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- Adenosine A3 receptor has been proposed to have significant roles in metabolism and immune responses. Check out this study to understand how it affects metabolic dysfunction-associated steatotic liver progression. Subscribe to the Dr. GPCR Newsletter 📰 and get the latest GPCR News delivered to your inbox ➡️https://buff.ly/42b6ra3 #gpcr #drgpcr | Dr. GPCR Ecosystem
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- We’re excited to announce our strategic partnership with Celtarys Research, a biotech company specializing in fluorescent ligand technologies and real-time, non-radioactive GPCR assays. This collaboration combines Dr. GPCR’s global platform with Celtarys’ innovative chemical biology tools, making it easier than ever for scientists to study ligand-receptor interactions, visualize binding, and accelerate drug discovery. We’re proud to welcome Celtarys to the Dr. GPCR ecosystem to support researchers worldwide and expand access to high-performance tools for GPCR-targeted therapeutics. ✳️Read the complete press release: https://www.ecosystem.drgpcr.com/post/dr-gpcr-and-celtarys-research-join-forces-to-expand-access-to-innovative-gpcr-tools #GPCR #DrGPCR #CeltarysResearch #DrugDiscoveryTools #FluorescentLigands #GPCRresearch #ScientificPartnership | Dr. GPCR Ecosystem
GPCR ecosystem to support researchers worldwide and expand access to high-performance tools for GPCR-targeted GPCR ecosystem to support researchers worldwide and expand access to high-performance tools for GPCR-targeted
- Dr. GPCR Podcast Audience-Survey | Dr. GPCR Ecosystem
Take our quick 5-minute audience survey to help us tailor our content to your needs. GPCR Podcast Audience Survey Thanks for listening to this podcast episode Follow us on your favorite Podcast Player Be our Guest Listen and subscribe where you get your podcasts
- Subscribe to the Dr. GPCR Newsletter 📰 and get the latest GPCR News delivered to your inbox Unlocking the activation process of PTH1R: New computational insights into its molecular interactions bring us closer to better osteoporosis treatments! ➡️https://www.ecosystem.drgpcr.com/receptor-activation-and-signaling/key-interaction-changes-determine-the-activation-process-of-human-parathyroid-hormone-type-1-receptor #gpcr #drgpcr | Dr. GPCR Ecosystem
Home → Flash News → Subscribe to the Dr. key-interaction-changes-determine-the-activation-process-of-human-parathyroid-hormone-type-1-receptor #gpcr #drgpcr Published on February 6, 2025 Category GPCR Weekly News Subscribe
- What do GPCRs, acidic endosomes, and cancer immunotherapy have in common? Find out in our latest episode featuring Ian Chronis, where we explore the surprising ways GPR65 signals in different environments! ✅ Tune in: https://buff.ly/FTB69y9 #GPCR #DrGPCR #SciencePodcast | Dr. GPCR Ecosystem
Find out in our latest episode featuring Ian Chronis, where we explore the surprising ways GPR65 signals Find out in our latest episode featuring Ian Chronis, where we explore the surprising ways GPR65 signals
- Did you know? 🌟 Researchers have developed reversibly photoswitchable allosteric modulators for Class A GPCRs! 🧬💡 These innovative compounds, “Photo-BQCisA” and “Photo-BQCtrAns,” offer subtype-selective precision by combining allosteric modulation with light control, paving the way for new therapeutic strategies targeting muscarinic receptors (M1-M5). 🔬✨ Learn more about this breakthrough in the Ecosystem! | Dr. GPCR Ecosystem
🧬💡 These innovative compounds, “Photo-BQCisA” and “Photo-BQCtrAns,” offer subtype-selective precision 🧬💡 These innovative compounds, “Photo-BQCisA” and “Photo-BQCtrAns,” offer subtype-selective precision
- Abstract Submission Adhesion GPCR Workshop 2024 | Dr. GPCR Ecosystem
Submit your abstract for the Adhesion GPCR Workshop 2024. ABSTRACT SUBMISSION Adhesion GPCR workshop 2024 CINVESTAV, Mexico City, Mexico October 23-25 Submit your
