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Results found for "Tracy Handel"
- Innovative Data-Driven Solutions: The pHSense Revolution
Eric Trinquet, that moment arrived when his team successfully tracked GPCR internalization in native
- How to Design GPCR Drugs That Work in Vivo: Strategy, Tools, and Insights
Lanthanide donors + d2 acceptors = high SNR, low background Multiplex-compatible (e.g., IP1 + cAMP) for tracking
- Is Your GPCR Drug Discovery Program Built for Breakthroughs or Breakdowns?
Every time a problem arises, we trace it back to its root cause, implementing changes that prevent its
- Decoding Schild Analysis: The Pharmacologist’s Lens on Competitive Antagonism
adaptations underscore Schild’s resilience—it remains one of the few analytical frameworks flexible enough to handle
- Assay Volume Control: Your GPCR Drug Discovery Power Lever
Eric Trinquet traces how a series of bold pivots—from Cisbio’s HTRF platform to IP-One and now pHSense—reshaped
- How Collaboration Drives GPCR Discoveries
For Hodson, that moment came with a protein he’d been tracking for a decade: vitamin D binding protein
- Understanding Enzyme Inhibition In GPCR Discovery Programs
Plus: top tracks to watch at GPCR Forum 2025, fresh postdoc openings at the ADME/signaling interface
- Orthosteric vs. Allosteric Interactions: The Silent Decider of Safety and Success
AMAs where you can ask Terry your toughest questions Direct input on future topics, so the content tracks
- Targeting GPCRs in the CNS: Advances in Drug Discovery Strategies
Greater specificity : allows for selective tracking of receptor subtypes in complex brain tissues.
- Fentanyl and Xylazine: Why Breathing Fails in Overdose
By tracing those pathways, her research gives scientists, first responders, and policymakers the knowledge
- 📰 GPCR Weekly News, August 14 to 20, 2023
GPCR-Expressing Cell Membrane for Targeted Extraction Using Minimum Organic Solvent: An Investigative Study of Trace
- Discover the Hottest GPCR News of the Week: Oct 7-13, 2024!
and Taste Single-cell transcriptomic atlas of enteroendocrine cells along the murine gastrointestinal tract
- Biased Agonism at the GLP-1 Receptor: A Pathway to Improved Therapeutic Outcomes
advancing diabetes and obesity management, driving the obesity market toward $66 billion by 2030 and on track
- Enzyme Inhibition Pharmacology: The Hidden Gatekeepers of GPCR Drug Discovery
FDA Focus No enzyme class is more important—or more unpredictable—than cytochrome P450s .CYP3A4 alone handles
- Competitive vs Non-Competitive GPCR Antagonists: How to Interpret Pharmacology Data with Confidence
We’re also tracking major pipeline clearouts and the competitive landscape for oral GLP-1 drugs.
- The Hidden Burn: How Internal Misalignment Drains Your Biotech’s Runway
You track the burn rate. You watch the runway shrink. You delay hires.
- High-Content Screening for GPCR Programs: Overcoming Assay Limitations with Fluorescent Ligands
Plate Layout and Sample Handling Automated liquid handlers and randomized plate layouts are used to minimize
- Orthosteric vs Allosteric Interactions— and the pHSense Shift in Internalization
Subtype specificity: selectively track receptor subtypes in complex brain tissue.
- 📰 GPCR Weekly News
Tracking N- and C-termini of C. elegans polycystin-1 reveals their distinct targeting requirements and
- Feeder or trigger – CCR2 as a scavenger and regulator of cell migration
Hansell et al. 2011); and it may interfere with other chemokine receptors which share the ligands and
- Odorant receptors – a bit of smell for drug discovery
In the GI tract OR ligands drive an intracellular cascade that results in enhanced serotonin release
















