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- Paul Insel: Rethinking COVID-19 Pathobiology Through GPCR Signaling | Dr. GPCR Ecosystem
Paul Insel turned dry-lab science into a reframing of COVID-19 pathobiology as a GPCR signaling imbalance -19 didn't hold up. What came next was a series of papers reframing severe COVID-19 as a disease of signaling imbalance: Scientific Themes of the Conversation The angiotensin imbalance hypothesis of COVID-19 pathobiology — Severe COVID-19 may be a story of signaling imbalance, not just viral damage.
- Masha Niv: Bitter Taste Receptors and the Drug Discovery Blind Spot | Dr. GPCR Ecosystem
-19 pandemic. -19 and chemosensory science - how a global consortium formed from a handful of tweets and what it found COVID-19 taste loss was a scientific detour that became something larger Niv had not planned to work on COVID-19 - she had never worked on viruses and was cautious about entering a field she did not know -19 and chemosensory loss - how a global research consortium assembled from a handful of tweets 31:01
- GPCRs and the Science Behind Pain and Recovery with Dr. Alex Serafini | Dr. GPCR Ecosystem
From struggling to grip mice in early animal studies to thesis delays during COVID-19, Serafini's journey
- Dr. Arthur Christopoulos | Dr. GPCR Ecosystem
Pandemic Journey and Global Challenges Yamina and Arthur discussed Arthur's experiences during the Covid -19 pandemic, his journey as a research fellow in Australia, and his transition to the role of Dean. personal health struggles, the growth of his university, and the faculty's successful response to the Covid
- Dr. Arthur Christopoulos | Dr. GPCR Ecosystem
Pandemic Journey and Global Challenges Yamina and Arthur discussed Arthur's experiences during the Covid -19 pandemic, his journey as a research fellow in Australia, and his transition to the role of Dean. personal health struggles, the growth of his university, and the faculty's successful response to the Covid
- Terry Hébert | Dr. GPCR Ecosystem
Terry Hebert was recorded in spring 2020, when Montreal was the national epicenter of the COVID-19 pandemic
- Dr. John Janetzko | Dr. GPCR Ecosystem
Both agreed on the importance of adaptability, as unexpected situations like the Covid-19 pandemic can
- Eleonora Comeo: Fluorescent Ligands and the Pharmacology of Adenosine Receptors | Dr. GPCR Ecosystem
We also touched on how COVID-19 affected her Ph.D. work.
- Fresh, Fresh, GPCR News ❇ Feb 17 - 23, 2025 | Dr. GPCR Ecosystem
GPCR research, developing biosensors for G protein activity, networking, mentorship, PhD resilience, COVID -19 challenges, and his aspiration to transition into biotechnology investment opportunities. Next Call for GPCR Papers Special Issue on Adhesion GPCRs GPCR Events, Meetings, and Webinars March 19
- Yamina Berchiche: Beyond the Lab — From Chemokine Receptors to the Dr. GPCR Ecosystem | Dr. GPCR Ecosystem
GPCR during COVID — the career arc behind the ecosystem built for the field's unreached receptors. << Berchiche to leave the bench after a COVID-era redundancy, and examines the motivation behind founding GPCR was founded in March 2020 after a COVID-era redundancy at Generate Biomedicines. variants that weren't the same 17:00 NIH and the pull toward a 30,000-foot view of the field 21:00 COVID
- Lauren Solano: Mapping Careers Beyond the Bench | Dr. GPCR Ecosystem
as a research method for career planning The limits and real signals of "company culture" in biotech COVID-era Transferable skills scientists undervalue 14:16 The informational interview — permission granted 23:57 The COVID
- Silvio Gutkind: Building a Lab That Doesn't Shut Down | Dr. GPCR Ecosystem
Silvio Gutkind sheds light on his work and life since the beginning of COVID restrictions. Silvio Gutkind highlights how his past experience proves useful in current COVID times and potential
- Dr. John Streicher: Reorganizing Opioid Signaling Beyond the Receptor | Dr. GPCR Ecosystem
puzzle — why ERK does a million things 13:31 What happened to biased agonism — replications in trouble 19 student's side project that blocked morphine reward 59:52 Running a lab through the first months of COVID John started grad school in 1999 and spent some time figuring out what he was interested in.
