Advance your GPCR research career with Dr. GPCR University. Access 20+ on-demand GPCR courses, 200+ expert talks, weekly news, and a global scientist network. Join Premium today. Dr. GPCR University Your professional home in GPCR science. University is your professional home in GPCR science — premium intelligence, live Masterclasses, job listings, events, and a community of scientists who have your back. Everything you need, in one place. See what it feels like — $49 for 14 days Already know this is home? Join University — $499/year 1,400+ GPCR scientists reached 200+ Expert talks available $499 Per year — less than $10/week Live Masterclass In the room with the scientist, not watching from the audience Live scientific exchanges where you engage directly with leading GPCR experts. The question you've been holding — this is where you ask it. Dr. Marsha Pierce | Midewestern University Introduction to GLP-1 pharmacology Translational Pharmacology & Disease Models October 29, 2026 Dr. Katarina Nemec and Dr. Romy Thomas Conformational Biosensors for GPCR Activation Assay Development December 10, 2026 Explore Live Masterclasses → On-demand Masterclass library 200+ expert sessions, available anytime Full recordings of every Masterclass session. Revisit the science at your pace — filter by category, level, or instructor. Explore Masterclasses On Demand → Who it's for? Whether you're just starting out or 20 years in — this is your place University is designed for GPCR scientists at every career stage who want to stay sharp, connected, and supported. 🎓 Early-career researchers Find your footing in the field. Access the experts, the intelligence, and the community that accelerates your growth. 🔬 Discovery scientists Stay at the frontier. Live Masterclasses and Premium Weekly News keep you ahead of the field — not chasing it. 🏆 Senior investigators Your career stage doesn't matter. Your commitment to the science does. Connect, contribute, and stay current. What's inside? The rooms in your professional home University isn't a bundle of features — it's a place where your GPCR professional life is supported. Here's what's waiting for you inside. Live Masterclass Live scientific exchanges with leading GPCR experts. You're in the room with the scientist, asking your question — not watching from the audience. Explore Live Masterclass → Job Listings GPCR-specific job opportunities curated for the community. Your next role is already here — opportunities find you when you're inside the ecosystem. Masterclass On Demand Full recordings of every session, available anytime. Revisit the science at your pace — over 200 expert talks in the library and growing. Explore Masterclass on Demand → GPCR Events A calendar of relevant conferences, meetings, and events in the GPCR field. Your next conference is already here. Premium Weekly News The complete GPCR intelligence — classified publications, industry news, job listings, and events calendar. Know what's coming before it becomes consensus. See Weekly News → Ask the Ecosystem The question you've been sitting on — someone in this ecosystem has the answer. A discussion forum where members share insights and get answers from the community. The comparison A society membership costs more and gives you less Most GPCR scientists belong to at least one scientific society. Here's how that compares to University. Typical Scientific Society $150 – $500+/year A journal subscription A conference discount A newsletter Occasional networking events Dr. GPCR University $499/year — less than $10 a week Live Masterclasses with leading GPCR scientists 200+ on-demand expert sessions Premium Weekly News intelligence GPCR job board and events calendar Community forum & ecosystem access Intelligence Hub dashboard Grandfather guarantee — your rate never increases "The one membership that has your back." $49 for 14 days - Strat Now What others are saying Scientists inside the ecosystem I am a convert! I will keep Dr. GPCR and the offered resources in my work sphere Dr. Hoare is very experienced in the field. What came as a pleasant surprise was how didactical and well-thought-out his course was—highly recommended. The really unexpected was that the Q&A sessions reached the highest level—beyond excellent. GPCR researcher The content had enough depth to satisfy the hunger for theory while being full of practical knowledge GPCR researcher Dr. Hoare's extensive and elaborative explanation of the topics at hand was excellent and very digestible. Thoroughly enjoyed learning from him GPCR researcher The course was very practical and easily translatable to experiments that we could do in our own labs. It was clear that Dr. Hoare is very in touch with the technical and human challenges we encounter in our work GPCR researcher Thank you for bringing this course with Dr. Kenakin. I wish Dr. GPCR the best for the sake of promoting more educational opportunities that are sorely needed in the field GPCR researcher The best pharmacology teacher teaming up with the best GPCR community platform to help train and inspire the next generation of scientists. Also super-valuable for those of us learning how to teach pharmacology GPCR researcher Dr. Kenakin is a leading expert in the field. Aside from his vast experience in drug development, not to mention his extensive publication record, Dr. Kenakin is a masterful teacher and communicator. GPCR researcher Common questions Thinking it over? Fair enough. Here are the concerns we hear most — and honest answers. "It's too expensive." At less than $10 a week, University gives you live access to leading GPCR scientists, 200+ on-demand talks, premium intelligence, a job board, events calendar, and a global community of peers. One insight, one connection, one 'aha' moment — can save months of research time. "I'm not sure I'll use it often." Even one Masterclass or one new collaboration can make a difference. Members often find value in ways they didn't expect — from expert feedback to career-changing introductions. That's why we offer a 14-day trial, so you can experience it first. "I already get what I need from papers." Papers inform. University helps you understand and apply that knowledge — through expert context, structured scientific exchanges, and real interaction with peers from academia and industry. "Will this really help my career?" Yes. Members grow visibility, confidence, and connections that open doors. It’s not just about learning — it’s about being seen, supported, and part of something bigger . Frequently asked questions What is Dr. GPCR University? Dr. GPCR University is an educational platform that provides in-depth learning and training resources on G protein-coupled receptors (GPCRs). At Dr.GPCR University, you’ll find: Courses: Dive deep into curated educational content designed by experts in GPCR research. Our courses provide comprehensive, on-demand learning to help you expand your knowledge and stay current in the field. Symposia Engage with leading scientists through our symposia, featuring in-depth discussions on cutting-edge research and breakthroughs in GPCR science. Each session brings together a community of experts to share insights and advancements. Summit A global gathering of researchers and professionals showcasing the latest developments in GPCR research. Participate in presentations, networking opportunities, and collaborative sessions. Virtual Café Listen to casual, interactive discussions with experts in the field. How do I register for Dr. GPCR University Masterclasses? To register for any course, you must have a FREE Ecosystem member account. We carefully screen anyone signing up to ensure they are real humans working on GPCRs, so you might not receive confirmation immediately. When signing up for the first time, try to complete as much information as possible about yourself. Who are the Dr. GPCR University Masterclasses designed for? The classes are designed for researchers, students, and professionals in biology, pharmacology, and biochemistry, but anyone interested in GPCR research is welcome to join. What topics are covered in the masterclasses? Masterclasses cover a variety of track including but not limited to pharmacology foundations, agonists, antagonists & core mechanisms , allosteric modulation & kinetics, advanced quantitative approaches and innovation & strategic application Can I register my team for a Dr. GPCR University Masterclasses? To register as a team, one of you must be a Premium Member. This person must email hello@drgpcr.org indicating how many people will register for the course, the names of the participants, and their emails. We will contact each person individually to help them set up a FREE Ecosystem Membership. They will be asked to join a private group to keep updated with the latest announcements about the course. Are the masterclasses on-demand or live? Dr. GPCR University offers both on-demand and live classes led by experts in the field. On-demand classes are only available for Premium Members. Do I need prior knowledge of GPCRs to join the masterclasses? Some classes may require basic knowledge of GPCRs, but many are designed to accommodate beginners as well as advanced learners. What kind of certification will I receive upon completing a masterclass? Participants will receive a certificate of completion from Dr. GPCR University, which can be used to showcase your expertise and enhance your professional credentials. Can I access the course material after completing the course? Yes, if you are a premium member. Move in. Look around. See if it's home. For 14 days, this is what it feels like to have everything in one place — intelligence, learning, community, and opportunities. Your first Masterclass is waiting. See what it feels like Already know this is home? Join University — $499/year Your 14-day trial is $50. If University feels like home, it's $499/year — less than $10 a week. Grandfather guarantee: your rate never increases. No surprise charges.

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Access expert CRO advisory services through the Dr. GPCR Ecosystem. Get guidance, strategies, and insights to optimize your GPCR research and drug discovery projects. Home About Services News Get in Touch Welcome CRO & Vendor Advisory Your Science Is Strong. Your Process Should Be, Too. I help CRO teams bring structure to collaboration—so your data gets acted on, not overlooked. When biotech partners trust your process, they come back again and again. You deliver high-quality data. But when timelines shift, expectations blur, or feedback loops break down, even the best work can lose momentum. Let’s turn your scientific rigor into results that move programs—and people—forward. Power My Discovery Biotech Clients Want Results - Not Confusion Every CRO I work with has great science—but clients still struggle to understand the value. Here's what I hear from biotech teams: “We’re not sure what we’re getting—or when we’re getting it.” “The science is solid, but the communication is scattered.” “The data looks fine, but it doesn’t help us make decisions.” Great science isn’t enough if clients don’t feel aligned, informed, and in control. That’s where I come in. How I Help CROs Deliver High-Impact Science That Biotech Teams Trust Biotech Clients Stay in Sync With Your Team I work to strengthen communication & collaboration: • Facilitate smoother communication between technical teams and biotech clients • Set clear expectations and deliverables to build trust and reduce delays • Align teams across roles—from assay execution to client updates Data Turns Into Decisions—Not Delays I help turn great science into clear deliverables • Define program objectives and guide assay plans that support partner decisions • Translate discovery data into clear, actionable formats biotech teams can use • Streamline deliverables to reduce review cycles and accelerate go/no-go calls & shorten timelines Your Science Stays Focused on What Matters We work together to position your CRO for growth • Refine your offering to match what biotech teams actually need • Position your services to shorten sales cycles and increase repeat business • Turn client feedback into improvements that boost trust and outcomes Here's What CROs Are Saying "Before working with Yamina, we were generating high-quality data across biotech programs but often navigating evolving expectations and goals from different stakeholders. After partnering with her, communication became clearer, deliverables were better defined, and collaboration across teams ran more smoothly. She helped streamline complex projects and made the CRO–client relationship more effective and productive." - Anne Marie Quinn, CEO Montana Molecular Frequently Asked Questions 01 What kinds of CROs do you work with? Any CRO focused on GPCRs, pharmacology, discovery biology, or antibody discovery—regardless of size or location. 02 What happens when I reach out? We'll start with a focused conversation about your programs and current challenges. You'll leave with clarity—even if we don't end up working together. 03 Can you help on an ongoing basis? Yes. I offer both short-term consulting and ongoing partnerships depending on your needs. Power My Discovery Send me a message First name* Last name Company name* Email* How Can I Help?* Send Message or Book My Call Menu Home Services About Ready to collaborate? Let’s talk about how I support GPCR discovery, pharmacology strategy, and cross-functional execution across biotech, VC, and CRO teams. Get in touch Connect LinkedIn Podcast Dr. GPCR Calendly ©2023-2025 All rights reserved by FindYooour, LLC & Dr. GPCR Corp Proudly created with Wix.com

