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Questions about how opioids impair breathing, why xylazine complicates interventions, and how receptor-level While writing a literature review on opioid and alcohol addiction susceptibility, something shifted. This approach makes her models not just rigorous, but translational—bridging the gap between receptor She is especially interested in mu-opioid receptor signaling  and how xylazine, as an alpha-2 adrenergic That personal loss transforms complex receptor pharmacology into something immediate and human.

Bigger Picture: GPCR Science Meets Public Health At its core, Catherine Demery’s research  is about receptors and signaling pathways—how mu-opioid  and alpha-2 adrenergic receptors  interact to disrupt breathing Fentanyl acts with devastating potency at the mu-opioid receptor , while xylazine exerts sedative effects Fentanyl, through the mu-opioid receptor, blunts the brainstem’s inspiratory drive so that each breath By displacing opioids from the mu-opioid receptor, it restores breathing within minutes.

There, she chose to write a review on genetic variation in susceptibility to alcoholism and opioid addiction—a Returning to the Opioid Questions That Mattered Now, as a PhD candidate in the Traynor and Anand labs at the University of Michigan, Catherine is focused on the mechanisms of opioid-induced respiratory "I've always been really passionate and somewhat sensitive to people who struggle with opioid abuse.

John Streicher: Reorganizing Opioid Signaling Beyond the Receptor The dominant strategy for improving , delta, and kappa opioid receptors. drug design The current state and replication troubles of biased agonism at the mu opioid receptor Downstream In the brain, HSP90 promotes ERK activation downstream of the mu opioid receptor and is required for John Streicher 01:49 From heart failure to opioids — a path through signaling 07:49 Why the mu receptor

Amynah Pradhan on why mu opioids worsen migraine, why delta agonists may relieve it, and how chronic Receptor and the Migraine Paradox Chronic migraine sits at a peculiar crossroads in opioid pharmacology : sustained mu opioid receptor activation is a well-documented driver of medication-overuse headache, Scientific Themes of the Conversation The mu/delta asymmetry in migraine — why two receptors in the same Paul Clarck , where she studied opioid receptors.

glutamate receptors, and the calcium-sensing receptor, the molecular mechanisms governing their activation opioid receptor by Kobilka, Gnäder, Roth, and Shokat as an illustration of what pathway-selective drug A decade on one receptor: the cost and the clarity it produces Fan has worked on the GABA-B receptor precision medicine 19:03 - GPCRs as drug targets: allosteric sites, biased signaling, and what the mu opioid receptor example demonstrated 23:37 - What full-length structures in multiple states still need