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- Removing the GPCR-mediated brake on exocytosis enhances insulin action, promotes adipocyte browning, and protects against diet-induced obesity
obesity Date & Time Friday, November 3rd / 2:45 PM Abstract Coming Soon Authors and Affiliations Ryan P. Ayala 5, Owen P. McGuinness 5, Sheila Collins 1,5, Heidi E.
- Dr. Thomas P. Sakmar | Dr. GPCR Ecosystem
Thomas P. Sakmar About Dr. Thomas P. Thomas P.
- Posters | Adhesion GPCR Workshop 2024 | Dr. GPCR Ecosystem
Functional Coupling Between Extracellular and Transmembrane Regions of a Holo-Adhesion GPCR Szymon P. Functional Coupling Between Extracellular and Transmembrane Regions of a Holo-Adhesion GPCR Szymon P. affiliation: Department of Structural Biology, Genentech, South San Francisco, CA, USA" About Szymon P. Szymon P. mice displayed trends for increased anxiety-like behaviors in the elevated plus maze test and in the open
- University | Dr. GPCR Ecosystem
Weekly research, careers & event intelligence 🤝 Members-only networking, AMAs & matchmaking 💡 Support open Members grow visibility, confidence, and connections that open doors. Masterclasses cover a variety of track including but not limited to p harmacology foundations, agonists
- GPCR Courses
Anonymous The course was very practical and easily translatable to experiments that we could do in our own Weekly research, careers & event intelligence 🤝 Members-only networking, AMAs & matchmaking 💡 Support open Masterclasses cover a variety of track including but not limited to p harmacology foundations, agonists
- A well-updated profile opens doors to collaborations and exciting GPCR projects 🚀 Don’t miss out—update yours now! | Dr. GPCR Ecosystem
Home → Flash News → A well-updated profile opens doors to collaborations and exciting GPCR projects 🚀 GPCR Profiles A well-updated profile opens doors to collaborations and exciting GPCR projects 🚀 Don’
- Session I | Adhesion GPCR Workshop 2024 | Dr. GPCR Ecosystem
ECR-mediated mechanism opens new possibilities for drugging aGPCRs. contexts will shed light on this fascinating family of receptors. " Authors & Affiliations "Kordon Szymon P.1
- Seeking to gain more knowledge on signaling bias? We’ve got the perfect opportunity for you 🚀 Registrations open until February 14th ⚠️ Last spots available for “The Practical Assessment of Signaling Bias” with Dr. Terry Kenakin ✳️Register today at https://www.ecosystem.drgpcr.com/event-details-registration/the-practical-assessment-of-signaling-bias #gpcr #drgpcr | Dr. GPCR Ecosystem
We’ve got the perfect opportunity for you 🚀 Registrations open until February 14th ⚠️ Last spots available We’ve got the perfect opportunity for you 🚀 Registrations open until February 14th ⚠️ Last spots available
- Game-changer for GPCR research! 🔬🧪 Molecular glues offer a new way to fine-tune receptor signaling, opening doors for next-gen drug discovery Subscribe to the Dr. GPCR Newsletter 📰 and get the latest GPCR News delivered to your inbox ➡️https://www.ecosystem.drgpcr.com/reviews/molecular-glues%3A-a-new-approach-to-modulating-gpcr-signaling-bias #gpcr #drgpcr | Dr. GPCR Ecosystem
🔬🧪 Molecular glues offer a new way to fine-tune receptor signaling, opening doors for next-gen drug 🔬🧪 Molecular glues offer a new way to fine-tune receptor signaling, opening doors for next-gen drug
- In case you haven’t heard, our next Dr.GPCR University course is open for registrations 🙂 Learn about "The Practical Assessment of Signaling Bias" with Dr. Terry Kenakin. 🙌 Hands-on exercises included! ✳️Only 25 spots available ➡️Enjoy a 25% discount with your Premium Membership https://www.ecosystem.drgpcr.com/event-details-registration/the-practical-assessment-of-signaling-bias #gpcr #drgpcr | Dr. GPCR Ecosystem
Home → Flash News → In case you haven’t heard, our next Dr.GPCR University course is open for registrations 24, 2025 Category GPCR University In case you haven’t heard, our next Dr.GPCR University course is open
- 📢 All 2025 Dr.GPCR Courses Are Open for Registration! Which one will you choose? 🚀 Whether you're diving into GPCR drug discovery, pharmacology, or advanced modeling, there's a course for you. 💡 Bonus: Premium Members enjoy 25% off on all courses! 🔗 Explore & register today: https://www.ecosystem.drgpcr.com/gpcr-courses #GPCR #DrGPCR #Biotech #DrugDiscovery #Pharmacology | Dr. GPCR Ecosystem
