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studies reveal how phosphorylation barcodes shape arrestin engagement, a biased NTSR1 modulator targets pain Barcodes Shape Arrestin Engagement with ACKR3   A β-Arrestin-2-Biased NTSR1 Modulator for Non-Addictive Pain

highlighted a new hydrophobic conserved motif composed of phenylalanine (F)/leucine (L) and methionine (M)

has pro-nociceptive properties, suggesting that blockade of Gq/11 signalling could be beneficial for pain Experimental approach: We used a series of behavioural assays to evaluate the acute responses of mice to painful

receptors are G-protein-coupled receptors (GPCRs) part of cell signaling paths of direct interest to treat pain Pain may associate with inflamed tissue characterized by acidic pH. The potentially low pH at tissue targeted by opioid drugs in pain management could impact drug binding

Shampo, M. A. & Kyle, R. A. Sir Bernard Katz--winner of Nobel Prize in physiology or medicine. Ekaterini Tiligada, C., Tiligada, E. & Ennis, M.

Dysregulation of RGS proteins has been implicated in a range of diseases, including cardiovascular disease, pain Relating to pain, RGS4 in pain regulation is a topic of increasing interest because it has been identified G-Protein Signaling (RGS) Protein Modulation of Opioid Receptor Signaling as a Potential Target for Pain Avrampou, K., et al., RGS4 Maintains Chronic Pain Symptoms in Rodent Models.

Opioids are analgesic drugs consumed non-medically for euphoric feelings and medically for pain relief most important in regulating the response to nociception, i.e. the response of the nervous system to painful Given their pathophysiological significance in pain, addiction and depression opioid receptors represent Morphine is one of the most widely used and proven analgesic for the treatment of severe acute or chronic pain Complex Persistent Opioid Dependence-an Opioid-induced Chronic Pain Syndrome.

Regulation of PLCβ Signaling by Gq-Coupled and μOpioid Receptors Opposes Opioid- Mediated Antinociception "Pain The current frontline approach for pain-management is the use of opioid analgesics.

of the proton-sensing GPCR, GPR65 on fibroblast-like synoviocytes contributes to inflammatory joint pain of the proton-sensing GPCR, GPR65 on fibroblast-like synoviocytes contributes to inflammatory joint pain

EGFR "Background Fentanyl is an opioid analgesic and is widely used in ovarian cancer patients for pain

preclinical data supports the applicability of CB2 activation in autoimmune and inflammatory diseases, pain

preclinical data support the applicability of CB2 activation in autoimmune and inflammatory diseases, pain

rights to develop certain retained compounds for Charcot-Marie-Tooth type 1A neuropathy (CMT1A) and pain

trafficking of DOR, facilitating its downregulation and influencing cellular signaling pathways essential for pain

drawback of causing damage to healthy cells in the process, leading to side effects that can include pain

molecular dynamic simulations "The δ-opioid receptor (DOR) is a critical pharmaceutical target for pain

September 2022 "Morphine, the most widely used analgesic, relieves severe pain by activating the μ-opioid

leading to the development of drugs with superior efficacy and reduced side effects in heart disease, pain

various diseases, such as idiopathic pulmonary fibrosis, cancers, cardiovascular diseases and neuropathic pain

Therapeutic potential of opioid receptor heteromers in chronic pain and associated comorbidities. Investigating the potential of GalR2 as a drug target for neuropathic pain.

evidence implicates the G-protein coupled receptor (GPCR) GPR183 in the development of neuropathic pain

Library-based screening methodology for engineering small protein GPCR ligands Paolini-Bertrand, M.

Photopharmacological manipulation of amygdala metabotropic glutamate receptor mGlu4 alleviates neuropathic pain GPCRs in Oncology and Immunology Pan-cancer functional analysis of somatic mutations in G protein-coupled

MRGPRs), a subfamily of GPCRs, are largely expressed by sensory neurons and known to modulate itch and pain

ENDO 2024 Highlighting Therapeutic Potential of its GPCR Drug Discovery Platform GPCRs and Emotional Pain

Therapeutic antagonism of the neurokinin 1 receptor in endosomes provides sustained pain relief.

Must-read publications:  β-arrestin2-biased allosteric modulator for pain beyond opioids & GPR3 regulated

Some studies have also reported GPR84 involvement in pain, atherosclerosis, and even metabolic disorders

Multi-omics integration analysis of GPCRs in pan-cancer to uncover inter-omics relationships and potential Function Identification of a potential structure-based GPCR drug for interstitial cystitis/bladder pain

has a new website Confo Therapeutics Announces Global Licensing Agreement with Lilly for Peripheral Pain