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striatal neurons Rafael Rivas-Santisteban , Ana Muñoz , Jaume Lillo , Iu Raïch , Ana Rodríguez-Pérez , Gemma Navarro , José Labandeira-García , Rafael Franco Endomembrane GPCR signaling: 15 years on, the quest

between the concentration of two distinct pro-inflammatory stimuli, lipopolysaccharide and interferon gamma Here we show that lipopolysaccharide and interferon gamma influence messenger RNA abundances of the microglial

October 2022 "Enzymatic and cellular signalling biosensors are used to decipher the activities of complex biological systems. Biosensors for monitoring G protein-coupled receptors (GPCRs), the most drugged class of proteins in the human body, are plentiful and vary in utility, form and function. Their applications have continually expanded our understanding of this important protein class. Here, we briefly summarize a subset of this field with accelerating importance: transducer biosensors measuring receptor-coupling and selectivity, with an emphasis on sensors measuring receptor association and activation of heterotrimeric signalling complexes." Read more at the source #DrGPCR #GPCR #IndustryNews Subscribe to the Newsletter HERE

Source: Navarro G, Sotelo E, Raïch I, Loza MI, Brea J, Majellaro M. References Navarro G, Sotelo E, Raïch I, Loza MI, Brea J, Majellaro M.

Navarro G, Sotelo E, Raïch I, Loza MI, Brea J, Majellaro M.

Curr Issues Mol Biol. 2024 Oct 19;46(10):11646-11664. doi: 10.3390/cimb46100691   Navarro G, Sotelo E

proteins block the internalization of cognate GPCRs and disrupt downstream intracellular signaling Mónica Navarro-Sánchez

its collaboration agreement with Indivior PLC (LON: INDV) for discovering and developing novel oral gamma-aminobutyric

Receptor 2C Signaling GPCRs in Oncology and Immunology CaaX-motif-adjacent residues influence G protein gamma

receptors belong to class A of G protein-coupled receptors or GPCRs and signaled mainly through Gai/o, beta/gamma