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where he identified and characterized novel components of the Wnt signaling pathway and a new class of E3 ubiquitin ligases .

Shenoy’s postdoctoral research discovered that ubiquitination of mammalian G protein-coupled receptors is a tag for lysosomal degradation, whereas ubiquitination of the adaptor protein, β-arrestin, is a Her laboratory has continued to work on identifying the molecular mechanisms that ascribe ubiquitin code understand the regulation of GPCR and beta-arrestin signaling in the heart and vascular endothelium by the deubiquitinating

Adriano’s research has contributed to our understanding of the role that ubiquitin plays in GPCR signaling GPCR signaling by -arrestins and post-translational modifications (PTMs), such as phosphorylation, ubiquitination

Read Publication April 4, 2026 ROS disrupt COP9 signalosome-mediated ABCA1 protection and trigger its ubiquitination in GPCR agonist-induced ABCA1 destabilization via COP9 signalosome disruption and cullin3-mediated ubiquitination

Among other projects, I studied the role of β-arrestin in G protein trafficking, the impact of GPCR ubiquitination

two beta-arrestin isoforms, structurally nearly identical, mediate the signaling, endocytosis, and ubiquitination

They are the largest, most versatile, and most ubiquitous class of plasma membrane receptors and serve