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Her team at InterAx models receptor signaling pathways as systems of time-dependent equations, then runs in Graz, she spent six and a half years at Novo Nordisk in early drug discovery, focused on incretin receptors With a well-constructed computational model and a small set of kinetic assays, one compound on one receptor The next challenge is multi-receptor, multi-disease complexity. The computational tools that now describe single receptors will need to extend to how multiple receptors

Duke University (1994-1997), where he and his colleagues investigated the role of G protein-coupled receptor kinases and beta-arrestin in regulating G protein-coupled receptor endocytosis, trafficking, and signaling His research career has focused on the investigation of the regulation of G protein-coupled receptors Institutes of Health Research (CIHR) for his research investigating the role of metabotropic glutamate receptor

Duke University (1994-1997), where he and his colleagues investigated the role of G protein-coupled receptor kinases and beta-arrestin in regulating G protein-coupled receptor endocytosis, trafficking, and signaling His research career has focused on the investigation of the regulation of G protein-coupled receptors Institutes of Health Research (CIHR) for his research investigating the role of metabotropic glutamate receptor

the development of approaches to quantify ligand bias and the identification of beta-arrestin-biased receptors The main focus of his lab’s research is on the mechanisms underlying biased agonism at chemokine receptors The chemokine system is relatively unique in having multiple receptors and multiple ligands that display His group and others have shown that many of these ligands act as biased agonists for the same receptor

Fast, clear, live-cell receptor trafficking detection. This technology supports robust analysis even at low endogenous receptor expression levels. Internalization into acidic compartments = signal activation: Upon receptor-mediated endocytosis, the View Product pHSense Eu SNAP Labeling Reagent Can be used to label receptors and membrane proteins carrying All four formats are validated in well-established models like GLP1R and Mu opioid receptor (MOR), and

GPCRs, Receptors of Infinite Variety When asked about his favorite GPCR, Nicoli refused to pick. .” – Alessandro Nicoli He emphasized that olfactory receptors , while underexplored, present an incredible Modeling the Invisible: Olfactory Receptors Nicoli’s work centers on predicting ligand binding and receptor – Alessandro Nicoli He shared a detailed case study of working on a specific odorant receptor (R5VK1) His research focuses on a group of 400 transmembrane proteins known as olfactory receptors, which mediate

From early discoveries in cyclic AMP signaling to uncovering ultrasensitive receptor responses at femtomolar ligand concentrations, her work highlights why receptor localization and protein complex assembly matter Inside This Episode How ultrasensitive GPCR signaling emerges from pre-assembled receptor–effector complexes Why receptor localization and scaffolding dramatically shift functional readouts in disease models. The moment when femtomolar ligand concentrations uncovered unexpected receptor sensitivity.

In my PhD, I studied the nanoscale spatial organization of G protein-coupled receptors (GPCRs) at the Importantly, my work revealed heterogeneous spatial patterns of receptor density and activation, that Alice Ting developing programmable receptors for molecular sensing and controlling cellular behaviour

at Hyderabad, India, where he studied the interaction of membrane cholesterol with the serotonin-1A receptor and its effects on receptor signaling and endocytosis. molecular pharmacology, subcellular trafficking, and membrane biology to better understand how the dynamic receptor

A combined in silico approach to design peptide ligands with increased receptor-subtype selectivity Adam A2B adenosine receptor-triggered intracellular calcium mobilization: Cell type-dependent involvement May 20 - 22, 2025 |4th GPCRs-Targeted Drug Discovery Summit June 22 - 26, 2025 | G Protein-coupled Receptor selectivity Ligand-Independent Spontaneous Activation of Purinergic P2Y6 Receptor Under Cell Culture Soft Substrate 🔎 GPCR KEYWORDS Class-A G protein-coupled receptors , Lophotrochozoa , echinoderms ,

