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Home → Flash News → How does nanoscale GPCR organization shape signaling? 🤔 We explore this & more with Dr. Gabriele Kockelkoren, a physicist-turned-biologist with expertise in GPCR spatial dynamics. And if you wonder what his favorite GPCR could be, here’s the answer 😉 ✅Listen now Ep 162 with Dr. Gabriele Kockelkoren #gpcr #drgpcr Published on March 20, 2025 Category Dr. GPCR Podcast How does nanoscale GPCR organization shape signaling? 🤔 We explore this & more with Dr. Gabriele Kockelkoren, a physicist-turned-biologist with expertise in GPCR spatial dynamics. And if you wonder what his favorite GPCR could be, here’s the answer 😉 ✅Listen now Ep 162 with Dr. Gabriele Kockelkoren #gpcr #drgpcr Previous Next Recent Articles

Home → Flash News → ep 169 with sokhom pin some 2 Published on July 10, 2025 Category Dr. GPCR Podcast Build the team you always wished you had. At Alkermes, Sokhom S. Pin didn’t just lead a lab. He built a culture. His team became known as “the happiest group in the company.” Why? Empowerment, trust, and zero tolerance for toxicity. It wasn’t luck. It was leadership. ✳️ Watch Ep. 169: https://www.ecosystem.drgpcr.com/dr-gpcr-podcast/ep-169-with-dr-sokhom-pin #biotechleadership #GPCRresearchcommunity #DrGPCR #teamculture Previous Next Recent Articles

Home → Flash News → "Solving financial puzzles feels just like solving scientific ones," says Joe St. Germain from Company Launch Partners. Behind every successful research organization, there is a rock-solid operations team. Don’t miss this rare conversation bridging science, structure, and strategy with Chuck DeWeese & Joe St. Germain. ✳️ Tune in now: Ep 165 with Chuck DeWeese & Joe St. Germain #gpcr #DrGPCR #ScienceStartup Published on May 1, 2025 Category Dr. GPCR Podcast "Solving financial puzzles feels just like solving scientific ones," says Joe St. Germain from Company Launch Partners.Behind every successful research organization, there is a rock-solid operations team. Don’t miss this rare conversation bridging science, structure, and strategy with Chuck DeWeese & Joe St. Germain. ✳️ Tune in now: Ep 165 with Chuck DeWeese & Joe St. Germain #gpcr #DrGPCR #ScienceStartup Previous Next Recent Articles

Discover what 40+ years of pharmacology reveal. Terry’s Corner AMA distills advanced GPCR insights into clear, practical frameworks for drug discovery. Home → Flash News → ama session sept 18 post 2 What happens when 40+ years of discovery experience get distilled into one conversation? Published on October 29, 2025 Category Terry's Corner What happens when 40+ years of discovery experience get distilled into one conversation? That’s exactly what our first-ever AMA session with Terry Kenakin set out to do. Terry’s Corner was built to make advanced pharmacology practical: a space where scientists don’t just learn passively—they shape the curriculum and bring their toughest questions forward. As Terry shared during the AMA: “This is a labor of love. Pharmacologists are almost always working in systems they don’t fully understand. The more we can see, the better choices we make.” Through live Q&A, targeted modules, and short, focused lessons, Terry’s Corner gives discovery teams the frameworks to: Decode complex GPCR signaling. Rethink outdated models. Translate early data into better decisions. This is more than another course. It’s an open vault of knowledge. 🟢 Read More → https://www.ecosystem.drgpcr.com/post/accelerating-gpcr-drug-discovery-what-40-years-of-pharmacology-reveal ✳️ Next AMA Session: October 30 | 12–1 PM EST #GPCR #DrGPCR #Pharmacology #DrugDiscovery #AllostericModulation #Kinetics #AssayDevelopment #EarlyDiscovery #PharmaR&D #BiotechInnovation Previous Next Recent Articles

Home → Flash News → Do you know that dilated cardiomyopathy, a disease that makes it harder for the heart to pump blood to the rest of the body, results from the deficiency of Latrophilin-2? Check out this paper to understand the function of Latrophilin-2 and how it leads to dilated cardiomyopathy. Subscribe to the Dr. GPCR Newsletter 📰 and get the latest GPCR News delivered to your inbox. Published on October 31, 2024 Category GPCR Weekly News Do you know that dilated cardiomyopathy, a disease that makes it harder for the heart to pump blood to the rest of the body, results from the deficiency of Latrophilin-2? Check out this paper to understand the function of Latrophilin-2 and how it leads to dilated cardiomyopathy. Subscribe to the Dr. GPCR Newsletter 📰 and get the latest GPCR News delivered to your inbox. ➡️ https:// www.ecosystem.drgpcr.com/gpcrs-in-cardiology-endocrinology-and-taste/latrophilin-2-deletion-in-cardiomyocyte-disrupts-cell-junction%2C-leading-to-d-cmp Previous Next Recent Articles

