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Questions about how opioids impair breathing, why xylazine complicates interventions, and how receptor-level While writing a literature review on opioid and alcohol addiction susceptibility, something shifted. This approach makes her models not just rigorous, but translational—bridging the gap between receptor She is especially interested in mu-opioid receptor signaling  and how xylazine, as an alpha-2 adrenergic That personal loss transforms complex receptor pharmacology into something immediate and human.

Bigger Picture: GPCR Science Meets Public Health At its core, Catherine Demery’s research  is about receptors and signaling pathways—how mu-opioid  and alpha-2 adrenergic receptors  interact to disrupt breathing Fentanyl acts with devastating potency at the mu-opioid receptor , while xylazine exerts sedative effects Fentanyl, through the mu-opioid receptor, blunts the brainstem’s inspiratory drive so that each breath By displacing opioids from the mu-opioid receptor, it restores breathing within minutes.

There, she chose to write a review on genetic variation in susceptibility to alcoholism and opioid addiction—a Returning to the Opioid Questions That Mattered Now, as a PhD candidate in the Traynor and Anand labs at the University of Michigan, Catherine is focused on the mechanisms of opioid-induced respiratory "I've always been really passionate and somewhat sensitive to people who struggle with opioid abuse.

journey highlights the transition from general drug development to a deep dive into G protein-coupled receptors on positive allosteric modulators (PAMs) targeting opioid receptors. from the University of Minnesota in 2022, studying the pharmacokinetics and pharmacodynamics of NMDA receptor focuses on determining the mechanisms of action of a series of positive allosteric modulators of the mu-opioid receptor.

Fast, clear, live-cell receptor trafficking detection. This technology supports robust analysis even at low endogenous receptor expression levels. Internalization into acidic compartments = signal activation: Upon receptor-mediated endocytosis, the View Product pHSense Eu SNAP Labeling Reagent Can be used to label receptors and membrane proteins carrying All four formats are validated in well-established models like GLP1R and Mu opioid receptor (MOR), and

Committee Sponsors GPCR Retreat Program < Back to schedule Regulation and role of mitochondria delta opioid receptors Date & Time Friday, November 3rd / 10:40 AM Abstract Coming Soon About Louis Gendron "Dr Louis pharmacology and has published seminal papers where he used various approaches to describe the role of opioid receptors in pain and anagesia as well as to study the mechanisms involved in the cellular trafficking of the delta opioid receptor.