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After years of living with unresolved pain following surgery for a pilonidal cyst, Alex was left without This is a story about how chronic pain doesn't just shape lives — it reshapes careers. “I wasn’t able to get stronger pain meds,” he said. “So I had to understand the biology myself.” Mike Caterina on pain mechanisms in the peripheral nervous system. , pain neuroscience

Watch Episode 170 What We’re Missing in Pain Research In GPCR drug discovery, receptors typically steal Signaling (RGS proteins)  might hold some of the most untapped therapeutic opportunities, particularly in pain neuroscience. Venetia Zachariou  introduced him to the power of RGS proteins — particularly RGS4  — in modulating pain models and hints that RGS proteins could modulate pain chronification itself .

Watch Episode 170 Thinking Differently Pain research has long followed a familiar route: from molecule conventional bottom-up approach often fails to deliver therapies that truly help patients, especially in the pain patient-centric and behavior-first approach uncovered robust gene expression signatures  linked to pain Why This Approach Matters In pain research, bottom-up approaches often fail to translate. Alex Serafini makes the case for building pain research from the clinic down, not the bench up. _____

Strategy: From Personal Pain to Scientific Purpose Dr. pain research at Hopkins and later an MD-PhD at Mount Sinai. Pain became more than biology — it became a personal strategy. “Half the time, in pain, what works in vivo doesn’t translate to clinic. by AI ________ About Alex Serafini Alex was born and raised in the Bay Area and received his BS/MS Neuroscience

published seminal papers where he used various approaches to describe the role of opioid receptors in pain Dr Gendron is co-director of the FRQS-funded Quebec Pain Research Network and the Editor-in-Chief in Louis Gendron on the web Université de Sherbrooke Neurosciences Sherbrooke RQRD Pubmed Google Scholar

.” – Ben Clements His pivot into neuroscience and pharmacology during grad school at the University of “We’re enhancing the powerful pain-relieving effects of opioids while limiting respiratory depression He is particularly excited by the novel application of PAMs in chronic and neuropathic pain models , Discovering breakthrough results in neuroma pain models via a spontaneous collaboration. and mechanisms of allostery, as well as efficacy studies in mouse and rat models of acute and chronic pain