Home → Flash News → Adenosine A3 receptor has been proposed to have significant roles in metabolism and immune responses. Check out this study to understand how it affects metabolic dysfunction-associated steatotic liver progression. Subscribe to the Dr. GPCR Newsletter 📰 and get the latest GPCR News delivered to your inbox ➡️https://buff.ly/42b6ra3 #gpcr #drgpcr Published on January 16, 2025 Category GPCR Weekly News Adenosine A3 receptor has been proposed to have significant roles in metabolism and immune responses. Check out this study to understand how it affects metabolic dysfunction-associated steatotic liver progression. Subscribe to the Dr. GPCR Newsletter 📰 and get the latest GPCR News delivered to your inbox ➡️https:// www.ecosystem.drgpcr.com/receptor-activation-and-signaling/a3ar-antagonism-mitigates-metabolic-dysfunction-associated-steatotic-liver-disease-by-exploiting-monocyte-derived-kupffer-cell-necroptosis-and-inflammation-resolution #gpcr #drgpcr Previous Next Recent Articles

GPCR collaboration at Monash shows how shared lab ecosystems can reshape innovation and accelerate drug discovery. Home → Flash News → How GPCR Collaboration Built an Innovation Engine How GPCR Collaboration Built an Innovation Engine Published on November 16, 2025 Category Dr. GPCR Podcast Collaboration isn’t a soft skill — it’s an innovation strategy. At Monash Institute of Pharmaceutical Sciences, a quiet experiment challenged the traditional PI-silo model: no private labs, shared infrastructure, pooled funding, and student rotations. The result? An ecosystem where GPCR innovation accelerated — not because of a single star scientist, but because the system itself made collaboration unavoidable. “No one had their own lab. That meant no one could build a fiefdom — and everyone had to talk.” — Michelle Halls This structure: Multiplied research capacity Attracted talent and funding Created a durable innovation hub This is more than a story — it’s a blueprint for GPCR science, biotech R&D, and CRO partnerships. 🎧 Listen to the full episode: Leadership, Luck, and GPCR Signaling 🔓 Learn more: Dr. GPCR Premium #GPCR #DrGPCR #DrugDiscovery #Innovation #ScienceLeadership #Collaboration Previous Next Recent Articles

Home → Flash News → How do GPCRs sense pH changes? New cryo-EM structures of GPR4 and GPR68 reveal how extracellular histidines act as proton sensors-trigger activation and biased G protein coupling! Did you know that we work hard to bring you the most recent GPCR News, weekly? Catch up today in the Ecosystem using your free site membership! ➡️https://www.ecosystem.drgpcr.com/structural-and-molecular-insights-into-gpcr-function/structural-basis-and-biased-signaling-of-proton-sensation-by-gpcrs-mediated-by-extracellular-histidine-rearrangement #gpcr#drgpcr Published on May 26, 2025 Category GPCR Weekly News How do GPCRs sense pH changes? New cryo-EM structures of GPR4 and GPR68 reveal how extracellular histidines act as proton sensors-trigger activation and biased G protein coupling! Did you know that we work hard to bring you the most recent GPCR News, weekly? Catch up today in the Ecosystem using your free site membership! ➡️ https://www.ecosystem.drgpcr.com/structural-and-molecular-insights-into-gpcr-function/structural-basis-and-biased-signaling-of-proton-sensation-by-gpcrs-mediated-by-extracellular-histidine-rearrangement #gpcr#drgpcr Previous Next Recent Articles Decoding Schild Analysis: The Pharmacologist’s Lens on Competitive Antagonism Drug discovery often assumes receptor inhibition follows simple rules—agonist binds, antagonist blocks, and data fit neatly into predictable curves. Yet, any pharmacologist who’s pushed beyond textbook theory knows: biology rarely plays fair. Schild analysis remains one of the few conceptual anchors that can tell us when “simple” truly is simple—and when deeper receptor dynamics are at play. Terry's Desk 4 hours ago How GPCR Collaboration Built an Innovation Engine When you walk into a typical academic lab, the boundaries are obvious: this PI’s corner, that group’s benches, their grants, their silos. But in Melbourne, a quiet experiment challenged that model — and it worked. Dr. GPCR Podcast 4 hours ago From Pipettes to Platforms: The Evolution of GPCR Research The first time Michelle ran a cyclic AMP assay, she did it with a single-channel pipette, trays of melting ice, and the kind of focus that only comes from knowing one mistake could waste weeks of work. Dr. GPCR Podcast 2 days ago How GPCR Spatial Signaling Sparked a Scientific Journey Michelle hadn’t mapped out a scientific empire. She was a student expecting tedium, not inspiration. Yet that summer research placement cracked open a new reality: the thrill of asking questions no one else could answer. Dr. GPCR Podcast 4 days ago Molecular creativity in drug discovery Most pharmacologists are trained to chase targets. But what if the real opportunity lies in the chemical matter we throw at them? That’s exactly what Terry’s Corner delivers this week: a deep dive into molecular creativity, rational design, and the overlooked role of chemistry in innovation. Breakthroughs this week: Orphan receptor GPRC5B in neurogenesis; Septerna’s pill-based weight-loss strategy; Atrogi’s new CEO announcement. Dr. GPCR News 5 days ago

