany, 2. Institute of Innate Immunity, University Hospital Bonn, University of Bonn, 3. Centre for Experimental Medicine, Institute for Biocehmistry and Molecular Cell Biology, University Medical Center Hamburg-Eppendorf" About Anastasia Georgiadi "Head of Junior Group Endocrine Pharmacology, Institute of Diabetes and Cancer (IDC). Professional Background Since 2021 Group Leader, Institute for Diabetes and Cancer, Helmholtz Diabetes Centre, Munich 2018 - 2021 Project Team Leader, Institute for Diabetes and Cancer, Helmholtz Diabetes Centre, Munich 2015 - 2018 Postdoctoral fellow, Department of Adipose Tissue Biology, Institute for Diabetes and Cancer, Helmholtz Diabetes Centre, Munich 2012 - 2015 Postdoctoral fellow, Department of Cell and Molecular Biology, Karolinska Institute, Sweden" Anastasia Georgiadi on the web Endocrine Pharmacology Google Scholar ADGRF5-mediated regulation of cardiac health and disease Douglas Tilley Abstract Only available for AGPCR 24 Attendees About Douglas Tilley "Research in the Tilley laboratory focuses primarily upon aspects of GPCR regulation of cardiac function, inflammation and remodeling during HF or following acute cardiac injury. Much of this work centered on elucidating novel mechanisms by which β-adrenergic receptors impact cardiac structure and function, and has evolved to encompass their roles in regulating immune cell response to acute cardiac injury or chronic stress. Additionally, the lab has begun to investigate potential roles for previously unrecognized cardiac-expressed GPCRs in the regulation of physiologic/pathologic function in the heart in an effort to uncover novel therapeutic directions for HF, including adhesion GPCRs (AGPCRs). In all, research in the Tilley lab spans molecular pharmacology to pathophysiology studies focused primarily in the cardiovascular realm." Douglas Tilley on the web Lewis Katz School of Medicine at Temple University < Previous Session Next Session >

Home → Flash News → Think βCGRP is just αCGRP’s understudy? Think again. New research shows that βCGRP triggers distinct receptor signaling profiles across the CGRP receptor family, challenging the long-held assumption of redundancy. 🔬 A closer look reveals differences in G protein coupling, second messenger production, and receptor trafficking. 📊 This could reshape how we understand CGRP-related physiology—and how we target it in drug design. 🧠 Pain, inflammation, metabolism: the implications go far beyond signaling bias. 🔗 Read the full paper in Biochemistry: Unique Biased Agonism Profile of βCGRP on CGRP Family Receptors #GPCR #CGRP #DrugDiscovery #Pharmacology #SignalTransduction #Neuropeptides Published on June 16, 2025 Category GPCR Weekly News Think βCGRP is just αCGRP’s understudy? Think again. New research shows that βCGRP triggers distinct receptor signaling profiles across the CGRP receptor family, challenging the long-held assumption of redundancy. 🔬 A closer look reveals differences in G protein coupling, second messenger production, and receptor trafficking. 📊 This could reshape how we understand CGRP-related physiology—and how we target it in drug design. 🧠 Pain, inflammation, metabolism: the implications go far beyond signaling bias. 🔗 Read the full paper in Biochemistry : Unique Biased Agonism Profile of βCGRP on CGRP Family Receptors #GPCR #CGRP #DrugDiscovery #Pharmacology #SignalTransduction #Neuropeptides Previous Next Recent Articles

