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Results found for "Owen P. McGuinness"
Posts (147)
- Dr. Thomas P. Sakmar receives an honorary doctorate from Karolinska Institute
November 2021 "So proud and grateful to receive honorary doctorate yesterday from Karolinska Institute and celebrate with my family in Stockholm." Read more at the source #DrGPCR #GPCR #IndustryNews
- Lipid Modulation of a Class B GPCR: Elucidating the Modulatory Role of PI(4,5)P 2 Lipids
September 2022 "Phosphatidylinositol 4,5-bisphosphate (PI(4,5)P2) lipids have been shown to stabilize an active conformation of class A G-protein coupled receptors (GPCRs) through a conserved binding site, not present in class B GPCRs. For class B GPCRs, previous molecular dynamics (MD) simulation studies have shown PI(4,5)P2 interacting with the Glucagon receptor (GCGR), which constitutes an important target for diabetes and obesity therapeutics. In this work, we applied MD simulations supported by native mass spectrometry (nMS) to study lipid interactions with GCGR. We demonstrate how tail composition plays a role in modulating the binding of PI(4,5)P2 lipids to GCGR. Specifically, we find the PI(4,5)P2 lipids to have a higher affinity toward the inactive conformation of GCGR. Interestingly, we find that in contrast to class A GPCRs, PI(4,5)P2 appear to stabilize the inactive conformation of GCGR through a binding site conserved across class B GPCRs but absent in class A GPCRs. This suggests differences in the regulatory function of PI(4,5)P2 between class A and class B GPCRs." Read more at the source #DrGPCR #GPCR #IndustryNews
Other Pages (38)
- Removing the GPCR-mediated brake on exocytosis enhances insulin action, promotes adipocyte browning, and protects against diet-induced obesity
obesity Date & Time Friday, November 3rd / 2:45 PM Abstract Coming Soon Authors and Affiliations Ryan P. Ayala 5, Owen P. McGuinness 5, Sheila Collins 1,5, Heidi E.
- Dr. Thomas P. Sakmar | Dr. GPCR Ecosystem
Thomas P. Sakmar About Dr. Thomas P. Thomas P.
- GPCR Masterclass: Advanced Pharmacology & Drug Discovery | Dr. GPCR
Filter by Category Filter by Level Filter by Instructor <p class="font_8">Watch Now</p> Terry Kenakin Decoding Drug Action <p class="font_8">Watch Now</p> Terry Kenakin Seeing is Believing: Assaying Drug Action Coming Soon Terry Kenakin The Allosteric Advantage <p class="font_8">Watch Now</p> Sam Hoare CRC Super-User: Your Data Advantage <p class="font_8">Watch Now</p> Terry Kenakin The Art of Antagonism Coming Soon Sam Hoare The Agonist Effect: A Story of Bias <p class="font_8">Watch Now</p> Terry Kenakin
