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heterotrimeric G protein activity biosensors Marta Lopez-Balastegui, Antonella Di Pizio, Jiafei Mao, Jana Selent, et al. for their research on the Relevance of GPCR dynamics for receptor activation, signalling Principles of Pharmacology in Drug Discovery II - Advanced Methods for the Optimization of Candidate Selection

work on Highly biased agonism for GPCR ligands via nanobody tethering Elk Kossatz, Michel Bouvier, Jana Selent, et al. for their study on G protein-specific mechanisms in the serotonin 5-HT2A receptor regulate pancreatic polypeptide from a structural, functional, and therapeutic perspective Structural basis for selectivity

selectivity and signaling bias Quantifying Receptor Selectivity Requires Canceling the Cell In early True receptor selectivity must transcend the cell line. A “silent” ligand may be system-limited. No more “it looks selective.” Statistics decide. Receptor selectivity involves concentration separation.

Registration Logo Contest Committee Sponsors GPCR Retreat Program < Back to schedule Illuminating Functional Selectivity

Retreat Program < Back to schedule Distinct sub-cellular signal propagation as a component of functional selectivity

Committee Sponsors GPCR Retreat Program < Back to schedule Structure-based discovery of functionally selective Peter Gmeiner has been spokesman of the Research Training Group "Medicinal Chemistry of Selective GPCR