Full Agenda Adhesion GPCR workshop 2024 CINVESTAV, Mexico City, Mexico October 23-25 Download PDF Program HERE < Back to Full Agenda Session II AGPCR signaling pathways and trafficking Localization of putative ligands for adhesion G protein-coupled receptors in mouse tissues. Yuling Feng The ADGRF5/GPR116 receptor is a key regulator of lymphatic endothelial cell identity and function Monserrat Avila Zozaya Adhesion GPCR BAI1/ADGRB1 can block IGF1R-mediated growth signalling, increase radiosensitivity and augment survival in medulloblastoma. Erwin G. Van Meir Site Specific N-Glycosylation Of The N-Terminal Fragment Of ADGRG6 Drives Proteolytic Processing, Trafficking And Signalling Pal Kasturi Localization of putative ligands for adhesion G protein-coupled receptors in mouse tissues. Yuling Feng Abstract Only available for AGPCR 24 Workshop Attendees Authors & Affiliations "Shen,Tingzhen; Bernadyn,Tyler; Kwarcinski, Frank; Gandhi, Riya; Tall, Greg. University of Michigan." About Yuling Feng "I am currently a postdoctoral research fellow working with aGPCR pharmacology and physiology in rodents." Yuling Feng on the web LinkedIn The ADGRF5/GPR116 receptor is a key regulator of lymphatic endothelial cell identity and function Monserrat Avila Zozaya Abstract Only available for AGPCR 24 Workshop Attendees Authors & Affiliations "Serafin D. Stephen, Caron Kathleen M Department of Cell Biology and Physiology at UNC Chapel Hill 111 Mason Farm Road, MBRB, CB 7545. University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA 27599" About Monserrat Avila Zozaya "My doctoral research was focused on investigating the cellular effects of missense lung cancer-mutations in the G-protein-coupled receptor Autoproteolysis-Inducing (GAIN) domain of Latrophilin 3 receptor under the mentorship of Dr. Antony Boucard. I am currently a postdoctoral researcher fellow in Dr. Kathleen Caron's laboratory at UNC. My research focuses on understanding the molecular mechanisms of adhesion GPCRs (aGPCRs) in lymphatic endothelial cells (LECs), a cellular model with unique junction arrangements where aGPCRs are mainly unexplored. " Monserrat Avila Zozaya on the web LinkedIn Caron Lab Antony Boucard Lab Dr. GPCR Adhesion GPCR BAI1/ADGRB1 can block IGF1R-mediated growth signalling, increase radiosensitivity and augment survival in medulloblastoma. Erwin G. Van Meir Abstract Only available for AGPCR 24 Attendees Authors & Affiliations "Yamamoto, Takahiro 1,2*, De Araujo Farias, Virginea 1, Zhu, Dan3; Kuranaga, Yuki1, Parag, Rashed Rezwan 1,4,, Osuka, Satoru1,5 1 Department of Neurosurgery, School of Medicine, University of Alabama at Birmingham, Birmingham, Alabama, USA. 2 Department of Neurosurgery, Kumamoto University, Kumamoto, Japan 3 Department of Neurosurgery, Emory University School of Medicine, Atlanta, Georgia, USA 4 Graduate Biomedical Sciences, University of Alabama at Birmingham (UAB), Birmingham, Alabama, USA 5 O'Neal Comprehensive Cancer Center, University of Alabama at Birmingham (UAB), Birmingham, Alabama, USA " About Erwin G. Van Meir "Dr. Erwin Van Meir is a professor in the UAB Department of Neurosurgery. He was trained in molecular biology at the Universities of Fribourg and Lausanne, Switzerland where he obtained his Ph.D. in 1989. Dr. Van Meir pursued postdoctoral work at the Ludwig Institute for Cancer Research in San Diego and joined the faculty of Emory University in 1998. His research interest lies in understanding the molecular basis for human tumor development and how to use this knowledge to devise new therapeutics that will improve patient survival. Van Meir’s research examines how genetic alterations and hypoxia induce changes in cell biology that promote tumor formation with particular emphasis on adhesion GPCRs ADGRB1 and ADGRB3. Van Meir has developed novel therapeutic approaches for cancer using oncolytic adenoviruses and anti-angiogenic molecules and is currently developing novel small molecule inhibitors of the hypoxia-inducible factor pathway and the epigenetic reader MBD2 (methyl CpG binding protein 2). His research aims to translate these novel agents to testing in clinical trials with the hope to develop novel medicines for cancer treatment." Erwin G. Van Meir on the web Google Scholar Site Specific N-Glycosylation Of The N-Terminal Fragment Of ADGRG6 Drives Proteolytic Processing, Trafficking And Signalling Pal Kasturi Abstract "ADGRG6 is a member of the adhesion G-protein-coupled receptor (aGPCR) family, known to play a role in myelination, placentation, blood vessel, and inner ear development. Like many other aGPCRs, ADGRG6 undergoes autoproteolysis at the GPCR-autoproteolysis site (GPS) enclosed within the larger GAIN domain to generate the N-terminal (NTF) and C-terminal fragments (CTF). These cleaved fragments join to form the heteromeric ADGRG6 receptor complex. ADGRG6 NTF has multiple extracellular domains like CUB, PTX, SEA, hormone binding domain, and the GAIN domain, which regulate G-protein signaling by binding to extracellular matrix proteins and mechanotransduction. The short stachel sequence at the extreme N-terminal end of the CTF functions as a tethered agonist to activate cAMP signaling. GPCR signaling and trafficking can be regulated by several different post-translational modifications (PTM). Stehlik et al. have reported that ADGRG6 expressed in lipopolysaccharide stimulated human umbilical vein endothelial cells is N-glycosylated. However, it is unclear which domains of ADGRG6 are N-glycosylated and how this might affect the overall molecular pharmacology of the receptor. Furthermore, are there spatial roles of N-glycosylation in ADGRG6 processing, trafficking, signalling and in-vivo functions? To address these gaps in knowledge, we used biochemical and cell-biological approaches using cell-lines overexpressing wild-type and N-glycosylation mutants of ADGRG6. We observed that N-glycosylation specifically takes place in the NTF and not the CTF of ADGRG6. Our results demonstrate that specific N-glycan residues in different domains of the extracellular NTF of ADGRG6 have distinct roles in ADGRG6 autoproteolysis, furin cleavage, membrane trafficking, and G-protein signalling. In the future, we plan to decipher the roles of N-glycosylation of ADGRG6 in organogenesis and tissue development using zebrafish models." Authors & Affiliations "Anandhu Jayaraman: Department of Biology, Ashoka University Prabakaran Annadurai: Department of Biology, Ashoka University. Currently: University of Leipzig Mansi Tiwari: Department of Biology, Ashoka University. Currently: University of Aberdeen Priyadatha Sajan: Department of Biology, Ashoka University, Currently: University of Groningen Nayonika Chatterjee: Department of Biology, Ashoka University Prateek Sibal: Department of Biology, Ashoka University" About Pal Kasturi "I received my bachelor’s degree in Physiology from Presidency College, University of Calcutta and went on to complete my masters from Madurai Kamaraj University. During my PhD training, I worked in the laboratory of Dr. Kathryn Defea at the University of California, Riverside. For my PhD thesis, I worked on non-canonical, scaffold driven signaling by protease activated receptor-2 (PAR2). I joined University of Texas Southwestern Medical Center, for my postdoctoral training. Here, I worked on the regulation of the Sonic Hedgehog pathway by GPCRs which localized to the primary cilia. I then joined the laboratory of Dr. Velia Fowler, at the Scripps Research Institute, as a Judith Graham Poole postdoctoral fellow to work on the role of cytoskeletal proteins in megakaryocyte to platelet differentiation. I joined the Department of Biology at Ashoka University in 2020 as an assistant professor." Pal Kasturi on the web Ashoka University < Previous Session Next Session >

