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Results found for "Shane Wright"
- irreversible drugs post 2 | Dr. GPCR Ecosystem
Get it right, and you unlock durable efficacy with leaner dosing strategies.
- ep 175 with jens carlsson release picture | Dr. GPCR Ecosystem
His journey is a powerful reminder that the right career often reveals itself through “failure.”
- Biochemical Mechanisms Underlying Location Bias in GPCR Signaling
clinical focus is on pulmonary arterial hypertension, a disease of the pulmonary arterioles that causes right
- Atypical Structure and Function of Typical Chemokine Receptors
Although symptoms of GRIN disorder appear very early in childhood, it can take years to reach the right
- 🎧 Why Does GPCR Location Make All the Difference? GPCR location within the cell can change everything: function, pharmacology, and even drug response. In Ep.162 of the Dr.GPCR Podcast, Dr. Gabriele Kockelkoren dives into: 🔬 How GPCR trafficking shapes signaling outcomes 🚀 Career insights from the lab to the broader biotech world This episode is packed with knowledge for scientists, drug hunters, and anyone fascinated by GPCRs! 🎙️ Listen now https://buff.ly/fYZ1tSq #DrGPCR #GPCR #DrugDiscovery #Pharma #Biotech #SciencePodcast ✅ Tune in today! | Dr. GPCR Ecosystem
Gabriele Kockelkoren dives into: 🔬 How GPCR trafficking shapes signaling outcomes 🚀 Career insights Gabriele Kockelkoren dives into: 🔬 How GPCR trafficking shapes signaling outcomes 🚀 Career insights
- Exploring Career Paths in GPCR Research with Dr. Jacek Mokrosiński | Dr. GPCR Ecosystem
molecular mechanism through which rare genetic variation may lead to or protecting from excessive body weight In future talks and interviews, Jacek will share his stories and advice about GPCRs. They talked about their shared passion for advancing science and improving patient outcomes, and their Jacek shared his experience of working with Piketa and how he found a job in Seda's lab at Cambridge, , and their roles in regulating body weight and growth.
- Dr. Sudarshan Rajagopal | Dr. GPCR Ecosystem
clinical focus is on pulmonary arterial hypertension, a disease of the pulmonary arterioles that causes right
- Dr GPCR Ecosystem Feedback | Dr. GPCR Ecosystem
Share your thoughts and help shape the future of the Dr. GPCR Ecosystem. ’ve joined our University sessions, explored our Job Board, or attended a Happy Hour, your feedback shapes We’re growing — and your input helps us grow in the right direction. By sharing your thoughts, you directly influence how we design new features, events, and educational Your Voice Shapes Our Future Dr.
- Forget one receptor at a time. Go big.Ep.167 of the Dr.GPCR Podcast with Tom Sakmar & Ilana Kotliar is about scaling GPCR research with multiplexing, miniaturization, and collaboration. The tools are built. The data is free. What will you ask next? 📲 Dive in: Ep 167 with Drs. Tom Sakmar & Ilana Kotliar #GPCRtraining #GPCRresearchcommunity #DrGPCR #GPCRdata | Dr. GPCR Ecosystem
Breakthroughs this week: Orphan receptor GPRC5B in neurogenesis; Septerna’s pill-based weight-loss strategy
- Terry's Corner is Officially LIVE! 🎉 This is your new go-to for mastering drug discovery pharmacology. No fluff, just clear, on-demand insights from Terry Kenakin. Building core expertise? Master dose-response, binding, kinetics, and foundational models. Driving drug discovery? Apply pharmacology to selectivity, ADME, and strategic decision-making. An experienced drug hunter? Sharpen your edge with allosteric bias, residence time, and translational PK/PD. Learn on-demand, apply immediately: https://terrykenakin.com #DrGPCR #GPCR #pharmacology #TerrysCorner #DrugDiscovery | Dr. GPCR Ecosystem
Breakthroughs this week: Orphan receptor GPRC5B in neurogenesis; Septerna’s pill-based weight-loss strategy
- Every receptor tells a story | Dr. GPCR Ecosystem
Breakthroughs this week: Orphan receptor GPRC5B in neurogenesis; Septerna’s pill-based weight-loss strategy
