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And that moment, silly as it was, says a lot about how he sees science. “Science is fun. .” – Ben Clements Mentorship Is the Engine of Science Ben chose his current postdoc lab for its people , not just the science. in science, GTPγS assay, lab culture

Watch Episode 171 Mentoring in science is more than supervising—it’s about shaping the next generation Leadership as Shared Growth For Alessandro, mentorship is not about control but about growing together network and connect with peers shaping the next wave of discovery. ________ Keyword Cloud: #Mentoring #ScienceLeadership

She found herself drawn toward the science behind the drugs, rather than their clinical application. It was here that the disciplined structure of industry science helped her re-find purpose and build confidence The Spark of Addiction Science After two years in industry, Catherine enrolled in a master’s program The most impactful science is often personal.

Greetings, Pioneers of GPCR Science!

The Invisible Obstacle   👉 Brilliant science. Stalled progress. Science isn’t the problem; scientific thinking is. prioritize progress over perfection, and turn insight into execution. ✅  Leadership is not the opposite of science

Elevate Your GPCR Science with Essential Frameworks for Precision Drug Discovery: An Insight into Advanced competitive vs non-competitive antagonism isn’t optional — it’s essential for accurate, defensible science Yamina’s Corner tackles the critical disconnect between brilliant science and operational strategy, revealing a new series, "The GPCR Precision Blueprint," which provides a systematic framework to ensure your science Bridge science and strategy:  Ensure data and decision-making align with funding and milestones.

