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work on Germline mutations in a G protein identify signaling cross-talk in T cells Victoria Saca , Colin Burdette , and Thomas Sakmar for their excellent study on GPCR Biosensors to Study Conformational Dynamics

The clinical significance of GPR39 in colon cancer has never been reported. Materials: In our study, we compared GPR39 expression between colon cancers and tumor-adjacent tissues by retrieving TCGA data and detected the expression of GPR39 in colon cancers with qPCR and immunohistochemistry

are involved in a wide array of physiological and disease functions, yet knowledge of their role in colon together, we reveal that PAR-induced post-transcriptional regulation of β-catenin is centrally involved in colon

Here we demonstrate that GPR84 is highly upregulated in inflamed colon tissues of active ulcerative colitis Infiltrating GPR84+ macrophages are significantly increased in the colonic mucosa of both the UC patients GPR84 activation imposes pro-inflammatory properties in colonic macrophages through enhancing NLRP3 inflammasome

we demonstrate identification of a pleckstrin-homology (PH)-binding motif within PAR4, critical for colon The presence of PAR2 and PAR4 in biopsies of aggressive breast and colon cancer tissue specimens is demonstrated

orchestrate P-gp expression and highlight unappreciated connections between multiple pathways linked to colonic

In vitro, SACC cell proliferation and apoptosis were evaluated using Cell Counting Kit-8 and colon formation

widely distributed in the brain, lung, heart, liver, spleen, pancreas, kidney, stomach, jejunum, ileum, colon

1A, the dual A2B/A3 adenosine receptor fluorescent antagonist (CELT-327) was added to HCT116 cells (colon

D., & Collins, B. M. (2019).