Search Results

<< Back to podcast list Strategic Partner(s) Dr. Aaron Sato About this episode In this episode of the Dr. GPCR Podcast , I spoke to Dr. Aaron Sato from Twist Biopharma , a vertical within Twist Bioscience . Aaron is currently the Chief Scientific Officer and VP of Protein Engineering. He earned his Ph.D. at the Massachusetts Institute of Technology, where he studied MHC class II structure-function relationships. His path led him to work in an industry where he assumed various responsibilities and roles in the antibody space. Aaron has a proven track record as a biologics leader as he led teams to discover and develop novel first-in-class antibody therapeutics. Dr. Sato published over 30 peer-reviewed papers and contributed to 40 issued patents in the antibody space. During our time together, Aaron and I discussed how using Twist Bioscience’s proprietary technology to manufacture DNA at a scale, the team saw an opportunity to tackle the challenge of identifying novel functional antibodies targeting GPCRs by incorporating these natural binding partners into Twist’s antibody library design. We’d like to extend a special thanks to Twist Biopharma for sponsoring this episode of the Dr. GPCR podcast. Dr. Aaron Sato on the web LinkedIn Twitter Google Scholar Twist Bioscience Twist Biopharma Dr. GPCR Ecosystem Enjoying the Dr. GPCR Podcast? Leave a Review. Leave a quick review to help more scientists find the show—and help us keep improving every episode. It takes <60 seconds and makes a big difference. ★ Review on Apple Podcasts ★ Rate on Spotify ✉️ Send feedback to the team Recent Podcast Articles Asking Better Questions in Science: A Practical Guide for Emerging Researchers When the Islet Lit Up: Advancing GPCR Imaging in Native Tissue How Collaboration Sparked a GPCR Imaging Breakthrough in Chemical Biology Thanks for listening to this podcast episode Follow us on your favorite Podcast Player << Previous Podcast Episode Next Podcast Episode >>

Discover the rules and guidelines that govern your participation in the Dr. GPCR Ecosystem. Explore our Terms and Conditions page now! Terms and Conditions Dr. GPCR, Corp (“Dr. GPCR”) provides its Service to you through our websites referred to as Dr. GPCR, Ecosystem.DrGPCR.com, DrGPCR.com. 1. ACCEPTANCE OF TERMS: This is a legal document, outlining the Agreement on Terms of Service (the “ATS”) for our website, Ecosystem.DrGPCR.com (the “Website”). By using our Website, you agree to fully comply with and be bound by the following ATS each time you use our Website. Please review the following terms carefully. Dr. GPCR, Corp (“Dr. GPCR”) provides its Service (as defined below) to you through this website, subject to this ATS. By accepting this ATS or by accessing or using the Service or Website, you acknowledge that you have read, understood, and agree to be bound by this ATS. If you are entering into this ATS on behalf of a company, business, or other legal entity, you represent that you have the authority to bind such entity and its affiliates to this ATS. If you do not have such authority, or if you do not agree with this ATS, you must not accept this ATS and may not use the Service. Dr. GPCR, Corp (“Dr. GPCR”) may change this ATS from time to time without prior notice. You can review the most current version of this ATS at any time in our Website. The revised terms and conditions will become effective upon posting and if you use the Service after that date, your use will constitute acceptance of the revised terms and conditions. If any change to this ATS is not acceptable to you, stop accessing and using the Service. This agreement contains warranty disclaimers and other provisions that limit our liability to you. Please read these terms and conditions carefully and in their entirety, as using, accessing, and/or browsing our Website constitutes acceptance of these terms and conditions. If you do not agree to be bound to each and every term and condition set forth herein, please exit our website immediately and do not use access and/or access it further. 2. SERVICES: Ecosystem.DrGPCR.com is an online platform that provides to (i) individuals and businesses such as scientists, students, biotech companies, and others with access to advertise, to promote, and market their services and products related to the biotech industry; and to (ii) individuals and businesses who are seeking to buy, to sell, to invest, to rent, or those who wish to find services to assist or to represent her/his/them in consummating any of these transactions (the “Services”). Individuals and businesses under this section are defined as “Customer” or “Customers”. Such Services includes also access to the Website, and to all software (including the Software, as defined below), data, reports, text, images, sounds, video, and content made available through the Website or any additional instrument of communication (collectively referred to as the “Content”). Any new features implemented for the amelioration of the Services are also subject to this ATS. 3. GENERAL CONDITIONS. a. Access and Use of the Services: Customer(s) is/are required to register with Ecosystem.DrGPCR.com and to open an account in order to access and use certain features of the Services, which may include your own creation and posting your own page within the scope of the Services. If Customer(s) choose(s) to register for the Services, he/she/they agree(s) to provide and maintain true, accurate, current information about himself/herself/themselves. For use of data and other information please refer to our Privacy Policy. b. Membership Fees / Payment: By registering and opening an account with Ecosystem.DrGPCR.com on the Website in order to carry out the activity within the scope of the Services, the Customer(s) agree(s) to be bound by the terms of this ATS and to provide Ecosystem.DrGPCR.com with all the information necessary to process the monthly or yearly membership fee payment in order to access the Services within the Website. Service(s)’ payment for the membership fee shall be made in full, via Wix Payment. Paypal, Stripe, or Bank Transfer method of payment. The membership fee shall be on a monthly or yearly basis, with an option from the Customer for automatic renewal. 4. REFUND POLICY: Any payment made from the Customer to Ecosystem.DrGPCR.com to membership fees shall not be refunded under any circumstances. 5. ADDITIONAL TERMS: Subject to the terms and conditions of this ATS, the Customer shall access and use the Services only for lawful purposes. All rights, title, and interest in and to the Services and its components will remain with and belong exclusively to Ecosystem.DrGPCR.com. Customer shall not (a) sublicense, resell, rent, lease, transfer, assign, or otherwise dispose of, exploit or make the Services available to any third party; (b) use the Services in any unlawful manner or in any manner that interferes with or disrupts the integrity or performance of the Services or its components, or (c) modify the Services, or otherwise attempt to gain unauthorized access to the Services or its related systems or networks. Customer shall comply with any codes of conduct, policies, or other notices Ecosystem.DrGPCR.com provides to Customer or publishes in connection with the Services. Any software that may be made available by Ecosystem.DrGPCR.com in connection with the Services (“Software”) contains proprietary and confidential information that is protected by applicable intellectual property and other laws. Any rights not expressly granted herein are reserved and, except as expressly provided herein, no license or right to use any trademark of Ecosystem.DrGPCR.com is granted to you in connection with the Services. This ATS contains provisions that govern how claims between Customer and Ecosystem.DrGPCR.com are resolved. It also contains an arbitration clause, which will, with limited exception, require the Customer to submit claims it has against Ecosystem.DrGPCR.com to binding and final arbitration. 6. CUSTOMER INFORMATION: Customer is solely responsible for all data, information, and other materials that it upload, post, advertises, promotes, markets, delivers, provides, or otherwise transmits or stores, in connection with or relating to the Services (“Customer Information”). The customer is responsible to maintain the confidentiality of its login information and for all activities that occur under its login or account access information. Ecosystem.DrGPCR.com reserves the right to access the Customer’s account in order to respond to its requests for technical support. By posting Customer Information on or through the Services, Customer hereby does and shall grant Ecosystem.DrGPCR.com a worldwide, non-exclusive, perpetual, irrevocable, royalty-free, fully paid, sub-licensable, and transferable license to use, modify, reproduce, distribute, display, publish and perform Customer Information in connection with the Services. Ecosystem.DrGPCR.com has the right, but not the obligation, to monitor the Services, Content, or Customer Information. The customer further agrees that Ecosystem.DrGPCR.com may remove or disable any Content at any time for any or for no reason at all. Customer understands that the operation of the Services, including Customer Information, may involve (a) transmissions over various networks; (b) changes to conform and adapt to technical requirements of connecting networks or devices and (c) transmission to Ecosystem.DrGPCR.com third party vendors and hosting partners to provide the necessary hardware, software, networking, storage, and related technology required to operate and maintain the Services. Accordingly, the Customer acknowledges that he is solely responsible for adequate security, protection of Customer Information. Ecosystem.DrGPCR.com shall not be held liable towards the Customer for any unauthorized access or use of any of Customer Information, or any corruption, deletion, destruction, or loss of any of the Customer Information. 7. THIRD PARTIES: The Services may provide links or other access to other websites, and resources on the Internet. Ecosystem.DrGPCR.com has no control over such websites and resources, nor partner websites and resources, and Ecosystem.DrGPCR.com shall not be held responsible for and does not endorse such websites and resources. Such third parties, and not Ecosystem.DrGPCR.com, are the providers of other websites and resources and are solely responsible for providing any goods or services Customer purchases on third party or partner websites. The customer further acknowledges and agrees that Ecosystem.DrGPCR.com shall not be responsible or liable, directly or indirectly, for any damage or loss caused or alleged to be caused by or in connection with the use of such websites or resources. Any dealings Customer has with third parties found while using the Services are between the Customer and the third party, and the Customer agrees that Ecosystem.DrGPCR.com shall not be held liable for any loss or claim that Customer may have against any such third party. 8. OTHER SERVICES: The Customer may also enable various online services (application or external websites) to more effectively use Ecosystem.DrGPCR.com Services. To take advantage of these features, Ecosystem.DrGPCR.com may ask Customer to register for or log into the third-party services on the websites of their respective providers. By enabling third-party services within the Services, Customer is allowing Ecosystem.DrGPCR.com to pass Customer’s log-in information to these service providers. For more information please see our Privacy Policy. The manner in which third-party services use, store and disclose Customer Information is governed solely by the policies of such third parties, and Ecosystem.DrGPCR.com shall not be held liable or responsible for the privacy practices or other actions of any third party website. Ecosystem.DrGPCR.com shall not be responsible for the accuracy, availability, or reliability of any content made available in connection with third-party websites or services. 9. PAYMENT: As indicated in Section Three of this ATS, Customer is required to provide Ecosystem.DrGPCR.com with a valid Credit or Debit card through which membership fee payment shall be executed. Customer represents that it has full control of these Credit or Debit card and further agrees to hold Ecosystem.DrGPCR.com harmless for abuse or unauthorized use of these Credit or Debit Card by third parties 10. REPRESENTATIONS AND WARRANTIES: Customer represents and warrants to Ecosystem.DrGPCR.com that (i) Customer has full power and authority to enter into this ATS; (ii) Customer owns all Customer Information or has obtained all permissions, releases, rights or licenses required to engage in its billing, posting and other activities (and allows Ecosystem.DrGPCR.com to perform its obligations) in connection with the Services without obtaining any further releases or consents; (iii) Customer Information and other activities in connection with the Services, and Ecosystem.DrGPCR.com exercise of all rights and license granted by Customer herein, do not and will not violate, infringe, or misappropriate any third party’s copyright, trademark, right of privacy or publicity, or other personal or proprietary right, nor does Customer Information contain any matter that is defamatory, obscene, unlawful, threatening, abusive, tortious, sensitive to any particular social group or religion, offensive or harassing; and (iv) you are eighteen (18) years of age or older. 11. UNLAWFUL SERVICES: Ecosystem.DrGPCR.com shall not tolerate Customer(s), who knowingly or not, compromising the integrity of the Website by rendering Services in the Website that are false and untrue. In the event that Ecosystem.DrGPCR.com determines that any Services provided by any Customer in the Website can be found to be untrue or false, Ecosystem.DrGPCR.com reserves its sole right to terminate the membership of the Customer without further notice, and to take appropriate steps to ensure that any content of such Services is taken off the Website immediately. Ecosystem.DrGPCR.com reserves the right to contact any law enforcement authority in connection with the Services offered by a Customer considered to be unlawful. 12. TERMINATION: Customer has the right to terminate its account with the Ecosystem.DrGPCR.com at any time by sending a 30 (“Thirty”) day advance notice of termination to the company by email to Hello@DrGPCR.com. Ecosystem.DrGPCR.com reserves the right to (i) modify or discontinue, temporarily or permanently, the Services and (ii) refuse any and all current and future use of the Services, suspend or terminate Customer’s account or use of the Services and remove and discard any of Customer Information in the Services, for any reason. Ecosystem.DrGPCR.com shall not be liable to Customer or any third party for any modification, suspension or discontinuation of the Services. Ecosystem.DrGPCR.com may use good faith efforts to contact Customer to warn him prior to suspension or termination of Customer’s account by Ecosystem.DrGPCR.com. All accrued rights to membership fee payment(s) and the terms of Section 4 hereinabove shall survive termination of this ATS, and all fees paid to Ecosystem.DrGPCR.com are NON-refundable. 13. LIMITATION OF LIABILITY: In addition, to the extent permitted by applicable law, Ecosystem.DrGPCR.com (including our parent, subsidiaries, affiliates, officers, directors, agents and employees) is not liable, and Customer agrees not to hold Ecosystem.DrGPCR.com responsible, for any damages or losses (including, but not limited to, loss of money, goodwill or reputation, profits, or other intangible losses or any special, indirect, or consequential damages) resulting directly or indirectly from: Customer’s use of or his inability to use the Services; pricing or other guidance provided by Ecosystem.DrGPCR.com; delays or disruptions in the Services; viruses or other malicious software obtained by accessing, or linking to, the Services; damage to Customer’s hardware device from the use of the Services; the content, actions, or inactions of third parties, including items listed using the Services or the destruction of allegedly untrue or false information provided in the Services; a suspension or other action taken with respect to Customer’s account or breach of the ATS; the duration or manner in which the Customer’s listings appear in search results on the Website. SOME STATES DO NOT ALLOW THE EXCLUSION OF IMPLIED WARRANTIES OR LIMITATION OF LIABILITY FOR INCIDENTAL OR CONSEQUENTIAL DAMAGES, WHICH MEANS THAT SOME OF THE ABOVE LIMITATIONS MAY NOT APPLY TO CUSTOMER. IN THESE STATES, Ecosystem.DrGPCR.com LIABILITY WILL BE LIMITED TO THE GREATEST EXTENT PERMITTED BY LAW. Regardless of the previous paragraphs, in the event that Ecosystem.DrGPCR.com is found to be liable, the company’s liability to Customer or to any third party is limited to a maximum of $100 (“One Hundred Dollars”). 14. DISCLAIMER OF WARRANTIES: CUSTOMER AGREES THAT HE/SHE/IT IS MAKING USE OF THE SERVICES AT HIS/SHE/ITS OWN RISK, AND THAT THEY ARE BEING PROVIDED TO CUSTOMER ON AN “AS IS” AND “AS AVAILABLE” BASIS. ACCORDINGLY, TO THE EXTENT PERMITTED BY APPLICABLE LAW, Ecosystem.DrGPCR.com EXCLUDES ALL EXPRESS OR IMPLIED WARRANTIES, TERMS AND CONDITIONS INCLUDING, BUT NOT LIMITED TO, IMPLIED WARRANTIES OF MERCHANTABILITY, FITNESS FOR A PARTICULAR PURPOSE, AND NON-INFRINGEMENT. 15. NO WAIVER: The failure of Ecosystem.DrGPCR.com to exercise or enforce any right or provision of this ATS shall not be a waiver of that right. Customer acknowledges that this ATS is a contract between Customer and Ecosystem.DrGPCR.com, and it governs Customer’s use of the Services and takes the place of any prior agreements between Customer and Ecosystem.DrGPCR.com. 16. ASSIGNMENT: Customer may not assign this ATS without the written consent of Ecosystem.DrGPCR.com. On the other hand, Ecosystem.DrGPCR.com may assign or transfer this ATS, in whole or in part, without restriction at its sole discretion. 17. INDEMNIFICATION: Customer agrees to indemnify, defend and hold Ecosystem.DrGPCR.com and its partners, agents, officers, directors, employees, subcontractors, successors, assigns, attorneys, advertisers, product and service providers, and affiliates harmless from any liability, loss, claim and expense, including reasonable attorney’s fees, related to Customer’s violation of this ATS or use of the Website or the Services. 18. GOVERNING LAW AND JURISDICTION: This ATS shall be governed by the laws of the State of New York without regard to the principles of conflicts of law. Unless otherwise elected by Ecosystem.DrGPCR.com in a particular instance, Customer hereby expressly agrees to submit to the exclusive personal jurisdiction of the federal and state courts of New York County, New York for the purpose of resolving any dispute relating to Customer’s access to or use of the Services. Any legal controversy or legal claim arising out of or relating to this ATS and/or the Services, with the exclusion of any legal action taken by Ecosystem.DrGPCR.com to collect or recover damages for, or obtain any injunction relating to intellectual property, and the Services, shall be settled solely by binding arbitration in accordance with the commercial arbitration rules of the American Arbitration Association. Any such controversy or claim shall be arbitrated on an individual basis, and shall not be consolidated in any arbitration with any claim or controversy of any other party. The arbitration shall be conducted in New York, New York, and judgment on the arbitration award may be entered into any court having jurisdiction thereof. Either party in this agreement may seek any interim or preliminary relief from a court of competent jurisdiction in New York County, New York, necessary to protect the rights or property of Customer and Ecosystem.DrGPCR.com pending the completion of arbitration. Each party shall bear one-half of the arbitration fees and costs. 19. SEVERABILITY: If any provision of this ATS is held to be invalid, void or for any reason unenforceable, such provision shall be struck out and shall not affect the validity and enforceability of the remaining provisions of the agreement. 20. PRIVACY: Please see the company’s Privacy Policy to understand how Ecosystem.DrGPCR.com collects and uses personal information. Please read carefully our Legal Policies and Disclaimers to understand how Dr. GPCR conducts business Affiliate Policy Content and Conduct Policy Content Guidance Privacy Policy Terms and Conditions Trademark Policy