Following this tremendous experience, he was recruited to be the Principal Investigator of the Receptor To broaden his biomedical skill-set Stuart next accepted the position of Head of the Receptor Pharmacology Stuart’s current research, in the Receptor Biology Lab, focuses on the development of novel GPCR-based Stuart Maudsley on the web Maudsley Lab LinkedIn Google Scholar ResearchGate Maudsley Lab on Facebook Receptor

Following this tremendous experience, he was recruited to be the Principal Investigator of the Receptor To broaden his biomedical skill-set Stuart next accepted the position of Head of the Receptor Pharmacology Stuart’s current research, in the Receptor Biology Lab, focuses on the development of novel GPCR-based Stuart Maudsley on the web Maudsley Lab LinkedIn Google Scholar ResearchGate Maudsley Lab on Facebook Receptor

York) in 1990 and 1992, working with Ravi Iyengar on regulation/desensitization of the liver glucagon receptor His initial project to identify and clone taste receptors was unsuccessful, but led to the identification For this, we have worked in three main areas: the regulation of G protein-coupled receptor signaling particularly by the G protein-coupled receptor kinase (GRK) – beta-arrestin system, the coordination

Following this tremendous experience, he was recruited to be the Principal Investigator of the Receptor To broaden his biomedical skill-set Stuart next accepted the position of Head of the Receptor Pharmacology Stuart’s current research, in the Receptor Biology Lab, focuses on the development of novel GPCR-based Stuart Maudsley on the web Maudsley Lab LinkedIn Google Scholar ResearchGate Maudsley Lab on Facebook Receptor

York) in 1990 and 1992, working with Ravi Iyengar on regulation/desensitization of the liver glucagon receptor His initial project to identify and clone taste receptors was unsuccessful, but led to the identification For this, we have worked in three main areas: the regulation of G protein-coupled receptor signaling particularly by the G protein-coupled receptor kinase (GRK) – beta-arrestin system, the coordination

York) in 1990 and 1992, working with Ravi Iyengar on regulation/desensitization of the liver glucagon receptor His initial project to identify and clone taste receptors was unsuccessful, but led to the identification For this, we have worked in three main areas: the regulation of G protein-coupled receptor signaling particularly by the G protein-coupled receptor kinase (GRK) – beta-arrestin system, the coordination

York) in 1990 and 1992, working with Ravi Iyengar on regulation/desensitization of the liver glucagon receptor His initial project to identify and clone taste receptors was unsuccessful, but led to the identification For this, we have worked in three main areas: the regulation of G protein-coupled receptor signaling particularly by the G protein-coupled receptor kinase (GRK) – beta-arrestin system, the coordination

Sokhom recalls how binding assays at BMS introduced him to the depth and complexity of receptor pharmacology There’s allosterism, receptor desensitization… it opened a whole new world.” PhD entirely in the industry setting—efficient, targeted, and rooted in real-world projects like CGRP receptor He blends classical receptor pharmacology with biosensor technology, always adapting to new tools and About Sokhom Pin Sokhom Pin is a receptor pharmacologist with over 20 years of drug discovery research

These extraordinary receptors, about which there was not much known other than that they are huge and with the vast unknown biochemical and pharmacological territory that would be helpful to study orphan receptors Her postdoctoral work leads her to investigate a whole family of orphan receptors: adhesion GPCRs. With the little knowledge on these receptors available, there were multiple questions to tackle.

registers: the practical mechanics of holding a GPCR signaling lab together remotely; the continuity of receptor pipeline before the shutdown, including a newly accepted BRET-based platform for beta-1 adrenergic receptor , and illustrates how GPCR scientists reason about pharmacology problems well outside their primary receptor , with the beta-1 adrenergic receptor as a worked example. The beta-1 adrenergic receptor paper — a BRET-based platform for capturing downstream signaling, built