- Elva Zhao: G Protein Regulation and Biased Signaling at the GLP-1 Receptor | Dr. GPCR Ecosystem
student experience and the language gap 15:09 The mentor who made it safe to say "I don't understand" 19 effect problem 41:39 Work-life balance - running, Tilly, and what burnout taught about efficiency 52:58 COVID
- Graciela Pineyro: Resilience, Lab Life, and the Zoom Effect | Dr. GPCR Ecosystem
readability. 00:00 Introduction and 2020 Summit announcement 01:45 Welcoming a returning guest 02:02 How COVID
- Hacking GPCRs: Tools, Tech & Drug Discovery with Tom Sakmar & Ilana Kotliar | Dr. GPCR Ecosystem
envisions using these tools to detect GPCR autoantibodies , which are implicated in conditions like long COVID
- Jacob Lee and Jin Cho: Rebuilding the Software Layer Under Modern Research | Dr. GPCR Ecosystem
COVID-era conversations about why vaccines take eighteen months tend to focus on the clinical and regulatory
- Our History | Dr. GPCR Ecosystem
Lefkowitz , 2012 Nobel Laureate in Chemistry. 2nd Annual Summit Sep 13–19, 2021 — The 2nd Dr. First Symposium May 19, 2023 — Hosted the inaugural Dr.
- Antonella Di Pizio: Computational Pharmacology of Taste and Olfactory Receptors | Dr. GPCR Ecosystem
structures exist for most of them, sequence identity within the TAS2R family hovers between 15% and 19% amine-associated receptors on the edge of neuroscience 12:34 Anosmia and viruses of the olfactory system 19
- Paul Insel: Unbiased Discovery and the GPCRs We've Been Missing | Dr. GPCR Ecosystem
A career redirected by a dinner and an empty schedule In 1975, Dr. GPCR career 09:06 Evolving receptor loves: from adrenergic to purinergic to proton-sensing GPCRs 13:19 Proton-sensing GPCRs: what they are and why they matter 16:18 GPR68 and the feedback loop in pancreatic cancer 19 About this episode In 1975, Dr. During dinner with colleagues and Alfred Gillman , co-recipient of the 1994 Nobel Prize in Physiology
- Lin and Ball: GPCR Antibody Characterization and the Recombinant Shift | Dr. GPCR Ecosystem
that shaped the company 16:49 LGR5 - the GPCR that exposed how deep the antibody quality problem runs 19 instead 25:00 Five-pillar characterization in practice - KO lines, comparable antibodies, GPCR arrays 30:19
- Gunnar Schulte: Frizzled Receptors and the GPCR Identity Question | Dr. GPCR Ecosystem
Fewer than one in 19 Wnt ligands is currently available in a biologically active, tagged form suitable adenosine to frizzled: the postdoc decision that defined the lab 17:43 Frizzled receptors: 10 subtypes, 19 University in Berlin/Germany and a Ph.D. in molecular pharmacology (supervisor: Bertil B Fredholm; 1998
- Maria Waldhoer: Pharmacological Fingerprints and the Limits of Bias | Dr. GPCR Ecosystem
Maria Waldhoer, CSO of InterAx Biotech 02:19 — From zoology to GPCRs: fate, not choice 06:48 — Academia
- Brian Bender: Computational Probes for Orphan GPCR | Dr. GPCR Ecosystem
- and the pivot it forced 17:22 From NPY2 to ghrelin - when one receptor becomes a family question 19
- Jennifer Pluznick: Olfactory Receptors in the Kidney and the Gut-Microbe Signal | Dr. GPCR Ecosystem
and ligand screening when there's no antibody 17:06 What happens to OR expression in a disease kidney 19
- Silvio Gutkind: When GPCRs Drive Cancer | Dr. GPCR Ecosystem
00 Introduction 02:09 From Buenos Aires to NIH: a career that followed the science, not the field 06:19
- Amynah Pradhan: The Delta Opioid Receptor and the Migraine Paradox | Dr. GPCR Ecosystem
AI for readability. 00:00 Introduction 01:13 From McGill to migraine — a path through four labs 04:19
- Brian Arey - Part 2: GPCR Drug Discovery and the Science Nobody Publishes | Dr. GPCR Ecosystem
the professional cost 57:50 - Scientific identity, introversion, and putting yourself out there 01:05:19
- Kathryn Livingston: Allosteric Opioid Modulators and Receptor Signaling Beyond the Membrane | Dr. GPCR Ecosystem
Zastrow's lab and the internalization paradigm shift 14:17 How to choose a postdoc with no trial period 19
- Alexander Hauser: GPCR Pharmacogenomics and Precision Psychiatry | Dr. GPCR Ecosystem
- Mentoring philosophy - teaching through mistakes and sustaining relationships after departure 37:19






























