receptor kinases and beta-arrestin in regulating G protein-coupled receptor endocytosis, trafficking, and signaling His research career has focused on the investigation of the regulation of G protein-coupled receptors signaling of Health Research (CIHR) for his research investigating the role of metabotropic glutamate receptor signaling

engineers and computer scientists focusing on the basic mechanisms of G protein-coupled receptor (GPCR) signalling To study GPCR signalling, they develop and use innovative optical methods based on FRET and single-molecule microscopy, which allow them to directly observe signalling events in living cells and tissues with

research program is to gain a thorough and mechanistic understanding of processes that control cell signaling The precise control of PAR signaling is critical for proper temporal and spatial dynamics of signaling Discovering new aspects of PAR signaling is important for increasing the fundamental knowledge of GPCR She has made numerous important discoveries related to the mechanisms that control PAR1 signaling and

Unexpected data is the signal, not the noise A line Bouvier returns to throughout his career, originally - landing the postdoc that changed the trajectory 12:06 The meaning of unexpected data and what it signals Since 2001, he holds the Canada Research Chair in Signal Transduction and Molecular Pharmacology. He is a world-renowned expert in the field of cell signaling and GPCRs and made seminal contributions In addition to paradigm shifts including inverse agonism, biased signaling, and pharmacological chaperones

missing pharmacology of ~100 unassigned receptors GPCRs in oncology, immunology, and microbiome-host signaling Marshall's team at GSK cloned GABA-B1, tried to get it to signal, and couldn't. Marshall in the room — a new category of GPCR biology opened, with heterodimers as obligate signaling The shift came through the tumor microenvironment — immune cells, chemokine receptors, adenosine signaling readability. 00:00 Welcome and guest introduction 02:32 How an undergraduate lecture on β-adrenergic signaling

scientists audit what AI can and can't do for GPCR drug discovery — from orphan receptors and biased signaling years in early R&D at Novo Nordisk before turning to systems biology approaches for connecting in vitro signaling mathematician and computer scientist, his doctoral work focused on developing new methods for modeling GPCR signaling computational cost of molecular dynamics simulations needed to capture the dynamic conformations behind signaling 37:01 Reading GPCR signaling dynamics with computational models 39:53 Generative models, scoring functions

Beaulieu has pioneered work establishing a role for Beta-arrestin signaling in the brain in vivo and has demonstrated that mood stabilizer drugs (e.g. lithium) used for bipolar disorder therapy target signaling is presently investigating how cell surface express proteins can act as allosteric modulators of D2R signaling

His work is central to the quantitative framework used today to describe receptor signaling bias, allosteric He proposed one of the first mechanistic explanations of biased signaling and co-authored the widely He is the author of A Pharmacology Primer, Editor-in-Chief of the Journal of Receptors and Signal Transduction short-form mechanistic discussions, and ongoing dialogue with the GPCR community on receptor theory, biased signaling

Explore how GPCR signaling shapes mosquito feeding and mating behaviors with Dr. Laura Duvall. Her group works at the intersection of neuropeptide signaling, behavioral genetics, and vector biology family Duvall calls her favorite includes a receptor in the female mosquito that detects a male derived signal neuroscience and circadian rhythms as a graduate research focus - Studying pigment dispersing factor signaling "In some ways my view of neuroscience and signaling between the brain and the body is relatively narrow

Terry Kenakin on how allostery and biased signaling rewrote receptor pharmacology, and why the assay This conversation follows the thread from that hit through probe dependence to biased signaling, and CONVERSATION - Allostery and probe dependence as ordinary protein behavior rather than special cases - Biased signaling Kenakin frames probe dependence as the mechanism and biased signaling as the name pharmacology later He now expects a screen to return compounds that signal differently from the natural hormone, rather

projects, I studied the role of β-arrestin in G protein trafficking, the impact of GPCR ubiquitination on signaling My current research focuses on investigating GPCR signaling and trafficking in the context of inflammation I am particularly interested in spatial signaling bias or how GPCRs can redistribute to different subcellular compartments to trigger distinct signaling events. " Dr. Badr shared his passion for GPCR signalling and regulation, specifically in the context of pain and inflammation

she identified novel core cellular machinery critical for G protein-coupled receptor trafficking and signaling fundamental cell biological mechanisms regulating GPCR activity, including spatial control of GPCR signaling Caroline continued to undertake postdoctoral research in Oxford, investigating the signalling and trafficking

Hall describes the experiment designed to kill receptor signaling that instead amplified it, the tethered BAI1, BAI2 and GPR56, with a particular focus on disease associated mutations that disturb receptor signaling Signaling increased massively instead, and the same held for BAI1. science memoirs - 17:03 Nature walks, synaptic plasticity, and falling for the first event in cell signaling 34 Moving the lab toward orphan and adhesion GPCRs - 34:00 The truncation that was supposed to kill signaling