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Fast-track your biotech investments with VC Insights. Access expert guidance, vetted CROs, and data-driven strategies to invest smarter and move faster in GPCR drug discovery. Home About Services News Get in Touch Welcome VC Insights Fast Track Your Next Biotech Bet Get decision-grade data, vetted CROs, and expert guidance—so you move fast and invest smarter. I help you avoid costly delays, choose the right experiments, and unlock clear timelines that drive confident investment. Fast Track My Discovery The wrong CRO—or wrong experiments—can burn months and millions You're not here to fund academic detours. You're backing science that needs to move fast. But too often I hear: “We thought the experiments made sense—until the data didn’t help us decide.” “The CRO promised timelines they couldn’t hit.” “The team’s updates sound polished, but we can’t tell if they’re on track.” If you’ve said any of those, you’re not alone. That's where I come in : to pressure-test the science, align the strategy, and make sure every experiment earns its place. How I Drive Value Prioritize the Right Experiments Avoid noise. I help identify the experiments that truly matter—aligned to your milestones and inflection points. Translate project strategy into clear decision-driving assays Eliminate “nice to have” tests that stall timelines without payoff Match experiments to the specific phase and risk tolerance of the asset De-risk Your CRO Strategy I evaluate, select, and manage CROs that are fit-for-purpose—saving you time, cost, and rework. Audit and compare CRO options based on speed, quality, and fit Clarify deliverables and oversight to prevent rework and misfires Serve as a scientific bridge between VC, team, and CRO Move With Clarity and Speed Every week counts. I bring structure, decision frameworks, and momentum so your team stays on track. Build plans aligned to go/no-go moments, not busywork Drive regular check-ins that produce clear, actionable updates Anticipate delays and adapt quickly with contingency-ready paths " Yamina brings scientific clarity, leadership, and precision execution to complex pharmacological programs. I’ve worked with her on several discovery programs; in fragmented programs, she brought clarity and decision points that produced much better candidate progression. I am always delighted to work with Yamina as it always leads to an overall better and harmonious discovery program." - Terry Kenakin, PhD - UNC Chappel Hill Frequently Asked Questions 01 How quickly can you get started? I begin with a 30-minute call to understand your goals. From there, I deliver a roadmap or assessment within 1–2 weeks. 02 Do you only work post-investment? No—many VCs engage me before investing to assess targets, pressure-test science, or evaluate CRO readiness. 03 What if we already have a team? Perfect. I plug in as a strategic partner—complementing internal talent to bring execution clarity and scientific rigor. Let's turn complexity into confidence—with the data you need to move forward. Chat about My Discovery Send me a message First name* Last name Company name* Email* How Can I Help?* Send Message or Book My Call Menu Home Services About Ready to collaborate? Let’s talk about how I support GPCR discovery, pharmacology strategy, and cross-functional execution across biotech, VC, and CRO teams. Get in touch Connect LinkedIn Podcast Dr. GPCR Calendly ©2023-2025 All rights reserved by FindYooour, LLC & Dr. GPCR Corp Proudly created with Wix.com

Learn about Celtarys Research through the Dr. GPCR Ecosystem. Explore their innovative GPCR projects, collaborations, and contributions to cutting-edge drug discovery. Partnership Dr. GPCR x Celtarys Reseach Empowering medicinal biochemists Celtarys empowers medicinal biochemists by providing innovative fluorescent probes that de-risk the pre-clinical drug discovery phase. Our proprietary conjugation technology and unparalleled scientific expertise ensure researchers can confidently advance their projects with greater precision and reliability. Visit Website About Celtarys Research Celtarys Research develops and commercializes new chemical tools to spread the use of fluorescence-based methods in the pre-clinical phase of drug discovery. Our proprietary chemical conjugation technology allows us to grow, in a competitive manner and in a short time (<3 months), customized fluorescent ligands with optimal pharmacological and photophysical properties for any druggable target. We have a catalogue of over 30 fluorescent ligands for different families of GPCRs, including adenosine, dopamine, serotonin, cannabinoid and muscarinic receptors. We also offer our expertise in the form of custom development services, where we tackle challenging targets and synthesize probes with the most suitable properties for your needs. Meet the Celtarys Team Wilson Gomes CEO Wilson Gomes holds a Mechanical Engineering degree, an MBA from the University of North Carolina, and completed the General Management Program at Harvard Business School. He has over 20 years of experience in the medtech and diagnostics industries, having held senior roles at Johnson & Johnson and Danaher across the EMEA region in sales, marketing, and general management. He joined Celtarys as CEO in 2024, where he is responsible for driving strategy and growth. His focus is on expanding commercial reach and accelerating the adoption of the company’s GPCR assay technologies. Maria Majellaro Co-Funder and CSO Dr. Maria Majellaro earned her degree in Pharmaceutical Chemistry and Technology from the University of Bari and completed her PhD in Biomolecular Sciences in Pharmacology and Medicine as “Doctor Europeus” in 2018. She then joined the University of Santiago de Compostela as a postdoctoral researcher in Prof. Eddy Sotelo’s group, contributing to the IGNICIA tech transfer project and the validation of Celtarys’ core technology. In 2021, she co-founded Celtarys and now leads the company’s scientific direction. Her work focuses on organic synthesis, medicinal chemistry, and the development of GPCR-targeted tools for pharma, biotech, and academic partners. Webinar Fluorescent Probes for GLP-1R and GIPR Imaging: From Cell Assays to In Vivo Systems Fluorescent tools for imaging endogenous incretin receptors across biological systems See Webinar Page Podcast Episodes See Podcast Page See Podcast Page See Podcast Page See Podcast Page Celtarys News & Updates A2A Fluorescent Competitive Binding: Advancing NanoBRET® Target Engagement for GPCR Drug Discovery The A₂A adenosine receptor NanoBRET® competitive binding assay enables real-time quantification of ligand–receptor interactions in living cells. By combining NanoLuc-tagged receptors with fluorescent tracers, this approach allows direct measurement of binding displacement, delivering robust pIC₅₀ and pKᵢ values that align with established pharmacology. In this article, we examine the assay principle, validation strategy, and performance across reference antagonists and agonis Lucía from Celtarys Research Mar 10 5 min read Illuminating C5aR Biology: The Role of Fluorescent Ligands in GPCR Research GPCRs are one of the most important families of therapeutic targets in the pharmaceutical industry. They are involved in several pathologies, ranging from neurological, oncological, degenerative, metabolic, immunological… around a third of the drugs in clinical use are GPCR ligands Lucía from Celtarys Research Feb 20 6 min read 1 2 3 4 5 Our Partnership Dr. GPCR and Celtarys Research Join Forces to Expand Access to Innovative GPCR Tools Boston, MA and Santiago de Compostela, Spain — June 3rd, 2025 — Dr. GPCR, the global knowledge hub for G protein-coupled receptor (GPCR) research and education, is proud to welcome Celtarys Research to its partner ecosystem. This collaboration aims to amplify the visibility and adoption of Celtarys’ cutting-edge fluorescent ligand technology and accelerate the development of GPCR-targeted therapeutics. Celtarys Research develops high-quality, fluorescently labeled ligands and innovative chemical biology tools to support real-time, non-radioactive GPCR assays. These tools enable high-resolution binding studies, kinetic analysis, and live-cell imaging, empowering both academic and industrial scientists to uncover GPCR biology with greater precision and speed. “We’re thrilled to partner with Celtarys and introduce their high-performance fluorescent ligands to our global GPCR community,” said Dr. Yamina Berchiche, Founder and CEO of Dr. GPCR. “These tools can dramatically improve how scientists measure ligand-receptor interactions, visualize binding in live cells, and design better experiments, core to advancing GPCR-targeted discovery.” “Dr. GPCR provides a unique platform to reach scientists at every stage of GPCR research,” said Wilson Gomes, CEO of Celtarys Research. “This partnership will help accelerate the adoption of our chemical tools and foster collaborations that turn receptor biology into therapeutic breakthroughs.” “We’re excited to support the GPCR community with tools that deliver clarity, sensitivity, and speed,” added Dr. Maria Majellaro, CSO of Celtarys. “Working with Dr. GPCR allows us to engage with researchers worldwide who are shaping the future of receptor-targeted therapies.” To explore Celtarys Research’s catalog and learn more about their GPCR tools, visit https://www.ecosystem.drgpcr.com/celtarys-research Services & Expertise NEW! High Content Screening Service Live‑cell HCS imaging in HEK‑293T–hCB2R with fluorescent ligand CELT-331; confocal capture on Operetta CLS. GPCR Expertise Specialized knowledge in adenosine, dopamine, serotonin, cannabinoid and muscarinic receptors for advanced research. Fluorescent Probes Innovative fluorescent probes that de-risk the pre-clinical drug discovery phase with optimal pharmacological properties. Custom Development Customized fluorescent ligands developed in less than 3 months with optimal properties for any druggable target. Product Catalog GPCR Ligands Our GPCR fluorescent ligands are the ideal solution for your High Throughput Screening (HTS) needs. GPCR Functional Assay Fluorescent GTPγS enables sensitive, non-radioactive GPCR activity assays for drug discovery. Custom Development Tailored fluorescent probes designed for unique research requirements. Contact Celtarys Research First name* Last name Email* Write a message Submit Get in Touch Address Avda. Mestre Mateo 2, Santiago de Compostela, 15706, Spain Email Website LinkedIn

