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- Dr. Khaled Abdelrahman, Victoria Rasmussen and Madelyn Moore | Dr. GPCR Ecosystem
He has been also studying what aspects of GPCR signaling are regulated in a sex-selective manner and Thomas Sakmar’s laboratory at The Rockefeller University, where she study’s the signaling and degradation She is currently working to understand the signaling and degradation of GPCRs in disease states to help
- 📢 All 2025 Dr.GPCR Courses Are Open for Registration! Which one will you choose? 🚀 Whether you're diving into GPCR drug discovery, pharmacology, or advanced modeling, there's a course for you. 💡 Bonus: Premium Members enjoy 25% off on all courses! 🔗 Explore & register today: https://www.ecosystem.drgpcr.com/gpcr-courses #GPCR #DrGPCR #Biotech #DrugDiscovery #Pharmacology | Dr. GPCR Ecosystem
Due to Intellectual Property Gaps 👉 Why has intellectual property become a first-order fundraising signal intellectual property is no longer something that comes up late in the process. 👉 It has become an early signal to Avoid the Most Common Data Pitfalls Binding affinity appears straightforward: add ligand, measure signal
- A large-scale analysis of GPCR molecular dynamics reveals hidden allosteric sites and lateral gateways, unlocking new possibilities for drug discovery. Subscribe to the Dr. GPCR Newsletter 📰 and get the latest GPCR News delivered to your inbox ➡️https://www.ecosystem.drgpcr.com/structural-and-molecular-insights-into-gpcr-function/large-scale-investigation-of-gpcr-molecular-dynamics-data-uncovers-allosteric-sites-and-lateral-gateways #gpcr#drgpcr | Dr. GPCR Ecosystem
Due to Intellectual Property Gaps 👉 Why has intellectual property become a first-order fundraising signal intellectual property is no longer something that comes up late in the process. 👉 It has become an early signal to Avoid the Most Common Data Pitfalls Binding affinity appears straightforward: add ligand, measure signal
- "Solving financial puzzles feels just like solving scientific ones," says Joe St. Germain from Company Launch Partners. Behind every successful research organization, there is a rock-solid operations team. Don’t miss this rare conversation bridging science, structure, and strategy with Chuck DeWeese & Joe St. Germain. ✳️ Tune in now: Ep 165 with Chuck DeWeese & Joe St. Germain #gpcr #DrGPCR #ScienceStartup | Dr. GPCR Ecosystem
Due to Intellectual Property Gaps 👉 Why has intellectual property become a first-order fundraising signal intellectual property is no longer something that comes up late in the process. 👉 It has become an early signal to Avoid the Most Common Data Pitfalls Binding affinity appears straightforward: add ligand, measure signal
- An opportunity you won’t want to miss! ⚠️ The next 4-week course with Dr. Terry Kenakin, “Development of GPCR Ligands as Therapeutic Drugs” is coming up 🧐 Be the first to register, save your spot, and spread the word. This event will only happen once this year! ✳️Go to https://www.ecosystem.drgpcr.com/event-details-registration/development-of-gpcr-ligands-as-therapeutic-drugs for more information! #gpcr #drgpcr | Dr. GPCR Ecosystem
Due to Intellectual Property Gaps 👉 Why has intellectual property become a first-order fundraising signal intellectual property is no longer something that comes up late in the process. 👉 It has become an early signal to Avoid the Most Common Data Pitfalls Binding affinity appears straightforward: add ligand, measure signal
- New cryo-EM insights reveal how extracellular domains communicate with transmembrane regions in holo-adhesion GPCRs, uncovering mechanisms behind receptor activation. Subscribe to the Dr. GPCR Newsletter 📰 and get the latest GPCR News delivered to your inbox ➡️https://www.ecosystem.drgpcr.com/adhesion-gpcrs/conformational-coupling-between-extracellular-and-transmembrane-domains-modulates-holo-adhesion-gpcr-function #gpcr #drgpcr | Dr. GPCR Ecosystem
Due to Intellectual Property Gaps 👉 Why has intellectual property become a first-order fundraising signal intellectual property is no longer something that comes up late in the process. 👉 It has become an early signal to Avoid the Most Common Data Pitfalls Binding affinity appears straightforward: add ligand, measure signal
- A GPCR imaging breakthrough that didn’t start in a grant proposal | Dr. GPCR Ecosystem
Due to Intellectual Property Gaps 👉 Why has intellectual property become a first-order fundraising signal intellectual property is no longer something that comes up late in the process. 👉 It has become an early signal to Avoid the Most Common Data Pitfalls Binding affinity appears straightforward: add ligand, measure signal