In the Rajagopal Lab, Julia studies the mechanisms of 'biased signaling' at GPCRs, with a specific focus translocate to endosomes, and that the subcellular localization of the GRKs affects a GPCR's biased signaling

diabetes, and muscarinic receptors, her lab screens in disease-relevant cell lines and looks early for signaling beta-arrestin activity at a wild-type FFA2 receptor, suppressible by an inverse agonist that then redirects signaling receptor actually encounters in disease tissue - effectors like Go or Gz that are critical in neuronal signaling that made the G-protein bind better, some of which trapped the receptor in a state where it could not signal Is a 20% reduction of beta-arrestin signaling enough? I think it is probably cell-dependent.

The scientists who do this work accumulate expertise - in receptor signaling, cardiovascular physiology including the early identification of GPR56 as a mechanical sensor and his sustained case for the KLF2 signaling the first described synthetic agonists and antagonists of the FSHR and has been an early champion of signaling His recently published book on signaling bias, Biased Signaling in Physiology, Pharmacology, and Therapeutics

Annabelle’s Ph.D. work focuses on microbial-derived metabolites that signal through GPCRs expressed in In particular, she is looking at L- and D-lactate-activated HCAR1 signaling.

understanding the role of the membrane microenvironment in the subcellular organization, trafficking, and signaling the interaction of membrane cholesterol with the serotonin-1A receptor and its effects on receptor signaling

ubiquitination of the adaptor protein, β-arrestin, is a tag for receptor internalization and formation of signaling Current efforts aim to understand the regulation of GPCR and beta-arrestin signaling in the heart and

antibodies in their own labs and give structured feedback 📅 June 25, 2026 at 11:00:00 AM Details Receptor Signaling Kenakin - UNC Chappel Hill | Terry's Pharmacology Corner Topics Covered The biological basis of receptor signaling free, live online scientific sessions focused on G protein-coupled receptor biology, pharmacology, signaling GPCR pharmacology, signaling, structural biology, allosteric modulation, biased agonism, assay design

with neuroactive properties, with particular emphasis on identifying compounds that modulate neural signaling this Masterclass, she introduces the physiological and pharmacological foundations of GLP-1 receptor signaling

Dylan's graduate research focuses on the mechanisms underlying biased signaling at GPCRs, specifically , the role of differential receptor phosphorylation (phosphorylation barcodes) and subcellular GPCR signaling

regulating appetite, metabolism, and the immune system, and the molecular mechanisms underlying the signaling where he is now Associate Professor, establishing a lab focused on G protein-coupled receptor kinetics, signaling

she identified novel core cellular machinery critical for G protein-coupled receptor trafficking and signaling fundamental cell biological mechanisms regulating GPCR activity, including spatial control of GPCR signaling

Her team at InterAx models receptor signaling pathways as systems of time-dependent equations, then runs Conversation Kinetic versus endpoint characterization of GPCR ligands Systems biology modeling of receptor signaling Standard assay kits that read cAMP at thirty minutes or arrestin recruitment at ten collapse time-resolved signaling treats GPCR pharmacology the way engineers treat aircraft design: build the mathematical model of the signaling

Gloriam on orphan GPCR biology, GPCRDB, biased signaling, and how the data analysis bottleneck is reshaping this ambiguity as symptomatic of a deeper challenge: the field has not yet fully characterized which signaling He described the complete characterization of biased signaling pathways across all GPCRs as one such He is one of the coordinators of recommendations to describe ligand bias towards signaling probes and group recently developed an online resource of biased ligands and pathway effects to advance the biased signaling

pharmacology while performing various cell-based experiments to understand the binding, activation, and signaling Babu lab to progress in the understanding of spatiotemporal regulation of biased GPCR activation and signaling

communication, she is poised to make valuable contributions to the field and expand our understanding of GPCR signaling computational methods like molecular dynamics simulations and free energy landscape analysis to understand the signaling molecular pharmacology, his research focuses on elucidating the molecular basis of membrane protein signalling

Stuart Maudsley on why receptor signaling shifts across a lifetime, and how high dimensional data turns Scientific Themes of the Conversation Receptors as temporal systems: signaling that shifts across milliseconds More dimensions of signaling means more places a therapeutic can enter. What is the likelihood that a signaling system of this complexity is maintained with perfect fidelity

Melanogaster, three of the five known adhesion GPCRs had no documented function, expression pattern, or signaling Her research focuses on characterizing the localization, signaling, and in vivo function of previously The other three had no documented expression pattern, signaling data, or phenotype. Naming receptors after condiments signals where the field actually stands Ketchup, Mayo, and Remulate