Home → Flash News → 📢 All 2025 Dr.GPCR Courses Are Open for Registration! #Pharmacology Published on March 4, 2025 Category GPCR Weekly News 📢 All 2025 Dr.GPCR Courses Are Open
- In case you haven’t heard, registrations are open for the next 4-week course “Development of GPCR Ligands as Therapeutic Drugs,” with Dr. Terry Kenakin 👏 Spots are filling up fast, run and save yours, and enjoy a 25% discount with your Premium Membership 🚀 ✳️Go to https://www.ecosystem.drgpcr.com/event-details-registration/development-of-gpcr-ligands-as-therapeutic-drugs #gpcr #drgpcr | Dr. GPCR Ecosystem
Home → Flash News → In case you haven’t heard, registrations are open for the next 4-week course “Development GPCR Courses In case you haven’t heard, registrations are open for the next 4-week course “Development
- 220 GPCRs. One platform. Endless questions. In Ep.167 of the Dr. GPCR Podcast, Tom Sakmar and Ilana Kotliar reveal a full GPCR-RAMP interaction map—powered by Luminex, dual-tagged constructs, and open science. Big win for the GPCR community. ✳️ Listen now: Ep 167 with Drs. Tom Sakmar & Ilana Kotliar #GPCRresearch #DrGPCR #GPCRpodcast #GPCRtools #OpenScience | Dr. GPCR Ecosystem
Ilana Kotliar reveal a full GPCR-RAMP interaction map—powered by Luminex, dual-tagged constructs, and open Ilana Kotliar reveal a full GPCR-RAMP interaction map—powered by Luminex, dual-tagged constructs, and open
- Did you know registrations are already open for all our 2025 Dr.GPCR University Courses? Check out what you can learn this year from the master, Dr. Terry Kenakin 😉and save your spot soon! Remember Premium Members get a 25% discount 🙌 ✳️Click here and start your next learning experience https://www.ecosystem.drgpcr.com/gpcr-courses #gpcr #drgpcr | Dr. GPCR Ecosystem
Home → Flash News → Did you know registrations are already open for all our 2025 Dr.GPCR University Courses drgpcr Published on February 18, 2025 Category GPCR Weekly News Did you know registrations are already open
- Dr. GPCR | Explore the Ecosystem for GPCR Professionals and Enthusiasts
Industry Our vision is simple: empower the GPCR field through shared knowledge, collaboration, and open Weekly research, careers & event intelligence 🤝 Members-only networking, AMAs & matchmaking 💡 Support open Industry Our vision is simple: empower the GPCR field through shared knowledge, collaboration, and open
- Sponsorship Prospectus for Adhesion GPCR Workshop 2024 | Dr. GPCR Ecosystem
Opportunity to deliver opening remarks or introduce keynote speakers. Recognition during opening and closing remarks. Complimentary exhibition booth at the event. Recognition during opening and closing remarks. Complimentary registration for 1 representative. Company logo displayed on event website.Recognition during opening and closing remarks.
- What if you could map GPCR-RAMP interactions across the entire superfamily in a single experiment? That’s precisely what Dr. Kotliar from the Sakmar lab made possible! In Ep.167 of the Dr. GPCR Podcast, we chat with Drs. Tom Sakmar and Ilana Kotliar about how their lab developed: A multiplexed Luminex assay to screen hundreds of interactions at once A 220-clone DUET-tagged GPCR library, available on Addgene An online interface to search GPCR-RAMP data and antibody validations This is open-access science at its best, built for the GPCR research community. ✳️ Listen to the episode: Ep 167 with Drs. Tom Sakmar & Ilana Kotliar #GPCRresearch #DrGPCRecosystem #GPCRdrugdiscovery #GPCRtrainingprogram #GPCRpodcast | Dr. GPCR Ecosystem
available on Addgene An online interface to search GPCR-RAMP data and antibody validations This is open-access available on Addgene An online interface to search GPCR-RAMP data and antibody validations This is open-access
- Logo Contest for Adhesion GPCR Workshop 2024 | Dr. GPCR Ecosystem
creatures from Mexican folklore AND contain adhesion GPCRs Avoid copyrighted material unless a CC BY / open-use Requirements: Resolution 300 ppi max, JPEG/TIFF/EPS/PNG/PDF formats, 5MB max Open to all adhesion GPCR
- Session V | Adhesion GPCR Workshop 2024 | Dr. GPCR Ecosystem
Authors & Affiliations "Garbett, Krassimira, Kordon, Szymon P., Shearer, Tanner, Sando, Richard C.*,
- Hacking GPCRs: Tools, Tech & Drug Discovery with Tom Sakmar & Ilana Kotliar | Dr. GPCR Ecosystem
