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Maria Majellaro, the transition from lab work to leadership wasn’t meticulously planned, it was a bold “I was good in the lab… but would I be good outside of it? That was the question I had to answer.

Watch Episode 166 When’s the last time you argued in the lab about injecting GTPγS? Lab Culture Isn’t Just About Productivity Ben and his colleagues work hard in the lab. do our best work.” – Ben Clements Mentorship Is the Engine of Science Ben chose his current postdoc lab When undergraduate students enter the lab, Ben doesn’t just teach them how to pipette, he teaches why culture

Choosing the Right Lab The lab you choose plays a pivotal role in shaping your PhD journey. In my case, I was fortunate to be part of a program that allowed for lab rotations. These rotations gave me the opportunity to explore the culture of different labs, understand ongoing However, with multiple great options, choosing the right lab wasn't easy. interest in my success stood out, and after a series of insightful meetings, I decided to join her lab

A Long-Term Obsession, Reframed Sakmar’s lab had been focused on the secretin receptor family  for decades With the help of Luminex technology and collaborators at SciLifeLab in Sweden , the lab built a multiplex These tools are already in use by labs around the world, with over 500 clone requests processed.

Explore the partnership Multiplexing GPCR Discovery - Sakmar Lab’s Toolkit Goes Public The latest podcast Their global resource is now helping labs decode GPCR biology at scale.

September 2022 Cell Surface Calcium-Sensing Receptor Heterodimers: Mutant Gene Dosage Affects Ca 2+ Sensing but Not G Protein Interaction "The calcium-sensing receptor is a homodimeric class C G protein-coupled receptor (GPCR) that senses extracellular Ca2+ (Ca2+o ) via a dimeric extracellular Venus flytrap (VFT) unit that activates G protein-dependent signaling via twin Cysteine-rich domains linked to transmembrane heptahelical (HH) bundles. It plays a key role in the regulation of human calcium and thus mineral metabolism. However, the nature of interactions between VFT units and HH bundles, and the impacts of heterozygous or homozygous inactivating mutations, which have implications for disorders of calcium metabolism are not yet clearly defined. Herein we generated CaSR-GABAB1 and CaSR-GABAB2 chimeras subject to GABAB -dependent endoplasmic reticulum sorting to traffic mutant heterodimers to the cell surface. Transfected HEK-293 cells were assessed for Ca2+o -stimulated Ca2+i mobilization using mutations in either the VFT domains and/or HH bundle intraloop-2 or intraloop-3. When the same mutation was present in both VFT domains of receptor dimers, analogous to homozygous neonatal severe hyperparathyroidism (NSHPT), receptor function was markedly impaired. Mutant heterodimers containing one wild-type (WT) and one mutant VFT domain, however, corresponding to heterozygous familial hypocalciuric hypercalcemia type-1 (FHH-1), supported maximal signaling with reduced Ca2+o potency. Thus two WT VFT domains were required for normal Ca2+o potency and there was a pronounced gene-dosage effect. In contrast, a single WT HH bundle was insufficient for maximal signaling and there was no functional difference between heterodimers in which the mutation was present in one or both intraloops; ie, no gene-dosage effect. Finally, we observed that the Ca2+o -stimulated CaSR operated exclusively via signaling in-trans and not via combined in-trans and in-cis signaling. We consider how receptor asymmetry may support the underlying mechanisms. © 2022 The Authors. Journal of Bone and Mineral Research published by Wiley Periodicals LLC on behalf of American Society for Bone and Mineral Research (ASBMR)." Read more at the source #DrGPCR #GPCR #IndustryNews

Maria Majellaro shares her journey to founding Celtarys in "From Lab to Leadership". Maria Majellaro’s path from lab research to co-founding Celtarys, as told in her recent Dr.

For my postdoctoral training, I joined one of the labs that participated in Latrophilins’ discovery, the lab of Dr. asked if I was a student or a PI, I was more proud to say that I was coming as the founder of my own lab No wonder why Mexican cuisine has obtained the coveted status of UNESCO ́s Intangible Cultural Heritage PMID: 38758649 Member Simone Prömel’s lab shows that the nematode (C. elegans) homolog of CELSR, FMI-

and Finding Your Place Ben shares the moment he realized he mattered, when he was the only one in the lab

Whether supporting CROs, academic labs, or pharma teams, Celtarys engages deeply with collaborators to

Building for the Future The Sakmar lab built a system to meet that need: Dual-epitope tagged constructs

Robert Lefkowitz Lab NEW Postdoc Fellow - Dr. Robert Lefkowitz Lab Senior Research Specialist - Natural Sciences - Surgery Senior Scientist- Membrane Technologies Computational Protein Design (GPCR) Postdoctoral Fellow, Caron Lab Clinical Trial Associate

Rock your favorite design, spark conversations in the lab, and help power everything we build—one mug

Nicola Smith, Molecular Pharmacologist, lab head, and senior lecturer at UNSW Sydney.

Robert Lefkowitz Lab Postdoc Fellow - Dr. Robert Lefkowitz Lab Explore Dr. GPCR Ecosystem

Simone Promel / Promel Lab is doing on adhesion #GPCRs.

Explore Terry's Corner From Chemistry Lab to GPCR Partner – New Podcast with Celtarys Dr.

Annual Meeting IRN I-GPCRNet (October 25 - 27, 2023) GPCR Jobs NEW Postdoctoral Research Associate NEW Lab Affairs Associate Scientist - Technology Senior Research Scientist/Principal Scientist- Technology Tissue Culture Scientist/Tissue Culture Manager Postdoctoral Researcher Director - Targeted Oncology Explore Dr.

I keep an open door and you’ll find me among the team in the lab quite often. 

Robert Lefkowitz Lab Postdoc Fellow - Dr. Robert Lefkowitz Lab Senior Research Specialist - Natural Sciences - Surgery Senior Scientist- Membrane

Matthew Eddy and lab research on GPCR signaling mechanisms using NMR spectroscopy with labeled receptors Appoints Eva-Lotta Allan as Chair of its Board of Directors Novo Nordisk and Evotec collaborate to launch LAB

Morgan Healthcare Conference Isomorphic Labs Announces Strategic Multi-Target Research Collaboration Scientist Principal Investigator, In Vitro Biology Associate Scientist Postdoctoral Scholar - O’Neill Lab

Robert Lefkowitz Lab Postdoc Fellow - Dr. Robert Lefkowitz Lab Senior Research Specialist - Natural Sciences - Surgery Senior Scientist- Membrane

South Africa in early November, and an existing treatment has already shown positive results in the lab

method has several advantages: it is usually very robust, good yields, reagents are found in most chem labs

Ion Channels, and Transport Proteins (March 24 - 29, 2024) GPCR Jobs NEW Postdoctoral Fellow, Caron Lab

compliance, specific disposal methods and dedicated facilities, making them much easier to implement in any lab

Hannes Schihada and his lab team developed fluorescent analogues for real-time binding studies of orphan pyrophosphate acts as an extracellular signalling molecule to exert direct functional effects in primary cultures