<< Back to podcast list Strategic Partner(s) Dr. Pierre Eftekhari About Dr. Pierre Eftekhari "Clinical physiologist and biologist , with more than 25 years of experience in drug development. have been engaged in GPCR cellular and clinical pharmacology as scientist or PI in neonatal lupus, Cardiomyopathy, hypertension, chagas disease. I have participated and initiated methodologies for development of pharmacologically active anti-GPCR antibodies like agonist, antagonist, inverse agonist or blocker. During my Scholar period I have published or contributed in 38 published scientific work mainly in the field of immunology and pharmacology of GPCR. The majority of my research is concentrated on rhodopsin family with a few works on metabotropic receptor. Since the creation of Inoviem scientific in Nov. 2011 by myself we have been regularly working with GPCRs for our pharma and biotech clients. The latter mainly in target deconvolution and patient stratification." Dr. Pierre Eftekhari on the web Inoviem Scientific ResearchGate LinkedIn Twitter Dr. GPCR Unlock the Full Dr. GPCR Learning Ecosystem ✔ Full Masterclass library ✔ Terry's Pharmacology Corner ✔ Advanced GPCR courses ✔ Scientific discussions → Become Premium Upcoming Live Expert Sessions ➚ 🔒Explore the Full Masterclass ➚ Enjoying the Dr. GPCR Podcast? Leave a Review. Leave a quick review to help more scientists find the show—and help us keep improving every episode. It takes <60 seconds and makes a big difference. ★ Review on Apple Podcasts ★ Rate on Spotify ✉️ Send feedback to the team Thanks for listening to this podcast episode Follow us on your favorite Podcast Player << Previous Podcast Episode Next Podcast Episode >>

<< Back to podcast list Strategic Partner(s) Dr. Jean-Philippe Pin About Dr. Jean-Philippe Pin Jean-Philippe Pin participated in the discovery of metabotropic glutamate receptors. Since then, he has been studying the allosteric modulation and activation mechanism of this family of G protein-coupled receptors using innovative approaches, including biosensors, cryo-EM, photoswitchable ligands, and nanobodies as pharmacological tools and potential therapeutic agents. His studies led to new concepts in the GPCR field, such as the activation of cell surface receptors by intracellular proteins; the regulation of GPCRs by both negative and positive allosteric modulators, and the asymmetric functioning of GPCR dimers. Dr. Jean-Philippe Pin on the web LinkedIn ResearchGate CNRS Fondation Bettencourt Schueller FRC Neurodon Dr. GPCR Ecosystem Unlock the Full Dr. GPCR Learning Ecosystem ✔ Full Masterclass library ✔ Terry's Pharmacology Corner ✔ Advanced GPCR courses ✔ Scientific discussions → Become Premium Upcoming Live Expert Sessions ➚ 🔒Explore the Full Masterclass ➚ Enjoying the Dr. GPCR Podcast? Leave a Review. Leave a quick review to help more scientists find the show—and help us keep improving every episode. It takes <60 seconds and makes a big difference. ★ Review on Apple Podcasts ★ Rate on Spotify ✉️ Send feedback to the team Thanks for listening to this podcast episode Follow us on your favorite Podcast Player << Previous Podcast Episode Next Podcast Episode >>

Beatriz Blanco-Redondo on characterizing unknown adhesion GPCRs in Drosophila - receptor discovery, nocifensive behavior, and human disease links. << Back to podcast list Strategic Partner(s) Beatriz Blanco-Redondo: Adhesion GPCR Discovery in Drosophila Adhesion GPCRs are among the least characterized receptor families in the human genome , and in Drosophila Melanogaster, three of the five known adhesion GPCRs had no documented function, expression pattern, or signaling profile when Beatriz Blanco-Redondo's group began working on them. The receptors were named after condiments, ketchup, mayo, and remulate, not out of irreverence, but because no functional data yet existed to guide any other kind of nomenclature. Blanco-Redondo, group leader at the University of Leipzig, uses CRISPR engineering and in vivo behavioral assays to build the first systematic characterization of these receptors from the ground up. Her primary focus is Remulate, a neuronal adhesion GPCR with a human ortholog linked to vascular malformations and blood-brain barrier dysfunction in vertebrate models. The fly system makes it tractable: new lines in weeks, knockouts in months, and behavioral readouts that connect receptor loss to nocifensive phenotypes in larvae. For Blanco-Redondo, the pull toward this work is not abstract. Remulate is the receptor she secured funding to study, the one her first PhD student built an entire project around, and the one that still does not have a complete localization map. This conversation covers what it looks like to do receptor biology when you are writing the first chapter, without antibodies, no prior literature, and no established toolkit to fall back on. About the Guest Beatriz Blanco-Redondo is a group leader in the Department of Biochemistry at the University of Leipzig, where she studies adhesion GPCRs in Drosophila melanogaster. Her research focuses on characterizing the localization, signaling, and in vivo function of previously unknown adhesion receptors in the fly nervous system and gut. She trained in protein biochemistry and neuroscience, completing her PhD in Germany and her postdoctoral work at Columbia University, where she worked on ALS models using mouse systems. Since returning to Europe, her research has centered on receptor biology at the intersection of basic discovery and translational relevance. Scientific Themes of the Conversation First-contact receptor characterization, what it means to study a GPCR with no prior functional data Genetic tools for adhesion GPCR research in Drosophila, CRISPR, epitope tagging, and knockout strategies The logic of model organism selection : speed, genetic tractability, and translational value Nocifensive behavior as a readout for neuronal receptor function in larvae Human ortholog connections, from fly adhesion GPCRs to vertebrate vascular and neurological disease Career decisions in academic science, uncertainty, reentry, and the conditions that keep scientists in the lab Key Insights from the Conversation 1. Three adhesion GPCRs in Drosophila were functionally unknown until recently When Blanco-Redondo's group began this work, five adhesion GPCRs were known in the fly, but only two had any functional characterization. The other three had no documented expression pattern, signaling data, or phenotype. The approach was systematic: generate knockouts, introduce epitope tags, observe what breaks, and build the picture from scratch. There was no shortcut available because there was no prior literature to build on. 2. Naming receptors after condiments signals where the field actually stands Ketchup, Mayo, and Remulate were named in the absence of functional data that would normally guide nomenclature. It is a small detail, but it marks something real about the state of adhesion GPCR biology in insects: these receptors exist in a space where the biology precedes the vocabulary. The playfulness of the naming reflects the honesty of the situation. 3. Remulate connects fly neuroscience to human vascular and neurological pathology In the peripheral nervous system of Drosophila larvae, loss of Remulate disrupts nocifensive behavior - the animal's response to aversive stimuli. The human ortholog has been associated with vascular malformations and blood-brain barrier dysfunction in vertebrate models. That thread, from a behavioral assay in a fly larva to a clinical phenotype in mice, is what gives the model system its translational justification. 4. Antibody limitations drive the methodological design Because the antibody landscape for adhesion GPCRs is sparse and largely underdeveloped for fly receptors, Blanco-Redondo's group relies on CRISPR-introduced epitope tags to track receptor localization in vivo. This is not a workaround. It is a deliberate strategy that delivers spatial resolution that antibody-based approaches cannot offer for these targets at this stage of the field. 5. Drosophila generations close the experimental feedback loop A new fly line is ready in one to two weeks. A knockout can be generated and validated in two to three months. For receptor biology that requires iterative genetic manipulation - knocking out, tagging, rescuing, observing, this compression of experimental time changes which questions are tractable within a single grant period. It is not incidental to the science; it is part of the scientific logic. 6. Reconsidering a career is not the same as leaving science Blanco-Redondo describes a period after returning from New York when she was genuinely uncertain about continuing in the lab. The decision to stay came from a specific opportunity, a specific mentor, and a specific set of questions she hadn't yet answered. It did not resolve into a clean narrative. It was uncertain, and she says so plainly. 7. Negative results need infrastructure, not just tolerance Blanco-Redondo and Berchiche discuss the cost of unpublished negative data, particularly for PhD students working within three-year funding windows. The argument is not sentimental. If a failed approach were citable, it would shorten the path for the next researcher attempting the same thing. Some journals are beginning to accept negative data, and both agree this matters structurally. Episode Timeline Timestamps are AI-generated from the transcript and may not reflect the final edited episode precisely. Verify against the published video before use. 00:00 - Sponsor intro: GeneTex and Eurofins DiscoverX 00:29 - Introduction of Beatriz Blanco-Redondo; icebreaker 01:15 - Career path: from Spain to Germany, and the decision to go further 05:57 - Dr. GPCR University mid-roll 06:17 - Life in New York; comparing research cultures across continents 08:30 - How adhesion GPCRs entered the picture, and the shift toward receptor biology 11:49 - Research program in Leipzig: three unknown adhesion GPCRs in Drosophila 13:57 - Naming Remulate, ketchup, and mayo; why Remulate became the primary focus 15:47 - Lab methods: CRISPR, epitope tagging, colony generation timelines 17:29 - Behavioral and phenotypic readouts; nocifensive responses in larvae 18:48 - The human ortholog of Remulate and connections to vascular and neurological disease 22:58 - What first-contact receptor characterization actually looks like 26:02 - Career turning points; uncertainty on returning from the US 33:25 - Advice for scientists working on adhesion GPCRs and difficult model systems 35:26 - The case for publishing negative results; pressure on PhD timelines 40:54 - Upcoming GPCR conferences in Leipzig and Dusseldorf Selected Quotes "It's like there's nothing known at all about this receptor. And then you come into play and piece by piece you try to put the pieces together - it's like a puzzle. And then at the end, you can discover what a receptor that was there in the fly - nobody ever checked what it's doing." "When I moved back from the US, I was not sure I wanted to continue in science. Thanks to Toby, that gave me a position here, and I could stay. Yeah, I'm still here - so it means that I enjoy it." "You come from disease and then you're working on a receptor and you want to study what happens there. But then to see all the possibilities that this offers - that was also great." "Don't give up, because it's your passion, it's your job. We love what we do. And we have a lot of friends who don't like what they are doing. And this is very important." Unlock the Full Dr. GPCR Learning Ecosystem ✔ Full Masterclass library ✔ Terry's Pharmacology Corner ✔ Advanced GPCR courses ✔ Scientific discussions → Become Premium Upcoming Live Expert Sessions ➚ 🔒Explore the Full Masterclass ➚ Enjoying the Dr. GPCR Podcast? Leave a Review. Leave a quick review to help more scientists find the show—and help us keep improving every episode. It takes <60 seconds and makes a big difference. ★ Review on Apple Podcasts ★ Rate on Spotify ✉️ Send feedback to the team Thanks for listening to this podcast episode Follow us on your favorite Podcast Player << Previous Podcast Episode Next Podcast Episode >>

