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GPCR Functional ‘Volume Control’ in Cell Systems

Cover of the Eurofins DiscoverX white paper GPCR Functional Volume Control in Cell Systems

Is it your compound, or your assay?

The same GPCR ligand can behave like a full agonist, a partial agonist or show no agonism at all, depending on receptor density and assay sensitivity. This 16-page Eurofins DiscoverX white paper shows how to use that ‘volume control’ to reveal a compound’s true profile.

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Inside the white paper:

âž” How receptor density shapes what you measure

âž” Inducible cell lines for receptor density modulation

âž” Hidden efficacy, inverse agonism and PAM-agonism

âž” Models that predict compound effects in vivo

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