Biosensors for monitoring G protein-coupled receptors (GPCRs), the most drugged class of proteins in

October 2022 Intermolecular Interactions in G Protein-Coupled Receptor Allosteric Sites at the Membrane Simulations and Quantum Chemical Calculations "Allosteric modulators are called promising candidates in G

October 2022 Dual loss of regulator of G protein signaling 2 and 5 exacerbates ventricular myocyte arrhythmias Cardiac contractility, essential to maintaining proper cardiac output and circulation, is regulated by G Previously, the absence of regulator of G protein signaling (RGS) 2 and 5, separately, was shown to cause G protein dysregulation, contributing to modest blood pressure elevation and exaggerated cardiac hypertrophic Whether RGS2 and 5 redundantly control G protein signaling to maintain cardiovascular homeostasis is

G. Aditya Kumar About Dr. G. Aditya Kumar Dr. Aditya Kumar is a postdoctoral fellow at the University of Michigan Medical School. Aditya is interested in understanding the role of the membrane microenvironment in the subcellular organization G. Aditya Kumar on the web University of Michigan Puthenveedu Lab Google Scholar NIH ORCID LinkedIn Twitter

Jacobson , Katarina Nemec , G. Aditya Kumar , and Chloe Hicks . Dr.

< GPCR News < GPCRs in Oncology and Immunology Intermediate-state-trapped mutants pinpoint G protein-coupled the roles of intermediate states in signaling is pivotal to unraveling the activation processes of G transmembrane helix VI (TM6) and Helix8 that regulates cytoplasmic cavity opening as a "gatekeeper" for G Intermediate-state-trapped mutants will also provide useful information in relation to receptor-G protein