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Our guests were Maria Waldhoer , Tudor I. Oprea , Thomas Sakmar , Aurelien Rizk & Yaroslav Nikolaev .

Trabecular Identity Abhishek Kumar Singh Investigating The Role of ADGRB3 Loss of Expression in Brain Tumor Glioblastoma (GBM) is the most prevalent central nervous system tumor in LFS, with TP53 mutations detected member of the BAI1-3 subfamily of adhesion GPCRS, has been observed to have low expression in brain tumors These observations lead me to hypothesize that ADGRB3 functions as a tumor suppressor in the brain, and Standard of care for MB includes tumor resection, chemotherapy, and cranio-spinal radiation.

We showed that CD97 (ADGRE5), in particular, drives tumor growth via effects on GBM stem cell self-renewal patient-derived GBM xenografts in the brain of immunodeficient mice resulted in significant reduction of tumor Collectively, these data suggest that ADCs targeting CD97 impair tumor growth in preclinical GBM models As a clinician, he specializes in surgical treatment of brain tumors.

polyadenylation as a targetable driver of pancreatic cancer, and 2) dysregulation of the pancreatic tumor Ricky's group at UPenn to explore the GPCR side of the lab, which led to the discovery of potential tumor had a discussion about their research on GPCRs, specifically focusing on GPR68 and its role in the tumor his team's current focus on alprazolam, an anti-anxiety medication that has unexpected effects in the tumor his experiments and discoveries about GPR161 in mammary epithelial cells, the effect of alprazolam on tumors

How persistent binding alters structured tissue penetration — and why that matters for tumor targeting

antibodies for complex targets, with implications for overcoming challenges like drug resistance and tumor

High-affinity molecules can get trapped at the periphery of a tumor, never reaching the core.

protein-coupled receptors is increasingly recognized as an important immune checkpoint in the generation of anti-tumor

role of G protein-coupled receptor kinase 2 (GRK2), a known regulator of Gq-GPCR signaling in HNSCC tumor

His research interest lies in understanding the molecular basis for human tumor development and how to s research examines how genetic alterations and hypoxia induce changes in cell biology that promote tumor

Richard Vile's lab at Mayo Clinic where she aided the evaluation of tumor-specific oncolytic viruses.

High-affinity molecules can get trapped at the periphery of a tumor, never reaching the core. How persistent binding alters structured tissue penetration — and why that matters for tumor targeting