Home → Flash News → 💡 GPCR drug development doesn’t have to be a mystery! Learn from Dr. Terry Kenakin in this 4-week immersive course covering ligand development & pharmacology. 🔹 What you’ll learn: ✅ Drug Development Basics – Absorption, metabolism, PK principles ✅ Clearance & Distribution – Renal & hepatic clearance, key pharmacokinetics ✅ PK-PD Modeling – Predicting drug behavior, non-linear PK ✅ Early Drug Safety – Toxicity risks & drug interactions 📌 Spots are filling fast! Sign up today 👉 Development of GPCR Ligands as Therapeutic Drugs | Dr. GPCR Ecosystem #GPCR #DrGPCR #Pharmacology #Biotech #DrugDiscovery Published on March 8, 2025 Category Dr. GPCR Courses 💡 GPCR drug development doesn’t have to be a mystery! Learn from Dr. Terry Kenakin in this 4-week immersive course covering ligand development & pharmacology. 🔹 What you’ll learn: ✅ Drug Development Basics – Absorption, metabolism, PK principles✅ Clearance & Distribution – Renal & hepatic clearance, key pharmacokinetics✅ PK-PD Modeling – Predicting drug behavior, non-linear PK✅ Early Drug Safety – Toxicity risks & drug interactions 📌 Spots are filling fast! Sign up today 👉 Development of GPCR Ligands as Therapeutic Drugs | Dr. GPCR Ecosystem #GPCR #DrGPCR #Pharmacology #Biotech #DrugDiscovery Previous Next Recent Articles Decoding Schild Analysis: The Pharmacologist’s Lens on Competitive Antagonism Drug discovery often assumes receptor inhibition follows simple rules—agonist binds, antagonist blocks, and data fit neatly into predictable curves. Yet, any pharmacologist who’s pushed beyond textbook theory knows: biology rarely plays fair. Schild analysis remains one of the few conceptual anchors that can tell us when “simple” truly is simple—and when deeper receptor dynamics are at play. Terry's Desk 4 hours ago How GPCR Collaboration Built an Innovation Engine When you walk into a typical academic lab, the boundaries are obvious: this PI’s corner, that group’s benches, their grants, their silos. But in Melbourne, a quiet experiment challenged that model — and it worked. Dr. GPCR Podcast 4 hours ago From Pipettes to Platforms: The Evolution of GPCR Research The first time Michelle ran a cyclic AMP assay, she did it with a single-channel pipette, trays of melting ice, and the kind of focus that only comes from knowing one mistake could waste weeks of work. Dr. GPCR Podcast 2 days ago How GPCR Spatial Signaling Sparked a Scientific Journey Michelle hadn’t mapped out a scientific empire. She was a student expecting tedium, not inspiration. Yet that summer research placement cracked open a new reality: the thrill of asking questions no one else could answer. Dr. GPCR Podcast 4 days ago Molecular creativity in drug discovery Most pharmacologists are trained to chase targets. But what if the real opportunity lies in the chemical matter we throw at them? That’s exactly what Terry’s Corner delivers this week: a deep dive into molecular creativity, rational design, and the overlooked role of chemistry in innovation. Breakthroughs this week: Orphan receptor GPRC5B in neurogenesis; Septerna’s pill-based weight-loss strategy; Atrogi’s new CEO announcement. Dr. GPCR News 5 days ago

Home → Flash News → We’re excited to announce our strategic partnership with Celtarys Research, a biotech company specializing in fluorescent ligand technologies and real-time, non-radioactive GPCR assays. This collaboration combines Dr. GPCR’s global platform with Celtarys’ innovative chemical biology tools, making it easier than ever for scientists to study ligand-receptor interactions, visualize binding, and accelerate drug discovery. We’re proud to welcome Celtarys to the Dr. GPCR ecosystem to support researchers worldwide and expand access to high-performance tools for GPCR-targeted therapeutics. ✳️Read the complete press release: https://www.ecosystem.drgpcr.com/post/dr-gpcr-and-celtarys-research-join-forces-to-expand-access-to-innovative-gpcr-tools #GPCR #DrGPCR #CeltarysResearch #DrugDiscoveryTools #FluorescentLigands #GPCRresearch #ScientificPartnership Published on June 3, 2025 Category Celtarys - Media Partner We’re excited to announce our strategic partnership with Celtarys Research , a biotech company specializing in fluorescent ligand technologies and real-time, non-radioactive GPCR assays. This collaboration combines Dr. GPCR’s global platform with Celtarys’ innovative chemical biology tools , making it easier than ever for scientists to study ligand-receptor interactions, visualize binding, and accelerate drug discovery. We’re proud to welcome Celtarys to the Dr. GPCR ecosystem to support researchers worldwide and expand access to high-performance tools for GPCR-targeted therapeutics. ✳️ Read the complete press release: https://www.ecosystem.drgpcr.com/post/dr-gpcr-and-celtarys-research-join-forces-to-expand-access-to-innovative-gpcr-tools #GPCR #DrGPCR #CeltarysResearch #DrugDiscoveryTools #FluorescentLigands #GPCRresearch #ScientificPartnership Previous Next Recent Articles Decoding Schild Analysis: The Pharmacologist’s Lens on Competitive Antagonism Drug discovery often assumes receptor inhibition follows simple rules—agonist binds, antagonist blocks, and data fit neatly into predictable curves. Yet, any pharmacologist who’s pushed beyond textbook theory knows: biology rarely plays fair. Schild analysis remains one of the few conceptual anchors that can tell us when “simple” truly is simple—and when deeper receptor dynamics are at play. Terry's Desk 4 hours ago How GPCR Collaboration Built an Innovation Engine When you walk into a typical academic lab, the boundaries are obvious: this PI’s corner, that group’s benches, their grants, their silos. But in Melbourne, a quiet experiment challenged that model — and it worked. Dr. GPCR Podcast 4 hours ago From Pipettes to Platforms: The Evolution of GPCR Research The first time Michelle ran a cyclic AMP assay, she did it with a single-channel pipette, trays of melting ice, and the kind of focus that only comes from knowing one mistake could waste weeks of work. Dr. GPCR Podcast 2 days ago How GPCR Spatial Signaling Sparked a Scientific Journey Michelle hadn’t mapped out a scientific empire. She was a student expecting tedium, not inspiration. Yet that summer research placement cracked open a new reality: the thrill of asking questions no one else could answer. Dr. GPCR Podcast 4 days ago Molecular creativity in drug discovery Most pharmacologists are trained to chase targets. But what if the real opportunity lies in the chemical matter we throw at them? That’s exactly what Terry’s Corner delivers this week: a deep dive into molecular creativity, rational design, and the overlooked role of chemistry in innovation. Breakthroughs this week: Orphan receptor GPRC5B in neurogenesis; Septerna’s pill-based weight-loss strategy; Atrogi’s new CEO announcement. Dr. GPCR News 5 days ago

