Search Results

Why the Myth of High and Low Affinity Binding Sites Could Be Slowing Your Pipeline   If you’re working The interpretation of high and low affinity binding sites  on GPCRs.   High and Low Affinity: What’s Really Going On? In many systems, a ligand may appear to bind with very high affinity when it facilitates formation of matters from what misleads Make confident, efficient decisions that keep your pipeline moving forward, toward

High-content screening (HCS) has become a cornerstone in GPCR and phenotypic drug discovery, enabling However, their limitations become increasingly important as drug discovery moves toward high-information , high-throughput formats. Evolution and impact of high content imaging. SLAS Discov. 2023 Oct;28(7):292-305.  Evolution and impact of high content imaging. SLAS Discov.  2023.

Traditional assays—particularly membrane-based radioligand binding—often provide high-throughput measurements Live-cell high-content screening (HCS) offers an increasingly valuable alternative. In contrast, high-content screening retains the full cellular architecture. Conclusion This case study highlights how live-cell high-content screening can transform early-stage As the field moves toward more nuanced understandings of CB2 signaling, tools that preserve cellular

Caron was an investigator of the Howard Hughes Medical Institute from 1992 to 2004, a member of the American

Caron was an investigator of the Howard Hughes Medical Institute from 1992 to 2004, a member of the American

From 2002-2006 he was a Howard Hughes Post-Doctoral Fellow at the University of Washington in Seattle