Home → Flash News → In case you haven’t heard, registrations are open for the next 4-week course “Development of GPCR Ligands as Therapeutic Drugs,” with Dr. Terry Kenakin 👏 Spots are filling up fast, run and save yours, and enjoy a 25% discount with your Premium Membership 🚀 ✳️Go to https://www.ecosystem.drgpcr.com/event-details-registration/development-of-gpcr-ligands-as-therapeutic-drugs #gpcr #drgpcr Published on February 22, 2025 Category Dr. GPCR Courses In case you haven’t heard, registrations are open for the next 4-week course “Development of GPCR Ligands as Therapeutic Drugs,” with Dr. Terry Kenakin 👏 Spots are filling up fast, run and save yours, and enjoy a 25% discount with your Premium Membership 🚀 ✳️Go to https://www.ecosystem.drgpcr.com/event-details-registration/development-of-gpcr-ligands-as-therapeutic-drugs #gpcr #drgpcr Previous Next Recent Articles

Home → Flash News → Interested in learning more about signaling bias? You’re in the right place! 🙌 Join an interactive workshop with the pharmacology master Dr. Terry Kenakin and deepen your knowledge. Reading materials are already available for registered participants 👀 ✳️ Go to https://www.ecosystem.drgpcr.com/event-details-registration/the-practical-assessment-of-signaling-bias #gpcr #drgpcr Published on February 10, 2025 Category Dr. GPCR Courses Interested in learning more about signaling bias? You’re in the right place! 🙌 Join an interactive workshop with the pharmacology master Dr. Terry Kenakin and deepen your knowledge. Reading materials are already available for registered participants 👀 ✳️ Go to https://www.ecosystem.drgpcr.com/event-details-registration/the-practical-assessment-of-signaling-bias #gpcr #drgpcr Previous Next Recent Articles

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A failed experiment led Dr. Jens Carlsson to his true calling—computational biochemistry. Discover how embracing failure turned frustration into a breakthrough career designing GPCR experiments before they happen. 🎧 Listen to his story on the Dr. GPCR Podcast. Home → Flash News → ep 175 with jens carlsson release picture Model. Predict. Discover. – Podcast Episode Release Published on October 22, 2025 Category Dr. GPCR Podcast What if a failed experiment became the best thing that ever happened to your career? Dr. Jens Carlsson started his journey aiming to be a biotech engineer. But during a summer internship in protein purification, he faced a harsh reality: lab work wasn’t his strength. The experiments didn’t work, the data didn’t flow, and it was frustrating. But in the quiet hours, he found himself drawn to the structures, to the models, to figuring out why things weren’t working. A professor noticed and called it out in a recommendation letter. That unexpected moment of clarity redirected his path. Today, Jens is a Professor of Computational Biochemistry at Uppsala University , where his lab uses structure-based modeling to predict GPCR-ligand interactions, before they’re ever tested in the lab. The mindset shift? Stop explaining experiments after they happen. Start designing them to happen. His journey is a powerful reminder that the right career often reveals itself through “failure.” Follow what lights you up. Notice where your mind naturally goes. And don’t ignore the signs, it might be your real path calling. 🎧 Listen to Jens’ full story on the Dr. GPCR Podcast : https://www.ecosystem.drgpcr.com/dr-gpcr-podcast/model-predict-discover #DrGPCR #GPCR #CareerInScience #ComputationalBiology #DrugDiscovery #PhDLife Previous Next Recent Articles

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Transform your biotech idea or data into a clear, strategic roadmap with aligned biology, timelines, and CRO partnerships for faster results. Home About Services News Get in Touch Welcome Biotech Growth Wherever You Are in Discovery—Let’s Build a Plan That Moves You Forward Align your biology, timeline and CRO roadmap. Take your idea, platform, or early data and turn it into a strategic roadmap with clear decisions, timelines, and results fast. Start My Discovery Plan Too Much Uncertainty, Not Enough Progress You’re not alone. Biotech teams often tell me: “We have too many CROs and not enough clarity.” “We don’t know what matters most right now.” “We’re running experiments before aligning on strategy.” That's where I come in. How I Help Biotechs Accelerate GPCR Discovery with Clarity, Speed & Confidence Decisions, Not More Data We'll define what matters, when to decide, and how to act—based on your biology, not just what's easy to test. Prioritize assays based on project phase and decision points Map go/no-go logic that guides program momentum Focus resources where they’ll change outcomes No More Strategy Swirl I build structure that sticks—from CRO engagement to assay cascades—so your team isn't guessing what's next. Build experiment timelines aligned with strategy, not spreadsheets Set up clear deliverables across internal and CRO teams Keep cross-functional teams moving with shared structure Impress Your Board and Your Team Walk into every update with a confident story, backed by data, decisions, and momentum. Distill discovery progress into board-ready insights Craft milestone updates that tie data to strategy Present clear next steps that build investor confidence Trusted by Biotech Innovators Before working with Yamina, we were navigating challenging decisions around corporate and early discovery strategy. After bringing her in, we made confident progress on a key program and gained clarity around where to focus next. She helped bring teams together and created momentum across both science and execution. - Murat Tunabolyu, CEO Antiverse Frequently Asked Questions 01 What size companies do you work with? I work with early-stage biotechs—typically preclinical through IND-enabling—who need strategic clarity and hands-on discovery support. 02 How involved are you day-to-day? I adapt to your needs. Some teams want regular strategy sessions. Others bring me in to fix one key problem fast. 03 What's the typical outcome? You walk away with a decision-ready roadmap, improved CRO output, and faster movement through your discovery funnel. Let's turn complexity into clarity—before your next program milestone. Start My Discovery Plan Send me a message First name* Last name Company name* Email* How Can I Help?* Send Message or Book My Call Menu Home Services About Ready to collaborate? Let’s talk about how I support GPCR discovery, pharmacology strategy, and cross-functional execution across biotech, VC, and CRO teams. Get in touch Connect LinkedIn Podcast Dr. GPCR Calendly ©2023-2025 All rights reserved by FindYooour, LLC & Dr. GPCR Corp Proudly created with Wix.com