Explore this week's edition of Weekly News, featuring expert insights on target engagement, a practical framework for irreversible drugs by Terry, and Dr. Jens Carlsson's take on predictive modeling. Gain valuable strategies to advance your covalent or tight-binding candidates and enhance your experimentation process. Read more for a premium sneak peek! Home → Flash News → Weekly News October 23 Dr. GPCR Weekly News - Oct 23 - The Power and Peril of Irreversible Drugs Published on October 23, 2025 Category GPCR Weekly News This week’s Weekly News breaks down how to control target engagement—so duration, penetration, and PK/PD separation serve your program, not sink it. Premium sneak peek inside. 🔹 Terry’s Corner: A practical framework for irreversible drugs—defining “irreversible” in real systems, anticipating PK/PD decoupling, and using k_inact/K_I when Ki falls short. 🔹 Podcast Spotlight: Dr. Jens Carlsson on predictive modeling—where structure-based design and MD guide experiments (and where AlphaFold still needs a chaperone). If you’re advancing covalent or tight-binding candidates—or building models meant to predict, not narrate —this edition is built to shorten cycles and reduce surprises. Read the full Weekly News ➤ https://bit.ly/3KVlL4m If it helps your team, share it forward. #DrGPCR #GPCR Previous Next Recent Articles

< Back This is a Title 03 This is placeholder text. To change this content, double-click on the element and click Change Content. This is placeholder text. To change this content, double-click on the element and click Change Content. Want to view and manage all your collections? Click on the Content Manager button in the Add panel on the left. Here, you can make changes to your content, add new fields, create dynamic pages and more. You can create as many collections as you need. Your collection is already set up for you with fields and content. Add your own, or import content from a CSV file. Add fields for any type of content you want to display, such as rich text, images, videos and more. You can also collect and store information from your site visitors using input elements like custom forms and fields. Be sure to click Sync after making changes in a collection, so visitors can see your newest content on your live site. Preview your site to check that all your elements are displaying content from the right collection fields. Previous Next News Get in Touch Menu • Home • Services • About Menu • Home • Services • About Menu • Home • Services • About Menu • Home • Services • About Menu • Home • Services • About

Home → Flash News → Check out the new optical BRET-based biosensor, Gαi bONE-GO! In neuronal cell lines, the use of Gαi bONE-GO revealed that several natural opioid neuropeptides act as partial agonists, contrary to their previous characterization as full agonists. Check out the latest GPCR news in the Ecosystem today! You’ll need to register but don’t worry, it’s Free! ➡️https://buff.ly/e6gAlBv #gpcr#drgpcr Published on April 21, 2025 Category GPCR Weekly News Check out the new optical BRET-based biosensor, Gαi bONE-GO! In neuronal cell lines, the use of Gαi bONE-GO revealed that several natural opioid neuropeptides act as partial agonists, contrary to their previous characterization as full agonists. Check out the latest GPCR news in the Ecosystem today! You’ll need to register but don’t worry, it’s Free! ➡️ https:// buff.ly/e6gAlBv #gpcr#drgpcr Previous Next Recent Articles