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Join the Adhesion GPCR Workshop 2024 in Mexico City at CINVESTAV, bringing together researchers to explore the latest in GPCR science. Welcome to the Adhesion GPCR Workshop 2024 , hosted in the vibrant heart of Mexico City at the prestigious venue, CINVESTAV - Centro de Investigación y de Estudios Avanzados del IPN (in English: Center for Research and Advanced Studies of the National Polytechnic Institute). About the venue Cinvestav: Centro de investigación y de Estudios Avanzados del IPN Av. Instituto Politécnico Nacional no 2508 Mexico City, C.P. 07360 Room: Auditorium Arturo Rosenblueth *Have an ID card ready (Passport, Driver's license, etc), as this will be required at the venue entrance Register now to join the exclusive Adhesion GPCR Workshop group and stay updated with all the latest event news. Preliminary Program Layout Date Time Title October 23, 2024 October 24, 2024 October 25, 2024 *Flash Presentations: 10 min *Talks 20 min (15 min+ 5 min questions Everything you need to know about the event Listen to Dr. Antony Boucard and Dr. Yamina Berchiche at the Dr.GPCR Newsletter Meet the Organizers behind the AGPCR24 Antony Boucard Jr, PhD Host and Organizer Cinvestav, Mexico City Yamina Berchiche, PhD Co-organizer Dr. GPCR, Boston Andreína Martín Website & Social Media Coordinator Dr. GPCR, Boston Ivanna Rey Executive Assistant Dr. GPCR, Boston

Discover Media Partner Packages with Dr. GPCR Ecosystem. Amplify your brand, reach a targeted scientific audience, and showcase your organization in the GPCR community. The Yearly Glow Only 12 companies per year are invited to become Yearly Glow partners. This isn't advertising — it's a strategic partnership that puts your brand at the center of the scientific conversations that matter most. 1,400+ GPCR scientists reached 25–50% Newsletter open rate 12 strategic partnerships per year — because quality matters Partner with us Today! Who Media Partnerships Are For? Companies that think in years, not quarters Strategic Media Partnerships are ideal for GPCR-focused companies that want to: Strengthen brand credibility and recognition within the GPCR research community Associate their brand with high-quality science, experts, and long-term ecosystem initiatives Be consistently visible across trusted educational and content platforms Build awareness and trust over time — not chase immediate leads If your primary goal is to drive inbound inquiries or make your services discoverable at the point of need, the GPCR CRO Bank may be a better fit. "Dr. GPCR is the world's largest nonprofit community focused on GPCRs. As a strtegic partner, you'll gain trusted access to an engaged audience of academic researchers, biotech teams, and drug discovery innovators — without having to fight for attention." Why Partner with Dr. GPCR? Featured across our nonprofit platform, trusted by thousands As a media partner, you'll be featured across our nonprofit platform, trusted by thousands of GPCR scientists and biotech professionals. Reach Qualified Researchers Connect with scientists who are actively looking for tools like yours, without the noise of general platforms. Build Trust Develop content that speaks their language and establishes your credibility in the GPCR research community. Join a Curated Ecosystem Become part of a collaborative, curated ecosystem — not just another name on a crowded vendor list. What You Get as Media Partner? Active visibility, not passive placement These touch points are designed to reinforce brand presence and credibility through repeated, trusted exposure — not direct lead generation. Yearly Glow Exclusive Gated Content Premium content assets created in partnership — gated to capture and nurture scientist engagement while contributing genuine value to the community. Strategy Partnership Ongoing strategic collaboration to align visibility initiatives with your goals and the community's needs. Launch Campaigns Strategic campaigns that actively drive scientist awareness and traffic toward your offerings, timed to maximize community attention. Logo Positioning Strategic Partner logos are featured across multiple high-traffic ecosystem pages, creating repeated visual association with trusted GPCR content and resources. Base Package — Included 🎙️ Featured Podcast Episode ✓ Be the guest on a dedicated episode of the Dr. GPCR Podcast ✓ Feature up to 3 team members to share your story ✓ Distributed across podcast platforms and social media ✨ Logo positioning ✓ Strategic Partner logos are featured across multiple high-traffic ecosystem pages, creating repeated visual association with trusted GPCR content and resources. 📣 Social Media Promotion ✓ Engaging posts about your organization ✓ Targeted to GPCR researchers and biotech professionals ✓ Shared on LinkedIn and X (Twitter) 📝 Blog Contributions ✓ Contribute to blog posts on the Dr. GPCR platform as a valued partner ✓ Share insights on product launches, scientific discoveries, or customer stories ✓ Reach a targeted scientific audience with your contributions. 📄 Custom Company Page ✓ Permanent company profile on the Dr. GPCR Ecosystem ✓ Logo, branding, and description of your mission ✓ Contact links and key highlights 📬 Newsletter Visibility ✓ Featured in our highly read weekly newsletter ✓ Tell your story with context, clarity, and purpose ✓ Bonus: Mentioned in podcast intros/outros 👩🔬 Premium Licenses ✓ 10 Scientists Premium Accounts ✓ 3 Non-Scientists Premium Accounts 🎤 Co-Branded Events & Training ✓ Collaborate on webinars and virtual training sessions to showcase your expertise ✓ Host educational events that focus on GPCR research ✓ Engage directly with the GPCR research community through these initiatives 12 per year — a commitment to quality Only 12 Yearly Glow seats are available each year to keep our ecosystem curated, impactful, and community-focused. Every partner deserves dedicated attention, personalized strategy, and genuine integration. This is real selectivity — a reflection of how seriously we take partner quality and community trust. Previous Partners Join these leading organizations Join these leading organizations in the GPCR research ecosystem. Book Book a 30-minute Strategy Call with Yamina Ready to Connect with the GPCR Community? With only 10 spots remaining for 2026... Secure your place in our exclusive media partner program today.

Share your thoughts and help shape the future of the Dr. GPCR Ecosystem. Your feedback guides improvements, new features, and community resources. Dr. GPCR Community Survey Help us build the next evolution of the GPCR Ecosystem — together. Every opinion counts. Whether you’ve joined our University sessions, explored our Job Board, or attended a Happy Hour, your feedback shapes what comes next. Let’s make Dr. GPCR more useful, connected, and inspiring for everyone in the field. 👉 Take the Survey Now Why Your Feedback Matters? We’re growing — and your input helps us grow in the right direction. By sharing your thoughts, you directly influence how we design new features, events, and educational programs. Your responses help us: Improve the Dr. GPCR University curriculum and resources. Make Retreats and Happy Hours more valuable and accessible. Build stronger connections between academia and industry. Develop new tools, training programs, and mentorship programs tailored to your specific needs. Your Voice Shapes Our Future Dr. GPCR was founded to bring the GPCR community together — and every survey response helps us strengthen that mission. This isn’t just a form — it’s how you influence the next generation of education, collaboration, and discovery. 💡 Start the Survey What We’d Love to Learn? We’ve grouped the questions into three sections so your feedback can make a real impact: 1. Your Experience How often do you use the Dr. GPCR platform? Which programs do you engage with most? (University, Retreat, Job Board, Newsletter, etc.) What has been your favorite experience so far? 2. Your Needs What topics or training modules would you like us to add next? What challenges do you face most in your research or biotech journey? How can we facilitate easier collaboration within the community? 3. Your Feedback How likely are you to recommend Dr. GPCR to a colleague? (1–10) What would make your experience even better? Any ideas, suggestions, or features you’d love to see in 2026? Survey 🙏 Thank You for Being Part of the Ecosystem Your feedback helps us: Keep events free or affordable Expand our shared knowledge base Support students and researchers entering the field Together, we’re building a home for everyone passionate about GPCR research and innovation.

