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47 items found for "Thomas P. Sakmar"
- Ep 50 with Dr. Thomas P. Sakmar
Thomas P. Sakmar About Dr. Thomas P. Sakmar Tom Sakmar is a physician-scientist and professor at Rockefeller University in New York. dynamics simulations and coarse-grain sampling approaches for membrane proteins in collaborations with Thomas Thomas P. Sakmar on the web LinkedIn ResearchGate Pubmed ORCHID Google Scholar Rockefeller University Wikipedia
- Ep 50 with Dr. Thomas P. Sakmar
Thomas P. Sakmar Tom Sakmar is a physician-scientist and professor at Rockefeller University in New York. dynamics simulations and coarse-grain sampling approaches for membrane proteins in collaborations with Thomas Thomas P. Sakmar on the web LinkedIn ResearchGate Pubmed ORCHID Google Scholar Rockefeller University Wikipedia
- 23-02 Dr GPCR Newsletter
Oliver Hartly , Bryan Roth , Thomas P. Sakmar , Graeme Milligan , Sudarshan Rajagopal , Christel Menet , Laurent Sabbagh , Niña Caculitan ,
- 23-01 Dr. GPCR Newsletter
Bryan Roth , Thomas P. Sakmar , Graeme Milligan , Sudarshan Rajagopal , Christel Menet , Laurent Sabbagh , Devki Suhktankar
- 21-09 Dr GPCR Newsletter
Thomas P. Sakmar . A special thank you to the Sakmar Lab for sponsoring this episode of the podcast.
- 21-11 Dr GPCR Newsletter
Thomas P. Sakmar receives an honorary doctorate from Karolinska Institute Positive Recommendation for Use of TAVNEOS
- 22-11 Dr GPCR Newsletter
Bryan Roth , Thomas P. Sakmar , Graeme Milligan , Sudarshan Rajagopal , Christel Menet , Laurent Sabbagh , Devki Suhktankar
- 21-08 Dr GPCR Newsletter
Thomas P. Sakmar Dr. CCR5 paracrine signaling Calcium signaling induces a partial EMT Deficiency of innate immunity against P.
- 22-12 Dr GPCR Newsletter
Bryan Roth , Thomas P. Sakmar , Graeme Milligan , Sudarshan Rajagopal , Christel Menet , Laurent Sabbagh , Devki Suhktankar
- Developing a PROTAC to Degrade the Constitutively Active Onco-GPCR in Uveal Melanoma
Thomas Sakmar’s laboratory at Rockefeller University, where she studies the signaling and degradation started her Ph.D. at the Tri-Institutional Ph.D. program in Chemical Biology, where she joined the lab of Thomas Sakmar at Rockefeller University.
- GPCR Retreat 2023 - Part II
Thomas Sakmar’s laboratory at The Rockefeller University, where she study’s the signaling and degradation started her Ph.D. at the Tri-Institutional Ph.D. program in Chemical Biology, where she joined the lab of Thomas Sakmar at The Rockefeller University.
- GPCR Retreat 2023 - Part II
Thomas Sakmar’s laboratory at The Rockefeller University, where she study’s the signaling and degradation started her Ph.D. at the Tri-Institutional Ph.D. program in Chemical Biology, where she joined the lab of Thomas Sakmar at The Rockefeller University.
- Ep 18 with Dr. Yamina Berchiche
Oprea , Thomas Sakmar , Aurelien Rizk & Yaroslav Nikolaev .
- Ep 18 with Dr. Yamina Berchiche
Oprea , Thomas Sakmar , Aurelien Rizk & Yaroslav Nikolaev .