Discover how Dr. Jens Carlsson’s lab at Uppsala University is redefining GPCR drug discovery with predictive molecular modeling that forecasts receptor behavior—before the first assay begins. Home → Flash News → ep 175 with jens carlsson clip 1 Can your model actually predict the outcome of a GPCR experiment? Published on October 27, 2025 Category Dr. GPCR Podcast “Explain” is no longer enough. Can your model actually predict the outcome of a GPCR experiment? At Uppsala University, Dr. Jens Carlsson and his team are redefining what computational modeling means in drug discovery. Their lab doesn’t just simulate receptor-ligand interactions after the fact; they aim to forecast receptor behavior before the first assay is run. By integrating molecular docking, molecular dynamics, and machine learning, they design ligands with the goal to anticipate biological outcomes. This kind of predictive modeling challenges the traditional role of computation in pharmacology, where models have too often served as post hoc rationalizations. But Carlsson’s lab stands out for another reason: knowing when not to predict. His team is candid about the limits of their models. If the resolution isn't good enough, or if the data is too uncertain, they’re not afraid to say, “We don’t know.” That scientific humility (combined with deep collaborations with medicinal chemists and pharmacologists) is exactly what makes their predictions so useful. This episode is essential listening for anyone thinking seriously about translational pharmacology and the future of GPCR drug discovery. 🎧 Explore how predictive modeling is reshaping GPCR science in this Dr. GPCR Podcast episode: model predict discover #DrGPCR #GPCR #MolecularModeling #PredictivePharmacology #DrugDiscovery Previous Next Recent Articles Decoding Schild Analysis: The Pharmacologist’s Lens on Competitive Antagonism Drug discovery often assumes receptor inhibition follows simple rules—agonist binds, antagonist blocks, and data fit neatly into predictable curves. Yet, any pharmacologist who’s pushed beyond textbook theory knows: biology rarely plays fair. Schild analysis remains one of the few conceptual anchors that can tell us when “simple” truly is simple—and when deeper receptor dynamics are at play. Terry's Desk 4 hours ago How GPCR Collaboration Built an Innovation Engine When you walk into a typical academic lab, the boundaries are obvious: this PI’s corner, that group’s benches, their grants, their silos. But in Melbourne, a quiet experiment challenged that model — and it worked. Dr. GPCR Podcast 4 hours ago From Pipettes to Platforms: The Evolution of GPCR Research The first time Michelle ran a cyclic AMP assay, she did it with a single-channel pipette, trays of melting ice, and the kind of focus that only comes from knowing one mistake could waste weeks of work. Dr. GPCR Podcast 2 days ago How GPCR Spatial Signaling Sparked a Scientific Journey Michelle hadn’t mapped out a scientific empire. She was a student expecting tedium, not inspiration. Yet that summer research placement cracked open a new reality: the thrill of asking questions no one else could answer. Dr. GPCR Podcast 4 days ago Molecular creativity in drug discovery Most pharmacologists are trained to chase targets. But what if the real opportunity lies in the chemical matter we throw at them? That’s exactly what Terry’s Corner delivers this week: a deep dive into molecular creativity, rational design, and the overlooked role of chemistry in innovation. Breakthroughs this week: Orphan receptor GPRC5B in neurogenesis; Septerna’s pill-based weight-loss strategy; Atrogi’s new CEO announcement. Dr. GPCR News 5 days ago

Home → Flash News → terrys corner predict drug behavior Published on July 12, 2025 Category Terry's Corner Linear, linkage, or probability? Dive into the logic of drug modeling with Terry Kenakin. In his latest lesson, he breaks down the essential models shaping modern pharmacology. Learn to “extend your eyes” and predict complex drug behaviors. 🟢 Browse the full catalog (and expect a new course every week!) ✳️ https://www.terrykenakin.com #pharmacology #drugmechanism #kenakin #GPCR #DrGPCR Previous Next Recent Articles

< Back This is a Title 02 This is placeholder text. To change this content, double-click on the element and click Change Content. This is placeholder text. To change this content, double-click on the element and click Change Content. Want to view and manage all your collections? Click on the Content Manager button in the Add panel on the left. Here, you can make changes to your content, add new fields, create dynamic pages and more. You can create as many collections as you need. Your collection is already set up for you with fields and content. Add your own, or import content from a CSV file. Add fields for any type of content you want to display, such as rich text, images, videos and more. You can also collect and store information from your site visitors using input elements like custom forms and fields. Be sure to click Sync after making changes in a collection, so visitors can see your newest content on your live site. Preview your site to check that all your elements are displaying content from the right collection fields. Previous Next News Get in Touch Menu • Home • Services • About Menu • Home • Services • About Menu • Home • Services • About Menu • Home • Services • About Menu • Home • Services • About

Home → Flash News → 🎧 Why Does GPCR Location Make All the Difference? GPCR location within the cell can change everything: function, pharmacology, and even drug response. In Ep.162 of the Dr.GPCR Podcast, Dr. Gabriele Kockelkoren dives into: 🔬 How GPCR trafficking shapes signaling outcomes 🚀 Career insights from the lab to the broader biotech world This episode is packed with knowledge for scientists, drug hunters, and anyone fascinated by GPCRs! 🎙️ Listen now https://buff.ly/fYZ1tSq #DrGPCR #GPCR #DrugDiscovery #Pharma #Biotech #SciencePodcast ✅ Tune in today! Published on March 18, 2025 Category Dr. GPCR Podcast 🎧 Why Does GPCR Location Make All the Difference? GPCR location within the cell can change everything: function, pharmacology, and even drug response. In Ep.162 of the Dr.GPCR Podcast, Dr. Gabriele Kockelkoren dives into: 🔬 How GPCR trafficking shapes signaling outcomes 🚀 Career insights from the lab to the broader biotech world This episode is packed with knowledge for scientists, drug hunters, and anyone fascinated by GPCRs! 🎙️ Listen now https://buff.ly/fYZ1tSq #DrGPCR #GPCR #DrugDiscovery #Pharma #Biotech #SciencePodcast ✅ Tune in today! Previous Next Recent Articles

