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Results found for "Jose Maldonado"
- Removing the GPCR-mediated brake on exocytosis enhances insulin action, promotes adipocyte browning, and protects against diet-induced obesity
Analisa Thompson Gray 2, Feyisayo Adegboye 2, Ainsley McDonald-Boyer 3, Fubiao Shi 1, Dianxin Liu 1, Jose Maldonado 5, Jiesi Feng 4, Yulong Li 4, Simon Alford 5, Julio E.
- Session I | Adhesion GPCR Workshop 2024 | Dr. GPCR Ecosystem
Jose Rizo-Rey as a graduate student to elucidate the mechanisms of neurotransmitter release. Jones (Harvard Medical School); Jeffrey S.
- irreversible drugs post 2 | Dr. GPCR Ecosystem
Learn why some inhibitors act long after dosing ends. slow-dissociating allosteric inhibitors can reshape signaling curves for hours — or even days — after dosing Get it right, and you unlock durable efficacy with leaner dosing strategies.
- Dr. Josh Pottel | Dr. GPCR Ecosystem
Josh Pottel About Dr. Josh Pottel "I lead Molecular Forecaster Inc. Josh Pottel on the web Molecular Forecaster LinkedIn BlueSky Google Scholar Twitter Dr.
- Dr. Demet Araç | Dr. GPCR Ecosystem
Jose Rizo-Rey as a graduate student to elucidate the mechanisms of neurotransmitter release. Yamina posed the question of what advice Demet would give his younger self, but Demet responded that
- Unlock your pharmacology potential with Terry’s Corner. No fluff. Just clear, on-demand insight from Dr. Terry Kenakin—built for scientists at every level. 🟢 Building core expertise? Learn dose-response, agonism, binding, bias, kinetics, and the models that build real confidence. 🟢 Driving drug discovery? Apply pharmacology to selectivity, ADME, early safety, and smarter decision-making. 🟢 Already a drug hunter? Sharpen your edge with allosteric modulation, residence time, molecular dynamics, and translational PK/PD. Learn on-demand. Apply immediately. Early access begins July 1 → https://www.terrykenakin.com #pharmacology #GPCRscience #drugdiscovery #TerrysCorner #biotechtraining | Dr. GPCR Ecosystem
Learn dose-response, agonism, binding, bias, kinetics, and the models that build real confidence. 🟢 Learn dose-response, agonism, binding, bias, kinetics, and the models that build real confidence. 🟢
- Terry's Corner is Officially LIVE! 🎉 This is your new go-to for mastering drug discovery pharmacology. No fluff, just clear, on-demand insights from Terry Kenakin. Building core expertise? Master dose-response, binding, kinetics, and foundational models. Driving drug discovery? Apply pharmacology to selectivity, ADME, and strategic decision-making. An experienced drug hunter? Sharpen your edge with allosteric bias, residence time, and translational PK/PD. Learn on-demand, apply immediately: https://terrykenakin.com #DrGPCR #GPCR #pharmacology #TerrysCorner #DrugDiscovery | Dr. GPCR Ecosystem
Master dose-response, binding, kinetics, and foundational models. Driving drug discovery? Master dose-response, binding, kinetics, and foundational models. Driving drug discovery?
- irreversible drugs post 3 | Dr. GPCR Ecosystem
replenishment dynamics — how offset rates control exposure windows, shape therapeutic durability, and influence dosing
- Session VI | Adhesion GPCR Workshop 2024 | Dr. GPCR Ecosystem
Injection of low-dose ketamine, an antidepressant, can lead to acute (in several hours) and sustained Restoration of synaptic connections induced by low-dose ketamine has been found associated with the sustained prefrontal cortical neurons of chronically stressed animals and their behavioral remission induced by low-dose
- When to Walk, When to Run: Lessons from the GPCR Trenches with Dr. Ben Clements | Dr. GPCR Ecosystem
We produce great data, but we also joke around. That’s how we work best.” “We found something incredible — a tenfold shift in the methadone dose-response with our PAM.” 10.
- Dr. Caron Tribute Part 3 | Dr. GPCR Ecosystem
Josh C Snyder (2012) Dr.
- Dr. Juan José Fung | Dr. GPCR Ecosystem
Juan José Fung About Dr. Juan José Fung Dr. Juan José Fung is a Principal Scientist at GPCR Therapeutics, Inc , a drug discovery company focused Juan José Fung on the web LinkedIn GPCR Therapeutics Dr. GPCR Ecosystem Enjoying the Dr.
- From Rare Earth Probes to Internalization Assays: The pHSense Story with Dr. Eric Trinquet | Dr. GPCR Ecosystem
What it felt like to see the first dose-response curves in native beta cells—and why that moment changed
- Flash News: Your Hub for GPCR Insights and Scientific Conference Programs
replenishment dynamics — how offset rates control exposure windows, shape therapeutic durability, and influence dosing slow-dissociating allosteric inhibitors can reshape signaling curves for hours — or even days — after dosing Get it right, and you unlock durable efficacy with leaner dosing strategies.
- Dr. Michael Feigin | Dr. GPCR Ecosystem
dosage and length of treatment in a mouse model and suggested using a biosensor-based assay to examine dose-response
- Revvity | Dr. GPCR Ecosystem
“When we saw dose-dependent internalization in endogenous GLP1R cells—without microscopy—that was the
- Did you know that certain ergot derivatives can produce wash-resistant signalling through the 5-HT2B receptor persisting for many hours without losing potency or efficacy? By using signalling assays, radioligand binding assay, and microscopy, Gaidarov et al. suggested that this phenomenon results from persistently/irreversibly internalised signalling receptor complexes. Check out the latest GPCR news in the Ecosystem today! You’ll need to register but don’t worry, it’s Free! ➡️ https://www.ecosystem.drgpcr.com/receptor-activation-and-signaling/mechanisms-of-constitutive-and-agonist-induced-5-ht2b-internalization%2C-persistent-endosomal-signaling-and-paradoxical-regulation-of-agonist-pharmacology #gpcr#drgpcr | Dr. GPCR Ecosystem
can produce wash-resistant signalling through the 5-HT2B receptor persisting for many hours without losing can produce wash-resistant signalling through the 5-HT2B receptor persisting for many hours without losing