Discover Media Partner Packages with Dr. GPCR Ecosystem. Amplify your brand, reach a targeted scientific audience, and showcase your organization in the GPCR community. Elevate Your GPCR Focused Company Visibility Reach 1400+ GPCR researchers. Build Scientific Credibility and Brand Recognition in the GPCR Ecosystem Only 12 partners are accepted per year. Partner with us Today! Who Media Partnerships Are For Strategic Partnerships are ideal for GPCR-focused companies that want to: Strengthen brand credibility and recognition within the GPCR research community Be consistently visible across trusted educational and content platforms Associate their brand with high-quality science, experts, and long-term ecosystem initiatives Build awareness and trust over time — not chase immediate leads If your primary goal is to drive inbound inquiries or make your services discoverable at the point of need, the GPCR CRO Bank may be a better fit. Connect With The GPCR Community You've built incredible tools, services, or platforms for GPCR researchers. But are the right scientists discovering them? Dr. GPCR is the world's largest nonprofit community focused on GPCRs. As a media partner, you'll gain trusted access to an engaged audience of academic researchers, biotech teams, and drug discovery innovators—without having to fight for attention. We only accept 12 media partners per year. Each one receives personalized support, targeted visibility, and a seat at the table in the GPCR ecosystem. Ready to share your company with the GPCR world? With only 12 media partner seats available each year, every partner gets intentional placement, dedicated support, and real visibility. No noise. No clutter. Only connections. Why Partner with Dr. GPCR? As a media partner, you'll be featured across our nonprofit platform, trusted by thousands of GPCR scientists and biotech professionals. 🎯 Reach Qualified Researchers Connect with scientists who are actively looking for tools like yours, without the noise of general platforms. 🤝 Build Trust Develop content that speaks their language and establishes your credibility in the GPCR research community. 🌐 Join a Curated Ecosystem Become part of a collaborative, curated ecosystem—not just another name on a crowded vendor list. With only 10 seats remaining in 2026, we're focused on quality over quantity - and on partnerships that deliver long-term value to the field. 12 Partners Accepted Per Year 1400+ GPCR Scientists Reached What You Get as Media Partner Becoming a Dr. GPCR media partner means more than visibility. It means integration into a trusted scientific ecosystem that's built to elevate your story. These touch points are designed to reinforce brand presence and credibility through repeated, trusted exposure — not direct lead generation. 🎙️ Featured Podcast Episode ✓ Be the guest on a dedicated episode of the Dr. GPCR Podcast ✓ Feature up to 3 team members to share your story ✓ Distributed across podcast platforms and social media 📄 Custom Company Page ✓ Permanent company profile on the Dr. GPCR Ecosystem ✓ Logo, branding, and description of your mission ✓ Contact links and key highlights ✨ Logo positioning ✓ Strategic Partner logos are featured across multiple high-traffic ecosystem pages, creating repeated visual association with trusted GPCR content and resources. 📬 Newsletter Visibility ✓ Featured in our highly read weekly newsletter ✓ Tell your story with context, clarity, and purpose ✓ Bonus: Mentioned in podcast intros/outros 📣 Social Media Promotion ✓ Engaging posts about your organization ✓ Targeted to GPCR researchers and biotech professionals ✓ Shared on LinkedIn and X (Twitter) 👩🔬 Premium Licenses ✓ 10 Scientists Premium Accounts ✓ 3 Non-Scientists Premium Accounts 📝 Blog Contributions ✓ Contribute to blog posts on the Dr. GPCR platform as a valued partner ✓ Share insights on product launches, scientific discoveries, or customer stories ✓ Reach a targeted scientific audience with your contributions. 🎤 Co-Branded Events & Training ✓ Collaborate on webinars and virtual training sessions to showcase your expertise ✓ Host educational events that focus on GPCR research ✓ Engage directly with the GPCR research community through these initiatives Present & Previous Partners Join these leading organizations in the GPCR research ecosystem Book Book a 30-minute Strategy Call with Yamina Ready to Connect with the GPCR Community? With only 10 spots remaining for 2026... Secure your place in our exclusive media partner program today.