- Increased protease-activated receptor 1 autoantibodies are associated with severe COVID-19
Kristina Sterner , Susanne Schinke , Nadja Käding , Jens Y Humrich , Otávio Cabral-Marques , Joana P Bernardes , Neha Mishra , Thomas Bahmer , Jeanette Franzenburg , Bimba F Hoyer , Andreas Glück , Martina
- The GPCR-Gαs-PKA signaling axis promotes T cell dysfunction and cancer immunotherapy failure
Meghana S Pagadala , Lauren M Clubb , Joshua Chiou , Sanju Sinha , Marin Matic , Francesco Raimondi , Thomas Rebecca Berdeaux , Dario A A Vignali , Ramiro Iglesias-Bartolome , Hannah Carter , Eytan Ruppin , Jill P
- Expression pattern and clinical significance of beta 2-adrenergic receptor in oral squamous cell carcinoma: an emerging prognostic indicator and future therapeutic target
higher in the case group as compared to the control group (positivity 40.31 ± 3.01 vs. 20.46 ± 1.93, p < 0.001; density 2.77 ± 1.17 vs. 1.28 ± 0.37, p < 0.001). mRNA level was also upregulated in patients compared to the controls (2.36 ± 1.30 vs. 1.09 ± 0.42, p < 0.001) and showed a positive correlation with immunostaining of protein in OSCC (r = 0.48, p = 0.011 differentiation (p = 0.013), clinical TNM stages (p = 0.014), and poor survival (p = 0.006) of patients
- PAXIP1-AS1 is associated with immune infiltration and predicts poor prognosis in ovarian cancer
Low PAXIP1-AS1 expression in OC was associated with age (P = 0.045), histological grade (P = 0.011), and lymphatic invasion (P = 0.004). Low PAXIP1-AS1 expression predicted a poorer overall survival (OS) (HR: 0.71; 95% CI: 0.55-0.92; P = survival (DSS) (HR: 0.67; 95% CI: 0.51-0.89; P = 0.006). PAXIP1-AS1 expression (HR: 0.711; 95% CI: 0.542-0.934; P = 0.014) was independently correlated with PFS
- Receptor autoantibodies: Associations with cardiac markers, histology, and function in human non-ischaemic heart failure
β1 AR) , M5-muscarinic (M5AR), and angiotensin II type 2 receptors (AT2R) were increased in HF (all P against α1 -adrenergic (α1 AR) and angiotensin II type 1 receptors (AT1R) were decreased in HF (all P < 0.05) and global longitudinal strain (r = -0.323, P < 0.05). In insulin-resistant HF patients, AT2R autoantibodies were decreased (r = -.240, P < 0.05), and AT1R autoantibodies were increased (r = 0.212, P < 0.05).
- [Inhibitory effect of downregulating G protein-coupled receptor class C group 5 member A expression on lipopolysaccharide-induced inflammatory response in human gingival fibroblasts]
to promote the expressions of GPRC5A compared with those of the NC group (1.00±0.01, 1.00±0.00)(all P< increase of GPRC5A at both gene and protein levels induced by LPS (1.30±0.10, 1.43±0.03) (F=208.38, P< 0.001; F=42.04, P<0.001). PTGS2 at the gene level in LPS group were highly increased compared with those in the NC group (all P< in the NC group, and siGPRC5A could effectively suppressed LPS-induced protein phosphorylation (all P<
- Ep 128 with Dr. Ilana Kotliar
Ilana Kotliar "Ilana Kotliar is a postdoctoral associate in the lab of Tom Sakmar at The Rockefeller
- Ep 128 with Dr. Ilana Kotliar
Ilana Kotliar "Ilana Kotliar is a postdoctoral associate in the lab of Tom Sakmar at The Rockefeller
- Severity of neurological long-COVID symptoms correlates with increased level of autoantibodies targeting vasoregulatory and autonomic nervous system receptors
of evaluated autoantibodes were significantly higher in Long-COVID compared to the 2 other groups (p higher number of patients with simultaneous detection of more than one autoantibody in Long-COVID group (p ARB1 and ARB2 correlated negatively CERAD Trail Marking A and B (R ≤ -0.26, p ≤ 0.043), while CHRM3 correlated positively with Chadler Fatigue Scale (R = 0.37, p = 0.0087).
- Ep 56 with Dr. Adriano Marchese
He then moved to Thomas Jefferson University in Philadelphia, PA, for his postdoctoral training in Jeff
- Molecular docking and dynamics simulation studies uncover the host-pathogen protein-protein interactions in Penaeus vannamei and Vibrio parahaemolyticus
However, Vibrio parahaemolyticus infection poses a major challenge in ensuring the success of P. vannamei conducted to identify the interaction sites and binding affinity between several immune-related proteins of P. The P. vannamei-V. parahaemolyticus protein-protein interaction of Complex 1 (Ferritin-HrpE/YscL family simulation analysis, which revealed these complexes greatly contribute to the interactions between P.
- Identification of S1PR4 as an immune modulator for favorable prognosis in HNSCC through machine learning
patients receiving CLAG-M/sorafenib at RP2D (OS: hazard ratio,0.24 [95% confidence interval, 0.07-0.82]; P = .023; EFS: hazard ratio, 0.16 [95% confidence interval, 0.05-0.53]; P = .003). Benefit was limited to patients with intermediate-risk disease (univariate analysis: P = .01 for OS; P = .02 for EFS).
- Ep 56 with Dr. Adriano Marchese
He then moved to Thomas Jefferson University in Philadelphia, PA, for his postdoctoral training in Jeff
- Respiratory infections predominate after day 100 following B-cell maturation antigen-directed CAR T-cell therapy
On multivariable analysis, hypogammaglobulinemia (hazard ratio [HR], 6.06; P = .044) and diagnosis of an early respiratory viral infection (HR, 2.95; P = .048) were independent risk factors for late respiratory Nadeem , Adam S Sperling , Noopur Raje , Nikhil Munshi , Matthew Frigault , Sara Barmettler , Sarah P