Hello GPCR Enthusiasts, Dive into this week's exciting updates on cutting-edge GPCR research, new learning opportunities, and industry news! Don't miss out—explore, learn, and elevate your expertise today! Weekly Highlights: Congrats to: Daniel Matúš , Simone Prömel , et al., for their work on The N terminus-only (trans) function of the Adhesion GPCR Latrophilin-1 controls multiple processes in reproduction of C. elegans Alexei Sirbu , Paolo Annibale , et al., for their study on Cell swelling enhances ligand-driven β-adrenergic signaling ✨ Reserve Your seat before these fill up! Our updated course schedule is designed to fit seamlessly into your routine, offering an enriched learning experience. Every Thursday at 10 AM EST: Principles of Pharmacology I October 3, 10, 17, 24 (four sessions) Topics: Pharmacologic activity measurement, mechanisms of action, and GPCR discovery strategies. Principles of Pharmacology II October 31, November 7, 14, 21, December 5 (five sessions) (we skipped Thanksgiving, of course!) Topics: New cellular assays, real-time kinetics, and unique GPCR behaviors. 🔥 Why You Should Enroll Now: Act Fast & Save Big! The Principles of Pharmacology I & II BUNDLE is your key to mastering the field. You can embrace a  25% OFF early bird discount as a premium member . But act fast – this offer is only available for a limited time. Not a premium member yet? No problem – we offer a 5-day FREE trial! And access over 500 minutes of recorded classes in our  GPCR courses with Drs. Terry Kenakin and Sam Hoare ! Affordable & Unique Learning Experience Our budget-friendly courses offer a unique approach to mastering pharmacology. Flexible Learning Rewatch sessions anytime to reinforce your learning. Our Students Love Us! Past students rave about the content and service of our courses. Join us for an exciting discussion with Dr. Terry Kenakin as he shares insights into what you can anticipate for the upcoming courses. Don't miss this fantastic opportunity to gain valuable knowledge and prepare for the forthcoming sessions! Exclusive Deal for Scientists Residing and Working in Developing Nations If you live and work  in a developing country, please complete this form to enjoy complimentary access to Dr. Kenakin's upcoming courses. Our goal is to ensure that education is within reach for everyone! Secure your spot today and dive into the evolving world of GPCRs! GPCR Event Spotlight Discovery on Target’s 19th Annual GPCR-Based Drug Discovery Targeting G Protein-Coupled Receptors for New Therapeutic Options 📍  Boston, MA 📅 October 2 -3, 2024 Join top researchers to explore the latest in GPCR-targeted drug design, including machine learning, new biophysical techniques, and medicinal chemistry. Register today for the GPCR Drug Discovery Conference and save $200 with discount code “ DRGPCR24 ”. 11th Adhesion GPCR Workshop    📍  Mexico City 📅 October 23-25, 2024 Connect with your colleagues and immerse yourself in the most recent advancements in adhesion GPCR biology. Stay tuned for the release of the full agenda! Are you interested in boosting your brand? Contact us at Hello@DrGPCR.com  for sponsorship opportunities. Classified GPCR News  Let’s dive into the   Classified GPCR News from September 2nd to 8th, 2024 Industry News Superluminal Medicines Closes $120 Million Series A Round Domain Therapeutics has been nominated for Prix Galien USA Carterra unveils its most sensitive biosensor platform; Carterra Ultra™ ushers in a new frontier in fragment and small molecule drug discovery Is the pharma community looking hard enough before trying to engage highly challenging neurology targets? Engaging multiple sclerosis by drugging a “simple” GPCR. This technique for studying cell receptors could have sweeping implications for drug development DeepCure team is excited to welcome Justin Potnick, to our Medicinal Chemistry group Call for GPCR Papers Emerging Voices in GPCR Biology in Special Issue of Molecular Pharmacology GPCR Events, Meetings, and Webinars September 5 - 6, 2024 | 4th Transatlantic ECI GPCR Symposium September 18, 2024 | FREE Webinar - The value of GPCR cell-based assays in drug discovery NEW September 22, 2024 | Biomolecular Horizons 2024 September 30 - October 3, 2024 | 22nd Discovery on Target October 2024 | Biologics US 2024   October 2 - 4, 2024 | 9th GPCRs in Medicinal Chemistry October 17, 2024 | Unprecedented fragment-based screening using Spectral Shift for GPCRs October 23 - 25, 2024 | 11th Adhesion GPCR Workshop November 5 - 7, 2024 | 16th Annual PEGS Europe   NEW November 26 - 28, 2024 | GPCRs-Targeted Drug Discovery Summit Europe July 12 - 17, 2026 | 20th World Congress of Basic and Clinical Pharmacology GPCR Jobs HIGHLIGHT Research Associate - Professor Graeme Milligan HIGHLIGHT Postdoc in Molecular Pharmacology - The Hauser Group Senior Scientist/Staff Scientist, Computational Chemistry Postdoc in GPCR mechanosensing   Postdoctoral Position Postdoctoral research position Adhesion GPCRs The N terminus-only (trans) function of the Adhesion GPCR Latrophilin-1 controls multiple processes in reproduction of C. elegans The G protein-coupled receptor ADGRG6 maintains mouse growth plate homeostasis through IHH Signaling GPCR Activation and Signaling Illuminating GPCR trafficking Cell swelling enhances ligand-driven β-adrenergic signaling Roles of the gate loop in β-arrestin-1 conformational dynamics and phosphorylated receptor interaction Early Events in β2AR Dimer Dynamics Mediated by Activation-Related Microswitches Nuclear translocation of the membrane oxoeicosanoid/androgen receptor, OXER1: Possible mechanisms involved An engineered trafficking biosensor reveals a role for DNAJC13 in DOR downregulation GPCRs in Cardiology, Endocrinology, and Taste Role of G protein coupled receptors in acute kidney injury Ligand-Dependent and G Protein-Dependent Properties for the Sweet Taste Heterodimer, TAS1R2/1R3 GPCRs in Neuroscience GPCR-Mediated Natural Products and Compounds: Potential Therapeutic Targets for the Treatment of Neurological Disease s Activation of GPR55 alleviates neuropathic pain and chronic inflammation Developmental exposures to common environmental pollutants result in long-term Reprogramming of hypothalamic-pituitary axis in mice GPCRs in Oncology and Immunology A disturbed metabolite-GPCR axis is associated with microbial dysbiosis in IBD patients: Potential role of GPR109A in macrophages Structural and Molecular Insights into GPCR Function Insights into the structure and activation mechanism of some class B1 GPCR family members Structural basis of Frizzled 4 in recognition of Dishevelled 2 unveils mechanism of WNT signaling activation Become a Premium Member! 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Watch Episode 175 When Jens Carlsson was a PhD student, he thought collaborations slowed science down Lessons from the Collaboration Blueprint Carlsson’s approach offers lessons across the spectrum of GPCR science Science advances faster when people invest in fluency beyond their own silo . forward, and why his model of collaboration is increasingly cited as a template for how modern GPCR science early-career scientists with real-world guidance, insider knowledge, and access to leaders in the field. 🎓 Mentorship

