Molecular creativity in drug discovery
- Dr. GPCR News
- Nov 13
- 3 min read
Welcome GPCR Fans,
Most pharmacologists are trained to chase targets. But what if the real opportunity lies in the chemical matter we throw at them?
That’s exactly what Terry’s Corner delivers this week: a deep dive into molecular creativity, rational design, and the overlooked role of chemistry in innovation.
Breakthroughs this week: Orphan receptor GPRC5B in neurogenesis; Septerna’s pill-based weight-loss strategy; Atrogi’s new CEO announcement.
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Must-read publications: Emerging targets, signaling dynamics, and acid-sensing receptors in disease.
Terry’s Corner: Why Chemistry Still Rules
For decades, discovery focused on targets. But drugs aren’t just biology—they’re chemical matter. And that matter shapes everything: selectivity, safety, efficacy, and innovation.
In this new course, Dr. Terry Kenakin reveals how drug chemistry defines function, not just fit.
What You’ll Learn on molecular creativity in drug discovery:
• Why Nature Was First: From opium to antibiotics, nature’s molecules still outperform many designed compounds.
• The Power of Structure: How privileged scaffolds and rational design open the door to dual activity and precision.
• Cheminformatics to Biologics: GPCR-focused chemical design is evolving—fast. Learn what’s next.
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Dr. GPCR Podcast: Leadership, Impact, and GPCR Signaling with Dr. Michelle Halls
This episode goes beyond the bench. Dr. Michelle Halls dissects how spatial GPCR signaling shifts discovery—and how leadership, mentorship, and vision shape translational success.
From cAMP to femtomolar ligands, she unpacks a career at the edge of precision signaling.
Key Insights:
• Receptor Localization Matters: Protein complexes pre-assemble at membranes, altering how ligands trigger responses.
• Assay Development Gets Real: Fluorescent tools and real-world biology don’t always match. She explains why.
• Training Builds Innovation: Her lab model at Monash is shaping the next generation of GPCR scientists.
A Note From Yamina: Building the Next Chapter of Dr. GPCR
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The complete Weekly News digest, curated jobs, upcoming events, classified GPCR publications, exclusive on-demand expert frameworks, and member-only discounts.
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The pace of GPCR innovation is accelerating. Those acting on the right signals today will shape tomorrow’s breakthroughs—and avoid delays others won’t see coming.
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