Home → Flash News → A newly engineered biosensor reveals DNAJC13 as a key player in GPCR trafficking, shedding light on its role in DOR downregulation and endosomal regulation. Check out the latest GPCR news in the Ecosystem today! You’ll need to register but don’t worry, it’s Free! ➡️https://www.ecosystem.drgpcr.com/receptor-activation-and-signaling/an-engineered-trafficking-biosensor-reveals-a-role-for-dnajc13-in-dor-downregulation #gpcr #drgpcr Published on March 24, 2025 Category GPCR Weekly News A newly engineered biosensor reveals DNAJC13 as a key player in GPCR trafficking, shedding light on its role in DOR downregulation and endosomal regulation. Check out the latest GPCR news in the Ecosystem today! You’ll need to register but don’t worry, it’s Free! ➡️ https:// www.ecosystem.drgpcr.com/receptor-activation-and-signaling/an-engineered-trafficking-biosensor-reveals-a-role-for-dnajc13-in-dor-downregulation #gpcr #drgpcr Previous Next Recent Articles

Join the Dr. GPCR Podcast community and shape our next season! Take our quick 5-minute audience survey to help us tailor our content to your needs. Your input matters in delivering exciting and informative episodes. Thank you for being part of our journey and for tuning in! Dr. GPCR Podcast Audience Survey Thanks for listening to this podcast episode Follow us on your favorite Podcast Player Be our Guest Listen and subscribe where you get your podcasts

Home → Flash News → Can we preserve opioid pain relief without the side effects? 🔬 On Ep.166 of the Dr.GPCR Podcast, Ben Clements shares how positive allosteric modulators (PAMs) at the mu-opioid receptor could revolutionize treatment —with a 10x boost in methadone efficacy. Tune in for a masterclass on translational pharmacology, curiosity-driven science, and meaningful mentorship. 🎧 Full episode: Ep 166 with Dr. Ben Clements #GPCRresearch #DrGPCR #GPCRpodcast #OpioidPharmacology #DrugDiscovery Published on May 15, 2025 Category Dr. GPCR Podcast Can we preserve opioid pain relief without the side effects? 🔬 On Ep.166 of the Dr.GPCR Podcast, Ben Clements shares how positive allosteric modulators (PAMs) at the mu-opioid receptor could revolutionize treatment —with a 10x boost in methadone efficacy. Tune in for a masterclass on translational pharmacology, curiosity-driven science, and meaningful mentorship. 🎧 Full episode: Ep 166 with Dr. Ben Clements #GPCRresearch #DrGPCR #GPCRpodcast #OpioidPharmacology #DrugDiscovery Previous Next Recent Articles

Discover how Timeline Strategy helps GPCR innovators scale their organizations through strategic planning, effective systems, and operational clarity. Home: Welcome Timeline Strategy x Dr. GPCR — Scaling Biotech Beyond the Bench Turning scientific excellence into scalable organizations. We help GPCR innovators design systems, strategies, and operating frameworks that drive predictable growth. See how we can help you About Timeline Strategy Founded by Attila Foris, Timeline Strategy partners with science-driven teams to bridge the gap between innovation and execution. Our work helps biotech startups, research organizations, and CROs design operating systems that enable clarity, accountability, and scale. Core themes: Strategic Planning for Biotech Growth Operational System Design (OS) Cross-functional Team Alignment Scaling Protocols & Decision Architecture From Chaos to Scale Timeline Strategy built to execute, not decorate slides Most strategies die in PowerPoints. Timeline Strategy lives in execution. In 3 fast steps , we turn your bottlenecks into momentum: 1. Diagnose the mess → where your growth stalls. 2. Build clarity → align people, process, priorities. 3. Scale with confidence → expand without burnout. Building the Strategic Backbone of GPCR Innovation In the rapidly evolving GPCR field, scientific progress alone isn’t enough — sustainable growth requires operational precision. Together with Dr. GPCR, we help organizations: ✅ Clarify vision and direction ✅ Translate research milestones into measurable objectives ✅ Build internal systems and workflows that support scale ✅ Create investor-ready operating structures Our Partners Benefit From: Strategy Audits & Growth Frameworks Operating System (OS) Implementation Leadership Alignment Sessions Scalable Team Protocols & Processes From the Strategy & Operations Blog Check back soon Once posts are published, you’ll see them here. Collaborate with Timeline Strategy Whether you’re leading a GPCR startup, a CRO, or an academic lab ready to scale, Timeline Strategy helps you design clarity into your growth process.

Join GPCR Happy Hour to connect with scientists across academia, biotech, and pharma - a free networking event. Sign up and join us! GPCR Happy Hour – Connect, Collaborate, Discover A global networking event where GPCR scientists break silos and build lasting connections. Sign Up to Get Event Updates Happy Hours Partners Why Join GPCR Happy Hour? Scientist-led : Built by GPCR researchers, for GPCR researchers. Cross-sector : Academia, biotech, pharma, CROs all in one room. Consistent : Monthly cadence ensures ongoing connections. Accessible : Online & free to join – no travel barriers. Action-oriented : Conversations designed to spark collaborations, not just chatter. How It Works? Step 1 Register Sign up once to access all upcoming GPCR Happy Hour events. Step 2 Get the Link Receive a secure calendar invite with Zoom/virtual event details. Step 3 Join the Conversation Show up to live sessions and meet GPCR scientists across disciplines. Step 4 Engage & Connect Breakout rooms + structured prompts maximize meaningful networking. Step 5 Follow Up Access shared contact lists and resources to keep collaborations alive. Pricing: Free (sponsored by Dr. GPCR & Partners) Upcoming and Past Happy Hours GPCR Happy Hour – Boston, Sept 2025 Every September, Boston welcomes the global biotech and drug discovery community. Scientists, investors, and CRO professionals fly in from around the world, while Boston’s own vibrant life sciences hub shows up in full force. GPCR Happy Hour is where these two worlds meet. It’s not just networking. It’s where partnerships spark, ideas collide, and the GPCR community grows stronger — together. GPCR Happy Hour Dr. GPCR News Aug 20 3 min read