Home → Flash News → Forget one receptor at a time. Go big.Ep.167 of the Dr.GPCR Podcast with Tom Sakmar & Ilana Kotliar is about scaling GPCR research with multiplexing, miniaturization, and collaboration. The tools are built. The data is free. What will you ask next? 📲 Dive in: Ep 167 with Drs. Tom Sakmar & Ilana Kotliar #GPCRtraining #GPCRresearchcommunity #DrGPCR #GPCRdata Published on June 5, 2025 Category Dr. GPCR Podcast Forget one receptor at a time. Go big.Ep.167 of the Dr.GPCR Podcast with Tom Sakmar & Ilana Kotliar is about scaling GPCR research with multiplexing, miniaturization, and collaboration. The tools are built. The data is free. What will you ask next? 📲 Dive in: Ep 167 with Drs. Tom Sakmar & Ilana Kotliar #GPCRtraining #GPCRresearchcommunity #DrGPCR #GPCRdata Previous Next Recent Articles Decoding Schild Analysis: The Pharmacologist’s Lens on Competitive Antagonism Drug discovery often assumes receptor inhibition follows simple rules—agonist binds, antagonist blocks, and data fit neatly into predictable curves. Yet, any pharmacologist who’s pushed beyond textbook theory knows: biology rarely plays fair. Schild analysis remains one of the few conceptual anchors that can tell us when “simple” truly is simple—and when deeper receptor dynamics are at play. Terry's Desk 4 hours ago How GPCR Collaboration Built an Innovation Engine When you walk into a typical academic lab, the boundaries are obvious: this PI’s corner, that group’s benches, their grants, their silos. But in Melbourne, a quiet experiment challenged that model — and it worked. Dr. GPCR Podcast 4 hours ago From Pipettes to Platforms: The Evolution of GPCR Research The first time Michelle ran a cyclic AMP assay, she did it with a single-channel pipette, trays of melting ice, and the kind of focus that only comes from knowing one mistake could waste weeks of work. Dr. GPCR Podcast 2 days ago How GPCR Spatial Signaling Sparked a Scientific Journey Michelle hadn’t mapped out a scientific empire. She was a student expecting tedium, not inspiration. Yet that summer research placement cracked open a new reality: the thrill of asking questions no one else could answer. Dr. GPCR Podcast 4 days ago Molecular creativity in drug discovery Most pharmacologists are trained to chase targets. But what if the real opportunity lies in the chemical matter we throw at them? That’s exactly what Terry’s Corner delivers this week: a deep dive into molecular creativity, rational design, and the overlooked role of chemistry in innovation. Breakthroughs this week: Orphan receptor GPRC5B in neurogenesis; Septerna’s pill-based weight-loss strategy; Atrogi’s new CEO announcement. Dr. GPCR News 5 days ago

Home → Flash News → What do you want to learn today? If you’re an Ecosystem Member, you can learn something new every day! 🚀 Take one of our courses On-Demand and expand your knowledge of GPCRs. ✳️Discover your next learning experience at https://www.ecosystem.drgpcr.com/gpcr-courses #gpcr #drgpcr Published on February 13, 2025 Category Dr. GPCR Courses What do you want to learn today? If you’re an Ecosystem Member, you can learn something new every day! 🚀 Take one of our courses On-Demand and expand your knowledge of GPCRs. ✳️Discover your next learning experience at https://www.ecosystem.drgpcr.com/gpcr-courses #gpcr #drgpcr Previous Next Recent Articles

Home → Flash News → Did you know that cell types can affect the GPCR-mediated signalling cascade? Check out this paper to know how different cell types affect the A2BR-mediated calcium signalling system. Check out the latest GPCR news in the Ecosystem today! You’ll need to register but don’t worry, it’s Free! ➡️https://www.ecosystem.drgpcr.com/receptor-activation-and-signaling/a2b-adenosine-receptor-triggered-intracellular-calcium-mobilization%3A-cell-type-dependent-involvement-of-gi%2C-gq%2C-gs-proteins-and-protein-kinase-c #gpcr #drgpcr Published on January 14, 2025 Category GPCR Weekly News Did you know that cell types can affect the GPCR-mediated signalling cascade? Check out this paper to know how different cell types affect the A2BR-mediated calcium signalling system. Check out the latest GPCR news in the Ecosystem today! You’ll need to register but don’t worry, it’s Free! ➡️ https:// www.ecosystem.drgpcr.com/receptor-activation-and-signaling/a2b-adenosine-receptor-triggered-intracellular-calcium-mobilization%3A-cell-type-dependent-involvement-of-gi%2C-gq%2C-gs-proteins-and-protein-kinase-c #gpcr #drgpcr Previous Next Recent Articles

Home → Flash News → New strategic partnership alert! 🚀 Dr.GPCR x Celtarys are teaming up to revolutionize fluorescent ligand development for GPCR research. Get custom, fast, and functional ligands backed by real scientists solving real assay problems. 🧪 “We don’t just deliver compounds. We solve assay problems.” – Dr. Maria Majellaro, CSO, Celtarys Listen to Ep. 168 now and meet your new assay partner 😉 ✳️ https://www.ecosystem.drgpcr.com/dr-gpcr-podcast/ep-168-with-dr.-maria-majellaro-from-celtarys #GPCRdrugDiscovery #FluorescentLigands #DrGPCR #BiotechTools #AssayDevelopment Published on June 10, 2025 Category Dr. GPCR Podcast New strategic partnership alert! 🚀 Dr.GPCR x Celtarys are teaming up to revolutionize fluorescent ligand development for GPCR research. Get custom, fast, and functional ligands backed by real scientists solving real assay problems. 🧪 “We don’t just deliver compounds. We solve assay problems.” – Dr. Maria Majellaro, CSO, Celtarys Listen to Ep. 168 now and meet your new assay partner 😉 ✳️ https://www.ecosystem.drgpcr.com/dr-gpcr-podcast/ep-168-with-dr.-maria-majellaro-from-celtarys #GPCRdrugDiscovery #FluorescentLigands #DrGPCR #BiotechTools #AssayDevelopment Previous Next Recent Articles