Retreat 2023 About Program Registration Logo Contest Committee Sponsors GPCR Retreat Program < Back to schedule G Proteins and GPCRs in Cancer: Novel Precision Targeted and Immunotherapies Date & Time Friday, November 3rd / 3:30 PM Abstract Coming Soon About J. Silvio Gutkind "Dr. Gutkind is a Distinguished Professor and Chair of the Department of Pharmacology, School of Medicine, and Associate Director for Basic Science at the Moores Cancer Center, University of California San Diego (UCSD). He served as Branch Chief at NIDCR, NIH, since 1998 until his recruitment to UCSD in 2015. His research team has pioneered the study of G proteins and G protein coupled receptors (GPCRs) in human malignancies. He is exploiting the emerging information on dysregulated signaling circuitries and individual genomic and molecular alterations to develop new precision cancer treatments, and to identify novel multimodal strategies to enhance the response to cancer immunotherapies." J. Silvio Gutkind on the web Gutkind Lab – UC San Diego Moores Cancer Center Gutkind Lab publications Pubmed LinkedIn Twitter UCSD Moores Cancer Center Dr. GPCR Previous Event Next Event Great Lakes GPCR Retreat and Club des Récepteurs à Sept Domaines Transmembranaires du Québec Great Lakes GPCR Retreat and Club des Récepteurs à Sept Domaines Transmembranaires du Québec 22nd GPCR Retreat Sponsored by

Explore sponsorship opportunities for the Adhesion GPCR Workshop 2024. Connect your organization with leading GPCR researchers and showcase your brand to the scientific community. SPONSORSHIP PROSPECTUS Adhesion GPCR workshop 2024 CINVESTAV, Mexico City, Mexico October 23-25 Sponsor We are delighted to present the sponsorship opportunities available for Adhesion GPCR Workshop 2024, a premier scientific meeting bringing together leaders and innovators in G Protein-Coupled Receptor (GPCR) biology. Adhesion GPCR Workshop 2024 will take place on October 23-25, 2024 at Centro de Investigación y de Estudios Avanzados del Instituto Politécnico Nacional (known as Cinvestav) in Mexico City, offering a dynamic platform for knowledge exchange, collaboration, and networking. About the Adhesion GPCR Workshop 2024: Adhesion GPCR Workshop 2024 is a high-profile expert conference, attracting attendees from across the globe. Our agenda includes keynote presentations, panel discussions, workshops, and networking sessions covering the latest advancements and challenges in Membrane Receptor biology. This event provides an unparalleled opportunity for sponsors to showcase their commitment to scientific excellence and innovation. Audience Profile: Basic Scientists Academics Clinical Scientists Industry Professionals Health Professionals Policy Makers Students Why Sponsor Adhesion GPCR Workshop 2024? Align your brand with scientific excellence and innovation. Showcase your products, services, and research initiatives to a targeted audience. Enhance brand visibility and recognition among key stakeholders in the field. Network with leading professionals and decision-makers in the industry. Support the advancement of knowledge and collaboration within the scientific community. Sponsorship Opportunities Platinum Sponsor Exclusive recognition as the Platinum sponsor in all promotional materials. Prime placement of company logo on event website, signage, and marketing collateral. Opportunity to deliver opening remarks or introduce keynote speakers. Complimentary exhibition booth in a prominent location at the event venue. Recognition in press releases and media coverage. Complimentary registration for 3 representatives. Opportunity to be designated in print on the 1 st ever “aGPCR Excellence and Mentoring Award” Customized sponsorship package available upon request. Gold Sponsor Prominent recognition as a Gold sponsor in all promotional materials. Company logo displayed on event website, signage, and marketing collateral. Opportunity to sponsor a keynote session or panel discussion. Recognition during opening and closing remarks. Complimentary exhibition booth at the event. Complimentary registration for 2 representatives. Customized sponsorship package available upon request. Silver Sponsor Recognition as a Silver sponsor in all promotional materials. Company logo displayed on event website and signage. Opportunity to sponsor a workshop or networking session. Recognition during opening and closing remarks. Complimentary registration for 1 representative. Customized sponsorship package available upon request. Bronze Sponsor Recognition as a Bronze sponsor in all promotional materials. Company logo displayed on event website.Recognition during opening and closing remarks. Additional Sponsorship Opportunities: Networking Reception Sponsorship Conference Cup and T-Shirt Sponsorship Conference Bag Sponsorship Lanyard Sponsorship Coffee Break Sponsorship Customized Opportunities Available Contact us for sponsorship Register for the Adhesion GPCR 2024 Learn more about the Adhesion GPCR workshop 2024 Up About the event Learn more about the Adhesion GPCR workshop 2024 and its preliminary program. Up About the venue Discover Cinvestav, the host venue for the upcoming workshop. Up Abstract Submission Submit your research abstracts following our guidelines to present at the conference. Up Traveling Tips Find essential tips about Mexico City, including transportation options and local insights.

Join GPCR Happy Hour to connect with scientists across academia, biotech, and pharma - a free networking event. Sign up and join us! GPCR Happy Hour – Connect, Collaborate, Discover A global networking event where GPCR scientists break silos and build lasting connections. Sign Up to Get Event Updates Happy Hours Partners Why Join GPCR Happy Hour? Scientist-led : Built by GPCR researchers, for GPCR researchers. Cross-sector : Academia, biotech, pharma, CROs all in one room. Consistent : Monthly cadence ensures ongoing connections. Accessible : Online & free to join – no travel barriers. Action-oriented : Conversations designed to spark collaborations, not just chatter. How It Works? Step 1 Register Sign up once to access all upcoming GPCR Happy Hour events. Step 2 Get the Link Receive a secure calendar invite with Zoom/virtual event details. Step 3 Join the Conversation Show up to live sessions and meet GPCR scientists across disciplines. Step 4 Engage & Connect Breakout rooms + structured prompts maximize meaningful networking. Step 5 Follow Up Access shared contact lists and resources to keep collaborations alive. Pricing: Free (sponsored by Dr. GPCR & Partners) Upcoming and Past Happy Hours GPCR Happy Hour – Boston, Sept 2025 Every September, Boston welcomes the global biotech and drug discovery community. Scientists, investors, and CRO professionals fly in from around the world, while Boston’s own vibrant life sciences hub shows up in full force. GPCR Happy Hour is where these two worlds meet. It’s not just networking. It’s where partnerships spark, ideas collide, and the GPCR community grows stronger — together. GPCR Happy Hour Dr. GPCR News Aug 20, 2025 3 min read

Alessandro Nicoli shares how he models olfactory GPCRs with AlphaFold, mentors students, and builds science from scratch in a new lab. A fresh look at computational GPCR research. << Back to podcast list Strategic Partner(s) Smells Like GPCR Spirit: Cracking Olfactory Codes with Alessandro Nicoli 1. The Accidental Path to Science Alessandro Nicoli didn’t grow up knowing he’d be a scientist. Like many, his path to GPCR research wasn’t linear—it evolved through academic exploration and mentorship. “I think I don’t have a linear trajectory… the beauty of seeing molecule design and reactions—thinking you can create molecules—was really exciting.” – Alessandro Nicoli He studied pharmaceutical chemistry in Padua, where his fascination with molecular design first took shape. But it wasn’t until meeting an inspiring professor, Prof. Moro, that he truly saw how molecules could go beyond the bench and interact with biology in powerful ways. 2. The Moment Chemistry Met Biology Nicoli’s turning point came when he realized that molecules weren’t static—they could act , bind , and modulate biological targets. “It was not just a molecule—it was a partner that goes to interact with something else… a protein, DNA, RNA. That opened up a new world.” – Alessandro Nicoli That early spark led him to discover the role of medicinal chemistry and, eventually, molecular modeling. For Nicoli, chemistry became more than reactions—it became a bridge to biological insight. 3. Falling for Computational Chemistry The "second academic love" arrived during his master’s thesis, where Nicoli dove into computational chemistry. “I got to know computational chemistry through a project on BCL2 proteins and drug discovery… I was in love with the topic.” – Alessandro Nicoli Working on docking and NMR studies for cancer-related proteins, he discovered the power of simulation in revealing molecular interactions. That experience convinced him to pursue a PhD and deepen his computational skills—eventually leading him to GPCRs. 4. Finding the Right Mentor and Lab A birthday email changed everything. Professor Moro forwarded a PhD opening from Prof. Antonella Di Pizio’s lab in Munich. It felt serendipitous—and it was. “We had a super match… and after a month, I was already in Germany. I was her first PhD student.” – Alessandro Nicoli Starting from scratch in a young lab wasn’t easy, but it created a unique bond between PI and student. Nicoli thrived in this setting—helping shape the lab and its direction, particularly in computational studies of olfactory GPCRs . 5. GPCRs, Receptors of Infinite Variety When asked about his favorite GPCR, Nicoli refused to pick. “Let’s embrace the challenge to study all of them… they’re unique in how they bind ligands, how selective they are.” – Alessandro Nicoli He emphasized that olfactory receptors , while underexplored, present an incredible challenge. With hundreds of subtypes and very few known ligands, the structure–function relationships remain largely mysterious—and incredibly exciting for a computational chemist. 6. AlphaFold: A Turning Point in GPCR Research When Nicoli began his PhD, AlphaFold hadn’t yet revolutionized the field. But once released, it changed everything. “AlphaFold gave us a face to those proteins… now we have 400 models to start with.” – Alessandro Nicoli He explained how AlphaFold’s predictions, surprisingly close to experimental structures, provided a powerful starting point for docking, dynamics, and ligand design—especially for receptors previously “invisible” to structural biology. 7. Modeling the Invisible: Olfactory Receptors Nicoli’s work centers on predicting ligand binding and receptor behavior for olfactory GPCRs. “The main challenge was: how do we get a face for these proteins when we don’t have ligands?” – Alessandro Nicoli He shared a detailed case study of working on a specific odorant receptor (R5VK1), where they leveraged known active/inactive ligands to validate models through iterative refinement , molecular docking , and mutagenesis-guided optimization . The goal? Build predictive models to discover new ligands . 8. Why Molecular Dynamics Matters For Nicoli, molecular dynamics is more than simulation—it’s how we watch biology move . “You simulate over time… see how receptors move in physiological conditions, with water, membranes, ligands.” – Alessandro Nicoli He emphasized that MD allows researchers to observe allosteric changes , mutation effects , and even ligand entry/exit paths , offering dynamic insights that static structures cannot. It’s a critical complement to experimental work. 9. From Researcher to Mentor: Growing Together Outside his research, Nicoli mentors students, manages interns, and even lectures. Balancing this with a PhD isn't easy, but it’s deeply rewarding. “You have people that rely on you… but you grow together, and that’s the most powerful thing.” – Alessandro Nicoli He reflected on learning to delegate—how hard it was initially to hand over tasks—but how vital it is for team science. He now sees mentoring as a way to shape the next generation while evolving himself as a scientist. 10. Advice, Tools, and the Future of GPCR Research Nicoli offered advice to wet-lab scientists curious about computational work: Start with passion. Learn Python. Explore online resources like “Talktorials.” “We’re living in a golden era for computational chemistry… the tools are out there. You just need the motivation to explore.” – Alessandro Nicoli As for what’s next? More structures, better tools, and deeper insights into the elegant, complex world of GPCRs. He sees a future where wet and dry labs converge , and where computational methods are fully integrated into GPCR drug discovery pipelines. Summary made with AI __________ Key Takeaway Alessandro Nicoli’s journey is a compelling example of how computational chemistry can unlock new frontiers in GPCR research , especially in complex areas like olfactory receptors. By bridging structural prediction, molecular dynamics, and ligand discovery, his work not only deciphers biological mysteries but also inspires a new generation of scientists to think computationally. Keyword Cloud GPCR research community , Dr. GPCR ecosystem , GPCR online course , GPCR scientist network , GPCR drug discovery , GPCR training program , G protein-coupled receptors , GPCR podcast , GPCR webinar series , GPCR data platform Summary created by AI ________ About Alessandro Nicoli Alessandro Nicoli is currently a PhD student in the Molecular Modeling group led by Prof. Dr. Antonella Di Pizio at the Leibniz Institute for Food Systems Biology at the Technical University of Munich (Germany). He obtained an MSc degree in Chemistry and Pharmaceutical Technology from the University of Padua (Italy). His training and passion for computational chemistry started in 2019 during his time at the Molecular Modeling Section (MMS) under the supervision of Prof. Stefano Moro, where he worked on integrated Nuclear magnetic resonance (NMR) and computational modeling strategies to target the antiapoptotic BCL-2 protein family, key regulators of cell survival, using small molecules. He then moved to Germany in 2019 to pursue his PhD. His research focuses on a group of 400 transmembrane proteins known as olfactory receptors, which mediate the sense of smell. Beyond the olfactory epithelium, these receptors are expressed in various tissues, where they play important but not yet fully understood roles in various physiological and pathological processes. Despite their relevance, they remain understudied due to the limited knowledge of their ligands and the lack of experimental structures. Alessandro PhD work aims to fill these gaps by leveraging computational structure-based tools and develop specific protocols to accelerate OR ligand discovery and improve our understanding of olfactory function at the molecular level. Alessandro Nicoli on the web Leibniz Institute for Food Systems Biology at the Technical University of Munich Technical University of Munich Google Scholar Pubmed ORCID ResearchGate X Bluesky Github Enjoying the Dr. GPCR Podcast? Leave a Review. Leave a quick review to help more scientists find the show—and help us keep improving every episode. It takes <60 seconds and makes a big difference. ★ Review on Apple Podcasts ★ Rate on Spotify ✉️ Send feedback to the team Recent Podcast Articles Asking Better Questions in Science: A Practical Guide for Emerging Researchers When the Islet Lit Up: Advancing GPCR Imaging in Native Tissue How Collaboration Sparked a GPCR Imaging Breakthrough in Chemical Biology Thanks for listening to this podcast episode Follow us on your favorite Podcast Player << Previous Podcast Episode Next Podcast Episode >>