- How do GPCRs sense pH changes? New cryo-EM structures of GPR4 and GPR68 reveal how extracellular histidines act as proton sensors-trigger activation and biased G protein coupling! Did you know that we work hard to bring you the most recent GPCR News, weekly? Catch up today in the Ecosystem using your free site membership! ➡️https://www.ecosystem.drgpcr.com/structural-and-molecular-insights-into-gpcr-function/structural-basis-and-biased-signaling-of-proton-sensation-by-gpcrs-mediated-by-extracellular-histidine-rearrangement #gpcr#drgpcr | Dr. GPCR Ecosystem
Breakthroughs this week: Orphan receptor GPRC5B in neurogenesis; Septerna’s pill-based weight-loss strategy
- 💡 GPCR drug development doesn’t have to be a mystery! Learn from Dr. Terry Kenakin in this 4-week immersive course covering ligand development & pharmacology. 🔹 What you’ll learn: ✅ Drug Development Basics – Absorption, metabolism, PK principles ✅ Clearance & Distribution – Renal & hepatic clearance, key pharmacokinetics ✅ PK-PD Modeling – Predicting drug behavior, non-linear PK ✅ Early Drug Safety – Toxicity risks & drug interactions 📌 Spots are filling fast! Sign up today 👉 Development of GPCR Ligands as Therapeutic Drugs | Dr. GPCR Ecosystem #GPCR #DrGPCR #Pharmacology #Biotech #DrugDiscovery | Dr. GPCR Ecosystem
Breakthroughs this week: Orphan receptor GPRC5B in neurogenesis; Septerna’s pill-based weight-loss strategy
- We’re excited to announce our strategic partnership with Celtarys Research, a biotech company specializing in fluorescent ligand technologies and real-time, non-radioactive GPCR assays. This collaboration combines Dr. GPCR’s global platform with Celtarys’ innovative chemical biology tools, making it easier than ever for scientists to study ligand-receptor interactions, visualize binding, and accelerate drug discovery. We’re proud to welcome Celtarys to the Dr. GPCR ecosystem to support researchers worldwide and expand access to high-performance tools for GPCR-targeted therapeutics. ✳️Read the complete press release: https://www.ecosystem.drgpcr.com/post/dr-gpcr-and-celtarys-research-join-forces-to-expand-access-to-innovative-gpcr-tools #GPCR #DrGPCR #CeltarysResearch #DrugDiscoveryTools #FluorescentLigands #GPCRresearch #ScientificPartnership | Dr. GPCR Ecosystem
Breakthroughs this week: Orphan receptor GPRC5B in neurogenesis; Septerna’s pill-based weight-loss strategy
- ep 175 with jens carlsson clip 1 | Dr. GPCR Ecosystem
Breakthroughs this week: Orphan receptor GPRC5B in neurogenesis; Septerna’s pill-based weight-loss strategy
- Yamina's Corner | Dr. GPCR Ecosystem
Actionable Scientific Validation: Ensure target companies execute the right GPCR pharmacology experiments GPCR Calendly ©2023-2025 All rights reserved by FindYooour, LLC & Dr.
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, and innovators in a relaxed setting Job Board: helping researchers and biotech companies find the right
- From Rare Earth Probes to Internalization Assays: The pHSense Story with Dr. Eric Trinquet | Dr. GPCR Ecosystem
Eric Trinquet shares the inside story behind the development of pH Sense, Revvity’s latest innovation and product development, Eric takes us through the highs, failures, and scientific “aha” moments that shaped Episode How Eric and his team reimagined rare earth complexes to develop pH-sensitive probes with tunable brightness
- Media Partner Packages | Dr. GPCR Ecosystem
But are the right scientists discovering them? Dr. Ready to share your company with the GPCR world? GPCR Podcast ✓ Feature up to 3 team members to share your story ✓ Distributed across podcast platforms ✓ Engaging posts about your organization ✓ Targeted to GPCR researchers and biotech professionals ✓ Shared GPCR platform as a valued partner ✓ Share insights on product launches, scientific discoveries, or customer
- CRO Advisory | Dr. GPCR Ecosystem
GPCR Calendly ©2023-2025 All rights reserved by FindYooour, LLC & Dr.