Discover the essence of GPCR Retreat, an international GPCR Event that empowers the GPCR field. Retreat 2023 About Program Registration Logo Contest Committee Sponsors GPCR Retreat The GPCR Retreat focuses on advances in our understanding of how GPCRs operate in cell communication. The main goal of the GPCR Retreat is to provide a venue for students, post-doctoral fellows, and principal investigators from academia and industry to discuss and debate existing and novel concepts in GPCR biology. One of the core values of this international meeting is to promote interactions among all participants of all diversity backgrounds, particularly between trainees and principal investigators. Each year, approximately 2/3 of the participants are trainees. Registration to the GPCR Retreat is capped at 200 participants to promote an intimate environment. Most importantly, the GPCR Retreat dedicates time for two trainee symposia, an initiative that began in the Ottawa 2017 edition, to showcase the breadth of diversity in GPCR trainee communities. For the Ottawa 2017 GPCR Retreat, of the ten talks from trainees 80% were from women and 60% from visible minorities. Over the years, the meeting has grown into one of the most recognized international events in the field. That reputation has led to broad participation from the Great Lakes region and beyond. Conference History The GPCR Retreat is an annual joint meeting with the Club des récepteurs à Sept Domaines Transmembranaires du Québec that rotates around locations in Canada and the United States surrounding the Great Lakes region. The first Great Lakes GPCR Retreat was conceived, organized and held in London, Ontario, Canada in October 1999. The following year, the Great Lakes GPCR Retreat partnered with the annual symposium of the Club des Récepteurs à Sept Domains Transmembranaires du Québec . The meeting tours through many of the major universities in the Great Lakes region in both Canada and the United States. The past few GPCR retreats have been held in : Niagara-on-the-lake (2022) Bromont, Québec (2019) Detroit, Michigan (2018) Ottawa, Ontario (2017) Chicago, Illinois (2016) Toronto, Ontario (2015) Bromont, Québec (2014) Cleveland, Ohio (2013) London, Ontario (2012)

Home → Flash News → ⏳ In case you haven’t heard—registration for “Development of GPCR Ligands as Therapeutic Drugs” closes March 18th! If you’re working on GPCR drug discovery, you know that finding a promising candidate is just the start. A drug must also: ✅ Be absorbed into the body ✅ Reach the right target ✅ Stay long enough to be effective ✅ Cause no harm 📢 Spots are limited—register by March 18th! 👉 Development of GPCR Ligands as Therapeutic Drugs | Dr. GPCR Ecosystem #GPCR #DrGPCR #Pharmacology #Biotech #DrugDiscovery Published on March 10, 2025 Category Dr. GPCR Courses ⏳ In case you haven’t heard—registration for “Development of GPCR Ligands as Therapeutic Drugs” closes March 18th! If you’re working on GPCR drug discovery , you know that finding a promising candidate is just the start. A drug must also:✅ Be absorbed into the body✅ Reach the right target✅ Stay long enough to be effective✅ Cause no harm 📢 Spots are limited—register by March 18th! 👉 Development of GPCR Ligands as Therapeutic Drugs | Dr. GPCR Ecosystem #GPCR #DrGPCR #Pharmacology #Biotech #DrugDiscovery Previous Next Recent Articles