Home → Flash News → Did you know? 🌟 Researchers have developed reversibly photoswitchable allosteric modulators for Class A GPCRs! 🧬💡 These innovative compounds, “Photo-BQCisA” and “Photo-BQCtrAns,” offer subtype-selective precision by combining allosteric modulation with light control, paving the way for new therapeutic strategies targeting muscarinic receptors (M1-M5). 🔬✨ Learn more about this breakthrough in the Ecosystem! Published on December 3, 2024 Category GPCR Weekly News Did you know? 🌟 Researchers have developed reversibly photoswitchable allosteric modulators for Class A GPCRs! 🧬💡 These innovative compounds, “Photo-BQCisA” and “Photo-BQCtrAns,” offer subtype-selective precision by combining allosteric modulation with light control, paving the way for new therapeutic strategies targeting muscarinic receptors (M1-M5). 🔬✨ Learn more about this breakthrough in the Ecosystem! ➡️ buff.ly/4fgX4ZH #gpcr #drgpcr Previous Next Recent Articles

Join the Dr. GPCR Podcast community and shape our next season! Take our quick 5-minute audience survey to help us tailor our content to your needs. Your input matters in delivering exciting and informative episodes. Thank you for being part of our journey and for tuning in! Dr. GPCR Podcast Audience Survey Thanks for listening to this podcast episode Follow us on your favorite Podcast Player Be our Guest Listen and subscribe where you get your podcasts

<< Back to podcast list Strategic Partner(s) Dr. Daniel Wacker About Dr. Daniel Wacker I obtained my B.Sc. degree from the University of Munich performing work in the lab of Dr. Roland Beckmann with a brief stay at Cambridge University, UK, working in the lab of the late Dr. Kiyoshi Nagai . I then obtained an M.Sc. at the University in Munich working e.g. in the lab of Patrick Cramer . I next moved to Rockefeller University in NYC to work in the lab of the late Dr. Guenter Blobel , before starting my Ph.D. in 2009 at The Scripps Research Institute in La Jolla. There I obtained my Ph.D. in the lab of Dr. Ray Stevens in 2013 solving several GPCR crystal structures, including that of the first serotonin receptor. I then moved to UNC at Chapel Hill to do postdoctoral work in the lab of Dr. Bryan Roth where I established GPCR structural biology and learned the ins and outs of molecular pharmacology and in vitro drug discovery. In 2018 I started my own lab at the Icahn School of Medicine at Mount Sinai in NYC, where I have been working on structure-function and drug discovery of GPCRs and transporters. Dr. Daniel Wacker on the web Website LinkedIn Twitter PubMed Dr. GPCR Ecosystem Enjoying the Dr. GPCR Podcast? Leave a Review. Leave a quick review to help more scientists find the show—and help us keep improving every episode. It takes <60 seconds and makes a big difference. ★ Review on Apple Podcasts ★ Rate on Spotify ✉️ Send feedback to the team Recent Podcast Articles Asking Better Questions in Science: A Practical Guide for Emerging Researchers When the Islet Lit Up: Advancing GPCR Imaging in Native Tissue How Collaboration Sparked a GPCR Imaging Breakthrough in Chemical Biology Thanks for listening to this podcast episode Follow us on your favorite Podcast Player << Previous Podcast Episode Next Podcast Episode >>

Watch expert talks, interviews, and insights on Dr. Channel — your video hub for GPCR science, innovation, and community stories. Dr. Channel -Under Construction-

Explore the milestones of Dr. GPCR, from its founding to today’s global community, and discover the journey that’s shaping the future of GPCR science. From Vision to Global Impact What began as a simple idea — to connect GPCR scientists and share knowledge freely — has grown into a global ecosystem driving collaboration, innovation, and discovery. Since 2020, Dr. GPCR has united researchers across disciplines and continents through conversations, summits, and shared milestones. 2020 🌱 The Beginning of a Community Vision & Launch Driven by a simple but powerful idea — to bring GPCR scientists together — Dr. Yamina Berchiche launched the Dr. GPCR Ecosystem , a space designed to break silos, spark collaboration, and open real dialogue across disciplines. Early Initiatives Feb 18, 2020 — The very first podcast episode was recorded. Jun 2020 — The first newsletter went out — to just three people . A small start, but the spark had been lit. Podcast Debut Jul 7, 2020 — The first Dr. GPCR Podcast episode premiered, featuring Dr. Paul Insel from UC San Diego — marking the beginning of hundreds of scientist-to-scientist conversations that would follow. First Summit Sep 14–18, 2020 — The inaugural Dr. GPCR Summit brought together researchers from five continents , with 5 live sessions , 26 pre-recorded talks , and five industry sponsors . A milestone moment that proved the power of community — even in a virtual world. Featured Appearances Aug 2020 — Featured on 17 Minutes of Science with Advancing GPCR Drug Discovery Through Collaboration . Oct 2020 — Presented at ERNEST with Beyond the Lab . Nov 2020 — Invited to the 9th GDR Meeting with Beyond the Lab . 2021 Expanding the Conversation Podcast Milestones Jan 2021 — Episode #26 released featuring Dr. Debbie Hay , University of Otago. Feb 2021 — Episode #27 released featuring Dr. Robert J. Lefkowitz , 2012 Nobel Laureate in Chemistry. 2nd Annual Summit Sep 13–19, 2021 — The 2nd Dr. GPCR Summit expanded the community’s reach and impact, featuring 27 live talks , 10 pre-recorded sessions , and five sponsors . Featured Appearances Jul 2021 — Featured at ECR Transatlantic with From Idea to Ecosystem . Oct 2021 — Featured at ERNEST with Where All GPCRs Are Created Equal . 2022 Building Momentum Podcast Growth May 2022 — Episode #37 released featuring Dr. Sam Hoare , Pharmechanics. May 2022 — Episode #42 released featuring Dr. Randy Hall , Emory University. New Programs Aug 11, 2022 — Virtual Café Series launched, featuring 16 episodes . Sep 20, 2022 — First contributor article published: Therapeutic validation of an orphan G protein‐coupled receptor by Inês Pinheiro . Oct 10–16, 2022 — Hosted the 3rd Annual Dr. GPCR Summit , featuring 34 live talks , 12 poster presentations , one pre-recorded session , and four partners . Dec 9, 2022 — GPCR Weekly News launched — now over 120 editions published . Community Engagement Mar 2022 — Featured at ERNEST with Dr. GPCR Ecosystem 2.0: Collaborating Better . Mar 2022 — Featured at ERNEST with Beyond the Lab . Mar 2022 — Media Partner at GPCR Targeted Drug Discovery Summit . May 2022 — Media Partner at GPCR Retreat . Jul 2022 — Media Partner at GPCR ECI Transatlantic . Nov 2022 — Featured at PhageMed Unige with Leadership Is a Learned Skill . 2023 A Year of Reflection and Growth Podcast Milestones Jan 2023 — Released the Dr. Marc Caron Tribute Episodes ( #100 , #101 & #102 ), featuring over 30 expert guests , including Dr. Kathleen Caron and Dr. Brian Kobilka , 2012 Nobel Laureate in Chemistry. First Symposium May 19, 2023 — Hosted the inaugural Dr. GPCR Symposium , bringing together over 100 attendees and featuring 11 live talks Community Engagement Feb 2023 — Media Partner at GPCR Targeted Drug Discovery Summit . Jun 2023 — Featured Talk Molecular Pharmacology GRC and GRS in Switzerland. Jun 2023 — Hosted Meet the Inoviem Team session. Nov 2023 — Co-organized the 22nd Great Lakes GPCR Retreat 2024 Strengthening Foundations and Expanding Horizons Educational Initiatives Feb 8, 2024 — Launched Dr. GPCR University with the first GPCR Course led by Dr. Terry Kenakin , enrolling 30+ students . Podcast Milestones May 9, 2024 — Episode #150 introduced the Dr. GPCR Team . May 16, 2024 — Episode #151 featured the Dr. GPCR Board . Community Engagement Mar 2024 — Media Partner at 3rd GPCR Targeted Drug Discovery Summit . Apr 2024 — Media Partner at Endocrine and Metabolic GPCRs meeting. Oct 2024 — Co-organized the Adhesion GPCR Workshop in Mexico City, with by 65+ participants . Oct 2024 — Media Partner at Discovery on Target . Non Profit Status Apr 2024 — Officially obtained non-profit organization status . Jul 12, 2024 — Hosted the first Board Meeting . Community Impact & Reach Podcast 180+ episodes 200+ guests 4,500+ hours of interviews 49,000+ plays Community 1,300+ ecosystem members 4 team members 6+ symposiums 15+ virtual café episodes Content 4,500+ GPCR papers categorized 200+ weekly news editions 100+ contributor articles 6 university courses Reach 3,800+ Twitter followers 3,000+ LinkedIn followers 100,000+ site sessions 400+ job listings shared

No plans available Once there are plans available for purchase, you’ll see them here.

