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PDF Program HERE < Back to Full Agenda Session III Molecular tools and biosensors directed at AGPCR signaling Häfner bioSens-All: A Multiparametric BRET-Based Platform for Comprehensive Profiling of adhesion GPCR Signaling and Pharmacology-Enabling Drug Discovery Laurent Sabbagh Characterizing hADGRE5/CD97 Activation and Signaling Laurent Sabbagh on the web Domain Therapeutics Characterizing hADGRE5/CD97 Activation and Signaling: My expertise lies in exploring the biological properties and signaling pathways activated by aGPCRs,

Thomas Sakmar’s laboratory at Rockefeller University, where she studies the signaling and degradation She is currently working to understand the signaling and degradation of GPCRs in disease states to help

How advanced assay design is essential for translating cell-based GPCR signals to therapeutic outcomes Why strategic flexibility in exploring non-canonical signaling pathways is critical for GPCR-targeted Researchers refining strategies for high-throughput screening or exploring biased signaling. fellowship at GSK, where he entered the GPCR field and became proficient in aptamer selection and cell signaling

Beaulieu has pioneered work establishing a role for Beta-arrestin signaling in the brain in vivo and has demonstrated that mood stabilizer drugs (e.g. lithium) used for bipolar disorder therapy target signaling is presently investigating how cell surface express proteins can act as allosteric modulators of D2R signaling

the past two decades, his lab has published numerous groundbreaking findings shedding light on the signaling Most recently, his lab has made a number of seminal contributions to understanding the signaling, regulation has a special interest in studying disease-associated mutations to human GPCRs that perturb receptor signaling

I then undertook my first project where I demonstrated that MRAP2 regulates the signaling of multiple Concurrently, I described the mechanisms by which MRAP2 regulates GHSR1a signaling; this project brought Using this novel technique, I showed that MRAP2 biased GHSR1a signaling and shut down its constitutive activity; this work resulted in a first author publication in Science Signaling. to create a scientific session at the American Physiology Summit (APS) 2024 dedicated to GPCR biased signaling

she obtained her Ph.D. at the University of Western Ontario, working on the regulation of G proteins signaling Her current research focuses on class B GPCRs and understanding how GPCR signaling and function is mediated

Today he and his team are working on understanding receptor signaling in specialized cellular environments favorite GPCR is the angiotensin 1 receptor, especially for its ability to activate a large variety of signaling

In the Rajagopal Lab, Julia studies the mechanisms of 'biased signaling' at GPCRs, with a specific focus translocate to endosomes, and that the subcellular localization of the GRKs affects a GPCR's biased signaling

Beaulieu has pioneered work establishing a role for Beta-arrestin signaling in the brain in vivo and has demonstrated that mood stabilizer drugs (e.g. lithium) used for bipolar disorder therapy target signaling is presently investigating how cell surface express proteins can act as allosteric modulators of D2R signaling

understanding the role of the membrane microenvironment in the subcellular organization, trafficking, and signaling the interaction of membrane cholesterol with the serotonin-1A receptor and its effects on receptor signaling

Annabelle’s Ph.D. work focuses on microbial-derived metabolites that signal through GPCRs expressed in In particular, she is looking at L- and D-lactate-activated HCAR1 signaling.

ubiquitination of the adaptor protein, β-arrestin, is a tag for receptor internalization and formation of signaling Current efforts aim to understand the regulation of GPCR and beta-arrestin signaling in the heart and

Dylan's graduate research focuses on the mechanisms underlying biased signaling at GPCRs, specifically , the role of differential receptor phosphorylation (phosphorylation barcodes) and subcellular GPCR signaling

innovative methods for in-cellulo measurement of protein-protein interactions, receptor trafficking and signalling His research program also studies the allosteric, biased signalling regulation of GPCR and has contributed

regulating appetite, metabolism, and the immune system, and the molecular mechanisms underlying the signaling where he is now Associate Professor, establishing a lab focused on G protein-coupled receptor kinetics, signaling

Since 2001, he holds the Canada Research Chair in Signal Transduction and Molecular Pharmacology. He is a world-renowned expert in the field of cell signaling and GPCRs and made seminal contributions In addition to paradigm shifts including inverse agonism, biased signaling, and pharmacological chaperones

October 23-25 Download PDF Program HERE < Back to Full Agenda Session V Structural mechanisms of AGPCR signaling CELSR1 extracellular region reveal a compact multidomain module of fourteen domains which regulates signaling CELSR1 extracellular region reveal a compact multidomain module of fourteen domains which regulates signaling employ cellular assays with full-length CELSR1 and truncation constructs to assess the adhesive and signaling CADH1-8 module as necessary for cell adhesion and we show the C-terminal CAHD9-GAIN module regulates signaling

she identified novel core cellular machinery critical for G protein-coupled receptor trafficking and signaling fundamental cell biological mechanisms regulating GPCR activity, including spatial control of GPCR signaling

I will also present ongoing work on the signaling mechanisms of how ADGRCs regulate synapse formation My long-term research interests involve resolving signaling pathways downstream of aGPCRs and establishing how/if these receptors’ adhesive properties influence signaling events, and in turn whether signaling I initially became interested in GPCR signal transduction during my graduate training in the Department

research program is to gain a thorough and mechanistic understanding of processes that control cell signaling The precise control of PAR signaling is critical for proper temporal and spatial dynamics of signaling Discovering new aspects of PAR signaling is important for increasing the fundamental knowledge of GPCR She has made numerous important discoveries related to the mechanisms that control PAR1 signaling and

she identified novel core cellular machinery critical for G protein-coupled receptor trafficking and signaling fundamental cell biological mechanisms regulating GPCR activity, including spatial control of GPCR signaling Caroline continued to undertake postdoctoral research in Oxford, investigating the signalling and trafficking

live online scientific sessions focused on G protein-coupled receptor (GPCR) biology, pharmacology, signaling entering drug discovery If you work directly with receptor systems, ligand design, efficacy modeling, or signaling These webinars are designed for scientists with foundational knowledge in receptor pharmacology, signaling models • Allosteric modulators (PAMs and NAMs) • Biased agonism • Dose–response modeling • Calcium and signaling

About Joshua Gross "I am a neuropharmacologist interested in exploiting GPCR biased signaling to design With my expertise in reward behavior, neurophysiology, GPCR signaling, and preclinical drug development

He is one of the coordinators of recommendations to describe ligand bias towards signaling probes and group recently developed an online resource of biased ligands and pathway effects to advance the biased signaling

pharmacology while performing various cell-based experiments to understand the binding, activation, and signaling Babu lab to progress in the understanding of spatiotemporal regulation of biased GPCR activation and signaling

in particular, the ligand identification, physiological functions and molecular mechanism of biased signaling For arrestin mediated biased signaling, we have proposed the “flute model” and “poly proline region docking

projects, I studied the role of β-arrestin in G protein trafficking, the impact of GPCR ubiquitination on signaling My current research focuses on investigating GPCR signaling and trafficking in the context of inflammation I am particularly interested in spatial signaling bias or how GPCRs can redistribute to different subcellular compartments to trigger distinct signaling events. " Dr. Badr shared his passion for GPCR signalling and regulation, specifically in the context of pain and inflammation

All my formal training was in the area of signal transduction, and I continued to work on this area since communication via heterotrimeric G-proteins (Gαβγ) because they represent major intracellular hubs of signaling

different modes of action of Adhesion GPCRs and found that they do not only mediate classical G protein signals Today, she and her team are working on the questions of how Adhesion GPCRs integrate the different signals