Search Results

In this podcast episode , Alessandro Nicoli shares how becoming the first PhD student in a new lab shaped Antonella Di Pizio’s lab , there was almost nothing—no team, no culture, not even proper desks. As the lab grew, so did his responsibilities: from building computational models of GPCRs to guiding Over the years you see the lab establishing, and for both of us, of course, growing.”  

His lab sits at the crossroads of structure-based modeling, computational chemistry, and drug discovery To tackle these, the lab employs molecular docking, molecular dynamics simulations, and ligand-based For Carlsson, a prediction is only valid if it survives wet-lab testing.   The “Predict, Not Explain” Ethos What sets the Carlsson lab apart is its internal rule : results must The lab has witnessed both spectacular accuracy and puzzling failures.

Maria Majellaro, the transition from lab work to leadership wasn’t meticulously planned, it was a bold “I was good in the lab… but would I be good outside of it? That was the question I had to answer.

What makes you excel in the lab can quietly sabotage your leadership in the boardroom. 👉 Scientific These instincts are critical in the lab, but they often undermine leadership when blindly applied in Startups Play by Different Rules — and Most Scientific Founders Miss That   A research lab is designed Leadership isn’t in your lab notebook; it’s in how you decide     How to Know If You're Still Leading And if your thinking is still shaped by academic norms, your startup will keep running like a lab, not

At Alkermes , Sokhom Pin wasn’t just leading GPCR programs; he was building culture from the ground up And that culture worked. The Challenge: Build a Team. Build a Lab. Build the R in R&D. empowerment , not micromanagement He hired based on attitude and team fit , not just credentials He designed lab Why Culture Matters in Drug Discovery You can’t innovate under pressure. From Lab Bench to Boardroom His work at Alkermes didn’t just improve drug screening outcomes, it redefined

It wasn’t about whose lab it was. Most labs operated like small, competing startups. Engineering Collaboration: The Monash Lab Model Traditional academic labs mirror feudal structures. At Monash, GPCR collaboration wasn’t just a cultural value — it was a deliberate strategy to build capacity Culture as Infrastructure: How Trust Was Built Collaboration at this scale doesn’t happen by chance.

Watch Episode 166 When’s the last time you argued in the lab about injecting GTPγS? Lab Culture Isn’t Just About Productivity Ben and his colleagues work hard in the lab. our best work.” – Ben Clements Mentorship Is the Engine of Science Ben chose his current postdoc lab When undergraduate students enter the lab, Ben doesn’t just teach them how to pipette, he teaches why culture

And it certainly wasn’t something a single lab could unpick with isolated tools. That mindset shaped his partnership with JB, the chemist who would eventually help his lab visualize They appeared because one lab’s bottleneck became another lab’s engineering challenge — and together, This collaboration reshaped the way Hodson’s lab studies receptor biology. The shift toward team science isn’t cultural. It’s technical.

Watch Episode #177 The Experiment That Was Never Meant to Succeed When David Hodson’s lab teamed up with Labs were competing. The idea was simple — turn signaling on or off with a flash of light. Most labs would have stopped there — archived the data, moved on, written it off as a failed bet. effects Why GPCR Imaging Tools Matter More Than Ever This tool could not have emerged from a single lab This is the part labs often underplay: scientific culture shapes scientific possibility.

Choosing the Right Lab The lab you choose plays a pivotal role in shaping your PhD journey. In my case, I was fortunate to be part of a program that allowed for lab rotations. These rotations gave me the opportunity to explore the culture of different labs, understand ongoing However, with multiple great options, choosing the right lab wasn't easy. interest in my success stood out, and after a series of insightful meetings, I decided to join her lab

And most importantly, no single lab could cover the full terrain alone . Biochemistry at Uppsala University and one of the strongest advocates for an approach that too many labs From Lone Modeler to Collaborative Architect Carlsson’s lab is built to plug directly into a larger ecosystem Closing the Trust Gap If collaboration is so effective, why do so many labs avoid it? Carlsson’s lab is a proof point : collaboration is not just a cultural preference.

for inflammatory disease treatment; growth strategies from Tectonic Therapeutics Upcoming events : Lab-in-the-Loop limitations with insights from both pharma and startup environments Read Maria Majellaro's Full Recap ➤ Lab Leadership Without Ego: A Model for R&D Success Scientific rigor doesn’t thrive in cultures defined At Alkermes, Sokhom Pin built an in vitro pharmacology group from scratch—not just a lab, but a culture accelerated outcomes and laid the cultural foundation for the next generation of biotech innovation.

Antonella Di Pizio’s lab  in Munich. Within weeks, he moved to Germany and became her first PhD student—helping build a lab from the ground From Empty Lab to GPCR Discovery Starting in an empty lab with just a shared desk, Alessandro and Antonella

Breaking the Mold Most scientists follow the usual script—graduate school, lab rotations, dissertation As a lab technician at Johns Hopkins, he was fascinated by science but also grounded in real-life responsibilities Worked BMS funded the research, salary, and even tuition UConn accepted the research done in the BMS lab

A Long-Term Obsession, Reframed Sakmar’s lab had been focused on the secretin receptor family  for decades With the help of Luminex technology and collaborators at SciLifeLab in Sweden , the lab built a multiplex These tools are already in use by labs around the world, with over 500 clone requests processed.

medication in the midst of the opioid crisis, he turned to the one place that still offered answers: the lab His new obsession led him to Johns Hopkins, where he worked in the lab of Dr. in med school, Serafini aims to follow the physician-scientist path: part-time clinical work, mostly lab-based

Explore the partnership Multiplexing GPCR Discovery - Sakmar Lab’s Toolkit Goes Public The latest podcast Their global resource is now helping labs decode GPCR biology at scale.