<< Back to podcast list Strategic Partner(s) Yao Lu (Jackie) About Yao Lu (Jackie) "Jackie is a Ph.D. student, at Monash University, Australia, investigating the role of functional selectivity in a novel class of potential antipsychotics for the treatment of schizophrenia. Her work involves the pharmacological and structural characterisation of novel putative antipsychotic small molecules. Her research aims to provide a molecular explanation of small molecules for their pre-clinical efficacy and to support the design of novel therapeutics. " Yao Lu (Jackie) on the web Monash University Georgina Sweet Fellowship Authorea Dr. GPCR Enjoying the Dr. GPCR Podcast? Leave a Review. Leave a quick review to help more scientists find the show—and help us keep improving every episode. It takes <60 seconds and makes a big difference. ★ Review on Apple Podcasts ★ Rate on Spotify ✉️ Send feedback to the team Recent Podcast Articles Asking Better Questions in Science: A Practical Guide for Emerging Researchers When the Islet Lit Up: Advancing GPCR Imaging in Native Tissue How Collaboration Sparked a GPCR Imaging Breakthrough in Chemical Biology Thanks for listening to this podcast episode Follow us on your favorite Podcast Player << Previous Podcast Episode Next Podcast Episode >>

Unleash your creativity with this logo contest for the GPCR Retreat 23. Design our brand's identity today! Retreat 2023 About Program Registration Logo Contest Committee Sponsors Logo Contest Introducing the GPCR Retreat Logo Contest In anticipation of the next GPCR Retreat, we are delighted to announce the GPCR Retreat Logo Contest. This competition invites creative minds to make a captivating logo representing the essence of GPCR research, collaboration, and scientific excellence. This contest is a unique opportunity to visually encapsulate the importance and impact of GPCRs in a single iconic symbol. GPCRs play critical roles in many physiological processes, making them a focal point of scientific research with implications for human health and disease. The logo should embody the multifaceted nature of GPCRs, showcasing their complexity, versatility, and potential for therapeutic interventions. Entrants are encouraged to incorporate material that reflects the diverse fields of study encompassing GPCR research, such as biochemistry, pharmacology, structural biology, and translational medicine. The organizers, including the GPCR retreat founders Dr. Stephen Ferguson and Dr. Richard Leduc, will carefully evaluate each submission based on originality, visual appeal, conceptual clarity, and ability to evoke a sense of scientific curiosity and importance. All attendees will then vote on the top-ranked logos at the meeting. The winning logo designer will receive well-deserved recognition and a cash prize of $250. Their artwork will become the official logo of the GPCR Retreat, featuring prominently on conference materials, websites, and promotional items. Submit your logo and become an integral part of the GPCR Retreat, leaving an indelible mark on our scientific community. ---> Submit your logo HERE <--- Great Lakes GPCR Retreat and Club des Récepteurs à Sept Domaines Transmembranaires du Québec 22nd GPCR Retreat Sponsored by

Learn all about the content guidelines for Dr. GPCR Ecosystem website. Get the information you need to create engaging and impactful content. Content and Conduct Policy Dr. GPCR, Corp, LLC (“Dr. GPCR”) provides its Service to you through our websites referred to as Dr. GPCR, Ecosystem.DrGPCR.com, DrGPCR.com. We rely heavily on users to report content that may violate our policies. After we are notified of a potential policy violation, we may review the content and take action, including restricting access to the content, removing the content, and limiting or terminating a user’s access to Ecosystem.DrGPCR.com products. Note that we may make exceptions to these policies based on artistic, educational, or documentary considerations or when there are other substantial benefits to the public from not taking action. We respect the freedom of speech. Please note that Ecosystem.DrGPCR.com is specializes in GPCR and related subjects. We occasionally modify these policies, so please check back here for updates. Beyond the guidelines listed below, please note that several products and features may have additional policies and terms; check the provided links for those specific requirements. Responsibility for Your Content You are solely responsible for Your Content, and once published, it may not always be withdrawn. You assume all risks associated with Your Content, including anyone's reliance on its quality, accuracy, or reliability, or any disclosure by you of information in Your Content that makes you personally identifiable. You represent that you own or have the necessary permissions to use and authorize your Content as described herein. You may not imply that Your Content is in any way sponsored or endorsed by Ecosystem.DrGPCR.com. You may expose yourself to liability if, for example, Your Content contains material that is false, intentionally misleading, or defamatory; violates any third-party right, including any copyright, trademark, patent, trade secret, moral right, privacy right, right of publicity, or any other intellectual property or proprietary right; contains unlawful material, including illegal hate speech or pornography; exploits or otherwise harms minors, or violates or advocates the violation of any law or regulation. Our Right to Use Your Content You also give Ecosystem.DrGPCR.com (Website) a perpetual, irrevocable, worldwide, royalty-free, and non-exclusive license to reproduce, adapt, modify, translate, publish, publicly perform, publicly display, distribute, store and create derivative works of the basic listing information about your entity that you provide to your Ecosystem.DrGPCR.com Account (such as the entity name, location, phone number, list of interest, business category, hours, services, product descriptions, text, videos, contents, and website) We may use Your Content in several different ways, including publicly displaying it, reformatting it, incorporating it into advertisements and other works, creating derivative works from it, promoting it, distributing it, and allowing others to do the same in connection with their websites and media platforms ("Other Media"). As such, you at this moment irrevocably grant us worldwide, perpetual, non-exclusive, royalty-free, assignable, sub-licensable, transferable rights to use Your Content for any purpose. Please note that you irrevocably grant the users of the Site and any Other Media the right to access Your Content in connection with their use of the Site and any Other Media. Finally, you irrevocably waive and cause to be waived against Ecosystem.DrGPCR.com and its users any claims and assertions of moral rights or attribution with respect to Your Content. By "use" we mean use, copy, publicly perform and display, reproduce, distribute, modify, translate, remove, analyze, commercialize, and prepare derivative works of Your Content. Ownership Between you and Ecosystem.DrGPCR.com, you own Your Content. We own the Ecosystem.DrGPCR.com Content, including but not limited to visual interfaces, interactive features, graphics, design, compilation, including, but not limited to, our compilation of User Content and other Site Content, computer code, products, software, aggregate user review ratings, and all other elements and components of the Site excluding Your Content, User Content and Third Party Content. We also own the copyrights, trademarks, service marks, trade names, and other intellectual and proprietary rights throughout the world ("IP Rights") associated with the Ecosystem.DrGPCR.com Content and the Site, which are protected by copyright, trade dress, patent, trademark laws and all other applicable intellectual and proprietary rights and laws. As such, you may not modify, reproduce, distribute, create derivative works or adaptations of, publicly display or in any way exploit any of the Ecosystem.DrGPCR.com Content in whole or in part except as expressly authorized by us. Except as expressly and unambiguously provided herein, we do not grant you any express or implied rights, and we retain all rights in and to the Site and the Ecosystem.DrGPCR.com Content. Advertising Ecosystem.DrGPCR.com and its licensees may publicly display advertisements and other information adjacent to or included with Your Content. You are not entitled to any compensation for such advertisements. The manner, mode, and extent of such advertising are subject to change without specific notice to you. Content We make some of the Ecosystem.DrGPCR.com Site Content available to third parties. You may access and use these content in order to display on your personal computer, website, or blog ("Your Site"), provided that (i) your use of the Feeds is for personal, non-commercial purposes only, (ii) your display of the Feed Content links back to the relevant pages on Ecosystem.DrGPCR.com Website's websites, and attributes Ecosystem.DrGPCR.com as the source of the Content, (iii) your use or display of the Content does not suggest that Ecosystem.DrGPCR.com promotes or endorses any third party causes, ideas, websites, products or services, including Your Site, (iv) you do not redistribute the Content, and (v) your use of the Content does not overburden Ecosystem.DrGPCR.com Website’s systems. Ecosystem.DrGPCR.com reserves all rights in the Content and may terminate the Content at any time. Other User Content (including any that may have been created by users employed or contracted by the Ecosystem.DrGPCR.com Website) does not necessarily reflect the opinion of Ecosystem.DrGPCR.com. We reserve the right to remove, screen, edit, or reinstate User Content at our sole discretion, for any reason or no reason, and without notice to you, from time to time. For example, we may remove a review if we believe it violates our Content Guidelines. We have no obligation to retain or provide you with copies of Your Content, nor do we guarantee any confidentiality with respect to Your Content. Illegal Activities Do not use our Services to engage in illegal activities or promote dangerous and illegal acts. Malicious and Deceptive Practices Do not transmit viruses, malware, or any other malicious or destructive code. Do not distribute content that harms or interferes with the operation of the networks, servers, or other infrastructure of Ecosystem.DrGPCR.com or others. Do not use our Services for phishing scams. Hate Speech Our products are platforms for free expression. But we don't support content that promotes or condones violence against individuals or groups based on race or ethnic origin, religion, disability, gender, age, nationality, veteran status, or sexual orientation/gender identity, or whose primary purpose is inciting hatred on the basis of these core characteristics. This can be a delicate balancing act, but if the primary purpose is to attack a protected group, the content crosses the line. Personal and Confidential Information Do not distribute other people’s personal and confidential information, such as credit card numbers, confidential national ID numbers, or account passwords, without their permission. Do not post or distribute images or videos of minors without the necessary consent from their legal representatives. Account Hijacking Do not access another user’s account without their permission. Child Exploitation Do not upload or share content that exploits or abuses children. This includes all child sexual abuse imagery (even cartoon images or videos) and all content that presents children in a sexual manner. We will remove such content and take appropriate action, which may include disabling accounts and reporting to the National Center for Missing & Exploited Children (NCMEC) and law enforcement. Note that this policy may additionally apply to any content uploaded or transmitted through Photos or Videos. If you find any content that you think exploits children in this manner, do not share or comment on such content, even if your intent is to bring it to Ecosystem.DrGPCR.com's attention. Instead, flag the content. If you find content elsewhere on the internet, please contact NCMEC directly. Spam Do not spam, including by sending unwanted promotional or commercial content, or mass solicitations. Do not aggressively follow people or aggressively message people that you do not know. Ranking Manipulation Do not manipulate rankings or relevancy using techniques such as repetitive or misleading keywords or metadata. Sexually Explicit Material Do not distribute sexually explicit or pornographic material. Do not drive traffic to commercial pornography sites. Note that your profile photo cannot include mature or offensive content. For example, do not use a photo that is a close-up of a person’s buttocks or cleavage. Harassment, Bullying, and Threats Do not engage in harassing, bullying, or threatening behavior, and do not incite others to engage in these activities. Anyone using our Services to single someone out for malicious abuse, to threaten someone with serious harm, to sexualize a person in an unwanted way, or to harass in other ways may have the offending content removed or be permanently banned from using the Services. In emergency situations, we may escalate imminent threats of serious harm to law enforcement. Keep in mind that online harassment is also illegal in many places and can have serious offline consequences for both the harasser and the victim. Violence Do not distribute depictions of graphic or gratuitous violence. Impersonation Do not use our Services to mislead or confuse users by pretending to be someone else or pretending to represent an organization you do not represent. Regulated Goods and Services Your content cannot promote regulated goods and services, including but not limited to alcohol, gambling, unapproved supplements, tobacco, fireworks, or weapons. If we receive a complaint that such content violates applicable laws and regulations, we will remove and delete the offending content or account. Contests and Promotions Ecosystem.DrGPCR.com allows contests, sweepstakes, and other promotions ("Promotions") to the extent permitted by law, subject to the following policy requirements and legal terms outlined below. 1. Generating spam or encouraging individuals to engage in spam or abuse is strictly prohibited. Please note that the definition of spam on Ecosystem.DrGPCR.com may develop and change over time, and that Ecosystem.DrGPCR.com reserves the right to determine what qualifies as spam. In order to play a part in helping us fight spam and abuse, we have the following specific requirements for Promotions: 1a. The official rules for your Promotion must include a clear statement that anyone found to have created multiple accounts in order to increase their chances of winning, or anyone who posts entries in excess of an entry limit you have set, will be disqualified from the Promotion. You must set an entry limit for your promotion below a level that is likely to encourage spam. 1b. If you ask participants to use tags and/or hashtags in their Promotion entries, they must be relevant to the kind of content users are posting. For example, do not ask for photos of sunsets with #spaghetti. 2. Promotions should not be used to try to circumvent any applicable terms or policies. 3. Do not run Promotions that offer potential rewards in exchange for sharing content, following a user, mentioning a user (other than the contest creator, sponsor, or an affiliate of the contest creator or sponsor), having other users enter the promotion, or voting in polls. Also, avoid running promotions that encourage users to post unoriginal or repetitive content. 4. Please note that doing a public search (via hashtag or otherwise) may not show every entry or every participant in your Promotion. Accordingly, you should not rely solely on the search feature to view or find all entries or participants in your Promotion. 5. Please note that some Promotion entries may be filtered, hidden, or removed from Ecosystem.DrGPCR.com for spam or quality reasons, or any of our other applicable policies or terms of service. Use of Multiple Accounts Do not create or use multiple accounts to evade our policies or bypass blocks or otherwise subvert restrictions placed on your account. For example, if you’ve been blocked by another user or suspended for abuse, don’t create a replacement account that engages in similar activity. Please read carefully our Legal Policies and Disclaimers to understand how Dr. GPCR conducts business Affiliate Policy Content and Conduct Policy Content Guidance Privacy Policy Terms and Conditions Trademark Policy

