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GPCR targeting of E3 ubiquitin ligase MDM2 by inactive β-arrestin.

Endosomal signaling via cAMP in parathyroid hormone (PTH) type 1 receptor biology β-arrestin1 is an E3 ubiquitin ligase adaptor for substrate linear polyubiquitination GPCR Binders, Drugs, and more Dual

degradation of insulin-like growth factor 1 receptor (IGF1R) by competitively binding to IGF1R with ubiquitin E3 ligase MDM2, thereby activating its downstream signaling pathways such as NF-κB, PI3K/AKT, and MAPK

where he identified and characterized novel components of the Wnt signaling pathway and a new class of E3 ubiquitin ligases .

Shenoy’s postdoctoral research discovered that ubiquitination of mammalian G protein-coupled receptors is a tag for lysosomal degradation, whereas ubiquitination of the adaptor protein, β-arrestin, is a Her laboratory has continued to work on identifying the molecular mechanisms that ascribe ubiquitin code understand the regulation of GPCR and beta-arrestin signaling in the heart and vascular endothelium by the deubiquitinating

Adriano’s research has contributed to our understanding of the role that ubiquitin plays in GPCR signaling GPCR signaling by -arrestins and post-translational modifications (PTMs), such as phosphorylation, ubiquitination