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heterotrimeric G protein activity biosensors Marta Lopez-Balastegui, Antonella Di Pizio, Jiafei Mao, Jana Selent, et al. for their research on the Relevance of GPCR dynamics for receptor activation, signalling Principles of Pharmacology in Drug Discovery II - Advanced Methods for the Optimization of Candidate Selection

work on Highly biased agonism for GPCR ligands via nanobody tethering Elk Kossatz, Michel Bouvier, Jana Selent, et al. for their study on G protein-specific mechanisms in the serotonin 5-HT2A receptor regulate pancreatic polypeptide from a structural, functional, and therapeutic perspective Structural basis for selectivity

This means they can be more selective, avoid pathway saturation, and preserve physiological nuance. that potentiate beneficial pathways without shutting down basal signaling entirely, or conversely, selectively The result is not just cleaner assay design but a sharper decision framework for selecting, prioritizing Translational Relevance: From Bench to Clinic Misjudging orthosteric vs allosteric behavior can derail dose selection

Registration Logo Contest Committee Sponsors GPCR Retreat Program < Back to schedule Illuminating Functional Selectivity

Retreat Program < Back to schedule Distinct sub-cellular signal propagation as a component of functional selectivity

Committee Sponsors GPCR Retreat Program < Back to schedule Structure-based discovery of functionally selective Peter Gmeiner has been spokesman of the Research Training Group "Medicinal Chemistry of Selective GPCR