- 🔥 New Course Alert! “Development of GPCR Ligands as Therapeutic Drugs” with Dr. Terry Kenakin is here! Spots are filling up fast—Premium Members get 25% off! This advanced course is exclusively available in the Ecosystem, so don’t miss your chance to learn from the best. 🔹 Secure your spot now! 👉 https://www.ecosystem.drgpcr.com/event-details-registration/development-of-gpcr-ligands-as-therapeutic-drugs #gpcr #drgpcr #pharmacolgy #drugdiscovery #research | Dr. GPCR Ecosystem
Due to Intellectual Property Gaps 👉 Why has intellectual property become a first-order fundraising signal intellectual property is no longer something that comes up late in the process. 👉 It has become an early signal to Avoid the Most Common Data Pitfalls Binding affinity appears straightforward: add ligand, measure signal
- In case you haven’t heard, registrations are open for the next 4-week course “Development of GPCR Ligands as Therapeutic Drugs,” with Dr. Terry Kenakin 👏 Spots are filling up fast, run and save yours, and enjoy a 25% discount with your Premium Membership 🚀 ✳️Go to https://www.ecosystem.drgpcr.com/event-details-registration/development-of-gpcr-ligands-as-therapeutic-drugs #gpcr #drgpcr | Dr. GPCR Ecosystem
Due to Intellectual Property Gaps 👉 Why has intellectual property become a first-order fundraising signal intellectual property is no longer something that comes up late in the process. 👉 It has become an early signal to Avoid the Most Common Data Pitfalls Binding affinity appears straightforward: add ligand, measure signal
- Did you know registrations are already open for all our 2025 Dr.GPCR University Courses? Check out what you can learn this year from the master, Dr. Terry Kenakin 😉and save your spot soon! Remember Premium Members get a 25% discount 🙌 ✳️Click here and start your next learning experience https://www.ecosystem.drgpcr.com/gpcr-courses #gpcr #drgpcr | Dr. GPCR Ecosystem
Due to Intellectual Property Gaps 👉 Why has intellectual property become a first-order fundraising signal intellectual property is no longer something that comes up late in the process. 👉 It has become an early signal to Avoid the Most Common Data Pitfalls Binding affinity appears straightforward: add ligand, measure signal
- New Episode Alert! 🎙️ Ep. 163 of the Dr. GPCR Podcast is here! 🚀 This time, we sit down with Dr. Dmitry Veprintsev to discuss the importance of asking the right GPCR questions. Whether you're a researcher, student, or GPCR enthusiast, this episode is packed with insights that will challenge how you think about your experiments. ✳️Tune in at https://www.ecosystem.drgpcr.com/dr-gpcr-podcast/ep-163-with-dr.-dmitry- #DrGPCR #GPCRPodcast #Pharmacology #DrugDiscovery #Biotech #GPCRs | Dr. GPCR Ecosystem
Due to Intellectual Property Gaps 👉 Why has intellectual property become a first-order fundraising signal intellectual property is no longer something that comes up late in the process. 👉 It has become an early signal to Avoid the Most Common Data Pitfalls Binding affinity appears straightforward: add ligand, measure signal
- Generic tools won’t solve tomorrow’s drug discovery challenges. That’s why Celtarys designs custom fluorescent probes for every target, built for real pharmacology, not just convenience. With Dr. GPCR and Celtarys joining forces, expect more visibility, more precision, and more scientific impact. 🚀 Get to know our media partner: https://www.ecosystem.drgpcr.com/celtarys-research-dr-gpcr-ecosystem #GPCRdrugDiscovery #GPCRecosystem #CustomLigands | Dr. GPCR Ecosystem
Due to Intellectual Property Gaps 👉 Why has intellectual property become a first-order fundraising signal intellectual property is no longer something that comes up late in the process. 👉 It has become an early signal to Avoid the Most Common Data Pitfalls Binding affinity appears straightforward: add ligand, measure signal
- Did you know? 🌟 Researchers have developed reversibly photoswitchable allosteric modulators for Class A GPCRs! 🧬💡 These innovative compounds, “Photo-BQCisA” and “Photo-BQCtrAns,” offer subtype-selective precision by combining allosteric modulation with light control, paving the way for new therapeutic strategies targeting muscarinic receptors (M1-M5). 🔬✨ Learn more about this breakthrough in the Ecosystem! | Dr. GPCR Ecosystem
Due to Intellectual Property Gaps 👉 Why has intellectual property become a first-order fundraising signal intellectual property is no longer something that comes up late in the process. 👉 It has become an early signal to Avoid the Most Common Data Pitfalls Binding affinity appears straightforward: add ligand, measure signal
