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GPCR Courses Expert knowledge, flexible courses - career-ready skills —build skills that translate at - Quantifying agonist pharmacology and biased agonism Class 3 - Antagonist pharmacology and binding assay the Optimization of Candidate Selection Lecture 1: The Eyes to See- The Importance of Pharmacologic Assays Ligand Kinetics to Candidate Design Lecture 4: Unconventional GPCR Ligands as Drugs Lecture 5: Unique Aside from his vast experience in drug development, not to mention his extensive publication record,

His team develops fluorescence-based and chemically engineered tools to study gpcr internalization and engagement in intact islets and neuronal circuits — insights that inform next-generation functional assay development and translational therapeutic design. on biological context Balanced innovation with the need for reproducible, well-controlled functional assays His group develops imaging and chemical biology tools to reveal how GLP-1 and GIP receptors operate within

He is the Research director at INSERM with a specific interest in G protein-coupled receptors by developing original BRET and TR-FRET assays. loss-of-function variants of the MT2 melatonin receptors that are associated with type 2 diabetes (TD2) development His lab was among the first to discover mitochondrial functions of GPCRs. GPCR Ecosystem Enjoying the Dr. GPCR Podcast? Leave a Review.

I study the cell and tissue level consequences of its failure in foetal development and of its reemployment Since staring my postdoctoral training, I have continued to develop my expertise to answer fundamental and gene expression assays. ), is widely expressed in developing brains but diminishes in adult stage except in the hippocampus, Ligand-induced GPR110 signaling stimulates neurogenesis and synaptogenesis during development, and the

Karine Pichavant , I contributed to the development of a drug to treat hypovolemic shock after severe an activated GPCR for the first time. Chemistry which described the molecular mechanisms of MRAP2 regulation of the GHSR1a, and where I notably developed I also invested a tremendous amount of time in developing my leadership skills. GPCR Enjoying the Dr. GPCR Podcast? Leave a Review.

John Traynor , Kathryn worked to develop and understand first-in-class allosteric modulators of opioid There she researched the beta-2 adrenergic receptor and developed assays to investigate real-time activity Kathryn’s passion is developing solutions to problems in whatever form is most efficient: novel instrumentation GPCR Ecosystem Enjoying the Dr. GPCR Podcast? Leave a Review. Imaging in Native Tissue How Collaboration Sparked a GPCR Imaging Breakthrough in Chemical Biology Thanks

I hope to develop my skillsets so as to be able to establish my own lab in future to work on adhesion Recent studies implicate the dysregulation of adhesion G-Protein coupled receptors (GPCRs) in GBM development A mouse model of Zhu-Tokita-Takenouchi-Kim syndrome reveals indispensable SON functions in organ development This research focuses on the design of a new endogenous ADGRB1 activation reporter assay to test analogs About Jesse Stillwell "Jesse Stillwell is a 3rd year graduate student with a research focus in drug development

The conversation ended with Arthur's ongoing research and his development of a new operational model. Allosteric Modulation and Hybrid Molecules Arthur and Yamina discussed the development of an operational also discussed the potential of certain drugs, like flumazenil, as 'nails' or compounds that could be developed and Reproducibility Yamina and Arthur discussed the concept of a target product profile (TPP) in drug development GPCR Podcast? Leave a Review.

He is passionate about developing more rational ways to understand and engineer biology. technologies in gene synthesis, DNA information storage, gene editing, and large-scale multiplexed assays GPCR Ecosystem Enjoying the Dr. GPCR Podcast? Leave a Review. Better Questions in Science: A Practical Guide for Emerging Researchers When the Islet Lit Up: Advancing GPCR Imaging in Native Tissue How Collaboration Sparked a GPCR Imaging Breakthrough in Chemical Biology Thanks

His journey highlights the transition from general drug development to a deep dive into G protein-coupled Despite the availability of modern tools, Ben stresses the enduring value of classical methods like GTPγS assays mentorship, open communication, and peer learning — especially from undergraduate trainees — shape his development Using site-directed mutagenesis and pharmacological synergy assays , his team aims to understand how Clements' work is primarily focused on translational developments of small molecule therapeutics, and

modeling that forecasts receptor behavior—before the first assay begins. GPCR Podcast “Explain” is no longer enough. receptor-ligand interactions after the fact; they aim to forecast receptor behavior before the first assay GPCR Podcast episode: model predict discover #DrGPCR #GPCR #MolecularModeling #PredictivePharmacology are interpreted—and how those interpretations quietly shape SAR, lead selection, and development timelines

