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University of Birmingham Upcoming Live Expert Sessions ➚ 🔒Explore the Full Masterclass ➚ Unlock the Full Dr Native Tissue How Collaboration Sparked a GPCR Imaging Breakthrough in Chemical Biology Enjoying the Dr

on the web LinkedIn Upcoming Live Expert Sessions ➚ 🔒Explore the Full Masterclass ➚ Unlock the Full Dr Native Tissue How Collaboration Sparked a GPCR Imaging Breakthrough in Chemical Biology Enjoying the Dr

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A structured session inside Terry’s Corner by Dr. Terry Kenakin. 7, 2026 GPCR Selectivity Beyond the Receptor — Live April 9th with Bryan Roth Bryan Roth joins the Dr

Genemode on the web Website Jacob Lee on LinkedIn Jacob Lee on Dr. GPCR Ecosystem Jin Choe on LinkedIn Jin Choe on Dr. GPCR Ecosystem Upcoming Live Expert Sessions ➚ 🔒Explore the Full Masterclass ➚ Unlock the Full Dr. Native Tissue How Collaboration Sparked a GPCR Imaging Breakthrough in Chemical Biology Enjoying the Dr

Dr. ResearchGate X Bluesky Github Upcoming Live Expert Sessions ➚ 🔒Explore the Full Masterclass ➚ Unlock the Full Dr Native Tissue How Collaboration Sparked a GPCR Imaging Breakthrough in Chemical Biology Enjoying the Dr

. 🚀 Develop New GPCR Skills Join Dr. Tune in to Ep.160 of the Dr.

🎓 Kicking Off Today: Dr. Watch Dr. Kenakin as he introduces the key concepts of this brand-new course.

Explore how subcellular location and temporal dynamics revolutionize GPCR signaling through nanodomains, endosomal compartments, and phase separation mechanisms. < Back The Spatiotemporal Revolution in GPCR Biology May 21, 2026 10:00 AM - 11:30 AM EST 🔒 Watch Recordings - Join Premium Access the full library of recorded Masterclass sessions. Get Live Updates Be notified when new live Masterclasses are scheduled. Introduction Classical GPCR signaling models assumed uniform receptor distribution and immediate signal termination upon ligand dissociation. Contemporary research reveals that subcellular location and temporal dynamics fundamentally determine signaling outcomes. This session examines how receptor nanodomains, endosomal signaling compartments, and biomolecular condensates create distinct signaling environments that prevent crosstalk and enable pathway specificity. The discussion spans location bias mechanisms that drive differential G protein versus arrestin activation, advanced imaging techniques that visualize these spatiotemporal processes, and the emerging role of liquid-liquid phase separation in organizing signaling complexes. Designed for structural pharmacologists, cell biologists, and drug discovery scientists working on GPCR systems where spatial organization influences therapeutic outcomes. Instructor Sudarshan Rajagopal is Associate Professor of Medicine in the Division of Cardiology at Duke University School of Medicine and Co-Director of the Duke Pulmonary Vascular Disease Center. His research has fundamentally advanced understanding of receptor regulatory mechanisms underlying cardiovascular and inflammatory diseases, particularly pulmonary hypertension. Since establishing his independent laboratory, his group has made defining contributions to biased agonism mechanisms and chemokine system signaling, with particular expertise in how spatial organization influences GPCR function in disease contexts. His work on spatiotemporal GPCR regulation directly informs the mechanistic framework addressed in this Masterclass. Upcoming Live Sessions

Strategic approaches to building GPCR research programs that translate fundamental discoveries into clinical impact and drug development. < Back How to Build Breakthrough GPCR Programs June 4, 2026 10 AM - 11:30 AM EST 🔒 Watch Recordings - Join Premium Access the full library of recorded Masterclass sessions. Get Live Updates Be notified when new live Masterclasses are scheduled. Introduction Building GPCR research programs that achieve both fundamental discovery and clinical translation requires strategic thinking from day one. This session addresses the structural and strategic decisions that determine whether breakthrough science reaches patients: securing funding aligned with translational potential, defining research directions that balance risk and impact, identifying discoveries worth pursuing to clinical endpoints, and navigating the pathway from academic research to drug development and spin-out companies. Andrew Tobin draws from his experience leading translational GPCR programs and co-founding Keltic Pharma to illustrate each strategic element. Intended for GPCR scientists, postdocs, and research leaders planning translational research programs. Instructor Andrew Tobin directs translational GPCR research focused on generating new medicines for brain disorders, severe asthma, and inflammatory gut disease. As co-founder and CEO of Keltic Pharma Therapeutics, he leads a biotechnology company developing a novel drug-discovery platform and working toward a radical cure for malaria. He also serves as Director of the Advanced Research Centre at the University of Glasgow, a £130M collaborative initiative housing over 550 researchers designed to redefine interdisciplinary research. His recent work on muscarinic acetylcholine receptor modulation and structure-guided design of M1 receptor agonists exemplifies the strategic approach to translational GPCR science that defines this Masterclass session. Upcoming Live Sessions

Explore GPCR signaling kinetics and temporal drug action mechanisms with Sam Hoare. Clinical insights on tachyphylaxis, tolerance, and kinetic-based therapeutics. < Back How Signaling Kinetics Shapes GPCR Drug Action May 14, 2026 10 AM - 11:30 AM EST 🔒 Watch Recordings - Join Premium Access the full library of recorded Masterclass sessions. Get Live Updates Be notified when new live Masterclasses are scheduled. Introduction GPCR signaling kinetics, the temporal dynamics of receptor activation and downstream signaling, directly influence therapeutic outcomes from beta-agonist tachyphylaxis to opioid tolerance. This session addresses the clinical landscape of kinetic-dependent drug action, biosensor-based measurement of signaling over time, and analytical approaches for extracting actionable kinetic parameters in drug discovery. Coverage spans tachyphylaxis mechanisms in beta-agonist therapy, tolerance development with opioid agonists, and therapeutic desensitization strategies at S1P1 and GnRH receptors. Designed for pharmacologists, drug discovery scientists, and translational researchers working on temporal aspects of GPCR therapeutics. Instructor Sam Hoare is a drug discovery consultant and founder of Pharmechanics LLC, specializing in kinetic analysis of drug action and the application of binding and signaling kinetics to therapeutic development. After completing his Ph.D. in biochemistry studying allosteric modulation of dopamine receptors at the University of Kent and postdoctoral training on Class B GPCRs at the National Institute of Mental Health, he spent 15 years as a pharmacology leader at Neurocrine Biosciences, guiding in vitro biology for numerous drug discovery campaigns. Sam is an editor at the NIH Assay Guidance Manual and regularly teaches advanced pharmacology and experimental design. His expertise in translating kinetic data from bench to bedside directly informs this Masterclass. Upcoming Live Sessions

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