<< Back to podcast list Strategic Partner(s) Dr. Bruno Giros About Dr. Bruno Giros Dr. Giros' lab investigates how molecular changes at the nerve synapse might impact integrated behavior and what we might learn from these mechanisms to cure mental illness. After doctoral training at the Pierre and Marie Curie University in Paris and a short internship at Genentech Inc. in South San Francisco, he joined the CNRS as a Research Fellow in 1987 in the INSERM Laboratory directed by Jean-Charles Schwartz in Paris, where he cloned and characterized dopamine D2 and D3 receptor subtypes. From 91 to 94, he was an assistant professor at Duke University in North Carolina, working with Marc Caron and Robert Lefkowitz (2012 Nobel Prize in Chemistry) to characterize several neurotransmitter transporters and kinases and establish the first knock-out for these genes. In 1999, in France, Dr. Giros created the INSERM/CNRS laboratory on the "Neurobiology of Psychiatric Disorders," first in Créteil with Marion Leboyer, then at the University of Paris-Sorbonne with Hervé Chneiweiss. Since 2008, he has arrived at McGill University as a Canada Research Chair. At McGill, his laboratory has two main axes of research: 1) Studying interindividual vulnerability to chronic stress and depression and; 2) Understanding the role of phenotypically defined subpopulations of striatal neurons in motor and cognitive functions. Bruno Giros has trained 59 master's, doctoral and postdoc students, most of his trainees obtain positions in the academic or private sectors or are currently pursuing postdoctoral research training or have entered medical studies. Dr. Giros has published more than 200 publications with an H factor of 79 and 32,000 citations (Google Scholar) and has received several distinctions, including the CNRS silver medal, the FRM "Young Researcher" prize, the ISI “Highly Cited” and F-1000 in Pharmacology, and recently received the Heinz Lehmann Award from the Canadian College of NeuroPsychopharmacology and the distinguished James B. McGill Professor Award. Dr. Bruno Giros on the web Dougles Research Center LinkedIn Google Scholar Researchgate Dr. GPCR Enjoying the Dr. GPCR Podcast? Leave a Review. Leave a quick review to help more scientists find the show—and help us keep improving every episode. It takes <60 seconds and makes a big difference. ★ Review on Apple Podcasts ★ Rate on Spotify ✉️ Send feedback to the team Recent Podcast Articles Asking Better Questions in Science: A Practical Guide for Emerging Researchers When the Islet Lit Up: Advancing GPCR Imaging in Native Tissue How Collaboration Sparked a GPCR Imaging Breakthrough in Chemical Biology Thanks for listening to this podcast episode Follow us on your favorite Podcast Player << Previous Podcast Episode Next Podcast Episode >>

Biotech founder Ajay Yekkirala shares how AI, GPCRs, and bold questions are driving next-gen pain therapeutics and drug discovery innovation. << Back to podcast list Strategic Partner(s) From Curiosity to Breakthrough: Ajay Yekkirala on GPCR Innovation What if the key to safer, more effective drugs lies in asking the right questions — and daring to challenge what’s “not possible”? In this episode, Dr. Ajay Yekkirala shares the pivotal moments that transformed him from a curious PhD student into a GPCR drug developer and entrepreneur. Dr. Ajay Yekkirala is a GPCR pharmacologist, biotech entrepreneur, and co-founder of Superluminal Medicines, a company using machine learning to unlock new GPCR-targeted therapies. In this wide-ranging conversation, he reflects on the mentors, failures, and bold questions that shaped his journey from academia to AI-powered drug discovery. Why This Matters Translating basic GPCR science into actual medicines is broken. Ajay unpacks why—and what it takes to fix it. AI is reshaping how we understand protein dynamics , but only when driven by deep biological questions. Young scientists are hungry for alternate career paths. This episode is a playbook for thinking bigger. Innovation doesn’t happen in isolation. Ajay reveals how humility, curiosity, and collaboration fuel the future of drug discovery. What You’ll Learn in This Episode How Ajay’s failed MD/PhD application rerouted his path toward a breakthrough GPCR research career The inside story behind founding Blue Therapeutics and targeting supraspinal pain pathway What it means to “teach AI protein dynamics,” and how Superluminal is using it to predict signaling bias The entrepreneurial lessons no one tells postdocs: how to pitch, fail, and build a team Why asking “what if it can be done?” is the heart of scientific innovation Who Should Listen PhD students and postdocs exploring biotech careers GPCR scientists interested in translational innovation Biotech investors and strategic leaders seeking new drug development models Anyone curious about where AI meets molecular pharmacology About Ajay Yekkirala Dr. Ajay Yekkirala is a molecular pharmacologist, biotech founder, and scientist whose career has been defined by bold questions and even bolder moves. Originally on track to pursue an MD/PhD, a rejection letter pivoted him into a PhD program at the University of Iowa, where he studied opioid pharmacology under the legendary Dr. Philip Portoghese. That “failure” became a launchpad: Ajay later joined the lab of Dr. Clifford Woolf at Boston Children’s Hospital and Harvard Medical School, where he deepened his understanding of pain biology and began dreaming bigger. Driven by the opioid crisis and the lack of non-addictive pain treatments, Ajay co-founded Blue Therapeutics, a biotech startup focused on targeting supraspinal GPCRs for chronic pain. But he didn’t stop there. Seeing the limits of traditional drug discovery, he later co-founded Superluminal Medicines, a company using machine learning to explore GPCR structure-function relationships and predict biased signaling with precision. Ajay’s work sits at the intersection of GPCR biology, AI, and translational medicine. He’s a strong advocate for cross-disciplinary thinking, mentoring young scientists, and building companies that solve real, unmet needs in human health. His story is one of relentless curiosity, humility in the face of complexity, and an unshakable belief in science’s power to do better. Ajay Yekkirala on the web Superluminal Medicines LinkedIn Tune in now to hear how asking “what if?” led Ajay Yekkirala to reshape the future of GPCR-targeted medicine. Enjoying the Dr. GPCR Podcast? Leave a Review. Leave a quick review to help more scientists find the show—and help us keep improving every episode. It takes <60 seconds and makes a big difference. ★ Review on Apple Podcasts ★ Rate on Spotify ✉️ Send feedback to the team Recent Podcast Articles Asking Better Questions in Science: A Practical Guide for Emerging Researchers When the Islet Lit Up: Advancing GPCR Imaging in Native Tissue How Collaboration Sparked a GPCR Imaging Breakthrough in Chemical Biology Thanks for listening to this podcast episode Follow us on your favorite Podcast Player << Previous Podcast Episode Next Podcast Episode >>

Dr. Eric Trinquet discusses the science and story behind pH Sense, Revvity’s innovative GPCR internalization assay, and his journey in GPCR product R&D. << Back to podcast list Strategic Partner(s) From Rare Earth Probes to Internalization Assays: The pHSense Story with Dr. Eric Trinquet What does it take to design a breakthrough GPCR assay—from idea to industrial impact? In this special episode, Dr. Eric Trinquet shares the inside story behind the development of pH Sense, Revvity’s latest innovation for tracking GPCR internalization. With a career spanning two decades at the intersection of fluorescence chemistry, functional assays, and product development, Eric takes us through the highs, failures, and scientific “aha” moments that shaped tools like the IP-One kit, Tag-lite, and now, pH Sense. If you’ve ever used HTRF or wondered what goes into making a product worthy of your next experiment, this is your backstage pass. You’ll hear what truly makes a reagent successful—and why academic–industry collaborations are essential for advancing GPCR research. ⸻ Inside This Episode How Eric and his team reimagined rare earth complexes to develop pH-sensitive probes with tunable brightness and lifetime. Why pH Sense enables high-throughput, no-wash tracking of GPCR internalization—even at endogenous expression levels. What shifted the team’s strategy from traditional calcium assays to IP1 accumulation—and why it mattered for Gq-coupled receptors. How collaborations with David Parker and Jean-Philippe Pin accelerated both probe chemistry and biological validation. What it felt like to see the first dose-response curves in native beta cells—and why that moment changed the trajectory of the project. Why the commercialization of a reagent is not the end, but the beginning of a feedback-driven innovation cycle. ⸻ Why It Might Hit Home If you’ve ever: Wrestled with unreliable endpoint assays or cumbersome radioactive protocols, Pushed for more physiologically relevant systems and hit the “overexpression ceiling,” Balanced scientific rigor with the unpredictability of product development, Or felt the thrill of seeing a tool you built drive real biological insight… …this episode will resonate. ⸻ About the Guest Dr. Eric Trinquet is Head of R&D for Life Sciences Reagents at Revvity, where he leads innovation in biochemical and cell-based assay platforms. With a foundational career at Cisbio Bioassays—later acquired by Revvity—Eric played a pivotal role in bringing technologies like HTRF, the IP-One kit, and the Tag-lite platform into widespread use. Originally trained as a physicist with a strong interest in photophysics and fluorescence chemistry, Eric transitioned into the GPCR field through hands-on assay development. His passion lies in turning cutting-edge probe chemistry into robust, scalable tools for drug discovery and basic research. What drives him? A mix of scientific curiosity, a tolerance for failure, and a commitment to delivering real-world impact—one product at a time. ⸻ More about Revvity pHSense Reagents GPCR Reagents Revvity on Dr. GPCR Dr. GPCR X Revvity Collaboration ⸻ Want more like this? Join the Dr. GPCR Premium Ecosystem for behind-the-scenes access to GPCR innovators, exclusive deep-dives, and practical tools to accelerate your research or career. 👥 Build connections. 🧪 Get insights. 🎧 Stay ahead. 👉 Join now Enjoying the Dr. GPCR Podcast? Leave a Review. Leave a quick review to help more scientists find the show—and help us keep improving every episode. It takes <60 seconds and makes a big difference. ★ Review on Apple Podcasts ★ Rate on Spotify ✉️ Send feedback to the team Recent Podcast Articles Asking Better Questions in Science: A Practical Guide for Emerging Researchers When the Islet Lit Up: Advancing GPCR Imaging in Native Tissue How Collaboration Sparked a GPCR Imaging Breakthrough in Chemical Biology Thanks for listening to this podcast episode Follow us on your favorite Podcast Player << Previous Podcast Episode Next Podcast Episode >>