Join us as a featured guest on the Dr. GPCR Podcast! Explore the fascinating career journeys, groundbreaking discoveries, and impactful contributions of experts in GPCR biology. Share your insights and be part of the conversation. Complete the form below to become a guest - we'll reach out within 48 hours. Don't miss this opportunity to showcase your expertise! Be Our Guest – Dr. GPCR Podcast Share Your Research. Inspire the GPCR Community. Every episode of the Dr. GPCR Podcast features leading scientists, innovators, and biotech professionals whose work is advancing the understanding of G Protein-Coupled Receptors (GPCRs). We discuss breakthrough discoveries, career paths in pharmacology and molecular biology, and how each guest’s research contributes to the global GPCR ecosystem. If you’re working on exciting GPCR-related research — from structural biology to drug discovery — we’d love to feature your story. Fill out the form below and our team will contact you within 48 hours. Fill out this form Frequently asked questions About the Dr.GPCR Podcast At the high of the pandemic, I created the Dr. GPCR Podcast with three major goals in mind: Share the latest scientific discoveries in the GPCR field through discussions with experts Provide researchers with a different outlet to make their work known and Inspire young scientists to work on GPCRs It’s been a privilege to chat with so many GPCR scientists since 2020. Dr. GPCR’s mission is to bring together the GPCR community from all corners of the world to connect, exchange, and collaborate to improve human health through a better understanding of GPCR biology. So far we have recorded and released over 156 episodes and hosted GPCR specialists from all over the world, including Dr. Bryan Roth , Dr. Robert Lefkowitz , Dr. Fiona Marshall , Dr. Sam Hoare , Dr. Graciela Pineyro , Dr. Debbie Hay , Dr. Randy Hall , tributes to Dr. Marc Caron with over 30 guests including Dr. Kathleen Caron , Dr. Brian Kobilka , and many other amazing scientists. What is the format of the Dr.GPCR Podcast? Our podcast typically follows an interview-style format. We aim to have engaging conversations about you as a scientist, your career, your work, and anything related to GPCRs to provide valuable insights for our listeners. How long will the podcast recording take? The duration of the podcast recording may vary depending on the episode's topic and the flow of the conversation. On average, recordings usually take around 1 hour. We strive to keep the conversation focused and efficient while allowing enough time for in-depth discussions. How do I book the meeting on Calendly? In the invitation we provided a booking link . When clicking the link you’ll see a calendar, pick any date, and the schedule options will pop up. Then you will be asked to leave your name and email for future automated messages around our meeting. Can I reschedule or cancel our meeting? Yes, you can reschedule or cancel our meeting through Calendly. What should I expect during the recording process? Before we hit record, we will have a few minutes to discuss any questions or concerns and give you time to get comfortable. During the recording process, we will begin by introducing the episode and presenting you as our guest. We'll then engage in a conversation centered around your career and how you got introduced to GPCRs. Feel free to share your thoughts, experiences, and insights openly. If there are specific questions or talking points we plan to cover, we'll provide them in advance to help you prepare. We aim to ensure you have a great time and give a sneak peek at who you are as a scientist to the GPCR community. How should I prepare for the podcast recording? We always send our guests a Podcast Episode Outline , which includes all the questions we typically ask during the recording. You can take some time to gather your thoughts around these key points. These questions just serve as a guide, and we don’t have to go through all of them. Think of our chat as a casual discussion at an in-person conference where we are meeting for the first time. Sometimes we don’t follow the questions outlined because the discussion takes us to an also relevant and interesting conversation. We want to make sure that you are comfortable and we will never ask questions that would make you uncomfortable. Do I need to bring any equipment for the recording? In most cases, you won't need to bring any equipment for the recording as computers usually have all the necessary equipment integrated. If you do have an external microphone or webcam you’d like to use, it will make a difference, just make sure they are connected and working properly before going into the meeting. Where will the recording take place? Recordings are done on Zoom. Always remember to test it before the meeting in case it needs to update. Are there any features you’d recommend to use? Recordings are done on Zoom. Touch-up- my appearance. Adjust for low light. We encourage you to have a headset with a good microphone. We also encourage you to be sitting in front of a window or in front of a sort of light so that your entire face can be seen in the recording. Please note that we do record audio and video. Can I promote my work or projects during the podcast? Absolutely! We encourage our guests to share information about their work, projects, or any relevant initiatives they are involved in. Our podcast is a great platform for you to showcase your expertise and connect with the GPCR community. Please feel free to mention and discuss your work during the conversation. Will there be an opportunity for me to ask questions or clarify any points? Yes, we value the interactive nature of our podcast and welcome your questions or requests for clarification. If you'd like to ask anything or any points you'd like to clarify before, during, or after the recording, please don't hesitate to speak up. We want to ensure that the discussion is engaging and informative for both our guests and our community. How will the podcast episode be promoted? Once the episode is recorded and edited*, we will promote it through various channels, including our website, multiple podcast streaming platforms, social media platforms, and email newsletters. We encourage you to share the episode with your audience as well. Together, we can maximize the episode's reach and impact. * Note that by editing, we mean removing any interruptions, or background noises, from the recording. We will not edit what you say unless you ask us to remove or add sections, sometimes we can re-record. When will the episode featuring me as a guest be released? The release date of the episode featuring you as a guest will depend on our podcast's production schedule and the order of episodes in the queue. We'll strive to provide you with an estimated release date after the recording. Once the episode is live, we'll notify you, and you can share it with your network. The approximate timeline is 4-6 weeks after recording. This might change in case we take a break from releasing episodes which we do at least once a year (typically between December 15 and January 15). Can I listen to the episode after it’s been recorded? If you would like to listen to the episode after being recorded, we are more than happy to send it to you for your review. That being said, if there’s anything you’d like us to edit, feel free to reach out so we can work on it before it gets published. Can I watch the video podcast after it’s been published? The podcast video recordings are only available for the Premium Members on our Ecosystem. Anyone with a Free website membership or with an account on the different streaming platforms will have access to the podcast version only. How can I stay updated on future episodes or collaborate again in the future? To stay updated on future episodes and potential collaboration opportunities, we recommend subscribing to our podcast on your preferred platform. If you are interested in collaborating again, you can always fill out this form again and/or write to any of the following emails: hello@drgpcr.com I am still an undergraduate, Ph.D. student, or a post-doc, am I welcome to join as a guest? Yes, we value what anyone in the GPCR field has to say. For Dr.GPCR you are an expert in your own project, and we highly encourage you to accept our invitation to participate in the Podcast. Don’t hesitate to reach out to us if you’d like to recommend a colleague as a guest. Do you have any suggestions in terms of podcast equipment? Yes, here’s a list of accessible items we recommend for podcast creators: Video conference Lighting Kit Wireless microphone Any tips on achieving good lighting for the video podcast recording? Good lighting is key for any type of video. Here are some easy tips: Sitting in front of a window is always the best option for good lighting on any type of video. If we are recording at night or you don’t have natural light in your usual space, you can always use a desk lamp and put it next to the computer. The front light is always more flattering than the top light, which is what we usually have in house spaces. If you want to go like a pro , you can turn on a front light, and a backlight, that way you won’t look plain on camera. Listen and subscribe where you get your podcasts

Browse past events hosted by the Dr. GPCR Ecosystem, featuring scientific meetings, workshops, and collaborations that brought the GPCR community together. Past Events - Where the Dr. GPCR community comes alive Welcome to the page where the heart of the Dr. GPCR community comes alive! Here, we celebrate the incredible moments that brought scientists, researchers, and GPCR enthusiasts together to share groundbreaking discoveries, spark new ideas, and forge lasting connections. From immersive workshops and high-energy summits to intimate retreats and virtual conferences, each event represents a milestone in our shared mission to advance GPCR science and collaboration worldwide. 👉 Dive into our event archive below to relive the energy, inspiration, and community spirit that make Dr. GPCR truly special. Be part of our journey — stay inspired by our collective passion for science, learning, and discovery. Filter Adhesion GPCR Workshop 2024 Endocrine Metabolic GPCRs Meet Inoviem Team GPCR ECI Transatlantic 2022 Editorial: GPCR and G Protein-Mediated Signalling Events in the Nervous System Dr. GPCR Ecosystem 2.0: Collaborating better Dr. GPCR: Advancing GPCR Drug Discovery Through Collaboration Discovery On Target 2024 GPCR targeted drug discovery Summit 2024 GPCR targeted drug discovery Summit 2023 The Dr. GPCR Podcast GPCR targeted drug discovery Summit 2022 Dr. GPCR: Where all GPCRs are created equal Dr. GPCR: Beyond the lab GRS and GRC Switzerland GPCR Retreat 2023 Leadership is a learned skill - PhageMed Unige GPCR Retreat 2022 Dr. GPCR: Beyond the lab Dr. GPCR: From idea to Ecosystem Dr. GPCR: Beyond the lab