- Can we preserve opioid pain relief without the side effects? 🔬 On Ep.166 of the Dr.GPCR Podcast, Ben Clements shares how positive allosteric modulators (PAMs) at the mu-opioid receptor could revolutionize treatment —with a 10x boost in methadone efficacy. Tune in for a masterclass on translational pharmacology, curiosity-driven science, and meaningful mentorship. 🎧 Full episode: Ep 166 with Dr. Ben Clements #GPCRresearch #DrGPCR #GPCRpodcast #OpioidPharmacology #DrugDiscovery | Dr. GPCR Ecosystem
Due to Intellectual Property Gaps 👉 Why has intellectual property become a first-order fundraising signal intellectual property is no longer something that comes up late in the process. 👉 It has become an early signal to Avoid the Most Common Data Pitfalls Binding affinity appears straightforward: add ligand, measure signal
- Dr. David E. Gloriam | Dr. GPCR Ecosystem
He is one of the coordinators of recommendations to describe ligand bias towards signaling probes and group recently developed an online resource of biased ligands and pathway effects to advance the biased signaling
- Dr. Katarina Nemec | Dr. GPCR Ecosystem
pharmacology while performing various cell-based experiments to understand the binding, activation, and signaling Babu lab to progress in the understanding of spatiotemporal regulation of biased GPCR activation and signaling
- Pharmacological and Genetic Preclinical Models of Ghrelin Receptor Functional Selectivity to Investigate Metabolic Disease Pathophysiology
About Joshua Gross "I am a neuropharmacologist interested in exploiting GPCR biased signaling to design With my expertise in reward behavior, neurophysiology, GPCR signaling, and preclinical drug development
- Plenary Lecture | Adhesion GPCR Workshop 2024 | Dr. GPCR Ecosystem
in particular, the ligand identification, physiological functions and molecular mechanism of biased signaling For arrestin mediated biased signaling, we have proposed the “flute model” and “poly proline region docking
- 🔬 Enhance Your GPCR Expertise with Dr.GPCR University! Looking to sharpen your skills in GPCR pharmacology, drug discovery, data analysis, or project management? Dr.GPCR University offers industry-focused courses designed to help you stay ahead in the field. ✅ Comprehensive course library covering cutting-edge GPCR science ✅ Practical insights for real-world drug discovery challenges ✅ Flexible, on-demand learning to fit your schedule 🚀 Elevate your expertise today: Start learning now #GPCR #Pharmacology #DrugDiscovery #Biotech #DrGPCR | Dr. GPCR Ecosystem
Due to Intellectual Property Gaps 👉 Why has intellectual property become a first-order fundraising signal intellectual property is no longer something that comes up late in the process. 👉 It has become an early signal to Avoid the Most Common Data Pitfalls Binding affinity appears straightforward: add ligand, measure signal
- Visualizing GPCRs in their native environment changes everything | Dr. GPCR Ecosystem
Due to Intellectual Property Gaps 👉 Why has intellectual property become a first-order fundraising signal intellectual property is no longer something that comes up late in the process. 👉 It has become an early signal to Avoid the Most Common Data Pitfalls Binding affinity appears straightforward: add ligand, measure signal
- irreversible drugs post 1 | Dr. GPCR Ecosystem
Due to Intellectual Property Gaps 👉 Why has intellectual property become a first-order fundraising signal intellectual property is no longer something that comes up late in the process. 👉 It has become an early signal to Avoid the Most Common Data Pitfalls Binding affinity appears straightforward: add ligand, measure signal
- We’re excited to announce our strategic partnership with Celtarys Research, a biotech company specializing in fluorescent ligand technologies and real-time, non-radioactive GPCR assays. This collaboration combines Dr. GPCR’s global platform with Celtarys’ innovative chemical biology tools, making it easier than ever for scientists to study ligand-receptor interactions, visualize binding, and accelerate drug discovery. We’re proud to welcome Celtarys to the Dr. GPCR ecosystem to support researchers worldwide and expand access to high-performance tools for GPCR-targeted therapeutics. ✳️Read the complete press release: https://www.ecosystem.drgpcr.com/post/dr-gpcr-and-celtarys-research-join-forces-to-expand-access-to-innovative-gpcr-tools #GPCR #DrGPCR #CeltarysResearch #DrugDiscoveryTools #FluorescentLigands #GPCRresearch #ScientificPartnership | Dr. GPCR Ecosystem