Home → Flash News → Did you know that GPR20, a potential therapeutic target to treat gastrointestinal stromal tumours, performs high constitutive activity when coupling with Gi? Check out this paper to see how molecular dynamics simulation can be used to explore its constitutive activation mechanism. Check out the latest GPCR news in the Ecosystem today! You’ll need to register but don’t worry, it’s Free! ➡️https://www.ecosystem.drgpcr.com/receptor-activation-and-signaling/exploring-the-constitutive-activation-mechanism-of-the-class-a-orphan-gpr20 #gpcr #drgpcr Published on February 13, 2025 Category GPCR Weekly News Did you know that GPR20, a potential therapeutic target to treat gastrointestinal stromal tumours, performs high constitutive activity when coupling with Gi? Check out this paper to see how molecular dynamics simulation can be used to explore its constitutive activation mechanism. Check out the latest GPCR news in the Ecosystem today! You’ll need to register but don’t worry, it’s Free! ➡️ https:// www.ecosystem.drgpcr.com/receptor-activation-and-signaling/exploring-the-constitutive-activation-mechanism-of-the-class-a-orphan-gpr20 #gpcr #drgpcr Previous Next Recent Articles

Home → Flash News → 🔥 New Course Alert! “Development of GPCR Ligands as Therapeutic Drugs” with Dr. Terry Kenakin is here! Spots are filling up fast—Premium Members get 25% off! This advanced course is exclusively available in the Ecosystem, so don’t miss your chance to learn from the best. 🔹 Secure your spot now! 👉 https://www.ecosystem.drgpcr.com/event-details-registration/development-of-gpcr-ligands-as-therapeutic-drugs #gpcr #drgpcr #pharmacolgy #drugdiscovery #research Published on February 24, 2025 Category Dr. GPCR Courses 🔥 New Course Alert! “Development of GPCR Ligands as Therapeutic Drugs” with Dr. Terry Kenakin is here! Spots are filling up fast—Premium Members get 25% off! This advanced course is exclusively available in the Ecosystem, so don’t miss your chance to learn from the best. 🔹 Secure your spot now! 👉 https://www.ecosystem.drgpcr.com/event-details-registration/development-of-gpcr-ligands-as-therapeutic-drugs #gpcr #drgpcr #pharmacolgy #drugdiscovery #research Previous Next Recent Articles

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Home → Flash News → What do GPCRs, acidic endosomes, and cancer immunotherapy have in common? Find out in our latest episode featuring Ian Chronis, where we explore the surprising ways GPR65 signals in different environments! ✅ Tune in: https://buff.ly/FTB69y9 #GPCR #DrGPCR #SciencePodcast Published on April 15, 2025 Category Dr. GPCR Podcast What do GPCRs, acidic endosomes, and cancer immunotherapy have in common? Find out in our latest episode featuring Ian Chronis, where we explore the surprising ways GPR65 signals in different environments! ✅ Tune in: https://buff.ly/FTB69y9 #GPCR #DrGPCR #SciencePodcast Previous Next Recent Articles

Home → Flash News → terrys corner no fluff pure insight Published on July 8, 2025 Category Terry's Corner The wait is over! Terry's Corner is LIVE! ✨ We've poured our passion for pharmacology into creating this essential resource, designed to meet you exactly where you are in your drug discovery journey. Dr. Terry Kenakin delivers razor-sharp insights, all on-demand. Ready to: Strengthen your pharmacology fundamentals? Bridge theory to practical drug development decisions? Push the boundaries with advanced concepts like allosteric modulation and residence time? Terry's Corner helps you make better decisions through better pharmacology. Enroll now: https://www.terrykenakin.com #pharmacology #GPCRscience #drugdiscovery #TerrysCorner #biotechtraining #ScienceEducation #Pharma #GPCR #DrGPCR Previous Next Recent Articles