Discover the incredible benefits of the Dr. GPCR University. ​All these benefits are designed to enhance your research experience and keep you informed about the latest developments in GPCR science.​ 🎓 Dr. GPCR University Your Professional Home in GPCR Science Join the community where GPCR researchers learn, connect, and advance together — with expert-led courses, live masterclasses, and career tools built for you. Which best describes you? Select your situation and we'll show you the best plan. I am a... Free Membership Stay connected with the weekly brief, podcast, and public resources. $0 Forever Join for Free Academic Teams Earn full Premium access for your students by teaching a GPCR course within the University. Free Apply as an Instructor Developing Countries Full Premium access for researchers in developing countries. 90% discount, subject to verification. $24.99/year Check Eligibility 14-Day Trial Experience everything the University offers for 14 days. No commitment beyond the trial. $49 14-Day Trial Start Your 14-Day Trial Premium for Teams Unified access for your whole team. 25% discount, minimum 5 seats. $374.25/year Per person Get Your Team Discount Premium Yearly Gift yourself a Premium Membership with a $500 donation to the Dr. GPCR Ecosystem — a 501(c)(3) nonprofit. Tax-deductible. $500/year Less than $10/week Donate & Join Premium Premium Yearly Full access to expert courses, live masterclasses, career tools, and the GPCR community. Easy to expense — we provide a receipt for reimbursement. $499/year Less than $10/week Join Premium Below👇 Team Access for Discovery Groups Full University Premium + Terry's Pharmacology Corner for your entire discovery team. Built for teams aligning pharmacology across programs — so everyone works from the same expert-led foundation. $2,249.25/year Per person, min 5 seats ( 25% team discount ) Get Team Access Premium + Terry's Pharmacology Corner Get full University & Dr. Terry Kenakin's pharmacology access with monthly AMA's — the complete GPCR learning experience in one membership. $2999/year Per person Get the Bundle 🔥 Upgrade to Premium Premium Yearly $499 $ 499 Every year 🚀 Everything you need to master GPCR science — in one membership. Valid until canceled Join Premium Today! 🎓 Full GPCR University + 🔬 200+ expert talks 🗞️ Weekly research, careers & event intelligence 🤝 Members-only networking, AMAs & matchmaking 💡 Support open resources for the global GPCR field 🧠 Designed for researchers at every career stage 🚀 Don’t just keep up — lead the way. 🔒 Grandfather Guarantee, your rate never increases Need access for your whole organization? Find the right plan for your team — from small groups to institution-wide access. Explore Team Options → Why is it Worth It? Common concerns and why Premium delivers exceptional value "It's too expensive." At less than $10 a week, University gives you live access to leading GPCR scientists, 200+ on-demand talks, premium intelligence, a job board, events calendar, and a global community of peers. One insight, one connection, one 'aha' moment — can save months of research time. "I already get what I need from papers." Papers inform. University helps you understand and apply that knowledge — through expert context, structured scientific exchanges, and real interaction with peers from academia and industry. "I'm not sure I'll use it often." Even one Masterclass or one new collaboration can make a difference. Members often find value in ways they didn't expect — from expert feedback to career-changing introductions. That's why we offer a 14-day trial, so you can experience it first. "Will this really help my career?" Yes. Members grow visibility, confidence, and connections that open doors. It’s not just about learning — it’s about being seen, supported, and part of something bigger . Premium Membership Benefits Everything you need to stay at the forefront of GPCR research and advance your career. Expert-Led GPCR Courses 200+ Expert Talks Events & Jobs Board Complete GPCR Coverage Community Tools Career Matchmaker Member feedback What scientists say after the session ends Unedited feedback from anonymous post-session surveys. We don’t ask for names — so people tell us what they actually think. What members are saying · AI-generated summary of member reviews Learners consistently describe Dr. GPCR Masterclasses as a rare chance to learn directly from leading GPCR pharmacologists, and they’re struck by how well these experts teach. Reviewers praise courses that balance theoretical depth with practical knowledge, and say instructors understand both the technical and the human challenges of lab work. In a field where literature can be overwhelming and AI-generated answers aren’t always reliable, members value live discussion and expert feedback on their own questions. Many say they’ll keep Dr. GPCR in their professional toolkit and hope to see more live Masterclasses on more topics. Themes members mention most Expert instructors who are also gifted communicators Depth of theory paired with practical, lab-ready knowledge Live Q&A sessions that exceed expectations Value for scientists who teach pharmacology, not just those who practice it A strong desire for more live Masterclasses on more topics “GPCR research can be overwhelming, with countless papers to review and AI-generated answers that aren't always reliable. The Dr. GPCR Masterclass gave me direct access to experts with decades of experience, allowing me to clarify complex scientific questions through live discussion and follow-up Q&A. The opportunity to get expert feedback on GPCR-related challenges made this a 10/10 learning experience. I’d love to see more live Masterclasses covering a wider range of scientific topics.” Masterclass attendee The content had enough depth to satisfy the hunger for theory while being full of practical knowledge. Masterclass attendee The course was very practical and easily translatable to experiments that we could do in our own labs. It was clear that Dr. Hoare is very in touch with the technical and human challenges we encounter in our work. Masterclass attendee The best pharmacology teacher teaming up with the best GPCR community platform to help train and inspire the next generation of scientists. Suzanne Levis Dr. Kenakin is a leading expert in the field. Aside from his vast experience in drug development, not to mention his extensive publication record, Dr. Kenakin is a masterful teacher and communicator. Masterclass attendee Dr. Hoare’s extensive and elaborative explanation of the topics at hand was excellent and very digestible. Thoroughly enjoyed learning from him. Masterclass attendee Thank you for bringing this course with Dr. Kenakin. I wish Dr. GPCR the best for the sake of promoting more educational opportunities that are sorely needed in the fieldellent and very digestible. Thoroughly enjoyed learning from him. Masterclass attendee Frequently Asked Questions Premium Pricing University What is Dr. GPCR Premium? Dr. GPCR Premium is a membership program that gives scientists, students, and industry professionals access to expert GPCR courses, 200+ research talks, career resources, and a global network of GPCR specialists. Who should join Dr. GPCR Premium? Researchers, biotech professionals, CRO teams, students, and anyone seeking deeper insights, networking opportunities, and tools to accelerate GPCR-related research and career growth. What’s included in the Premium membership? 20+ expert courses Complete GPCR coverage 200+ research talks Virtual Café Access Job board access and career tools Networking through the Dr. GPCR community Exclusive partner discounts and events How does Premium differ from the free membership? Free members get limited access to talks and resources, while Premium members enjoy full GPCR content, unlimited event replay access, and advanced networking and career tools. How much does Premium cost? Choose a package that works for you here. Is there a monthly payment option? Currently, the membership is billed annually for maximum savings and uninterrupted access. Choose a package that works for you here. Are the courses self-paced? Yes. All courses and talks are available on-demand so you can learn anytime. Can I register my entire team for Premium? Yes. The Team plan offers discounted rates for groups of 5 or more. Do you offer discounts for students or developing countries? Yes. Members from developing countries can join for $24.99/year. Students please reach out to hello@drgpcr.org What happens after I join? You’ll receive instant access to all Premium resources, your member dashboard, and exclusive community tools to start networking and learning right away. Ready to Join the Community? Start with a 14-day trial and experience everything the University has to offer. Start Your 14-Day Trial — $50