Five scientists audit what AI can and can't do for GPCR drug discovery — from orphan receptors and biased Random-forest classifiers trained on known peptide ligands can find new orphan-receptor pairings. Olfactory GPCRs — which account for a large fraction of the receptor class — have been systematically Selected Quotes "My computational team told me, 'this receptor is not using arrestin to internalize. G protein-coupled receptors (GPCRs) mediate a vast variety of critical biological processes and provide

Duvall discusses her lab’s work dissecting how GPCRs—especially neuropeptide Y (NPY) receptors—regulate and functional behavioral assays, including high-throughput and video-based methods, to reveal these receptors Why the study of conserved receptor pathways enables the development of broadly effective, species-independent How dissecting receptor function in non-neuronal tissues uncovers new parallels to human gut-brain communication If you often translate receptor mechanism findings from model organisms to human systems.

student visa was in the work, during which time I thoroughly reviewed the literature on the melanocortin receptor first project where I demonstrated that MRAP2 regulates the signaling of multiple G protein-coupled receptors contributed to an In-vivo project that showed that MRAP2 regulates the growth hormone secretagogue receptor necessary modification leading to a structural change granting the arrestins access to the core of the receptor Cone was the first to clone the melanocortin receptors (the GPCRs that led to the discovery of MRAP2)

, study multiple targets and signaling pathways, investigate target species variations, deorphanize receptors , and more Comprehensive Coverage >1500 Human GPCRs products, including: 90% Target coverage Orphan receptors cell line backgrounds Multiple Mechanisms of Actions (MOA) cAMP accumulation β-Arrestin recruitment Receptor validated portfolio for obesity and diabetes GPCR targets, including GLP-1, GIP, GCG, MC4, PYY, AMY receptors Apelin (APJ/AGTRL1) View representative data: GLP-1R multi-MOA profiling Eurofins DiscoverX's GLP-1 receptor

Summary Arthur's Career Journey and Allosteric Receptors Yamina and Arthur discussed Arthur's career journey and his contributions to the field of pharmacology, with a focus on allosteric receptors and They also discussed their own research on chemokine receptors and the importance of understanding the and GRKs, with Arthur recounting his initial collaboration with Patrick Sexton on RAMPs and amylin receptors They also delved into the different signaling of Class B receptors and the potential for modulation at

In parallel, his earlier work on orphan receptor deorphanization used co-evolution analysis and machine Together, these projects represent a rare attempt to connect the molecular detail of receptor pharmacology with the population-scale reality of how those receptors behave in living patients. genetic variants across human populations Co-evolution and machine learning as a framework for orphan receptor Orphan receptors can be systematically approached through evolutionary logic Rather than screening compound

recently their role in cancer was treated as marginal — a few curiosities around mas and muscarinic receptors side project nobody believed in to a recognized driver class in oncology, and explains why chemokine receptors His training began at the University of Buenos Aires on alpha-2 adrenergic receptors, continued at the Aberrant expression — a receptor in the wrong place at the wrong time, paired with autocrine or paracrine Early focus-formation assays using muscarinic receptors and carbachol produced transforming efficiencies

degree in biochemistry from Leipzig University (Germany) being already fascinated by G protein-coupled receptors They also discussed the challenges of studying metabolites and their receptors, the relationship between Challenges in Studying Metabolites and Receptors Claudia and Yamina discussed the challenges of studying metabolites and their receptors, particularly in relation to fermented foods. They also explored the potential for better tools to understand and discover new metabolites or receptors

Mark von Zastrow where she identified novel core cellular machinery critical for G protein-coupled receptor cell biological mechanisms regulating GPCR activity, including spatial control of GPCR signaling and receptor postdoctoral research in Oxford, investigating the signalling and trafficking of the G protein-coupled receptor (GPCR), calcium-sensing receptor, and its role in calcium homeostasis.

As a young researcher fascinated by chemokine receptors, molecular pharmacology, drug discovery, and GPCR, an ecosystem designed to bring together stakeholders interested in using G-Protein Coupled Receptors Her work focused on chemokine receptors, members of the GPCR family that control cell movement in the