<< Back to podcast list Strategic Partner(s) Dr. Arun Shukla About this episode In this episode of the Dr.GPCR podcast , my guest is Dr. Arun Shukla from the Indian Institute of Technology in Kanpur, India. Arun is currently an Associate Professor & Joy Gill Chair Professor, Intermediate Fellow, Wellcome Trust DBT India Alliance Swarnajayanti Fellow & EMBO Young Investigator at the Department of Biological Sciences and Bioengineering. He earned his master's degree in biotechnology from Jawaharlal Nehru University in India and it was during a biochemistry class where he learned about cell signaling that he became curious and wanted to learn more about it. Arun first started working on GPCRs and their structural characterization at the Max Planck Institute of Biophysics where he completed his doctoral studies in the lab of Dr. Hartmut Michel . Fascinated by GPCRs he wrote to Dr. Bob Lefkowitz and asked him if he could join his lab at Duke University. Dr. Shukla spent several years in the Lefkowitz lab and collaborated extensively with Dr. Brian Kolbika of Stanford University. Join us and learn more about Dr. Shukla’s research and how working in the lab instead of going to classes made him realize that research is what he wants to do for the rest of his life. Dr. Arun Shukla on the web Indian Institute of Technology Dr. Arun Shukla Lab Google Scholar PubMed Wikipedia LinkedIn Twitter Dr. GPCR Ecosystem Enjoying the Dr. GPCR Podcast? Leave a Review. Leave a quick review to help more scientists find the show—and help us keep improving every episode. It takes <60 seconds and makes a big difference. ★ Review on Apple Podcasts ★ Rate on Spotify ✉️ Send feedback to the team Recent Podcast Articles Asking Better Questions in Science: A Practical Guide for Emerging Researchers When the Islet Lit Up: Advancing GPCR Imaging in Native Tissue How Collaboration Sparked a GPCR Imaging Breakthrough in Chemical Biology Thanks for listening to this podcast episode Follow us on your favorite Podcast Player << Previous Podcast Episode Next Podcast Episode >>

Retreat 2023 About Program Registration Logo Contest Committee Sponsors GPCR Retreat Program < Back to schedule Structure-based discovery of functionally selective 5-HT1A receptor agonists Date & Time Saturday, November 4th / 9:05 AM Abstract Coming Soon About Peter Gmeiner "Prof. Dr. Peter Gmeiner received his Ph.D. from the University of Munich. He was a postdoc at the University of California in Berkeley, USA. He subsequently returned to Munich as a research associate at the Institute of Pharmaceutical Chemistry. Upon receiving his Dr. Habilitus, he was appointed at the University of Bonn as a Professor of Pharmaceutical Chemistry declining an offer for a professorship at the University of Heidelberg, at the same time. Peter has been chaired Full Professor of Pharmaceutical / Medicinal Chemistry at the Friedrich-Alexander University Erlangen-Nürnberg and declined an offer for the Chair for Pharmaceutical Chemistry at the University of Münster. Peter Gmeiner has been spokesman of the Research Training Group "Medicinal Chemistry of Selective GPCR Ligands" (GRK 1910). " Peter Gmeiner on the web Friedrich Alexander University Erlangen-Nürnberg Pubmed Google Scholar LinkedIn Dr. GPCR Previous Event Next Event Great Lakes GPCR Retreat and Club des Récepteurs à Sept Domaines Transmembranaires du Québec Great Lakes GPCR Retreat and Club des Récepteurs à Sept Domaines Transmembranaires du Québec 22nd GPCR Retreat Sponsored by

Full Agenda Adhesion GPCR workshop 2024 CINVESTAV, Mexico City, Mexico October 23-25 Download PDF Program HERE < Back to Full Agenda Session IV AGPCRs signaling in the nervous system BAI1/ADGRB1-mediated Regulation of Mitochondrial Morphology in Axons Joseph Duman Bai1 Is A Novel Neuronal Substrate Of The Psychiatric Risk Kinase TNIK Simeon R. Mihaylov Intricacies Of Complex Assembly And Ligand Interaction In The Adhesion GPCR Latrophilin/Cirl Anne Bormann BAI1/ADGRB1-mediated Regulation of Mitochondrial Morphology in Axons Joseph Duman Abstract Only available for AGPCR 24 Attendees Authors & Affiliations "Tolias, Kimberley F., Departments of Neuroscience and Biochemistry & Molecular Biology, Baylor College of Medicine, Houston, TX 77030" About Joseph Duman "Joseph Duman is an Assistant Professor in the Department of Neuroscience at Baylor College of Medicine, where he studies BAI1's role in the brain and the radiobiology of treatments for brain cancer. He trained at the University of California at Berkeley with John Forte and the University of Washington with Bertil Hille, before joining Kim Tolias' lab at Baylor College of Medicine." Joseph Duman on the web Baylor College of Medicine Kimberley Tolias Lab Bai1 Is A Novel Neuronal Substrate Of The Psychiatric Risk Kinase TNIK Simeon R. Mihaylov Abstract Only available for AGPCR 24 Attendees Authors & Affiliations "Flynn, Helen R.2, Sampedro-Castaneda, Marisol1, Claxton, Suzanne1, Skehel, Mark2, Ultanir, Sila K.1 1Kinases and Brain Development Laboratory, The Francis Crick Institute, UK 2Proteomics Science Technology Platform, The Francis Crick Institute, UK" About Simeon R. Mihaylov " I am a postdoctoral researcher in the kinases and brain development laboratory led by Dr Sila Ultanir at the Francis Crick Institute in London, England. I undertook my BSc in Biochemistry and Genetics at the University of Sheffield followed up by obtaining a PhD in molecular neuroscience at the Sheffield Institute for Translational Neuroscience. I then moved to King's College London, where my interest and passion for kinases in brain health and disease developed. I initially worked on mTOR in the pathogenesis of Tuberous Sclerosis Complex and then moved to the Francis Crick Institute working on the psychiatric risk kinase TNIK. I also work on multiple other kinases in our laboratory implicated in various neurodevelopmental and neurodegenerative disorders. My expertise includes biochemical approaches, proteomics and transcriptomics to name a few. I have recently also developed a strong interest in adhesion GPCRs and in particular, Bai1. " Simeon R. Mihaylov on the web Crick LinkedIn X (Twitter) Google Scholar Intricacies Of Complex Assembly And Ligand Interaction In The Adhesion GPCR Latrophilin/Cirl Anne Bormann Abstract Only available for AGPCR 24 Attendees Authors & Affiliations "Körner, Marek Benjamin; Dahse, Anne-Kristin; Ljaschenko, Dmitrij; Scholz, Nicole (Rudolf Schönheimer Institute of Biochemistry, Division of General Biochemistry, Faculty of Medicine, Leipzig University)" About Anne Bormann "I am a biochemist by training and studied at Leipzig University from 2015 to 2020. During my Bachelor's in 2018, I sought practical lab experience and found a position as a student assistant in Dr. Nicole Scholz's lab. My main topics were protein biochemistry, Drosophila husbandry, and genetics. I was fortunate that Nicole offered me an opportunity to do my Master's and later on a PhD thesis in her group. Since then, I have broadened my horizons with many more techniques in vivo and in vitro, with a main emphasis on the Adhesion GPCR Latrophilin/Cirl. Currently, I am in the final stages of my PhD, and I am looking forward to new projects and ideas." Anne Bormann on the web Rudolf-Schönheimer-Institut für Biochemie Scholz Lab < Previous Session Next Session >

<< Back to podcast list Strategic Partner(s) Dr. Kenneth A. Jacobson About Dr. Kenneth A. Jacobson Kenneth A. Jacobson received his BA in Liberal Arts from Reed College in 1976 and his Ph.D. in Chemistry from the University of California, San Diego in 1981. He completed postdoctoral training at the Weizmann Institute. In 1983, he joined the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) at the National Institutes of Health, in Bethesda, MD. He is currently the Senior Investigator and Chief of the Molecular Recognition Section, Laboratory of Bioorganic Chemistry. He adapts interdisciplinary approaches (synthesis, modeling, pharmacology) to study G protein-coupled receptors (GPCRs) and purinergic signaling and now has four compounds in clinical trials. He has published more than 800 scientific publications, with an H-index of 115. His numerous awards include: 2008 Sato Award; 2009 Medicinal Chemistry Hall of Fame (American Chemical Soc.); 2014 Goodman and Gilman Award; 2017 Tu Youyou Award; 2017 Smissman Award; 2023 Hershberg Award. Dr. Kenneth A. Jacobson on the web NIDDK Web of Science Google Scholar LinkedIn Twitter Dr. GPCR Enjoying the Dr. GPCR Podcast? Leave a Review. Leave a quick review to help more scientists find the show—and help us keep improving every episode. It takes <60 seconds and makes a big difference. ★ Review on Apple Podcasts ★ Rate on Spotify ✉️ Send feedback to the team Recent Podcast Articles Asking Better Questions in Science: A Practical Guide for Emerging Researchers When the Islet Lit Up: Advancing GPCR Imaging in Native Tissue How Collaboration Sparked a GPCR Imaging Breakthrough in Chemical Biology Thanks for listening to this podcast episode Follow us on your favorite Podcast Player << Previous Podcast Episode Next Podcast Episode >>

