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assay and Kd= 42nM in Tag-lite®). Competition experiments of binding of fluorescent ligand CELT-335 to living HEK-293 T cells expressing W.; Wu, Y.; Zhao, S.; Shui, W.; Li, S.; Korde, A.; Laprairie, R. B.; Stahl, E. L.; Ho, J. Cell   2016 , 167  (3), 750-762.e14. https://doi.org/10.1016/j.cell.2016.10.004 . (5)         Li, X.; A Fluorescent Ligand-Binding Alternative Using Tag-Lite® Technology.

cropped region, not a patch of fluorescence — the entire pancreatic islet , 100–200 microns across, lighting The Moment GPCR Imaging Became a Turning Point Before the islet lit up, the collaboration wasn’t even A ligand-based peptide probe could, offer the consistency and surface selectivity GPCR imaging demands The islet lighting up wasn’t the pinnacle. It was the proof of concept. If JB's story resonates 🎧 Listen to part 1 of this series with Dr.

Live-cell high-content screening (HCS) offers an increasingly valuable alternative. By quantifying ligand–receptor interactions directly in intact cells, HCS allows researchers to observe Using HEK-293 cells stably expressing CB2R, fluorescent tracers such as CELT-331 can report on ligand HCS can support CB2 ligand discovery: 1. CB2 ligand characterization.

<< Back to podcast list Dr. GPCR Podcast Strategic Partners Dr. Nicolas Gilles About Dr. His strongest expertise lies in therapeutic target identification and all the steps from venom manipulations When the pharmacological properties of these new ligands are deemed exceptional, a lead optimization Nicolas Gilles on the web Google Scholar LinkedIn Dr. GPCR Enjoying the Dr. GPCR Podcast? : The Evolution of GPCR Research How GPCR Spatial Signaling Sparked a Scientific Journey Thanks for listening

Home → Flash News → Terry's Corner is Officially LIVE! TerrysCorner #DrugDiscovery Published on July 2, 2025 Category Terry's Corner Terry's Corner is Officially LIVE But what if the real opportunity lies in the chemical matter we throw at them?

Terry Kenakin in this 4-week immersive course covering ligand development & pharmacology. 🔹 What you – Renal & hepatic clearance, key pharmacokinetics ✅ PK-PD Modeling – Predicting drug behavior, non-linear Sign up today 👉 Development of GPCR Ligands as Therapeutic Drugs | Dr. Sign up today 👉 Development of GPCR Ligands as Therapeutic Drugs | Dr. But what if the real opportunity lies in the chemical matter we throw at them?