xperience everything inside Dr. GPCR University for 14 days. Live Masterclasses, 200+ recordings, the GPCR Intelligence Hub, job listings, and a 1,400+ scientist community. $49 — credited toward your first year if you stay. 🎓 Dr. GPCR University See what it feels like to have a professional home in GPCR science 14 days. Full access. Everything inside University — Masterclasses, intelligence, jobs, community. And if you stay, your trial fee comes back as a credit. $49 14-days of full Premium access Credited toward your first year Start Your 14 Days Your $49 becomes a credit toward the $499/year membership. You pay $450 if you stay. 1,400+ Scientists in the community 200+ Recordings $0 Net risk if you convert The Hook The Masterclass alone is worth the trial Live sessions with leading GPCR scientists. Ask your question. Be in the room. This is the single experience that makes people realize what University is worth — and it's yours from day one of the trial. What's Inside Everything University members have. Nothing held back. For 14 days, you're not testing — you're experiencing what it's like to have a professional home in GPCR science. Live Masterclasses Monthly sessions with leading GPCR scientists. Ask questions, hear perspectives, be part of the scientific conversation — live. Premium Weekly News Curated GPCR intelligence with job listings, events calendar, and classified industry news that free members don't see. 200+ On-Demand Recordings Every past Masterclass, searchable and organized. Filter by category, level, or instructor and learn at your pace. Community & Forum Ask the Ecosystem. Connect with peers. Access the full member network of 1,400+ GPCR scientists worldwide. GPCR Intelligence Hub The most comprehensive searchable GPCR resource archive in the field. Every resource, every tool — filterable and at your fingertips. Job Listings & Events GPCR-specific positions and upcoming events curated for the community. See what's opening in your field — before everyone else. The Math Your trial fee is never lost The $49 comes back as a credit. Either way, you win. Your $49 becomes a coupon. The trial fee becomes an investment, not an expense. You Already Belong The trial opens the rest of the house If you're reading the Weekly News, listening to the podcast, or you attended a Happy Hour — you're already part of this community. Walk in. Weekly News reader - Podcast listener - Happy Hour attendee 🔥 Upgrade to Premium 14-Day Full Access Trial $49 $ 49 Get 14 days of full access to Dr. GPCR University for $49. Explore expert-led masterclasses, curated intel, and a scientific community shaping GPCR drug discovery. Valid for 14 days Join Premium Today! On-demand masterclass library Weekly curated intelligence briefings with expert analysis Community access — connect with scientists and biotech leade Full resource library and member tools Priority invitations to live expert Q&A sessions "The conversation you have inside a Masterclass — that alone changes how you think about your work. University is where GPCR scientists come to stay sharp." — Jay, Dr. GPCR University Member The Comparison A society membership costs more and gives you less Here's what $450 (net after trial credit) gives you inside Dr. GPCR University compared to a typical scientific society. Questions Before you walk in What do I get during the 14 days? Full Premium access to everything inside University — live Masterclass sessions, 200+ on-demand recordings, the GPCR Intelligence Hub, Premium Weekly News with job listings and events, Ask the Ecosystem forum, and the full member network. Nothing is restricted. What happens to my $49 if I become a member? It becomes a credit. You receive a $49 coupon toward the $499/year membership, so your net cost for the first year is $450. Your trial fee is never lost. Is this a free trial? No — and that's by design. The $49 means you're serious, and we're serious about giving you the full experience. Nothing is held back. You get everything Premium members have for 14 days. Can I start anytime? Yes. Your 14 days begin when you start. The trial is not tied to a specific Masterclass date — though starting near a live session means you'll get the highest-impact experience. What happens when the 14 days end? You'll receive a $49 coupon toward the $499/year membership. If you stay, you pay $450 for your first year. If you don't, you've spent 14 days with full access to the most comprehensive GPCR ecosystem in the field. Either way, you win. How does this compare to a society membership? Most GPCR-relevant society memberships cost $200–$600+ per year and offer a fraction of what University includes. Monthly live Masterclasses, a searchable intelligence archive, curated job listings, a weekly premium news digest, and a focused community — all for $450 net after trial credit. Come in. See if it's home. 14 days. Full access. $49. And if you stay, it comes back as a credit toward your first year. Start Your 14 Days $49 credited toward $499/year membership · Net cost $450 if you stay

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Discover the essence of GPCR Retreat, an international GPCR Event that empowers the GPCR field. GPCR Reatreat The GPCR Retreat focuses on advances in our understanding of how GPCRs operate in cell communication. The main goal of the GPCR Retreat is to provide a venue for students, post-doctoral fellows, and principal investigators from academia and industry to discuss and debate existing and novel concepts in GPCR biology. One of the core values of this international meeting is to promote interactions among all participants of all diversity backgrounds, particularly between trainees and principal investigators. Each year, approximately 2/3 of the participants are trainees. Registration to the GPCR Retreat is capped at 200 participants to promote an intimate environment. Most importantly, the GPCR Retreat dedicates time for two trainee symposia, an initiative that began in the Ottawa 2017 edition, to showcase the breadth of diversity in GPCR trainee communities. For the Ottawa 2017 GPCR Retreat, of the ten talks from trainees 80% were from women and 60% from visible minorities. Over the years, the meeting has grown into one of the most recognized international events in the field. That reputation has led to broad participation from the Great Lakes region and beyond. Conference History The GPCR Retreat is an annual joint meeting with the Club des récepteurs à Sept Domaines Transmembranaires du Québec that rotates around locations in Canada and the United States surrounding the Great Lakes region. The first Great Lakes GPCR Retreat was conceived, organized and held in London, Ontario, Canada in October 1999. The following year, the Great Lakes GPCR Retreat partnered with the annual symposium of the Club des Récepteurs à Sept Domains Transmembranaires du Québec. The meeting tours through many of the major universities in the Great Lakes region in both Canada and the United States. The past few GPCR retreats have been held in: - Niagara-on-the-lake (2022) - Bromont, Québec (2019) - Detroit, Michigan (2018) - Ottawa, Ontario (2017) - Chicago, Illinois (2016) - Toronto, Ontario (2015) - Bromont, Québec (2014) - Cleveland, Ohio (2013) London, Ontario (2012) Fairmont Le Château Montebello, Québec, Canada November 2-4, 2023 We are pleased to welcome you at Le Château Montebello, the 22nd Annual Great Lakes G Protein-Coupled Receptor Retreat held jointly with the Club des Récepteurs à Sept Domaines Transmembranaires du Québec. The meeting will be held on Nov. 2-4, 2023 at the Chateau Montebello, Québec. The Chateau Montebello is an exceptional venue, and is located 1 hr from Ottawa, or 1.5 hr from Montreal in the beautiful Laurentian Mountains of Canada. The fall colors of the leaves are spectacular, and the weekend of science is an intense and interactive experience, and a great training environment for our students and post-doctoral fellows. The meeting is launched on Thursday with two Trainee Symposia and the Plenary Lecture, followed by 6 symposia on Friday and Saturday and the closing Keynote Lecture. The deadline for registration is September 21, 2023. For the 22nd edition, the Organizing Committee has again lived up to the expectations by putting together an outstanding program with a special thought for Marc Caron (1946-2022) to commemorate his great contributions to the GPCR and Neurosciences fields. Dr. Kathleen Caron of the University of North Carolina at Chapel Hill, unquestionably one of the pioneers involved in deciphering how receptor activity-modifying proteins or RAMPs regulate GPCR function, is confirmed as Plenary Speaker of the inaugural Marc G. Caron keynote lecture on November 2nd. Additionally, there will be a Marc G. Caron Honorary Symposium by Caron Lab alumni to honor his memory. We have also confirmed Dr. Arthur Christopoulos of Monash University in Australia, one of the pioneers in the medicinal chemistry, computational and mathematical modelling of GPCRs, as Plenary Speaker of the Hyman B. Niznik keynote lecture, which will close the conference. The program will include also world-class and diverse GPCR scientists working in the arenas of structure and signaling, neuroscience, cancer, translational and model systems. As in previous editions, trainees are more than welcome to this unique meeting. Indeed, for the Montebello 2023 edition, we have organized two trainee symposiums to acknowledge formally the participation of our graduate students and post-doctoral fellows. Additionally, each symposium of the GPCR Retreat 2023 will include one trainee short talk selected from abstracts. Trainees of diversity groups are strongly encouraged to register to the meeting and submit an abstract for consideration for the trainee symposia and selected trainee short talks. Your participation has already made this unique event a success. We are thrilled by the overwhelming interest in this event by the GPCR research community. We trust that the collegial and intimate atmosphere provided by Le Château Montebello will be suited for an environment where graduate students, postdoctoral fellows and principal investigators can have stimulating discussions and debates on GPCR research presented at this meeting. We would like to thank all our Sponsors for their ongoing generous support of the meeting. Without their support, this meeting will not be possible. If you have any suggestions or comments for either this Retreat or future meetings, we look forward to receiving your feedback. Finally, Bienvenue and we hope you will enjoy your stay in Montebello and find the Retreat stimulating and satisfying. Sincerely, The Organizing Committee GPCR Retreat Organizers

<< Back to podcast list Strategic Partner(s) Dr. Simone Prömel & Dr. Ines Liebscher About Dr. Simone Prömel Simone Prömel is currently a professor of cell biology at the Heinrich Heine University Düsseldorf, Germany. Being a biochemist by training, she completed her Ph.D. at the Institute of Biochemistry at the University of Oxford, UK. During this time, she discovered her love for Adhesion GPCRs and started delineating the molecular mechanisms of the Adhesion GPCR Latrophilin-1. These extraordinary receptors, about which there was not much known other than that they are huge and somehow play important roles in health and disease, fascinated her so much that she continued working on them when she started her own lab at Leipzig University. There she focused on the different modes of action of Adhesion GPCRs and found that they do not only mediate classical G protein signals into cells but can also communicate solely via their N termini. Today, she and her team are working on the questions of how Adhesion GPCRs integrate the different signals on a molecular level and how these are translated into physiological functions in various model organisms. Together with Ines Liebscher, Simone is leading an EU-funded COST Network on Adhesion GPCRs: CA18240 Adher´n Rise. Dr. Simone Prömel on the web Prömel Lab Pubmed Researchgate Twitter Dr. GPCR Ecosystem About Dr. Ines Liebscher Dr. Liebscher is a Professor at the Rudolf Schönheimer Institute of Biochemistry at the Medical Faculty of the Leipzig University. During her medical studies in Leipzig, she had her first encounter with an orphan GPCR as the subject of her MD thesis. Being faced with the vast unknown biochemical and pharmacological territory that would be helpful to study orphan receptors she enrolled in the MD/Ph.D. program of Leipzig University. Her postdoctoral work leads her to investigate a whole family of orphan receptors: adhesion GPCRs. With the little knowledge on these receptors available, there were multiple questions to tackle. Starting with proving and characterizing G-protein coupling, Ines spends several years studying the activation mechanism of adhesion GPCRs. In collaboration with great fellow adhesion GPCR scientists around the globe she established a tethered agonist -extracellular matrix- mechano-activation- activation scenario that forms the basis for her current projects that focus on the structural and physiological implications of these findings. Together with Simone Prömel, Ines is leading a COST Network on adhesion GPCRs: CA18240 Adher'nRise. Dr. Ines Liebscher on the web Website LinkedIn Researchgate Dr. GPCR Ecosystem Unlock the Full Dr. GPCR Learning Ecosystem ✔ Full Masterclass library ✔ Terry's Pharmacology Corner ✔ Advanced GPCR courses ✔ Scientific discussions → Become Premium Upcoming Live Expert Sessions ➚ 🔒Explore the Full Masterclass ➚ Enjoying the Dr. GPCR Podcast? Leave a Review. Leave a quick review to help more scientists find the show—and help us keep improving every episode. It takes <60 seconds and makes a big difference. ★ Review on Apple Podcasts ★ Rate on Spotify ✉️ Send feedback to the team Thanks for listening to this podcast episode Follow us on your favorite Podcast Player << Previous Podcast Episode Next Podcast Episode >>