How Michelle Halls turned an unexpected summer project into a GPCR research career redefining spatial signaling and drug discovery. Home → Flash News → How GPCR Spatial Signaling Sparked a Scientific Journey How GPCR Spatial Signaling Sparked a Scientific Journey Published on November 12, 2025 Category Dr. GPCR Podcast When boredom met obsession. It started as a summer project.A reluctant student pipetting through the day, expecting nothing more than routine lab work. But for Michelle Halls, that first experiment flipped everything. One spark led to a PhD at Monash University, a fellowship at University of Cambridge, and eventually a leadership role at the forefront of GPCR spatial signaling — a field reshaping how we understand receptor biology and drug discovery. Michelle’s story isn’t just about science.It’s about what happens when curiosity takes over. From reluctant intern to scientific leader From local signaling to spatial pharmacology From spark to strategy Read the full story here🔗 https://www.ecosystem.drgpcr.com/post/how-gpcr-spatial-signaling-sparked-a-scientific-journey 🔓 Want deeper GPCR insights? Join Dr. GPCR Premium for exclusive content, expert access, and community. #GPCR #DrGPCR #SpatialSignaling #Pharmacology #DrugDiscovery #ScientificLeadership #Biotech Previous Next Recent Articles

Home → Flash News → Do you know we can discover allosteric modulators that bind to the intracellular allosteric binding site to better fine-tune the GPCRs’ activity? Check out the development of a NanoBRET assay platform to detect intracellular ligands for the chemokine receptors CCR6 and CXCR1. Check out the latest GPCR news in the Ecosystem today! You’ll need to register but don’t worry, it’s Free! Published on October 29, 2024 Category GPCR Weekly News Do you know we can discover allosteric modulators that bind to the intracellular allosteric binding site to better fine-tune the GPCRs’ activity? Check out the development of a NanoBRET assay platform to detect intracellular ligands for the chemokine receptors CCR6 and CXCR1. Check out the latest GPCR news in the Ecosystem today! You’ll need to register but don’t worry, it’s Free! ➡️ https://www.ecosystem.drgpcr.com/methods-and-updates-in-gpcr-research/development-of-a-nanobret-assay-platform-to-detect-intracellular-ligands-for-the-chemokine-receptors-ccr6-and-cxcr1 Previous Next Recent Articles

Home → Flash News → master gpcr pharmacologic models before its too late Published on July 11, 2025 Category GPCR Weekly News Most GPCR teams aren’t failing because of bad science. They’re stalling because of slow decisions, misapplied models, and buried priorities. This week’s GPCR Weekly News helps you fix that. Terry’s Corner breaks down the 4 pharmacologic models that separate forecasting from guessing. Dr. Sokhom S. Pin shares how he built high-output, low-burnout teams—and earned his PhD while working full time. Yamina’s Corner exposes the silent drift killing GPCR programs (and how to reverse it). 💡Plus: New tools from Celtarys Research . Biotech strategy moves from Catalio Capital Management . And your voice in our survey. If your competitors are already applying these insights… can you afford to skip this week’s update? ✳️ Read the Weekly News → https://www.ecosystem.drgpcr.com/post/crush-data-confusion-conquer-gpcr-drug-discovery?utm_content=bufferd9b30&utm_medium=social&utm_source=twitter.com&utm_campaign=buffer #GPCR #Pharmacology #DrugDiscovery #ScientificLeadership #DrGPCR Previous Next Recent Articles

Michelle Halls reminds us of something every scientist eventually learns: hard work is essential, but noticing the unexpected often defines your biggest breakthroughs. Home → Flash News → Scientific careers are not just built on brilliance Scientific careers aren’t just built on brilliance Published on November 14, 2025 Category Dr.GPCR Podcast Scientific careers aren’t just built on brilliance—they’re shaped by curiosity, timing, and paying close attention. In this conversation, Michelle Halls reminds us of something every scientist eventually learns: hard work is essential, but noticing the unexpected often defines your biggest breakthroughs. She also names a truth we rarely acknowledge out loud—luck and timing matter. Many talented scientists leave the field not because they lacked skill, but because the right opportunity didn’t land at the right time. And that’s why attention to detail, persistence, and a bit of serendipity can change the trajectory of a research career. 🎧 Watch this moment — then catch the full episode: https://www.ecosystem.drgpcr.com/dr-gpcr-podcast/leadership-luck-and-gpcr-signaling #GPCR #DrGPCR Previous Next Recent Articles

Home → Flash News → Did you know allosteric modulators can change the GPCR G protein subtype selectivity? Have a look at this study to dive deep into its molecular mechanism. Subscribe to the Dr. GPCR Newsletter 📰 and get the latest GPCR News delivered to your inbox. Published on December 12, 2024 Category GPCR Weekly News Did you know allosteric modulators can change the GPCR G protein subtype selectivity? Have a look at this study to dive deep into its molecular mechanism. Subscribe to the Dr. GPCR Newsletter 📰 and get the latest GPCR News delivered to your inbox. ➡ https:// www.ecosystem.drgpcr.com/gpcr-binders-drugs-and-more/design-of-allosteric-modulators-that-change-gpcr-g-protein-subtype-selectivity #gpcr #drgpcr Previous Next Recent Articles

