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How Fluorescence Polarization Assays Work: Principles and Applications in GPCR Research FP assays work Ligands Looking ahead, fluorescence polarization technology is expected to expand its role in GPCR research

September 2022 "T cells are master regulators of the immune response tuning, among others, B cells, macrophages and NK cells. To exert their functions requiring high sensibility and specificity, T cells need to integrate different stimuli from the surrounding microenvironment. A finely tuned signalling compartmentalization orchestrated in dynamic platforms is an essential requirement for the proper and efficient response of these cells to distinct triggers. During years, several studies have depicted the pivotal role of the cytoskeleton and lipid microdomains in controlling signalling compartmentalization during T cell activation and functions. Here, we discuss mechanisms responsible for signalling amplification and compartmentalization in T cell activation, focusing on the role of CD28, chemokine receptors and the actin cytoskeleton. We also take into account the detrimental effect of mutations carried by distinct signalling proteins giving rise to syndromes characterized by defects in T cell functionality." Read more at the source #DrGPCR #GPCR #IndustryNews

Why Purpose Matters in Science For some researchers, science is a job. For others, it’s a calling. , Catherine reflects on how her identity as a scientist took shape, why she’s committed to academic research That alignment between curiosity and urgency set her on the path toward doctoral research. What’s Next in Her Opioid Research Catherine’s current experiments focus on outcomes such as respiratory Catherine’s story shows that when purpose drives research, science becomes more than a job—it becomes

Michel Bouvier "Michel Bouvier is a professor of Biochemistry and Molecular Medicine and the CEO of the Institute for Research in Immunology and Cancer ( IRIC ) at the Université de Montréal. In 1989, he returned to Montréal as a professor of biochemistry and a scholar of the Medical Research Since 2001, he holds the Canada Research Chair in Signal Transduction and Molecular Pharmacology. He has supervised the research work of 75 graduate students and 40 post-doctoral fellows.

Michel Bouvier Michel Bouvier is a professor of Biochemistry and Molecular Medicine and the CEO of the Institute for Research in Immunology and Cancer ( IRIC ) at the Université de Montréal. In 1989, he returned to Montréal as a professor of biochemistry and a scholar of the Medical Research Since 2001, he holds the Canada Research Chair in Signal Transduction and Molecular Pharmacology. He has supervised the research work of 75 graduate students and 40 post-doctoral fellows.

Prabakaran; Demirbaş, Berkay; Kemkemer, Marguerite; Langenhan, Tobias; Scholz, Nicole Rudolf Schönheimer Institute Sabbagh undertook post-doctoral fellowships at the Ontario Cancer Institute and the University of Toronto disorders and cancer at Paraza Pharma Inc. in Montreal. Department of Biochemistry and Molecular Medicine, Institute for Research in Immunology and Cancer (IRIC the development of innovative treatments for a range of diseases, including psychiatric disorders and cancer