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Why the Myth of High and Low Affinity Binding Sites Could Be Slowing Your Pipeline   If you’re working The interpretation of high and low affinity binding sites  on GPCRs.   High and Low Affinity: What’s Really Going On? In many systems, a ligand may appear to bind with very high affinity when it facilitates formation of matters from what misleads Make confident, efficient decisions that keep your pipeline moving forward, toward

High-content screening (HCS) has become a cornerstone in GPCR and phenotypic drug discovery, enabling However, their limitations become increasingly important as drug discovery moves toward high-information , high-throughput formats. Evolution and impact of high content imaging. SLAS Discov. 2023 Oct;28(7):292-305.  Evolution and impact of high content imaging. SLAS Discov.  2023.

October 2022 High hedgehog signaling is transduced by a multikinase-dependent switch controlling the provide evidence that HH promotes the stabilization of SMO by switching its fate after endocytosis toward Moreover, in the presence of very high levels of HH, the second effect of FU leads to the local enrichment

Caron was an investigator of the Howard Hughes Medical Institute from 1992 to 2004, a member of the American

Caron was an investigator of the Howard Hughes Medical Institute from 1992 to 2004, a member of the American

From 2002-2006 he was a Howard Hughes Post-Doctoral Fellow at the University of Washington in Seattle