When he first began working in a lab, success seemed elusive: experiments often failed, and bench work While others refined lab techniques, he found himself gravitating toward structural models in his spare For Carlsson, this marked a shift in how his lab approached GPCR research. This perspective influences how his lab trains students. His lab has already begun using AlphaFold models to identify ligands for targets that lack experimental

Learning the Lab, Learning Herself During her time at the contract research organization (CRO) in Ann It was mostly just because, I need to be back in the lab.” Returning to the Opioid Questions That Mattered Now, as a PhD candidate in the Traynor and Anand labs Technical discipline is transferable—even across research cultures.

foundational lesson in Terry's Corner  cuts straight to it:   Why models are vital for translating lab

Michelle describes spending hours in the lab measuring cyclic AMP levels — without multi-channel pipettes Leadership, Luck, and the Lab The episode isn’t just about technology — it’s also about how careers are It’s a call to see your lab bench not as a constraint, but as a launchpad. 🎧  Listen to the full conversation

Watch Episode 176 She didn’t want to be in the lab. Instead of dreading lab time, she found herself chasing questions late into the night. She built on chance moments with deliberate moves—grants pursued, labs chosen, collaborations built.

His work in the lab of Dr. “There was this very interesting phenotype the lab found where, as a mouse was starting to enter what

chemistry and biology How to interpret drug behavior across tissues The truth behind those “confusing” lab

Maria Majellaro shares her journey to founding Celtarys in "From Lab to Leadership". Maria Majellaro’s path from lab research to co-founding Celtarys, as told in her recent Dr.

For Catherine, it became both—after years of uncertainty, pivots, and practical lab experience that grounded It was the first time late nights in the lab weren’t a burden but a sign of genuine engagement. makes Catherine’s work distinctive is how closely it reflects the conditions people face outside the lab

September 2022 Cell Surface Calcium-Sensing Receptor Heterodimers: Mutant Gene Dosage Affects Ca 2+ Sensing but Not G Protein Interaction "The calcium-sensing receptor is a homodimeric class C G protein-coupled receptor (GPCR) that senses extracellular Ca2+ (Ca2+o ) via a dimeric extracellular Venus flytrap (VFT) unit that activates G protein-dependent signaling via twin Cysteine-rich domains linked to transmembrane heptahelical (HH) bundles. It plays a key role in the regulation of human calcium and thus mineral metabolism. However, the nature of interactions between VFT units and HH bundles, and the impacts of heterozygous or homozygous inactivating mutations, which have implications for disorders of calcium metabolism are not yet clearly defined. Herein we generated CaSR-GABAB1 and CaSR-GABAB2 chimeras subject to GABAB -dependent endoplasmic reticulum sorting to traffic mutant heterodimers to the cell surface. Transfected HEK-293 cells were assessed for Ca2+o -stimulated Ca2+i mobilization using mutations in either the VFT domains and/or HH bundle intraloop-2 or intraloop-3. When the same mutation was present in both VFT domains of receptor dimers, analogous to homozygous neonatal severe hyperparathyroidism (NSHPT), receptor function was markedly impaired. Mutant heterodimers containing one wild-type (WT) and one mutant VFT domain, however, corresponding to heterozygous familial hypocalciuric hypercalcemia type-1 (FHH-1), supported maximal signaling with reduced Ca2+o potency. Thus two WT VFT domains were required for normal Ca2+o potency and there was a pronounced gene-dosage effect. In contrast, a single WT HH bundle was insufficient for maximal signaling and there was no functional difference between heterodimers in which the mutation was present in one or both intraloops; ie, no gene-dosage effect. Finally, we observed that the Ca2+o -stimulated CaSR operated exclusively via signaling in-trans and not via combined in-trans and in-cis signaling. We consider how receptor asymmetry may support the underlying mechanisms. © 2022 The Authors. Journal of Bone and Mineral Research published by Wiley Periodicals LLC on behalf of American Society for Bone and Mineral Research (ASBMR)." Read more at the source #DrGPCR #GPCR #IndustryNews

For my postdoctoral training, I joined one of the labs that participated in Latrophilins’ discovery, the lab of Dr. asked if I was a student or a PI, I was more proud to say that I was coming as the founder of my own lab No wonder why Mexican cuisine has obtained the coveted status of UNESCO ́s Intangible Cultural Heritage PMID: 38758649 Member Simone Prömel’s lab shows that the nematode (C. elegans) homolog of CELSR, FMI-

Eric Trinquet The Real Work Starts Before the Lab What most scientists don’t see is how long a product pH-sensitive dual response (brightness + lifetime) → Application to GPCR models with Jean-Philippe Pin’s lab Academic labs tested, challenged, and refined the tools.

is powerful, but can miss the forest for the trees The critical importance of translation —turning lab