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  • How-Signaling-Kinetics Shapes-GPCR-Drug-Action | Dr. GPCR Ecosystem

    Clinical insights on tachyphylaxis, tolerance, and kinetic-based therapeutics. < Back How Signaling Kinetics kinetics, the temporal dynamics of receptor activation and downstream signaling, directly influence therapeutic spans tachyphylaxis mechanisms in beta-agonist therapy, tolerance development with opioid agonists, and therapeutic pharmacologists, drug discovery scientists, and translational researchers working on temporal aspects of GPCR therapeutics specializing in kinetic analysis of drug action and the application of binding and signaling kinetics to therapeutic

  • Dr. Josephine (Pina) Cardarelli | Dr. GPCR Ecosystem

    Pina Cardarelli, CSO for GPCR Therapeutics Inc., based in South Korea, has recently been named President of GPCR Therapeutics, USA, a newly incorporated Biotechnology company in the Bay Area. The company’s mission is to discover and develop highly effective cancer therapeutics by targeting heteromers She was an integral contributor to two therapeutics that are FDA approved, Yervoy and Opdivo. patents including anti-PD-1 patents, 22 EP patents, and greater than 100 global patents centered around therapeutic

  • Dr. Nicolas Gilles | Dr. GPCR Ecosystem

    He is pioneering the investigation of animal toxins acting on GPCRs, the largest therapeutic target class His strongest expertise lies in therapeutic target identification and all the steps from venom manipulations pharmacological properties of these new ligands are deemed exceptional, a lead optimization is realized and its therapeutic

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