Sakmar, Debbie L. Hay, Lukas Grätz, and more. Check out some of the latest GPCR discoveries below!

November 2021 "Nov. 15, 2021 LONDON – There’s not yet proof of the pudding, but Omass Therapeutics Ltd.’s new structure-based technology has passed a key test, in enabling the discovery of orally available small molecules aimed at intractable and poorly drugged membrane and complex-bound protein targets. The targets, including G protein-coupled receptors (GPCRs), intracellular protein complexes and solute carriers, are relevant to immunology indications and rare diseases with high unmet need." Read more at the source #DrGPCR #GPCR #IndustryNews

Hailong Zhang, PhD, Shanghai Yogar Therapeutics Dr.

coupled receptors under diverse states Fan Liu , Han Zhou , Xiaonong Li , Liangliang Zhou , Chungong Yu , Haicang

conformational changes for the binding to the same GPCR to mediate differential regulatory effects (Haider

CXC chemokines with shallow binding near TM5, and CX3C chemokines with shallow binding near the ECL2 hairpin

disease-associated LPA6 missense mutants and a potential pharmacoperone therapy for autosomal recessive woolly hair

September 2022 "Sound is converted by hair cells in the cochlea into electrical signals, which are transmitted

damage to healthy cells in the process, leading to side effects that can include pain, nausea, and hair