I was recently awarded a Marie Sklodowska Curie PostDoc Fellowship in order to investigate and find better

the nerve synapse might impact integrated behavior and what we might learn from these mechanisms to cure After doctoral training at the Pierre and Marie Curie University in Paris and a short internship at Genentech the CNRS as a Research Fellow in 1987 in the INSERM Laboratory directed by Jean-Charles Schwartz in Paris From 91 to 94, he was an assistant professor at Duke University in North Carolina, working with Marc Neurobiology of Psychiatric Disorders," first in Créteil with Marion Leboyer, then at the University of Paris-Sorbonne

Maria Waldhoer "I am a pharmacologist with a ~30 years background in academia and industry, working both Maria Waldhoer on the web LinkedIn T witter Pubmed Dr. GPCR About Dr. JoAnn Trejo "Dr. GPCR About Anne Marie Quinn "Anne Marie Quinn has a long and varied work experience in the biocomputing Anne Marie Quinn attended Yale University from 1998 to 2000, where they earned a Master of Public Health Anne Marie Quinn on the web Google Scholar The Org LinkedIn Twitter Dr. GPCR Unlock the Full Dr.

International Centre for Genetic Engineering and Biotechnology in Trieste, then joined GSK in Stevenage as a Marie Curie Industrial Fellow working on aptamers against chemokine receptors. Biased agonism deserves a strict definition Around 2007, many Novartis scientists doubted that published Marro describes it as a genuine learning curve, given how few antibodies against GPCRs exist. the fact that a pill that would fit in the palm of your hand could treat symptoms and in some cases cure

Andrew Tobin Andrew Tobin studied Biochemistry at Queen Mary College, the University of London obtaining

." - Anne Marie Quinn, CEO Montana Molecular Frequently Asked Questions 01 What kinds of CROs do you

<< Back to podcast list Strategic Partner(s) Chris Langmead Chris Langmead is Professor, Deputy Director the field of psychiatry, where he has led multiple projects into late stage preclinical development, many Prior to joining Heptares, Chris was a neuroscience researcher at GlaxoSmithKline, UK (1998-2009). Chris serves on the editorial boards of the British Journal of Pharmacology, ACS Chemical Neuroscience

Anne Marie Quinn, CEO Montana Molecular As a CRO, we were delivering high-quality data across complex Bringing her in marked a meaningful shift.

Chris Tate co-founded Heptares after reading one paper on a Friday afternoon. . << Back to podcast list Strategic Partner(s) Chris Tate: Thermostabilizing GPCRs for Structural Biology The answer reveals whether someone is curious about science or merely using it. EPISODE TIMELINE Timestamps are AI-generated from the transcript and may vary slightly from the final Nature paper 49:05 Advice for young scientists: what it actually takes to survive science 54:35 The curiosity

Streicher on how HSP90 flips direction between brain and spinal cord, why isoform-selective inhibitors may plays directly opposite roles in the brain and the spinal cord, why isoform-selective HSP90 inhibitors may Mary Canals' group has argued that some of the apparent bias benefits may actually reflect low intrinsic

. << Back to podcast list Strategic Partner(s) Kari Johnson: mGlu2, Addiction, and the Brain Circuits Kari Johnson's research follows this receptor from the bench to the behaving animal, using optogenetics ABOUT THE GUEST Kari Johnson is an assistant professor of neuropharmacology at the Uniformed Services It is also a complication: a receptor that modulates so many circuits will inevitably produce wanted Kari Johnson on the web LinkedIn Google Scholar Research Gate USU Twitter Dr.

Marshall walks through the decade when membrane proteins kept failing to crystallize in detergent, and how Chris Chris Tate's thermostabilization strategy, which introduced stabilizing mutations selected by thermal Marshall's caution is hard-won: many animal-model-validated GPCR drugs have failed in the clinic precisely Chris Tate and Dr. Richard Henderson at the Laboratory of Molecular Biology in Cambridge, UK.