Bruns Fred Bruns discovered the first positive allosteric modulator (PAM) of a GPCR in the late 1980s During a joint postdoc with John W Daly at NIH and Solomon Snyder at Johns Hopkins, he developed the first adenosine receptor binding assay. GPCR Enjoying the Dr. GPCR Podcast? Leave a Review. Imaging in Native Tissue How Collaboration Sparked a GPCR Imaging Breakthrough in Chemical Biology Thanks

Work from our lab showed that the PCP components, including ADGRC2 and ADGRC3, are localized in the developing My research focus is the mechanisms of neural circuit development, function and disease." To exploit this expression profile, we have developed antibody-drug conjugates (ADCs) targeting CD97, We initially tested the ADC using in vitro WST-8 viability assays in human GBM cell lines and cell types oncogenesis in glioblastoma, the most common brain malignancy, and chromatin organization in human neural development

GPCR Ecosystem. clear expectations and deliverables to build trust and reduce delays • Align teams across roles—from assay Decisions—Not Delays I help turn great science into clear deliverables • Define program objectives and guide assay GPCR Calendly ©2023-2025 All rights reserved by FindYooour, LLC & Dr. GPCR Corp Proudly created with Wix.com

pharmacological chaperones, his work on bioluminescence resonance energy transfer (BRET) resulted in the development of screening assays that are now widely used for drug discovery. a member of the lab, I am humbled to have been able to work with him and his team and use the tools developed in his lab to better understand GPCR structure/function relationships. GPCR Ecosystem Enjoying the Dr. GPCR Podcast? Leave a Review.

They also discussed the ongoing developments in the GPCR field, the upcoming adhesion GPCR consortium He explained that initially, the field lacked adequate tools, and his lab had to develop new techniques through various approaches, including structural biology and signaling assays. Yamina expressed her appreciation for Demet's work and asked about the development of the GPCR field GPCR Field and Naming Convention Discussion Demet and Yamina discussed the ongoing developments in the

screening technologies enable deciphering host-microbiome communication and the development of drug 12 2022 12:40:00 GMT+0000 (Coordinated Universal Time) Details Getting the most from your biosensor assays GPCR Ecosystem Partners Tags Dr. GPCR Summit Dr. GPCR Summit 2022 Dr. GPCR Summit 2022 Schedule Dr. GPCR Summit Details Dr. GPCR Summit Pre-Recorded Talks Dr. GPCR Summit Live Talks Dr. GPCR Summit 2022 Submit Poster Presentation for Dr. GPCR Summit 2022

How I Help Biotechs Accelerate GPCR Discovery with Clarity, Speed & Confidence Decisions, Not More Data Prioritize assays based on project phase and decision points Map go/no-go logic that guides program momentum they’ll change outcomes No More Strategy Swirl I build structure that sticks—from CRO engagement to assay GPCR Calendly ©2023-2025 All rights reserved by FindYooour, LLC & Dr. GPCR Corp Proudly created with Wix.com

This is the kind of advance that matters for anyone building tools, assays, or therapeutics around receptor GPCR Podcast Read full article Back when GPCR assays were performed with single channel pipettes, failure To stay relevant in the next decade, it’s not about chasing the latest assay or tool. In this AMA session, you’ll learn how to: Decode GPCR signaling complexity using functional assay strategies Get it wrong, and the best molecule on paper stalls in development.

Full Agenda Adhesion GPCR workshop 2024 CINVESTAV, Mexico City, Mexico October 23-25 Download PDF Program GPCR Community Presentation Breaking Barriers: My Journey from Mexico to the Heart of the Dr. GPCR Ecosystem and beyond About Monserrat Avila Zozaya "My doctoral research was focused on investigating My research focuses on understanding the molecular mechanisms of adhesion GPCRs (aGPCRs) in lymphatic GPCR < Previous Session Next Session >

, to exploit a Ric-8-based technology to purify recombinant G proteins and to use the G proteins in assays to explore the mechanisms of action of the 33-member adhesion GPCR family or Family B2 GPCRs. We found that adhesion GPCRs are activated by a tethered peptide agonist mechanism that differed from Adhesion GPCRs pre-cleave themselves and the two resultant fragments of the receptor remain together GPCR Enjoying the Dr. GPCR Podcast? Leave a Review.