Home → Flash News → Terry's Corner is Officially LIVE! 🎉 This is your new go-to for mastering drug discovery pharmacology. No fluff, just clear, on-demand insights from Terry Kenakin. Building core expertise? Master dose-response, binding, kinetics, and foundational models. Driving drug discovery? Apply pharmacology to selectivity, ADME, and strategic decision-making. An experienced drug hunter? Sharpen your edge with allosteric bias, residence time, and translational PK/PD. Learn on-demand, apply immediately: https://terrykenakin.com #DrGPCR #GPCR #pharmacology #TerrysCorner #DrugDiscovery Published on July 2, 2025 Category Terry's Corner Terry's Corner is Officially LIVE! 🎉 This is your new go-to for mastering drug discovery pharmacology. No fluff, just clear, on-demand insights from Terry Kenakin. Building core expertise? Master dose-response, binding, kinetics, and foundational models. Driving drug discovery? Apply pharmacology to selectivity, ADME, and strategic decision-making. An experienced drug hunter? Sharpen your edge with allosteric bias, residence time, and translational PK/PD. Learn on-demand, apply immediately: https://terrykenakin.com #DrGPCR #GPCR #pharmacology #TerrysCorner #DrugDiscovery Previous Next Recent Articles Decoding Schild Analysis: The Pharmacologist’s Lens on Competitive Antagonism Drug discovery often assumes receptor inhibition follows simple rules—agonist binds, antagonist blocks, and data fit neatly into predictable curves. Yet, any pharmacologist who’s pushed beyond textbook theory knows: biology rarely plays fair. Schild analysis remains one of the few conceptual anchors that can tell us when “simple” truly is simple—and when deeper receptor dynamics are at play. Terry's Desk 4 hours ago How GPCR Collaboration Built an Innovation Engine When you walk into a typical academic lab, the boundaries are obvious: this PI’s corner, that group’s benches, their grants, their silos. But in Melbourne, a quiet experiment challenged that model — and it worked. Dr. GPCR Podcast 4 hours ago From Pipettes to Platforms: The Evolution of GPCR Research The first time Michelle ran a cyclic AMP assay, she did it with a single-channel pipette, trays of melting ice, and the kind of focus that only comes from knowing one mistake could waste weeks of work. Dr. GPCR Podcast 2 days ago How GPCR Spatial Signaling Sparked a Scientific Journey Michelle hadn’t mapped out a scientific empire. She was a student expecting tedium, not inspiration. Yet that summer research placement cracked open a new reality: the thrill of asking questions no one else could answer. Dr. GPCR Podcast 4 days ago Molecular creativity in drug discovery Most pharmacologists are trained to chase targets. But what if the real opportunity lies in the chemical matter we throw at them? That’s exactly what Terry’s Corner delivers this week: a deep dive into molecular creativity, rational design, and the overlooked role of chemistry in innovation. Breakthroughs this week: Orphan receptor GPRC5B in neurogenesis; Septerna’s pill-based weight-loss strategy; Atrogi’s new CEO announcement. Dr. GPCR News 5 days ago

Home → Flash News → Unlock your pharmacology potential with Terry’s Corner. No fluff. Just clear, on-demand insight from Dr. Terry Kenakin—built for scientists at every level. 🟢 Building core expertise? Learn dose-response, agonism, binding, bias, kinetics, and the models that build real confidence. 🟢 Driving drug discovery? Apply pharmacology to selectivity, ADME, early safety, and smarter decision-making. 🟢 Already a drug hunter? Sharpen your edge with allosteric modulation, residence time, molecular dynamics, and translational PK/PD. Learn on-demand. Apply immediately. Early access begins July 1 → https://www.terrykenakin.com #pharmacology #GPCRscience #drugdiscovery #TerrysCorner #biotechtraining Published on June 28, 2025 Category Terry's Corner Unlock your pharmacology potential with Terry’s Corner. No fluff. Just clear, on-demand insight from Dr. Terry Kenakin—built for scientists at every level. 🟢 Building core expertise? Learn dose-response, agonism, binding, bias, kinetics, and the models that build real confidence. 🟢 Driving drug discovery? Apply pharmacology to selectivity, ADME, early safety, and smarter decision-making. 🟢 Already a drug hunter? Sharpen your edge with allosteric modulation, residence time, molecular dynamics, and translational PK/PD. Learn on-demand. Apply immediately. Early access begins July 1 → https://www.terrykenakin.com #pharmacology #GPCRscience #drugdiscovery #TerrysCorner #biotechtraining Previous Next Recent Articles

Home → Flash News → Ever wondered how we perceive bitterness? 👅🔬 Researchers have unveiled the cryo-EM structure of TAS2R14, the most promiscuous bitter taste receptor, bound to the drug flufenamic acid (FFA) and its signaling partner gustducin! 🌟 This discovery reveals an unusual dual binding mode of FFA and offers tools for site-targeted compound design. 🧪✨ Learn more about this exciting breakthrough in bitter taste signaling. Published on December 5, 2024 Category GPCR Weekly News Ever wondered how we perceive bitterness? 👅🔬 Researchers have unveiled the cryo-EM structure of TAS2R14 , the most promiscuous bitter taste receptor, bound to the drug flufenamic acid (FFA) and its signaling partner gustducin! 🌟 This discovery reveals an unusual dual binding mode of FFA and offers tools for site-targeted compound design . 🧪✨ Learn more about this exciting breakthrough in bitter taste signaling. ➡️ https://www.ecosystem.drgpcr.com/receptor-activation-and-signaling/a-bitter-anti-inflammatory-drug-binds-at-two-distinct-sites-of-a-human-bitter-taste-gpcr?utm_campaign=5d751e7a-3ecb-4719-8ba3-974d17e9f596&utm_source=so&utm_medium=mail&cid=79a6b35e-7ba6-44a0-863b-0842f5a5cfd3 #gpcr #drgpcr #bittertaste Previous Next Recent Articles

Home → Flash News → In case you haven’t heard, Dr. Terry Kenakin will soon start the course Principles of Pharmacology II - Advanced Methods for the Optimization of Candidate Selection 📖 The five-lecture series describes essential additional elements to GPCR discovery programs that extend the discovery process and increase therapeutic opportunity. Published on October 22, 2024 Category Dr. GPCR Courses In case you haven’t heard, Dr. Terry Kenakin will soon start the course Principles of Pharmacology II - Advanced Methods for the Optimization of Candidate Selection 📖 The five-lecture series describes essential additional elements to GPCR discovery programs that extend the discovery process and increase therapeutic opportunity. ✳️ Register today! https://www.ecosystem.drgpcr.com/advanced-methods-for-the-optimization-of-candidate-selection #gpcr #drgpcr Previous Next Recent Articles