Get ready to connect, collaborate, and innovate at the Dr. GPCR Retreat — an immersive event uniting scientists, biotech leaders, and innovators in GPCR research. Dr. GPCR Retreat - Coming Soon - Please tell us your thoughts about scientific gatherings by filling out this short survey

Discover how Timeline Strategy helps GPCR innovators scale their organizations through strategic planning, effective systems, and operational clarity. Home: Welcome Timeline Strategy x Dr. GPCR — Scaling Biotech Beyond the Bench Turning scientific excellence into scalable organizations. We help GPCR innovators design systems, strategies, and operating frameworks that drive predictable growth. See how we can help you About Timeline Strategy Founded by Attila Foris, Timeline Strategy partners with science-driven teams to bridge the gap between innovation and execution. Our work helps biotech startups, research organizations, and CROs design operating systems that enable clarity, accountability, and scale. Core themes: Strategic Planning for Biotech Growth Operational System Design (OS) Cross-functional Team Alignment Scaling Protocols & Decision Architecture From Chaos to Scale Timeline Strategy built to execute, not decorate slides Most strategies die in PowerPoints. Timeline Strategy lives in execution. In 3 fast steps , we turn your bottlenecks into momentum: 1. Diagnose the mess → where your growth stalls. 2. Build clarity → align people, process, priorities. 3. Scale with confidence → expand without burnout. Building the Strategic Backbone of GPCR Innovation In the rapidly evolving GPCR field, scientific progress alone isn’t enough — sustainable growth requires operational precision. Together with Dr. GPCR, we help organizations: ✅ Clarify vision and direction ✅ Translate research milestones into measurable objectives ✅ Build internal systems and workflows that support scale ✅ Create investor-ready operating structures Our Partners Benefit From: Strategy Audits & Growth Frameworks Operating System (OS) Implementation Leadership Alignment Sessions Scalable Team Protocols & Processes From the Strategy & Operations Blog The Hidden Cost of Ambition in Biotech Leadership 👉 Ambition is the default setting of biotech. Platforms expand. Indications multiply. New opportunities appear constantly. That is not a flaw. It is the nature of scientific possibility. 👉 The problem begins when ambition grows faster than structure. What feels like momentum can quietly become dilution. More programs. Broader roadmaps. Increasing complexity. And slowly, strategic focus weakens . This is the hidden cost of ambition in biotech leadership. Not failure. Not poo Attila Foris Mar 2 The Real Cost of Strategic Overload in Biotech 👉 In early-stage biotech, activity often feels like strategy. The platform is advancing, multiple indications are progressing, a grant application is underway, and early partnership conversations are taking shape. At the same time, the team is preparing for biotech fundraising. On the surface, this looks like a strength. There is movement across the board. Each initiative has logic behind it. Each program appears to increase optionality and reduce risk. 👉 This is where str Attila Foris Feb 23 The Moment Biotech Founders Realize the Money Is Gone 👉 Most biotech founders do not realize they are in trouble when the money runs out. By then, the situation is already decided. 👉 The real issue begins earlier, at a point where the company is still operating, the science is progressing, and milestones are being met. On paper, things look fine. In reality, something more subtle starts to shift. 👉 Decision-making changes. Plans that once felt flexible start to feel constrained. Conversations move from options to assumption Attila Foris Feb 16 1 2 3 4 5 Collaborate with Timeline Strategy Whether you’re leading a GPCR startup, a CRO, or an academic lab ready to scale, Timeline Strategy helps you design clarity into your growth process.

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Browse past events hosted by the Dr. GPCR Ecosystem, featuring scientific meetings, workshops, and collaborations that brought the GPCR community together. Past Events - Where the Dr. GPCR community comes alive Welcome to the page where the heart of the Dr. GPCR community comes alive! Here, we celebrate the incredible moments that brought scientists, researchers, and GPCR enthusiasts together to share groundbreaking discoveries, spark new ideas, and forge lasting connections. From immersive workshops and high-energy summits to intimate retreats and virtual conferences, each event represents a milestone in our shared mission to advance GPCR science and collaboration worldwide. 👉 Dive into our event archive below to relive the energy, inspiration, and community spirit that make Dr. GPCR truly special. Be part of our journey — stay inspired by our collective passion for science, learning, and discovery. Adhesion GPCR Workshop 2024 Endocrine Metabolic GPCRs Meet Inoviem Team GPCR ECI Transatlantic 2022 Editorial: GPCR and G Protein-Mediated Signalling Events in the Nervous System Dr. GPCR Ecosystem 2.0: Collaborating better Dr. GPCR: Advancing GPCR Drug Discovery Through Collaboration Discovery On Target 2024 GPCR targeted drug discovery Summit 2024 GPCR targeted drug discovery Summit 2023 The Dr. GPCR Podcast GPCR targeted drug discovery Summit 2022 Dr. GPCR: Where all GPCRs are created equal Dr. GPCR: Beyond the lab GRS and GRC Switzerland GPCR Retreat 2023 Leadership is a learned skill - PhageMed Unige GPCR Retreat 2022 Dr. GPCR: Beyond the lab Dr. GPCR: From idea to Ecosystem Dr. GPCR: Beyond the lab

