into prolactin-releasing peptide receptor signaling and G-protein coupling selectivity Zhangsong Wu , Chen Qiu , Geng Chen , et al.

large-scale ways of empirically exploring questions in protein biochemistry, human genetic variation, gene Sri previously worked at the Wyss Institute and Harvard, where he built numerous technologies in gene synthesis, DNA information storage, gene editing, and large-scale multiplexed assays. He helped build Gen9, a gene synthesis company, as a member of the SAB and was the first employee of

Gobind Khorana at the Department of Chemistry at M.I.T. for postdoctoral training, where he learned gene functional micro-domains” and the “helix movement model of receptor activation” were confirmed later when Recently, Tom’s lab discovered, along with Yu Chen and Ping Chi , that a mutant of CYSLTR2 is a driver

When Dr. Muthuswamy moved to the University of Toronto, Mike joined the laboratory of Dr. drivers by co-developing GECCO, an algorithm for the identification of noncoding mutations driving gene Mike then transitioned to pancreatic cancer, questioning why genes are dysregulated in cancer, which led him to explore different aspects of gene regulation and its relation to cancer progression. congratulated Mike on his promotion and discussed the importance of flexibility in scientific research, even when

Gap Class B GPCRs represent one of the smaller subfamilies in the GPCR superfamily - just 15 receptor genes For Hay, who has studied RAMPs since they were first described and when working on them was a high-risk Career navigation across academia, big pharma, and biotech KEY INSIGHTS FROM THE CONVERSATION Fifteen Genes , Far More Than Fifteen Pharmacologies Class B GPCRs are a small family by gene count, but RAMP association Functional Dimer Is For obligatory heterodimers like RAMP-receptor complexes, knowing which component genes

The cloning race and the serendipity of the intronless gene — Competing against Genentech's molecular Receptors were an unproven concept when Lefkowitz chose to study them When Dr. Not only did they pull clean clones immediately — they found that the beta-2 adrenergic receptor gene contains no introns, only the third mammalian gene to that point discovered to be intronless. It is acquired by watching: how a scientist moves between problems, when they persist, when they drop

biotechs with Heidi Hamm - CUE Biotech and Caden Biosciences - developing G-protein C-terminal mini-gene The mini-gene origin: reading one paper, seeing the missing experiment While a postdoc in Heidi Hamm's therapeutics for GPCRs and the case for orphan receptor targeting 48:27 Two aha moments: the G-protein mini-gene When you have a finding that is completely unexpected, you follow it. Originally, Annette wanted to be a medical doctor but as luck has it, she didn’t get into medical school when

beta-adrenergic receptors localized to the inner nuclear membrane and their role in the regulation of gene

imaging software and lab robots to accelerate cancer research and automated Thermo Fisher Scientific’s gene

characterize several neurotransmitter transporters and kinases and establish the first knock-out for these genes

Claudia concluding that diseases might first affect the metabolites and not necessarily lack inherited genes Yamina highlighted the challenges of career choices, especially when family situations are involved.

Jennifer Pluznick ran as a postdoctoral fellow placed them, surprisingly, at the top of a kidney gene When Dr. readability. 00:00 Opening: newsletter, season close, and welcome 02:13 Becoming a scientist as a first-gen And somehow when he said it, it sounded like a much better idea." "You need to follow your data, even when it surprises you, even when it might go against what you assumed

. << Back to podcast list Strategic Partner(s) Silvio Gutkind: When GPCRs Drive Cancer GPCRs are the Most large cancer sequencing panels now include these genes — though most oncologists are still unsure Both required trusting the data when the conceptual framework was telling the team they must be wrong

initially prompted by a simple question from Tom Sakmar, demonstrated that variants encoded by the same gene

Most published models rely on inferred negatives — genes or molecules assumed inactive by convenience When one panelist replaced inferred negatives in an autophagy model with CRISPR-validated true negatives

particular focus on how chronic alcohol exposure disrupts those mechanisms across levels ranging from gene When alcohol exposure biases the brain toward habit formation, the circuit underlying that inflexibility

choice 31:33 The underground restaurant in San Francisco, born out of an immigration emergency — and Chef's