November 2021 Read more at the source #DrGPCR #GPCR #IndustryNews

In the high-stakes world of GPCR drug discovery , breakthrough science isn't enough. You can have the most brilliant minds and cutting-edge assays, but if your science isn't continuously disconnect between the lab and the boardroom  is precisely where programs get stuck—not because of bad science This reactive approach, driven by the prevailing wisdom of "going fast" and focusing only on the science This is the critical piece that often gets lost in the "go fast" culture—the integration of science with

Drug pipelines live and die by your ability to make fast, accurate calls. One wrong assumption about how your molecule behaves in a living system can sink months of work and millions in development costs. The real challenge? GPCR signaling almost never follows a straight path. Reflex arcs, compensatory pathways, and receptor trafficking can turn your expected outcome on its head, sometimes after you’ve already committed to a clinical strategy. This session gives you the tools to anticipate those twists before they hit your program. This article is about one big idea: GPCRs don’t act in isolation—they respond to the system they’re in, often through opposing processes that you must model to get reproducible results. In this session, you’ll gain: ✅ A mental model you can trust  for predicting how GPCR ligands behave in real physiology—not just in a dish. ✅ A pattern-recognition toolkit  to spot red flags early and make course corrections before trials derail. ✅ Practical strategies  for using receptor trafficking data and system set-points to design cleaner, more predictive experiments. Why Pipeline Efficiency Starts with Physiology Drug discovery doesn’t happen in a vacuum. Every ligand you design enters a system that is already balancing opposing forces—vasoconstriction vs. vasodilation, sympathetic vs. parasympathetic tone, signal activation vs. receptor downregulation. Ignore these forces, and your “selective” agonist may deliver surprises the first time it meets a patient. This lecture challenges the habit of treating in vitro data as destiny. Instead, you’ll walk through cardiovascular reflexes, surface signaling vs. internalization, and constitutive receptor activity to show how the body bends your molecule’s effect. If your job is to move molecules confidently toward the clinic, this is a blueprint for building a more reliable evidence base—one that accounts for biology’s counterpunch. When In Vitro Lies: The Patient vs. Volunteer Gap Many programs die in Phase II, not because the molecule is “bad,” but because its profile in patients was never truly understood. A renin inhibitor that lowers blood pressure in healthy volunteers might not drop blood pressure at all in heart failure patients, because increased cardiac output cancels the expected effect. You’ll understand why this is good news, not bad data, and how it can actually prevent harmful reflex tachycardia. The bigger lesson? Context matters. This section outlines the logic required to match preclinical models to patient physiology and avoid being misled by early screens. Once you see how patient physiology flips expected outcomes, the next step is to ask, could these reflexes work in your favor? Reflexes as Drug Design Partners Not all reflexes are enemies. Some can make a mediocre drug shine. Dobutamine’s dual action on beta and alpha receptors, for example, invites reflex bradycardia that blunts its heart rate liability—making it a better inotrope than isoproterenol in heart failure. Learn how to view reflexes not just as confounders but as potential allies. The teaser question How could you design your next lead to recruit the body’s own feedback loops in your favor? Surface vs. Internalized Signaling: Same Receptor, Different Story A GPCR response isn’t always over when the receptor leaves the membrane. In this module, you’ll explore how some receptor–agonist complexes continue signaling from endosomes, creating “protected” signaling that extracellular antagonists can’t block. This insight has huge implications for how you select and rank agonists in discovery campaigns. You’ll come away asking Which of my ligands might be producing hidden signaling from inside the cell—and how can I measure it before it surprises me downstream? System-Dependent Activity and Opposing Processes Partial agonists don’t wear single labels. The same compound can look like an activator in one system and a blocker in another—depending on basal tone. Terry illustrates this with classic β-receptor partial agonists, showing how heart rate set-points under different anesthetics can flip observed pharmacology. The takeaway? When you evaluate partial agonists, enzyme inhibitors, or antagonists, you must recreate the “working system” they’ll face in vivo—otherwise you risk throwing out molecules that would have worked. Constitutive Activity: When Doing Nothing Still Does Something Some GPCRs simply refuse to stay quiet. Ghrelin receptors, for example, signal spontaneously, meaning a neutral antagonist won’t suppress appetite; it just blocks added stimulation. Get a sense of why inverse agonists may be necessary to truly shift the physiological balance. This section raises a critical design question for teams Are you sure your “antagonist” is enough—or do you need an inverse agonist to get the clinical outcome you want? Your molecule isn’t failing—your model might be too simple. Terry’s Corner exists to fix that blind spot. Subscribe today and get direct access to decades of pharmacology experience that turn complex systems into better decisions. Why Terry’s Corner Most pharmacology training freezes at equilibrium snapshots. But drug discovery isn’t static — it’s a moving target. Ligands come and go, feedback loops kick in, and what you see in vitro rarely tells the whole story. Go inside the real-world playbook. Here’s what you’ll get: Weekly expert sessions  that turn messy data into clear decisions On-demand access  to a growing library of system-level case studies Unfiltered Q&A recordings  where challenging problems get solved live Direct input opportunities  so future sessions answer your  questions Battle-tested insight  from four decades of drug discovery experience If you’re serious about derisking your pipeline, this is where you sharpen the tools that actually move molecules forward. See beyond the equilibrium. Make decisions with confidence. 🟢 40 years of expertise at your fingertips: Explore the complete library ➤ ✳️ Want to know what’s inside? Read the latest articles ➤ Stay sharp between lectures. Subscribe to The Kenakin Brief today ➤