- From Curiosity to Breakthrough: Ajay Yekkirala on GPCR Innovation | Dr. GPCR Ecosystem
Biotech founder Ajay Yekkirala shares how AI, GPCRs, and bold questions are driving next-gen pain therapeutics Ajay Yekkirala on GPCR Innovation What if the key to safer, more effective drugs lies in asking the right Ajay Yekkirala shares the pivotal moments that transformed him from a curious PhD student into a GPCR In this wide-ranging conversation, he reflects on the mentors, failures, and bold questions that shaped
- Flash News: Your Hub for GPCR Insights and Scientific Conference Programs
Many talented scientists leave the field not because they lacked skill, but because the right opportunity didn’t land at the right time. Get it right, and you unlock durable efficacy with leaner dosing strategies. His journey is a powerful reminder that the right career often reveals itself through “failure.” 5 6 7 ... 7 🔔 Don’t Just Stay Updated—Stay Ahead Flash News gives you a glance at what’s happening right
- Xylazine, Fentanyl, and the Fight for Breath with Catherine Demery | Dr. GPCR Ecosystem
Catherine Demery shares how she found clarity and purpose in academic opioid research. In this gripping conversation, Catherine, a PhD candidate at the University of Michigan, shares how personal biochemistry from the University of Michigan, she deferred pharmacy school, unsure if that path felt right
- University Pricing | Dr. GPCR Ecosystem
GPCR Research Join a global community of scientists transforming how GPCR discoveries happen — through shared to the podcast 📤 Submit jobs & events to the community 📰 Science, tools & trends — no paywall 💸 Share Premium resources, your member dashboard, and exclusive community tools to start networking and learning right
- Foundry for GPCR Organizations | Dr. GPCR Ecosystem
In short: The Foundry gives you the right people, tools, and insight to move your GPCR programs forward
- GPCR Pharmacology, Career Twists & Serendipity with Sokhom Pin | Dr. GPCR Ecosystem
Sokhom Pin shares how he built a biotech career around GPCRs, designed a custom PhD path, and led teams He shares: "All my industry experience has been GPCR-focused." The Power of the Right Culture Whether it was Alkermes or Cerevel, Sokhom emphasized that team culture
- Dr. GPCR Affiliate Program | Earn by Empowering the GPCR Community
Share our ecosystem, courses, and events to advance drug discovery together. Dr. to build the best platform for the GPCR community and help you the scientists and business owners to share GPCR reserves the right to remove the least active members from the program. OK to use: - Writing, blogging, guest blogging, - Podcast, video, vlog - Social media sharing, - YouTube & TikTok channels, - Business Page and website, - Informational and fan sharing, - Presentations and
- How do GRK-specific phosphorylation barcodes influence β-arrestin binding to GPCRs? New cryo-EM structures from Chen et al. (Nature, 2025) reveal that β-arrestin1 and β-arrestin2 form distinct complexes with ACKR3 depending on whether it's phosphorylated by GRK2 or GRK5, shaping arrestin conformation, complex stability, and engagement mode. Surprisingly, arrestin’s finger loop didn’t dive into the receptor core. Instead, it latched onto the micelle surface, breaking canonical expectations. Also, β-arrestin2 lacks a membrane anchor, making it more dynamic — a potential clue to its functional specialization. These findings underscore how barcode location + arrestin isoform = unique signaling outcomes. open book Read the full study: Inside Out: Mapping GPCRs from Membrane Codes to Market Moves #GPCRs #Arrestin #ACKR3 #GRKs #CryoEM #StructuralBiology #SignalingBias #Phosphorylation #DrGPCR | Dr. GPCR Ecosystem
β-arrestin2 form distinct complexes with ACKR3 depending on whether it's phosphorylated by GRK2 or GRK5, shaping β-arrestin2 form distinct complexes with ACKR3 depending on whether it's phosphorylated by GRK2 or GRK5, shaping
- Privacy Policy | Dr. GPCR Ecosystem
Information Sharing and Disclosure Ecosystem.DrGPCR.com may disclose your personal information to third We will share personal data for these purposes only with third parties whose privacy policies are consistent Ecosystem.DrGPCR.com may otherwise disclose your personal information when: We have your express consent to share We need to protect the personal safety of the users of our websites or defend the rights or property
- Custom Molecules, Fluorescent Probes: When Chemists Think Like Biologists with Dr. Maria Majellaro from Celtarys | Dr. GPCR Ecosystem
Maria Majellaro, CSO of Celtarys Research, shares the story behind the company’s journey from academic GPCR and Celtarys, built on a shared commitment to empowering the GPCR research community. “We always start with the problem, then generate the right compound using our chemistry.