Your One-Stop-Shop for GPCR Drug Discovery and Development Researchers developing GPCR-targeted therapeutics need a reliable, comprehensive partner that spans discovery, optimization, and regulatory submission. Eurofins DiscoverX leads GPCR research innovation with 25+ years of expertise and provides you with product solutions including cell-based assays for basic research through therapeutic discovery and development. The assays are validated and accepted by industry and the scientific community, with thousands of peer-reviewed publications and billions of data points screened. These industry-standard assays, designed for regulatory submissions, are backed by partnerships with leading pharma and biotech companies worldwide. 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Access Product Solutions and Key Resources GPCR Functional Cell-Based Assays - Assessing Biased Signaling of Agonist Access White Paper Discover Your GPCR Solution - Find The Assay for Your Target of Interest Find Your Solutions The Human GPCRome - Obtain Your FREE Wall Poster for Your Laboratory Obtain Wall Poster Access GPCR Cell Line Assays, Ready-to-Use Kits, Mem Preps, & More Shop Products Supporting GPCR-focused Obesity and Diabetes Research Eurofins DiscoverX supports the ongoing obesity/diabetes revolution with the most comprehensive, validated portfolio for obesity and diabetes GPCR targets, including GLP-1, GIP, GCG, MC4, PYY, AMY receptors, and more. Browse products related to your obesity/diabetes target of interest: CALCRL and RAMP (AMs) GIPR GLP-1R GLP-2R GCGR GPR75 MC4R NPY2R (PYY) SSTR5 Activins CALCR and RAMPs (AMYs) Apelin (APJ/AGTRL1) View representative data: GLP-1R multi-MOA profiling Eurofins DiscoverX's GLP-1 receptor (GLP-1R) assay portfolio illustrates a comprehensive approach to obesity research, with complete MOA coverage for a single target: GLP-1. These assays enable complete pharmacological profiling across cAMP, β-arrestin, and internalization. GLP-1R representative assay results (dose-response curves) for exendin-4, tirzepatide, and retatrutide. A. cAMP dose–response; B. β-arrestin recruitment showing ligand bias; and C. Internalization profiles distinguishing highly versus weakly internalizing agonists. Together, these datasets exemplify the depth of pharmacological insight enabled by Eurofins DiscoverX platforms. 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How a bell-shaped FSH dose-response curve led to one of the earliest demonstrations of biased GPCR signaling - and a decade of pushback from the field. << Back to podcast list Strategic Partner(s) Brian Arey: Discovering Signaling Bias at the FSH Receptor Biased signaling - the idea that a single receptor can preferentially activate one downstream pathway over another depending on how it is engaged - is now a central concept in GPCR pharmacology and drug design. But for the researcher who first encountered it not as a theory but as an anomalous bell-shaped dose-response curve in an FSH receptor assay, it arrived as a problem that needed explaining. Brian Arey, Director of Mechanistic Pharmacology at Bristol-Myers Squibb, traces the origins of that discovery to a glycosylation difference between pituitary-purified and insect-cell-expressed FSH - a difference that turned out to encode physiologically distinct signaling outputs. The broader argument Arey has spent his career developing is that biased signaling is not a GPCR-specific phenomenon but an evolutionarily conserved principle present across all receptor classes. That argument eventually became a book, co-authored with Terry Kenakin, that Arey dedicated to his children - not because they are scientists, but because he wanted them to understand what he spent his life doing and why it mattered. ABOUT THE GUEST Brian Arey is Director of Mechanistic Pharmacology within the Discovery and Optimization organization at Bristol-Myers Squibb, where he leads research spanning GPCR pharmacology, enzymology, and protein homeostasis pathways. A physiologist by training, he completed his doctoral work on circadian regulation of prolactin secretion at Florida State University before postdoctoral research at Northwestern, and has spent over 25 years in pharmaceutical drug discovery across Wyeth and BMS. His early work at Wyeth's Women's Health Research Institute produced foundational observations on biased signaling at the FSH receptor, which were among the first experimental demonstrations that a GPCR could signal through parallel G protein pathways in a ligand-dependent manner. He is the author of a 2014 book on evolutionarily conserved receptor signaling, co-written with Terry Kenakin and published through Elsevier. SCIENTIFIC THEMES OF THE CONVERSATION Biased signaling at glycoprotein hormone receptors - the experimental origin Glycosylation isoforms as physiological regulators of differential receptor signaling Evolutionary conservation of biased receptor function across receptor classes The physiologist's approach to mechanistic drug discovery The erosion of pharmacology training in pharmaceutical research - and why it matters Career navigation across academia, industry, and the blurring boundary between them KEY INSIGHTS FROM THE CONVERSATION The bell-shaped curve was a hypothesis, not an artifact When insect-cell-expressed FSH produced a bell-shaped dose-response curve instead of a sigmoidal one, the obvious interpretation was contamination or a production problem. Arey treated it as a signal. The glycosylation difference between the recombinant material and pituitary-purified FSH had altered the receptor's downstream signaling profile - and the bell shape was the read-out. It took a pertussis toxin experiment, borrowed conceptually from Tom Burris's dopamine receptor work, to demonstrate that FSH receptor was signaling through both Gs and Gi simultaneously, and that the two glycoforms were biasing the system differently. Forty years of unresolved biology had a signaling answer The existence of multiple glycosylated isoforms of FSH, LH, and other glycoprotein hormones had been recognized for decades, but their physiological significance was not understood. Arey's data offered a functional explanation: different glycoforms stabilize different receptor conformations, which recruit different intracellular effectors with different affinities, driving different physiological outcomes in target cells. What had looked like biochemical noise in circulating hormone pools was, in this framework, a mechanism for fine-tuned signaling control. If the controls are right, the data has to be trusted When a substantial portion of the literature responded to Arey's published data by calling it wrong, he called his graduate advisor. The advice he received - that if all controls have been run appropriately and the result still holds, you have to have confidence in your data - has remained his operating principle for three decades. That conviction did not resolve the argument quickly. The field took nearly a decade to come around. But the data held. Biased signaling is not a GPCR specialty - it is a conserved principle The central argument of Arey's 2014 book is that the bimodal structure of receptor signaling - a ligand-binding pocket with one inherent affinity, and a cytoplasmic effector-binding pocket with its own independent affinity, both modulated by the conformational state the ligand stabilizes - is not unique to GPCRs. The same logic applies to cytokine receptors, nuclear hormone receptors, and receptor tyrosine kinases. Arey arrived at this hypothesis in the mid-1990s, before the structural and mechanistic data existed to support it, and spent years watching the field gradually produce that evidence. Techniques are tools in a toolbox - not endpoints One of the formative intellectual influences Arey credits from his graduate training is the principle that no technology is intrinsically interesting - it is only interesting insofar as it can answer a scientific question. That orientation shapes how he runs his team at BMS: a healthy skepticism toward established methods, including antibody-based assays that he views as 50-year-old technology capable of improvement, and a standing question of whether the current tool is actually capturing the biology being studied. Drug discovery needs modulators more than it needs hammers Arey's philosophy of drug discovery is grounded in a view of human physiology as inherently variable - shaped by evolution, divergent across populations, and rarely susceptible to single-target solutions. He argues for a therapeutic strategy built around modulators that can be combined, rather than single agents designed to dominate a pathway. That argument is not abstract: it is the conclusion of someone who has watched large programs fail to find silver bullets in multifactorial diseases for 25 years. EPISODE TIMELINE Timestamps are AI-generated from the transcript and may not perfectly reflect final edited audio. Verify against the published episode before using for navigation. 00:00 Introduction 01:48 Career overview - 25 years in drug discovery at Wyeth and BMS 06:03 Origin story - glassware, the first binding assay, and the decision not to become a physician 11:54 Graduate school - independently discovering a circadian rhythm regulating prolactin secretion still cited 30 years later 17:57 Leaving academia for Wyeth - a two-week decision, $18,000 a year, and the door that closed behind it 19:55 The FSH receptor anomaly - how a production shortcut produced the first experimental evidence of biased GPCR signaling 23:40 When the literature called the data wrong - holding the line for nearly a decade 30:41 The physiologist's lens - why Arey has never chased the trending field 35:00 Science, family, and the years he was a single father of two young children 40:35 Writing the book with Kenakin - the argument that biased signaling is evolutionarily conserved, and why he chose a book over a review 48:09 Dinner with Martin Rodbell - drawing the FSH data on a napkin and hearing "I'm not surprised" 53:07 Advice for scientists - follow the data, trust your controls, stay humble, give back 01:01:55 What pharmacologists bring to drug discovery that nobody else does SELECTED QUOTES "If you've done all the controls appropriately, and you've done the experiments to the best of your ability, and you've asked all the hard questions and you still get the same result, then you have to have confidence in your data." "What we study in pharmacology, whether it's a GPCR or whatever, what we're really studying is evolution at the base level. And when you think about it from that perspective, it's hard not to be awed by nature." "I'm not surprised." - Martin Rodbell, upon being shown Arey's FSH signaling data drawn on a dinner napkin, citing a 1972 paper in which Rodbell had proposed a similar mechanism. "Science is really a personal endeavor - it's creative and personal. I hate to say it because it's so overused, but it really is an art form and everybody approaches it differently." About this episode Brian Arey is Senior Director of Mechanistic Pharmacology within Leads Discovery and Optimization at Bristol-Myers Squibb Co . in Lawrenceville, NJ. He obtained both his MS and Ph.D. in Neuroendocrine Physiology at Florida State University before completing his postdoctoral training at Northwestern University. He then moved to work in the pharmaceutical industry where he has held positions of increasing responsibility. He currently leads a team that provides a mechanistic understanding of small molecule drug candidates across the entire portfolio of BMS. Brian has contributed to the discovery or development of 5 marketed drugs through his work spanning molecular, biochemical, cellular, and in vivo assessment of drug candidates in many different physiological systems. Dr. Arey’s laboratory discovered the first described synthetic agonists and antagonists of the FSHR and has been an early champion of signaling bias as a physiological mechanism of gonadotropin action. He continues to pioneer in drug discovery studying GPCRs and other target classes. His recently published book on signaling bias, Biased Signaling in Physiology, Pharmacology, and Therapeutics is available on Amazon . I sat down with Brian to chat about GPCRs, working in the industry, and being a leader. This is part 1 of our conversation. Dr. Brian Arey on the web LinkedIn ResearchGate Pubmed Dr. GPCR Ecosystem Unlock the Full Dr. GPCR Learning Ecosystem ✔ Full Masterclass library ✔ Terry's Pharmacology Corner ✔ Advanced GPCR courses ✔ Scientific discussions → Become Premium Upcoming Live Expert Sessions ➚ 🔒Explore the Full Masterclass ➚ Enjoying the Dr. GPCR Podcast? Leave a Review. Leave a quick review to help more scientists find the show—and help us keep improving every episode. It takes <60 seconds and makes a big difference. ★ Review on Apple Podcasts ★ Rate on Spotify ✉️ Send feedback to the team Thanks for listening to this podcast episode Follow us on your favorite Podcast Player << Previous Podcast Episode Next Podcast Episode >>

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<< Back to podcast list Strategic Partner(s) Dr. Daniel Isom About Dr. Daniel Isom "Dan was born and raised in the Cleveland area. He is a first-generation college graduate and academic. After spending two years at the Cleveland Institute of Art, he earned degrees in Biochemistry and Chemistry from Case Western Reserve University. He then went on to earn a Ph.D. in Molecular Biophysics from Johns Hopkins University, followed by postdocs at both Duke University and UNC Chapel Hill. Dr. Isom was recruited to the Molecular and Cellular Pharmacology Department at the University of Miami Miller School of Medicine in 2016, where he is currently a practicing molecular pharmacologist and biophysicist, systems and synthetic biologist, technologist, heavy CRISPR user, protein sequence- and structure-based informaticist, computational geometer, virtual screener, and Python, medical, and graduate educator leading a talented and multidisciplinary research team. " Dr. Daniel Isom on the web Isom Lab University of Miami Miller School of Medicine LinkedIn X (Twitter) BlueSky Dr. GPCR Unlock the Full Dr. GPCR Learning Ecosystem ✔ Full Masterclass library ✔ Terry's Pharmacology Corner ✔ Advanced GPCR courses ✔ Scientific discussions → Become Premium Upcoming Live Expert Sessions ➚ 🔒Explore the Full Masterclass ➚ Enjoying the Dr. GPCR Podcast? Leave a Review. Leave a quick review to help more scientists find the show—and help us keep improving every episode. It takes <60 seconds and makes a big difference. ★ Review on Apple Podcasts ★ Rate on Spotify ✉️ Send feedback to the team Thanks for listening to this podcast episode Follow us on your favorite Podcast Player << Previous Podcast Episode Next Podcast Episode >>

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