Did you register for our next Dr. GPCR Virtual Cafe? Register today! Addgene's Dr. Joanne Kamens is our guest. If you need a plasmid for your research or you want to share your materials, this is the place to go. https://www.ecosystem.drgpcr.com/dr-gpcr-virtual-cafe/ #gpcr #drgpcr #virtualcafe #addgene

that our co-founder Margaux Duchamp has been selected as a 30 under 30 Europe Forbes ranking 2022 for science #ForbesUnder30 #ArcoScreen #sciences #EPFL" Read more at the source #DrGPCR #GPCR #IndustryNews

More than a technical overview, this is a story of curiosity, persistence, and using science to meet The Role of Mentorship and Collaboration Initially set on a career in medicine, Ajay’s plan was to pursue Throughout his career, Ajay benefited from mentors who not only guided his science, but challenged him Takeaway: Ajay Yekkirala’s story is not just about GPCR science or startup success. Ajay's career is proof that in science, the detours are often the real path forward

established her own group within the Drug Discovery Biology theme at Monash Institute of Pharmaceutical Sciences She emphasizes leadership not as titles but as creating spaces where science thrives . Not from polished plans—but from patterns of curiosity, risk-taking, and mentorship loops.

Different supervisors offer different styles of mentorship, but it’s crucial to find one who genuinely The Importance of Experimental Controls Experiments are at the heart of a PhD in the sciences, and one

Terry Kenakin to elevate your science and sharpen your decisions. Learn from a pioneer:  Hear how mentorship and team science are fueling innovation in the field and providing GPCR Premium Membership Gives You an Edge Staying at the forefront of GPCR science is not just a goal—it This isn’t just a newsletter; it's a strategic tool for your career and your science.