Falling in Love with GPCRs GPCR pharmacology captured his scientific curiosity. Sokhom recalls how binding assays at BMS introduced him to the depth and complexity of receptor pharmacology GPCR ecosystem , GPCR scientist network , GPCR drug discovery , GPCR training program , GPCR online course , G protein-coupled receptors , GPCR podcast , GPCR webinar series , GPCR data platform Summary created GPCR Podcast? Leave a Review.

His research interest lies in understanding the molecular basis for human tumor development and how to Van Meir has developed novel therapeutic approaches for cancer using oncolytic adenoviruses and anti-angiogenic molecules and is currently developing novel small molecule inhibitors of the hypoxia-inducible factor His research aims to translate these novel agents to testing in clinical trials with the hope to develop ) family, known to play a role in myelination, placentation, blood vessel, and inner ear development.

Full Agenda Adhesion GPCR workshop 2024 CINVESTAV, Mexico City, Mexico October 23-25 Download PDF Program , Marisol1, Claxton, Suzanne1, Skehel, Mark2, Ultanir, Sila K.1 1Kinases and Brain Development Laboratory Mihaylov " I am a postdoctoral researcher in the kinases and brain development laboratory led by Dr Sila moved to King's College London, where my interest and passion for kinases in brain health and disease developed I have recently also developed a strong interest in adhesion GPCRs and in particular, Bai1. " Simeon

A breakthrough in GPCR imaging reveals a full native pancreatic islet and advances how GLP-1R can be Flash News → Lighting up a native pancreatic islet isn’t just a technical win it’s a shift in what GPCR GPCR blog breaks down the moment Dr. This is the kind of advance that matters for anyone building tools, assays, or therapeutics around receptor are interpreted—and how those interpretations quietly shape SAR, lead selection, and development timelines

Yamina will continue to develop and manage the Dr. Badr recounted Badr's Journey, Multiplexing Assays, and Collaboration Badr shared his learning process Yamina emphasized the potential of multiplexing assays in expanding the scope of scientific exploration understanding how Badr’s experiences influenced his current role, and Badr stressed the need for individuals to develop GPCR to serve as a global hub for the GPCR community.

GPCR Ecosystem: uniting scientists, biotech, and innovators to advance GPCR research worldwide. GPCR Ecosystem We unite the GPCR Community to advance drug discovery Where GPCR Experts Move Science GPCR began as a podcast. GPCR Symposium with over 100 attendees 2024 GPCR University Launched comprehensive courses and expert Premium Members Include: ✔ Drug hunters at early-stage biotechs ✔ CRO leaders building assays and tools

Subscribe to the Adhesion GPCR Workshop 2024 newsletter. Adhesion GPCR workshop 2024 CINVESTAV, Mexico City, Mexico October 23-25 Register AGPCR Newsletter Adhesion GPCR Consortium Newsletter - May 2024 Welcome to the 4th official Adhesion GPCR Consortium newsletter GPCR News Register for the Adhesion GPCR 2024 Learn more about the Adhesion GPCR workshop 2024 Up About the event Learn more about the Adhesion GPCR workshop 2024 and its preliminary program.

Full Agenda Adhesion GPCR workshop 2024 CINVESTAV, Mexico City, Mexico October 23-25 Download PDF Program Many ADGRs are autoproteo-lytically cleaved at the GPCR proteolysis site (GPS), an HXS/T motif within are conserved adhesion G protein-coupled receptors; they are essential for embryogenesis and neural development We employ cellular assays with full-length CELSR1 and truncation constructs to assess the adhesive and ) domain that catalyzes receptor self-cleavage at a GPCR proteolysis site (GPS).

Home → Flash News → Weekly News October 16 Published on October 16, 2025 Category GPCR Weekly News Enzymes Eric Trinquet —how structured play turns into assays and why serendipity belongs in your build process #DrGPCR #GPCR Previous Next Recent Articles Why Biotech Fundraising Fails Due to Intellectual Property Operating cadence Attila Foris Dec 24, 2025 GPCR Binding Affinity Experiments: Interpreting Data With are interpreted—and how those interpretations quietly shape SAR, lead selection, and development timelines