- Did you know that certain ergot derivatives can produce wash-resistant signalling through the 5-HT2B receptor persisting for many hours without losing potency or efficacy? By using signalling assays, radioligand binding assay, and microscopy, Gaidarov et al. suggested that this phenomenon results from persistently/irreversibly internalised signalling receptor complexes. Check out the latest GPCR news in the Ecosystem today! You’ll need to register but don’t worry, it’s Free! ➡️ https://www.ecosystem.drgpcr.com/receptor-activation-and-signaling/mechanisms-of-constitutive-and-agonist-induced-5-ht2b-internalization%2C-persistent-endosomal-signaling-and-paradoxical-regulation-of-agonist-pharmacology #gpcr#drgpcr | Dr. GPCR Ecosystem
By using signalling assays, radioligand binding assay, and microscopy, Gaidarov et al. suggested that By using signalling assays, radioligand binding assay, and microscopy, Gaidarov et al. suggested that
- Dr. GPCR Summit 2021 | Dr. GPCR Ecosystem
GPCR Summit Partners - Click to Explore - Dr. GPCR Summit 2021 Welcome to the official page of the Dr. GPCR Virtual Summit 2021! Be sure to register. How can I sponsor the 2021 Summit? GPCR Summit Partners - Click to Explore - Tags Dr. GPCR Summit Dr. GPCR Summit 2021 Dr. GPCR Summit 2021 Pre-Recorded Talks Dr. GPCR Summit 2021 Live Talks
- How do GRK-specific phosphorylation barcodes influence β-arrestin binding to GPCRs? New cryo-EM structures from Chen et al. (Nature, 2025) reveal that β-arrestin1 and β-arrestin2 form distinct complexes with ACKR3 depending on whether it's phosphorylated by GRK2 or GRK5, shaping arrestin conformation, complex stability, and engagement mode. Surprisingly, arrestin’s finger loop didn’t dive into the receptor core. Instead, it latched onto the micelle surface, breaking canonical expectations. Also, β-arrestin2 lacks a membrane anchor, making it more dynamic — a potential clue to its functional specialization. These findings underscore how barcode location + arrestin isoform = unique signaling outcomes. open book Read the full study: Inside Out: Mapping GPCRs from Membrane Codes to Market Moves #GPCRs #Arrestin #ACKR3 #GRKs #CryoEM #StructuralBiology #SignalingBias #Phosphorylation #DrGPCR | Dr. GPCR Ecosystem
Surprisingly, arrestin’s finger loop didn’t dive into the receptor core. Instead, it latched onto the micelle surface, breaking canonical expectations. Surprisingly, arrestin’s finger loop didn’t dive into the receptor core. Instead, it latched onto the micelle surface, breaking canonical expectations.
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- Submit a Problem | Dr. GPCR Ecosystem
Submit a problem! Get detailed information about incidents and find solutions. Join us today! Who is submitting this incident? Upload File Upload supported file (Max 15MB) Submit Thanks for submitting!
- Dr. GPCR Summit 2022 | Dr. GPCR Ecosystem
GPCR Summit 2022 Dr. GPCR Summit This year the Summit will be held between October 10th and 16th. GPCR Summit Dr. GPCR Summit 2022 Dr. GPCR Summit 2022 Schedule Dr. GPCR Summit 2022 Details Dr. GPCR Summit 2022 Submit Live Talk Presentation for Dr. GPCR Summit 2022 Submit Poster Presentation for Dr. GPCR Summit 2022
- Distinct sub-cellular signal propagation as a component of functional selectivity
Program Registration Logo Contest Committee Sponsors GPCR Retreat Program < Back to schedule Distinct sub-cellular He has supervised the research work of 75 graduate students and 40 post-doctoral fellows.
- Summit | Dr. GPCR Ecosystem
GPCR Summit! Embracing innovation and technology, we connect global scientific communities. GPCR Summit We live in a new world, and we think it's an opportunity to try new things and use current
- Partners Submition Form | Dr. GPCR Ecosystem
Submit your partnership request with our easy-to-use online form. Join Dr. Strategic Partners Back to Partners List Submit Thanks for submitting!