Michelle Halls dissects how spatial GPCR signaling shifts discovery—and how leadership, mentorship, and GPCR evolved from a grassroots effort to a global force in GPCR science—one rooted in connection, sustainability

Jens Carlsson’s path into science was anything but straightforward. Finding Science Through Serendipity Carlsson didn’t grow up with a vision of becoming a scientist. about breakthroughs like the cloning of Dolly the sheep and genetically modified foods, he saw life sciences He also underscores the importance of mentorship—not just for guidance, but for perspective. thought leaders, technical resources, and deep-dive content you won’t find anywhere else. 🔬 Fuel your science

Watch Episode 172 The Bigger Lesson Purpose-driven science works because it creates resilience. Why Purpose Matters in Science For some researchers, science is a job. For others, it’s a calling. The Moment Science Became Purpose Catherine didn’t begin her career with a clear plan to pursue a PhD That urgency, more than titles, positions, or prestige, is what sustains a lasting career in science. Catherine’s story shows that when purpose drives research, science becomes more than a job—it becomes

A GPCR program can have world-class science, top-tier talent, and millions in funding — and still fail Not because the science is wrong. Not because the people aren’t brilliant. Your program isn’t slipping because of bad science — it’s bleeding money because your systems were broken They’re hired for science, not for building operational scaffolding. Because the truth is harsh: in drug discovery, you don’t run out of science. You run out of money.

Watch Episode 170 Why We’re Here What if your own body pushed you into science? For Dr. The Value of Lived Experience in Science What makes Serafini’s trajectory so compelling isn’t just his Takeaway Science isn’t always about curiosity. Sometimes, it’s about necessity. Dr.

But at Monash Institute of Pharmaceutical Sciences, a different idea took root: what if collaboration This wasn’t just a clever idea on paper — it changed how science happened, day to day. Most GPCR discoveries aren’t blocked by science — they’re blocked by structures that make sharing hard collaborations and industry partnerships take root Today  — Model continues to produce high-impact GPCR science GPCR science thrives in complexity — meaning no single lab or company can do it alone.

Maria Majellaro shares her story of innovation and listening-driven science.   efficacy, and design smarter GPCR pharmacology screens, anchored in real-world lessons and cutting-edge science Stay curious, stay connected, because the future of GPCR science is being written pathway by pathway.

Most teams don’t stall because the science is weak. They stall because the data becomes a mess. The Hidden Cost of Good Science Without Systems I’ve seen this pattern again and again—across academia Strong science. Promising data. But no systems to turn it into momentum. drgpcr/yamina-corner Or explore how we can work together: 👉 Yamina.org 🔑 Key Takeaways ✅ Even strong science

It began in Bari, Italy, with a love for science nurtured by her father and fueled by childhood cartoons without the delays and frustrations that often plague probe development. 👉 Learn more about Celtarys’ science-driven

GPCR, it was with a simple goal: to connect people who shared a passion for GPCR science and discovery These resources continue to bring the latest in GPCR science and industry updates to thousands across GPCR Foundry  — our R&D and biotech hub designed to bridge GPCR science with execution. The Dr. GPCR Foundry: Science Meets Execution The Foundry is where we bring together biotech innovators, Venture the podcast and blog to our Premium ecosystem and Foundry initiatives, our mission is to advance GPCR science

Scroll down for the science, the strategy, and the sweet stuff 🍬 Dr. Wear Your Science – Dr. GPCR merch is here! Show off your receptor pride and support the mission.

signaling, and inflammation-linked GPCRs — and curated roles in computational and membrane protein science scientists Influence   the curriculum with your topic suggestions Weekly new releases  to stay ahead of the science new episodes will drop bi-weekly on Wednesday mornings  — giving you mid-week insights that connect science It’s about how Revvity turns deep science into tools that endure. Read the full story➤ Why Dr.

Scientists, investors, and CRO professionals fly in from around the world, while Boston’s own vibrant life sciences Our mission is simple: bridge science and industry  by connecting researchers, biotech, CROs, and pharma chance to be part of the conversations that will ripple far beyond Boston. ✨ GPCR Happy Hour: Where science