Amynah Pradhan on why mu opioids worsen migraine, why delta agonists may relieve it, and how chronic Clarke and completed postdoctoral work at AstraZeneca, with Brigitte Kieffer in Strasbourg, and with Chris Delta agonists may finally have a disease. After failed trials in depression and pain, Dr. Her "bugaboo": we still do not know reliably where many GPCRs live — which cell type, which compartment Chris Evans at UCLA.

She began her Ph.D. at Imperial College London with Prof Aylin Hanyaloglu, Prof Gary Frost, and Dr.

I’m really curious about your career trajectory. Dr. Joseph Kim: Sure. Some studies also suggest that the galanin receptors may interact with the μ-opioid receptor. In fact, some groups believe there may even be dimeric interactions between the receptors. Whenever I hear about peptide-binding GPCRs with buried or hydrophobic binding pockets, I immediately The endogenous peptide is buried laterally within the receptor, which means an exogenous small molecule

Maria Majellaro—and learn what their new partnership with Dr. curiosity to biotech force. Translating Science into Business Like many scientists-turned-entrepreneurs, Maria faced the challenge About Maria Majellaro Dr. at the University of Bari (Italy) in 2018.

Failure is documented, not buried.

Joining the conversation are Maria Majellaro (CSO and co-founder of Celtarys Research), Johannes Broichhagen Broichhagen About the Guests Maria Majellaro, PhD Dr. Maria Majellaro is the Chief Scientific Officer and co-founder of Celtarys Research , a biotech spin-off She earned her PhD in medicinal chemistry from the University of Bari in 2018, including research training Guests on The Web Maria Majellaro LinkedIn ResearchGate Ecosystem Johannes Broichhagen LinkedIn Google

Maria Majellaro Co-Funder and CSO Dr. Maria Majellaro earned her degree in Pharmaceutical Chemistry and Technology from the University of Bari validation strategy, and performance across reference antagonists and agonis Lucía from Celtarys Research Mar Maria Majellaro, CSO of Celtarys. “Working with Dr.

He trained with Gary Lynch at UC Irvine on ionotropic glutamate receptors, then with Thomas Soderling

. << Back to podcast list Strategic Partner(s) From Curiosity to Breakthrough: Ajay Yekkirala on GPCR Ajay Yekkirala shares the pivotal moments that transformed him from a curious PhD student into a GPCR Ajay reveals how humility, curiosity, and collaboration fuel the future of drug discovery. translational innovation Biotech investors and strategic leaders seeking new drug development models Anyone curious His story is one of relentless curiosity, humility in the face of complexity, and an unshakable belief

selection and optimization decisions Why potency alone is not enough for candidate-level decisions 📅 May The chat, the Q&A, the shared curiosity — the community thinking together in real time.

GPCR Podcast - The Voice of the Community Whether you’re a scientist, student, or just curious, you’ll

Like many, his path to GPCR research wasn’t linear—it evolved through academic exploration and mentorship Advice, Tools, and the Future of GPCR Research Nicoli offered advice to wet-lab scientists curious about

The biological implications of many of these complexes are still being resolved. The advice she offers to incoming PhD students centers not on technique but on disposition: stay curious

Along the way, he reflects on key career moments, the role of mentorship, and how curiosity continues

That curiosity laid the foundation for a broader investigation into receptor activity-modifying proteins From Curiosity to Collaboration “We decided to evaluate the multiplexing methods... and found this Luminex From Many to One: De-Orphanization and Precision Focus “You can use this system to de-orphanize receptors In Ilana’s words, it’s a powerful way to “go from many back to one.”

Curiosity, collaboration, and a love of translating chemical concepts into biological insight drive his

The proximity assay that resulted, inspired by marine bioluminescence, became one of the most widely two - invoking the Axelrod anecdote not to diminish intelligence but to make the case that sustained curiosity why Bouvier has never had a favorite receptor 20:03 The origin of BRET - dimerization controversy, marine Michel’s scientific contributions were recognized by the attribution of many awards and distinctions As some of you may know, Michel was one of my professors at the Universite de Montreal.

Maria Waldhoer at the Medical University of Graz, Austria, and received my Ph.D. in Molecular Medicine At the height of curiosity, a seemingly naïve idea at the dinner table led to a side project by which