- Posters | Adhesion GPCR Workshop 2024 | Dr. GPCR Ecosystem
In conclusion, we successfully generated collecting duct-specific GPR56 knockout mouse and found no defective My predoctoral work was supported by an American Heart Association fellowship. Altogether, this data demonstrates conformational and functional coupling between the ECR and 7TM, suggesting Authors & Affiliations "Cechova Kristina (3), Bandekar Sumit J.(1, 2), Leon Katherine (1, 2), Dutka Przemysław and Molecular Pharmacology and Therapeutics, Columbia University Vagelos College of Physicians and Surgeons
- Plenary Lecture | Adhesion GPCR Workshop 2024 | Dr. GPCR Ecosystem
Receptors and Hearing and Balance Receptors Abstract Only Available for AGPCR24 Attendees About Jin-Peng Sun We have identified the receptor subfamily to sense the steroid hormones. Jin-Peng Sun on the web Google Scholar LinkedIn < Previous Session Next Session >
- ep 175 with jens carlsson release picture | Dr. GPCR Ecosystem
But during a summer internship in protein purification, he faced a harsh reality: lab work wasn’t his
- Full Agenda for Adhesion GPCR Workshop 2024 | Dr. GPCR Ecosystem
Characterization of Adhesion GPCRs As Steroid Hormone Receptors and Hearing and Balance Receptors Jinpeng Sun Melkumyan Read More 3:00 PM Session V Structural mechanisms of AGPCR signaling and function Fabian Pohl · Sumit Break with pastries announcement of the aGEM award Read More 4:00 PM Closing remarks Read More Jinpeng Sun GPCR BAI1/ADGRB1 can block IGF1R-mediated growth signalling, increase radiosensitivity and augment survival Mihaylov Bai1 Is A Novel Neuronal Substrate Of The Psychiatric Risk Kinase TNIK Sumit Bandekar Structural
- Dr. Demet Araç | Dr. GPCR Ecosystem
GPCR AI Summary AI-generated content may be inaccurate or misleading. Always check for accuracy. Summary Personal Backgrounds and GPCR Interest Yamina and Demet had a discussion about their personal Demet, who had studied various subjects including chemistry, physics, biology, and math, shared his interest project since 2013, screening about 20 adhesion GPCRs, with the Latrophilin 3 construct proving most successful
- Complimentary Reception dinner | Adhesion GPCR Workshop 2024 | Dr. GPCR Ecosystem
dinner MENU Four Mushroom Soup Tomato, Panela Cheese, and Spinach tower with Oregano Vinaigrette Cane Sugar
- Session V | Adhesion GPCR Workshop 2024 | Dr. GPCR Ecosystem
extracellular region reveal a compact multidomain module of fourteen domains which regulates signaling Sumit extracellular region reveal a compact multidomain module of fourteen domains which regulates signaling Sumit About Sumit Bandekar "I am an NIH F32 postdoctoral fellow in the Araç Laboratory at the University of Sumit Bandekar on the web Araç Laboratory at UChicago X (Twitter) LinkedIn Unveiling the GPS Cleavage individual states during the reaction, and provides insight into the structural determinants for a successful
- Principles of Pharmacology in Drug Discovery II | Dr. GPCR Ecosystem
Terry Kenakin Get Started Premium Members benefits: - Subscribe and save 25% on every GPCR Course - Early-bird
- Dr. Gregory Tall | Dr. GPCR Ecosystem
are to understand the basic mechanism by which Ric-8 proteins fold all heterotrimeric G protein alpha subunits
- Dr. Andrew Tobin | Dr. GPCR Ecosystem
In this Andrew runs a research laboratory of around 15 staff supported by basic research grants investigating
- YC-Blog (List) | Dr. GPCR Ecosystem
Let’s talk about how I support GPCR discovery, pharmacology strategy, and cross-functional execution
- Dr. Bruno Giros | Dr. GPCR Ecosystem
directed by Jean-Charles Schwartz in Paris, where he cloned and characterized dopamine D2 and D3 receptor subtypes vulnerability to chronic stress and depression and; 2) Understanding the role of phenotypically defined subpopulations
- The Scientist's Compass: From Academia to Entrepreneurship with Dr. Dmitry Veprintsev | Dr. GPCR Ecosystem
Whether in academia or industry, success comes from curiosity, persistence, and knowing your values. Summary made with AI About Dmitry Veprintsev Dmitry is Professor of Molecular and Cellular Pharmacology postdoctoral fellow and later as a staff scientist, focusing on the biophysical studies of the tumour suppressor
- Yao Lu (Jackie) | Dr. GPCR Ecosystem
research aims to provide a molecular explanation of small molecules for their pre-clinical efficacy and to support