<< Back to podcast list Strategic Partner(s) Dr. G. Aditya Kumar About Dr. G. Aditya Kumar Dr. Aditya Kumar is a postdoctoral fellow at the University of Michigan Medical School. Aditya is interested in understanding the role of the membrane microenvironment in the subcellular organization, trafficking, and signaling of GPCRs. He received his Ph.D. from the Centre for Cellular and Molecular Biology at Hyderabad, India, where he studied the interaction of membrane cholesterol with the serotonin-1A receptor and its effects on receptor signaling and endocytosis. In addition, he explored the role of the host membrane in the entry of intracellular pathogens into macrophages. He currently uses high-resolution fluorescence microscopy and biochemistry to study GPCR trafficking mechanisms. In his (future) independent research career, Aditya aims to work at the interface of GPCR molecular pharmacology, subcellular trafficking, and membrane biology to better understand how the dynamic receptor microenvironment contributes to GPCR organization and function. Dr. G. Aditya Kumar on the web University of Michigan Puthenveedu Lab Google Scholar NIH ORCID LinkedIn Twitter Dr. GPCR Enjoying the Dr. GPCR Podcast? Leave a Review. Leave a quick review to help more scientists find the show—and help us keep improving every episode. It takes <60 seconds and makes a big difference. ★ Review on Apple Podcasts ★ Rate on Spotify ✉️ Send feedback to the team Recent Podcast Articles Asking Better Questions in Science: A Practical Guide for Emerging Researchers When the Islet Lit Up: Advancing GPCR Imaging in Native Tissue How Collaboration Sparked a GPCR Imaging Breakthrough in Chemical Biology Thanks for listening to this podcast episode Follow us on your favorite Podcast Player << Previous Podcast Episode Next Podcast Episode >>

Principles of Pharmacology in Drug Discovery I Dr. Terry Kenakin Get Started Premium Members benefits: - Subscribe and save 25% on every GPCR Course - Early-bird access - Recordings will be available < Back to GPCR courses Watch recording Your Instructor Dr. Terry Kenakin

Full Agenda Adhesion GPCR workshop 2024 CINVESTAV, Mexico City, Mexico October 23-25 Download PDF Program HERE < Back to Full Agenda Session VI AGPCRs shaping the nervous system ADGRCs in glutamatergic synapse formation, maintenance and degeneration Yimin Zou Antibody-drug conjugates targeting CD97 in glioblastoma Dimitris Placantonakis Adhesion G protein-coupled receptor latrophilin-3 (ADGRL3) modulation of dopaminergic neurotransmission Nicole Perry-Hauser ADGRCs in glutamatergic synapse formation, maintenance and degeneration Yimin Zou Abstract "ADGRCs (Celsr1-3) are components of the conserved planar cell polarity (PCP) pathway, which establishes and maintains cell and tissue polarity along the tissue plane in all tissues. Work from our lab showed that the PCP components, including ADGRC2 and ADGRC3, are localized in the developing and adult synapses and interact with synaptic scaffold proteins and glutamate receptors and are responsible for the formation and stability of the vast majority of glutamatergic synapses in the mammalian brain. Initial impairment of synaptic functions, which occurs early in Alzheimer’s disease, and subsequent massive loss of synapses are closely correlated with the decline of cognitive function. We showed that oligomeric Aβ binds to ADGRC3 on the same domain required for the interaction with Frizzled3, weakens their interaction and assists Vangl2 in disassembling synapses. Conditionally knocking out Ryk, required for Vangl2 function, protected synapses and preserved cognitive function in a mouse model for Alzheimer’s. Massive synapse loss in the prefrontal cortex is a hallmark of massive depressive disorder. Injection of low-dose ketamine, an antidepressant, can lead to acute (in several hours) and sustained (up to several weeks) antidepressive effects. Restoration of synaptic connections induced by low-dose ketamine has been found associated with the sustained antidepressive effects. We showed that ADGRC2 and ADGRC3 are required for the restoration of glutamatergic synapses in prefrontal cortical neurons of chronically stressed animals and their behavioral remission induced by low-dose ketamine. I will also present ongoing work on the signaling mechanisms of how ADGRCs regulate synapse formation, maintenance and plasticity." About Yimin Zou "I received Ph.D from University of California at Davis and San Diego in 1995 and then postdoctoral training from University of California, San Francisco in 2000. I was an assistant and then associate professor with tenure at the University of Chicago from 2000 to 2006 and moved to University of California San Diego as an Associate Professor in 2006. I became full professor in 2011 and Vice Chair of the Neurobiology Department at UC San Diego in 2012. I served as the Chair of the Neurobiology Department at UC San Diego from 2014 to 2017. My research focus is the mechanisms of neural circuit development, function and disease." Yimin Zou on the web UC San Diego Antibody-drug conjugates targeting CD97 in glioblastoma Dimitris Placantonakis Abstract "Glioblastoma (GBM) is the most common and aggressive primary brain malignancy. Several adhesion G protein-coupled receptors (aGPCRs) have recently been shown to play critical roles in GBM biology. We showed that CD97 (ADGRE5), in particular, drives tumor growth via effects on GBM stem cell self-renewal and metabolism, but also has a therapeutically favorable expression pattern: it is highly expressed in all GBM specimens, but is absent from healthy brain tissue. To exploit this expression profile, we have developed antibody-drug conjugates (ADCs) targeting CD97, by screening a synthetic human antibody library. We initially tested the ADC using in vitro WST-8 viability assays in human GBM cell lines and cell types that lack CD97. We observed significantly lower LD50 values in patient-derived and U87 GBM cell cultures vs. CD97-lacking cells. We also found significantly lower LD50 values when treating human GBM cells with the ADC (0.6788 nM), as compared to control ADC targeting RSV glycoprotein F (19.964 nM). In vivo intratumoral administration of the ADC in patient-derived GBM xenografts in the brain of immunodeficient mice resulted in significant reduction of tumor growth and prolongation of survival of host mice. Collectively, these data suggest that ADCs targeting CD97 impair tumor growth in preclinical GBM models and are promising candidates for future clinical trials." Authors & Affiliations "Groff, Karenna; Donaldson, Hayley; Anderson, Sebastian; Pitti, Kiran; Wang, Shuai; Park, Christopher; Hattori, Takamitsu; Koide, Shohei; Placantonakis, Dimitris New York University Grossman School of Medicine" About Dimitris Placantonakis "Dimitris Placantonakis is a neurosurgeon-scientist at NYU Grossman School of Medicine in New York. As a clinician, he specializes in surgical treatment of brain tumors. His laboratory studies oncogenesis in glioblastoma, the most common brain malignancy, and chromatin organization in human neural development. His group has been particularly interested in the role adhesion GPCRs play in glioblastoma biology and their therapeutic targeting." Dimitris Placantonakis on the web Placantonakis Lab Google Scholar LinkedIn Adhesion G protein-coupled receptor latrophilin-3 (ADGRL3) modulation of dopaminergic neurotransmission Nicole Perry-Hauser Abstract Only available for AGPCR 24 Attendees Authors & Affiliations "Nicole A. Perry-Hauser1,2, Arturo Torres Herraez1,2, Dan Lowes1,2, Ying Zhu1,2, Siham Boumhaouad1,3, Eugene V. Mosharov1,2,4, David Sulzer1,2,4, Christoph Kellendonk1,2, and Jonathan A. Javitch1,2 1Departments of Psychiatry and Molecular Pharmacology and Therapeutics, Columbia University, New York, NY 10032; 2Division of Molecular Therapeutics, New York State Psychiatric Institute, New York, NY 10032; 3 Physiology and Physiopathology, Faculty of Sciences, Mohammed V University, Rabat 1014, Morocco; 4Department of Neurology, Columbia University, New York, NY 10032" About Nicole Perry-Hauser "I am an associate research scientist endeavoring to build a productive, independent scientific research career in adhesion G protein-coupled receptor (aGPCR) biology. My long-term research interests involve resolving signaling pathways downstream of aGPCRs and establishing how/if these receptors’ adhesive properties influence signaling events, and in turn whether signaling impacts synapse formation and neuronal wiring. I initially became interested in GPCR signal transduction during my graduate training in the Department of Pharmacology at Vanderbilt University where I studied under the co-mentorship of Dr. Vsevolod V. Gurevich and Dr. Tina M. Iverson. I then pursued a postdoctoral research position under the mentorship of Dr. Jonathan A. Javitch in the Department of Psychiatry at Columbia University Irving Medical Center." Nicole Perry-Hauser on the web LinkedIn Research Gate Pubmed Dr. GPCR < Previous Session Next Session >

Full Agenda Adhesion GPCR workshop 2024 CINVESTAV, Mexico City, Mexico October 23-25 Download PDF Program HERE < Back to Full Agenda Leave for dinner reception Coming Soon < Previous Session Next Session >

Retreat 2023 About Program Registration Logo Contest Committee Sponsors GPCR Retreat Program < Back to schedule Regulation and role of mitochondria delta opioid receptors Date & Time Friday, November 3rd / 10:40 AM Abstract Coming Soon About Louis Gendron "Dr Louis Gendron, PhD is tenured Professor and Chair of the Department of Pharmacology-Physiology at the Université de Sherbrooke. He has 20+ years of experience in in vitro and in vivo GPCR pharmacology and has published seminal papers where he used various approaches to describe the role of opioid receptors in pain and anagesia as well as to study the mechanisms involved in the cellular trafficking of the delta opioid receptor. Recently, his group reported the first in vivo GPCR interactome, revealing an important number of new potential proteins interacting with GPCRs. Dr Gendron is co-director of the FRQS-funded Quebec Pain Research Network and the Editor-in-Chief in the journal Progress in Neuro-Psychopharmacology & Biological Psychiatry." Louis Gendron on the web Université de Sherbrooke Neurosciences Sherbrooke RQRD Pubmed Google Scholar LinkedIn Twitter Dr. GPCR Previous Event Next Event Great Lakes GPCR Retreat and Club des Récepteurs à Sept Domaines Transmembranaires du Québec Great Lakes GPCR Retreat and Club des Récepteurs à Sept Domaines Transmembranaires du Québec 22nd GPCR Retreat Sponsored by

Retreat 2023 About Program Registration Logo Contest Committee Sponsors GPCR Retreat Program < Back to schedule Welcome Reception and Poster Session 1 Date & Time Thursday, November 2nd / 5:30 PM Previous Event Next Event Great Lakes GPCR Retreat and Club des Récepteurs à Sept Domaines Transmembranaires du Québec Great Lakes GPCR Retreat and Club des Récepteurs à Sept Domaines Transmembranaires du Québec 22nd GPCR Retreat Sponsored by

Retreat 2023 About Program Registration Logo Contest Committee Sponsors GPCR Retreat Program < Back to schedule Using food perception and bioamine signaling networks to slow aging Date & Time Saturday, November 4th / 10:10 AM Abstract Coming Soon Authors and Affiliations Hillary A. Miller 1, Shijiao Huang 1, Elizabeth S. Dean 1, and Scott F. Leiser 1 1. University of Michigan About Scott Leiser "Scott Leiser is an Assistant Professor in the Research in the Molecular & Integrative Physiology Department at the University of Michigan. The Leiser laboratory is focused on the molecular mechanisms of aging, with an emphasis on stress response and metabolism. The lab works with multiple models, including Caenorhabditis elegans, in vitro tissue culture, and mice, to better understand the conserved mechanisms of aging. Recent research in his laboratory focuses on how organisms perceive and respond to environmental stress though cell non autonomous signaling mechanisms, and how these signals affect the health and longevity of the animal." Scott Leiser on the web University of Michigan Pubmed ResearchGate LinkedIn Dr. GPCR Previous Event Next Event Great Lakes GPCR Retreat and Club des Récepteurs à Sept Domaines Transmembranaires du Québec Great Lakes GPCR Retreat and Club des Récepteurs à Sept Domaines Transmembranaires du Québec 22nd GPCR Retreat Sponsored by