Due to Intellectual Property Gaps 👉 Why has intellectual property become a first-order fundraising signal intellectual property is no longer something that comes up late in the process. 👉 It has become an early signal to Avoid the Most Common Data Pitfalls Binding affinity appears straightforward: add ligand, measure signal
- 💡 GPCR drug development doesn’t have to be a mystery! Learn from Dr. Terry Kenakin in this 4-week immersive course covering ligand development & pharmacology. 🔹 What you’ll learn: ✅ Drug Development Basics – Absorption, metabolism, PK principles ✅ Clearance & Distribution – Renal & hepatic clearance, key pharmacokinetics ✅ PK-PD Modeling – Predicting drug behavior, non-linear PK ✅ Early Drug Safety – Toxicity risks & drug interactions 📌 Spots are filling fast! Sign up today 👉 Development of GPCR Ligands as Therapeutic Drugs | Dr. GPCR Ecosystem #GPCR #DrGPCR #Pharmacology #Biotech #DrugDiscovery | Dr. GPCR Ecosystem
Due to Intellectual Property Gaps 👉 Why has intellectual property become a first-order fundraising signal intellectual property is no longer something that comes up late in the process. 👉 It has become an early signal to Avoid the Most Common Data Pitfalls Binding affinity appears straightforward: add ligand, measure signal
- irreversible drugs post 3 | Dr. GPCR Ecosystem
Due to Intellectual Property Gaps 👉 Why has intellectual property become a first-order fundraising signal intellectual property is no longer something that comes up late in the process. 👉 It has become an early signal to Avoid the Most Common Data Pitfalls Binding affinity appears straightforward: add ligand, measure signal
- Lighting up a native pancreatic islet isn’t just a technical win it’s a shift in what GPCR imaging can reveal | Dr. GPCR Ecosystem
Due to Intellectual Property Gaps 👉 Why has intellectual property become a first-order fundraising signal intellectual property is no longer something that comes up late in the process. 👉 It has become an early signal to Avoid the Most Common Data Pitfalls Binding affinity appears straightforward: add ligand, measure signal
- Did you know that GPR180 helps regulate lipid metabolism and may play a role in preventing obesity? recent study shows that overexpression of GPR180 in adipose tissue improves lipid metabolism and protects against HFD-induced obesity, while its knockout worsens lipid accumulation. This finding highlights GPR180 as a potential therapeutic target for metabolic disorders! Catch up on this exciting research in the Ecosystem today! 🏆📖 You’ll need to register, but don’t worry—it’s free! ➡️https://www.ecosystem.drgpcr.com/gpcrs-in-cardiology-endocrinology-and-taste/gpr180-reduces-adiposity-by-inhibiting-lipogenesis-and-fatty-acid-uptake-in-adipocytes #gpcr #drgpcr #metabolism #obesity | Dr. GPCR Ecosystem
Due to Intellectual Property Gaps 👉 Why has intellectual property become a first-order fundraising signal intellectual property is no longer something that comes up late in the process. 👉 It has become an early signal to Avoid the Most Common Data Pitfalls Binding affinity appears straightforward: add ligand, measure signal
- Self-Learning, Collaboration, and Delegation in Science with Dr. Badr Sokrat | Dr. GPCR Ecosystem
projects, I studied the role of β-arrestin in G protein trafficking, the impact of GPCR ubiquitination on signaling My current research focuses on investigating GPCR signaling and trafficking in the context of inflammation I am particularly interested in spatial signaling bias or how GPCRs can redistribute to different subcellular compartments to trigger distinct signaling events. " Dr. Badr shared his passion for GPCR signalling and regulation, specifically in the context of pain and inflammation
- Anything BUT GPCRs with Dr. Mikel Garcia-Marcos | Dr. GPCR Ecosystem
All my formal training was in the area of signal transduction, and I continued to work on this area since communication via heterotrimeric G-proteins (Gαβγ) because they represent major intracellular hubs of signaling
- ep 175 with jens carlsson clip 1 | Dr. GPCR Ecosystem
Due to Intellectual Property Gaps 👉 Why has intellectual property become a first-order fundraising signal intellectual property is no longer something that comes up late in the process. 👉 It has become an early signal to Avoid the Most Common Data Pitfalls Binding affinity appears straightforward: add ligand, measure signal
- insights into g protein coupling preference from cryo em structures of gq bound PTH1R | Dr. GPCR Ecosystem
biased agonist design A critical advance for anyone working on class B1 GPCRs, bone biology, or biased signaling






