Search Results

the GPR37-mTOR-S6K1 Signaling GPCRs in Neuroscience Astrocyte Gi-GPCR signaling corrects compulsive-like

Although such pheromone/receptor systems are likely to function in both mate choice and prezygotic isolation

Gs-coupled receptors enriched in SKM has only a limited impact on whole-body glucose homeostasis, most likely

Moreover, advanced AI models like AlphaFold3, which can predict complex protein-molecule interactions

This highlights the power of advanced imaging techniques like cryo-EM in solving complex biological puzzles

Diagnose hidden effects like mixed receptor systems or slope deviations before they distort your interpretation

Most labs operated like small, competing startups.

That’s why we partner with innovators like Revvity , whose new reagent family— pHSense™ —isn’t just another

Hearing Terry speak is more than an academic experience — it’s like being handed a new set of tools to

CCR2 was also shown to be resistant to degradation and most likely recycling through the trans-Golgi D’Amico et. al 2000), becoming incapable of promoting cell migration, a phenomenon which is likely to

Structurally they characterize by a long extracellular region of adhesion-like domains which modulate possible to know that ADGRL3 can activate and form stable complexes with Gs, Gi, Gq, and G12, where like

low relatedness Industry News Nobel Laureates Highlight Symposium Celebrating Lefkowitz’s 50 Years at Duke

But before we delve into the latest news, we'd like to highlight some upcoming events and resources:

Given the sensitive allosteric nature of GPCRs with their binding partners, tags or modifications are likely able to detect interaction with the strongest coupling partner Gαs (Figure 2A), and for the glucagon-like-peptide Manchanda and colleagues [37] showed that for the glucagon-like-peptide-1 receptor (GLP-1R), mini-Gs inhibited β-arrestin recruitment, receptor internalisation, and endosomal trafficking for the glucagon-like-peptide

If you are interested in giving a talk, contact us at Hello@DrGPCR.com, and if you would like to present

the evolutionary conservation of these residues can lead to the development of drugs that are less likely

contrast, when the GPR55 receptor is simulated in complex with the selective agonist ML186, agonist-like

cell mobilization when combined with propranolol Discovery of 3-Phenyl Indazole-Based Novel Chemokine-like

conformational sampling in advance of docking or receptor conformational adjustment after docking are more likely

GPCR X Revvity Collaboration ⸻ Want more like this? 👉 Join the Dr.

that slow down or prevent good science from reaching patients — particularly in underfunded fields like

excelling in the PCAT and gaining admission to pharmacy school at the University of Michigan, it seemed like

If you have any research you would like to showcase to our community, you can submit a poster presentation

Revealing the tissue-level complexity of endogenous glucagon-like peptide-1 receptor expression and signaling

Efforts will likely be made to develop AI models that can provide transparent explanations for their The sharing and collaboration of data across academia, industry, and regulatory bodies will likely increase

Allosterics , in contrast, act more like tuning knobs—modulating receptor ensembles in partnership with

Depending on the type of GPCR, it can lead to different secondary messengers , like cAMP, IP3, which

The same compound can look like an activator in one system and a blocker in another—depending on basal

protein signalling and modulates excitability of human induced pluripotent stem cell-derived nociceptive-like

Gives You an Edge Premium delivers curated, noise-free intelligence every week: expert frameworks  (like