evolved into a comprehensive resource for the GPCR research community — bridging wet-lab experimentation, open-access like Emily Lorenzen catalyzed a transition from single-receptor studies to multiplexed approaches , opening These tools are fully open to academic researchers , with wide applicability beyond just RAMPs — including Driving Impact through Open Science “500+ requests have come in for these clones.” – Tom Sakmar Dr. The system is modular and adaptable, opening doors for systems biology and context-specific interaction
- About Dr. GPCR Ecosystem | Uniting the GPCR Community to Advance Drug Discovery
Our Vision A world where GPCR insights translate quickly into real‑world therapies through an open, trusted field priorities CTA: Contact us to partner Our Values Scientific Rigor — Evidence first; hype last Openness
- Exploring Career Paths in GPCR Research with Dr. Jacek Mokrosiński | Dr. GPCR Ecosystem
They also shared their career journeys, emphasizing the value of being open-minded, proactive, and embracing Jacek highlighted the importance of being open-minded and proactive, emphasizing that he learned by doing Yamina agreed with Jacek's sentiments and spoke about her own journey, expressing her happiness in discussing emphasized the importance of finding a job that aligns with one's interests and strengths and being open Networking for Professional Growth Jacek and Yamina discussed the importance of building a network and being open
- Lauren Celano | Dr. GPCR Ecosystem
Working in a lab allows scientists to gain amazing hard and soft skills, which opens the doors to several
- ama session sept 18 post 2 | Dr. GPCR Ecosystem
It’s an open vault of knowledge. 🟢 Read More → https://www.ecosystem.drgpcr.com/post/accelerating-gpcr-drug-discovery-what
- How do GRK-specific phosphorylation barcodes influence β-arrestin binding to GPCRs? New cryo-EM structures from Chen et al. (Nature, 2025) reveal that β-arrestin1 and β-arrestin2 form distinct complexes with ACKR3 depending on whether it's phosphorylated by GRK2 or GRK5, shaping arrestin conformation, complex stability, and engagement mode. Surprisingly, arrestin’s finger loop didn’t dive into the receptor core. Instead, it latched onto the micelle surface, breaking canonical expectations. Also, β-arrestin2 lacks a membrane anchor, making it more dynamic — a potential clue to its functional specialization. These findings underscore how barcode location + arrestin isoform = unique signaling outcomes. open book Read the full study: Inside Out: Mapping GPCRs from Membrane Codes to Market Moves #GPCRs #Arrestin #ACKR3 #GRKs #CryoEM #StructuralBiology #SignalingBias #Phosphorylation #DrGPCR | Dr. GPCR Ecosystem
These findings underscore how barcode location + arrestin isoform = unique signaling outcomes. open book
- University Pricing | Dr. GPCR Ecosystem
Members grow visibility, confidence, and connections that open doors. Weekly research, careers & event intelligence 🤝 Members-only networking, AMAs & matchmaking 💡 Support open
- Dr. Ralf Jockers | Dr. GPCR Ecosystem
Many MT2 variants are biased and their defects are signaling pathway-specific opening new perspectives
- Forget one receptor at a time. Go big.Ep.167 of the Dr.GPCR Podcast with Tom Sakmar & Ilana Kotliar is about scaling GPCR research with multiplexing, miniaturization, and collaboration. The tools are built. The data is free. What will you ask next? 📲 Dive in: Ep 167 with Drs. Tom Sakmar & Ilana Kotliar #GPCRtraining #GPCRresearchcommunity #DrGPCR #GPCRdata | Dr. GPCR Ecosystem
Yet that summer research placement cracked open a new reality: the thrill of asking questions no one
- Terry's Corner is Officially LIVE! 🎉 This is your new go-to for mastering drug discovery pharmacology. No fluff, just clear, on-demand insights from Terry Kenakin. Building core expertise? Master dose-response, binding, kinetics, and foundational models. Driving drug discovery? Apply pharmacology to selectivity, ADME, and strategic decision-making. An experienced drug hunter? Sharpen your edge with allosteric bias, residence time, and translational PK/PD. Learn on-demand, apply immediately: https://terrykenakin.com #DrGPCR #GPCR #pharmacology #TerrysCorner #DrugDiscovery | Dr. GPCR Ecosystem
Yet that summer research placement cracked open a new reality: the thrill of asking questions no one
- Every receptor tells a story | Dr. GPCR Ecosystem
Yet that summer research placement cracked open a new reality: the thrill of asking questions no one