Home → Flash News → A large-scale analysis of GPCR molecular dynamics reveals hidden allosteric sites and lateral gateways, unlocking new possibilities for drug discovery. Subscribe to the Dr. GPCR Newsletter 📰 and get the latest GPCR News delivered to your inbox ➡️https://www.ecosystem.drgpcr.com/structural-and-molecular-insights-into-gpcr-function/large-scale-investigation-of-gpcr-molecular-dynamics-data-uncovers-allosteric-sites-and-lateral-gateways #gpcr#drgpcr Published on March 17, 2025 Category GPCR Weekly News A large-scale analysis of GPCR molecular dynamics reveals hidden allosteric sites and lateral gateways, unlocking new possibilities for drug discovery. Subscribe to the Dr. GPCR Newsletter 📰 and get the latest GPCR News delivered to your inbox ➡️ https:// www.ecosystem.drgpcr.com/structural-and-molecular-insights-into-gpcr-function/large-scale-investigation-of-gpcr-molecular-dynamics-data-uncovers-allosteric-sites-and-lateral-gateways #gpcr#drgpcr Previous Next Recent Articles

Home → Flash News → The GPCR world is waiting to see YOU. Update your profile today and be part of the biggest GPCR community in the world 🌏 ✳️Visit https://www.ecosystem.drgpcr.com/account/my-account and share your updated information 😉 #gpcr #drgpcr Published on February 11, 2025 Category Dr. GPCR Profiles The GPCR world is waiting to see YOU. Update your profile today and be part of the biggest GPCR community in the world 🌏 ✳️ Visit https://www.ecosystem.drgpcr.com/account/my-account and share your updated information 😉 #gpcr #drgpcr Previous Next Recent Articles

Meet the GPCR Retreat 2023 Organizers. Dr. Paul Albert Dr. Michel Bouvier Dr. Stéphane Laporte Dr. Martin Audet Dr. Stephen Ferguson Dr. Richard Leduc Dr. Yamina Berchiche Dr. Patrick Giguère Dr. Mario Tiberi ! Widget Didn’t Load Check your internet and refresh this page. If that doesn’t work, contact us. GPCR Retreat Organizers Dr. Paul Albert Dr. Michel Bouvier Dr. Stéphane Laporte Dr. Martin Audet Dr. Stephen Ferguson Dr. Richard Leduc Dr. Yamina Berchiche Dr. Patrick Giguère Dr. Mario Tiberi Great Lakes GPCR Retreat and Club des Récepteurs à Sept Domaines Transmembranaires du Québec 22nd GPCR Retreat Sponsored by

Home → Flash News → Generic tools won’t solve tomorrow’s drug discovery challenges. That’s why Celtarys designs custom fluorescent probes for every target, built for real pharmacology, not just convenience. With Dr. GPCR and Celtarys joining forces, expect more visibility, more precision, and more scientific impact. 🚀 Get to know our media partner: https://www.ecosystem.drgpcr.com/celtarys-research-dr-gpcr-ecosystem #GPCRdrugDiscovery #GPCRecosystem #CustomLigands Published on June 27, 2025 Category Celtarys - Media Partner Generic tools won’t solve tomorrow’s drug discovery challenges. That’s why Celtarys designs custom fluorescent probes for every target, built for real pharmacology, not just convenience. With Dr. GPCR and Celtarys joining forces, expect more visibility, more precision, and more scientific impact. 🚀 Get to know our media partner: https://www.ecosystem.drgpcr.com/celtarys-research-dr-gpcr-ecosystem #GPCRdrugDiscovery #GPCRecosystem #CustomLigands Previous Next Recent Articles

Home → Flash News → We’re proud to welcome Celtarys as our media partner! Known for their fluorescent ligand innovation, Celtarys is helping researchers make biology visible, faster, smarter, and with more precision. Their chemistry speaks the language of biology, and now, they’re speaking to the global GPCR community through this powerful collaboration. 🔗 Explore Celtarys on the Dr. GPCR Ecosystem: https://www.ecosystem.drgpcr.com/celtarys-research-dr-gpcr-ecosystem #DrGPCR #GPCRtools #FluorescentLigands #BiotechInnovation Published on June 4, 2025 Category Celtarys - Media Partner We’re proud to welcome Celtarys as our media partner! Known for their fluorescent ligand innovation, Celtarys is helping researchers make biology visible, faster, smarter, and with more precision. Their chemistry speaks the language of biology, and now, they’re speaking to the global GPCR community through this powerful collaboration. 🔗 Explore Celtarys on the Dr. GPCR Ecosystem: https://www.ecosystem.drgpcr.com/celtarys-research-dr-gpcr-ecosystem #DrGPCR #GPCRtools #FluorescentLigands #BiotechInnovation Previous Next Recent Articles

Home → Flash News → The Dr. GPCR Podcast is back! After a long break, a new episode will be released today 🎧 Join us in 2025 with a year filled with GPCRs, as we share with specialists about their career paths, the latest breakthroughs, their advice, and inspiring stories. 📅 Ep. 157 drops today January 9th at 10 AM EST. Don’t miss it! ✅ Stay tuned & subscribe at https://www.ecosystem.drgpcr.com/dr-gpcr-podcast/ep-157-with-dr.-nagarajan-vaidehi Published on January 9, 2025 Category Dr. GPCR Podcast The Dr. GPCR Podcast is back! After a long break, a new episode will be released today 🎧 Join us in 2025 with a year filled with GPCRs, as we share with specialists about their career paths, the latest breakthroughs, their advice, and inspiring stories. 📅 Ep. 157 drops today January 9th at 10 AM EST. Don’t miss it! ✅ Stay tuned & subscribe at https://www.ecosystem.drgpcr.com/dr-gpcr-podcast/ep-157-with-dr.-nagarajan-vaidehi Previous Next Recent Articles